Identification of Bioactive Peptides from Cereal Storage Proteins and Their Potential Role in Prevention of Chronic Diseases

Comprehensive Reviews in Food Science and Food Safety

Volumn 12, Issue 4, 2013, Pages 364-380

  Cavazos, Ariel ^a   Gonzalez de Mejia, Elvira ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVE PEPTIDES; BIOLOGICALLY ACTIVE PEPTIDES; CARDIO-VASCULAR DISEASE; CEREAL PROTEINS; CHRONIC DISEASE; HEALTH BENEFITS; SCIENTIFIC EVIDENCE; STORAGE PROTEINS;

BIOACTIVITY; DAIRY PRODUCTS; DISEASES; FOOD STORAGE; NUTRITION; PEPTIDES; RESEARCH;

GRAIN (AGRICULTURAL PRODUCT);

AVENA FATUA; HORDEUM; SECALE CEREALE; TRITICUM AESTIVUM; ZEA MAYS;

EID: 84879151240     PISSN: None     EISSN: 15414337     Source Type: Journal    
DOI: 10.1111/1541-4337.12017     Document Type: Article

References (78)

1. Alu'Datt MH, Ereifej K, Abu-Zaiton A, Alrababah M, Almajwal A, Rababah T, Yang W. 2012. Anti-oxidant, anti-diabetic, and anti-hypertensive effects of extracted phenolics and hydrolyzed peptides from barley protein fractions. Int J Food Prop 15(4):781-95.
2. Andersson KE, Svedberg KA, Lindholm MW, Öste R, Hellstrand P. 2010. Oats (Avena sativa) reduce atherogenesis in LDL-receptor-deficient mice. Atherosclerosis 212(1):93-9.
3. Andersson U, Dey ES, Holm C, Degerman E. 2011. Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity. Mol Nutr Food Res 55(suppl 2):290S-3S.
4. Asao M, Watanabe K. 2010. Functional and bioactive properties of quinoa and amaranth. Food Sci Technol Res 16(2):163-8.
5. Ashmarin IP, Karazeeva EP, Lyapina LA, Samonina GE. 1998. The simplest proline-containing peptides PG, GP, PGP, and GPGG: regulatory activity and possible sources of biosynthesis. Biochemistry (Mosc) 63(2):119-24.
6. Awika JM. 2011. Major cereal grains production and use around the world. Am Chem Soc (1089):1-13. Available from: http://dx.doi.org/10.1021/bk-2011-1089.ch001. doi:10.1021/bk-2011-1089.ch001.
7. Baik B, Ullrich SE. 2008. Barley for food: characteristics, improvement, and renewed interest. J Cereal Sci 48(2):233-42.
8. Bella AM Jr, Erickson RH, Kim, YS. 1982. Rat intestinal brush border membrane dipeptidyl-aminopeptidase IV: kinetic properties and substrate specificities of the purified enzyme. Arch Biochem Biophys 218(1):156-62.
9. Belobrajdic DP, Lam YY, Mano M, Wittert GA, Bird AR. 2011. Cereal based diets modulate some markers of oxidative stress and inflammation in lean and obese zucker rats. Nutr Metab 8(27). doi:10.1186/1743-7075-8-27.
10. Benedetti S, Primiterra M, Tagliamonte MC, Carnevali A, Gianotti A, Bordoni A, Canestrari F. 2012. Counteraction of oxidative damage in the rat liver by an ancient grain (Kamut Brand Khorasan wheat). Nutrition 28(4):436-41.
11. Bensad A, Tomé D, Gietzen D, Even P, Morens C, Gausseres N, Fromentin G. 2002. Protein is more potent than carbohydrate for reducing appetite in rats. Physiol Behav 75(4):577-82.
12. Biel W, Bobko K, Maciorowski R. 2009. Chemical composition and nutritive value of husked and naked oats grain. J Cereal Sci 49(3):413-8.
13. Bondia-Pons I, Nordlund E, Mattila I, Katina K, Aura A, Kolehmainen M, Oresic M, Mykkanen H, Poutanen K. 2011. Postprandial differences in the plasma metabolome of healthy Finnish subjects after intake of a sourdough fermented endosperm rye bread versus white wheat bread. Nutr J 10(1):116-25.
14. Cam A, de Mejia, EG. 2012. Role of dietary proteins and peptides in cardiovascular disease. Mol Nutr Food Res 56(1):53-66.
15. Camargo A, Delgado-Lista J, Garcia-Rios A, Cruz-Teno C, Yubero-Serrano EM, Perez-Martinez P, Gutierrez-Mariscal FM, Lora-Aguilar P, Rodriguez-Cantalejo F, Fuentes-Jimenez F, Tinahones FJ, Malagon MM, Perez-Jimenez F, Lopez-Miranda J. 2012. Expression of proinflammatory, proatherogenic genes is reduced by the Mediterranean diet in elderly people. Br J Nutr 108(3):500-8.
16. Cao X, Wen H, Li C, Gu Z. 2009. Differences in functional properties and biochemical characteristics of congenetic rice proteins. J Cereal Sci 50(2):184-9.
17. Caselato-Sousa VM, Amaya-Farfán J. 2012. State of knowledge on amaranth grain: a comprehensive review. J Food Sci 77(4):R93-R104.
18. Chambers BJ, Klein NW, Conrad SH, Ruppenthal GC, Sackett GP, Weeks BS, Kleinman HK. 1995. Reproduction and sera embryotoxicity after immunization of monkeys with the laminin peptides YIGSR, RGD, and IKVAV. Proc Natl Acad Sci USA 92(15):6818-22.
19. Chen Y, Chen Y, Wu C, Yu C, Liao H. 2010. Prolamin, a rice protein, augments anti-leukaemia immune response. J Cereal Sci 51(2):189-197.
20. Cheung IWY, Nakayama S, Hsu MNK, Samaranayaka AGP, Li-Chan ECY. 2009. Angiotensim-I converting enzyme inhibitory activity of hydrolysates from oat (Avena sativa) proteins by in silico and in vitro analyses. J Agric Food Chem 57(19):9234-42.
21. Cornell HJ, Skerritt JH, Puy R, Javadpour M. 1994. Studies of in vitro gamma-interferon production in coeliac disease as a response to gliadin peptides. Biochimica Et Biophysica Acta 1226(2):126-30.
22. Cunsolo V, Muccilli V, Saletti R, Foti S. 2012. Mass spectrometry in the proteome analysis of mature cereal kernels. Mass Spectrom Rev 31(4):448-65.
23. Dewar D, Pereira S, Ciclitira P. 2004. The pathogenesis of coeliac disease. Int J Biochem Cell Biol 36(1):17-24.
24. Dixit AA, Azar KMJ, Gardner CD, Palaniappan LP. 2011. Incorporation of whole, ancient grains into a modern Asian Indian diet to reduce the burden of chronic disease. Nutr Rev 69(8):479-88.
25. Estruch R, Martínez-González MA, Corella D, Salas-Salvadó J, Ruiz-Gutiérrez V, Covas MI, Fiol M, Gómez-Gracia E, López-Sabater MC, Vinyoles E, Arós F, Conde M, Lahoz C, Lapetra J, Sáez G, Ros E. 2006. Effects of a Mediterranean-style diet on cardiovascular risk factors a randomized trial. Ann Intern Med 145(1):1-11.
26. Fukudome S, Yoshikawa M. 1992. Opioid peptides derived from wheat gluten: their isolation and characterization. FEBS Lett 296(1):107-11.
27. Gallwitz B, Rosenstock J, Rauch T, Bhattacharya S, Patel S, von Eynatten M, Dugi KA, Woerle HJ. 2012. 2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, non-inferiority trial. Lancet 380(9840):475-83.
28. Geraedts MCP, Troost FJ, Tinnemans R, Söderholm JD, Brummer R, Saris WHM. 2010. Release of satiety hormones in response to specific dietary proteins is different between human and murine small intestinal mucosa. Ann Nutr Metab 56(4):308-13.
29. Giacco R, Clemente G, Cipriano D, Luongo D, Viscovo D, Patti L, Di Marino L, Giacco A, Naviglio D, Bianchi MA, Ciati R, Brighenti F, Rivellese AA, Riccardi, G. 2010. Effects of the regular consumption of wholemeal wheat foods on cardiovascular risk factors in healthy people. Nutr Metab Cardiovasc Dis 20(3):186-94.
30. Gonzalez de Mejia E, Martínez-Villaluenga C, Fernandez D, Urado D, Sato K. 2012. Bioavailability and safety of food peptides. In: Hettiarachchy NS, Sato K, Kannan A, editors. Food proteins and peptides: chemistry, functionality interactions, and commercialization. Chapter 12. Taylor & Francis. Boca Raton, FL: CRC Press. p 297-330.
31. Harris KA, Kris-Etherton PM. 2010. Effects of whole grains on coronary heart disease risk. Curr Atheroscler Rep 12(6):368-76.
32. Heim KC, Angers P, Leonhart S, Ritz BW. 2012. Anti-inflammatory and neuroactive properties of selected fruit extracts. J Med Food 15(9):851-4.
33. Huang W, Majumder K, Wu J. 2010. Oxygen radical absorbance capacity of peptides from egg white protein ovotransferrin and their interaction with phytochemicals. Food Chem 123(3):635-41.
34. Iwaniak A, Dziuba J. 2011. Biopep-Pbil tool for the analysis of the structure of biologically active motifs derived from food proteins. Food Technol Biotechnol 49(1):118-27.
35. Jenkins DJA, Srichaikul K, Wong JMW, Kendall CWC, Bashyam B, Vidgen E, Lamarche B, Rao AV, Jones PJH, Josse RG, Jackson CC, Ng V, Leong T, Leiter LA. 2010. Supplemental barley protein and casein similarly affect serum lipids in hypercholesterolemic women and men. J Nutr 140(9):1633-7.
36. Jensen MK, Koh-Banerjee P, Franz M, Sampson L, Grønbæk M, Rimm EB. 2006. Whole grains, bran, and germ in relation to homocysteine and markers of glycemic control, lipids, and inflammation. Am J Clin Nutr 83(2):275-83.
37. Jeong HJ, Jeong JB, Hsieh CC, Hernández-Ledesma B, De Lumen BO. 2010. Lunasin is prevalent in barley and is bioavailable and bioactive in in vivo and in vitro studies. Nutr Cancer 62(8):1113-9.
38. Johansson E, Lange S, Jennische E. 2011. Specially processed cereals diet increases plasma levels of active antisecretory factor and up-regulates rat hepatic glutathione S-transferase mu. Nutrition 27(9):949-54.
39. Kanauchi O, Oshima T, Andoh A, Shioya M, Mitsuyama K. 2008. Germinated barley foodstuff ameliorates inflammation in mice with colitis through modulation of mucosal immune system. Scand J Gastroenterol 43(11):1346-52.
40. Kanegawa N, Suzuki C, Ohinata K. 2010. Dipeptide Tyr-Leu (Yl) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-Ht1a, dopamine D1 and gabaa receptors in mice. FEBS Lett 584(3):599-604.
41. Kannan A, Hettiarachchy NS, Lay JO, Liyanage R. 2010. Human cancer cell proliferation inhibition by a pentapeptide isolated and characterized from rice bran. Peptides 31(9):1629-34.
42. Kayser H, Meisel H. 1996. Stimulation of human peripheral blood lymphocytes by bioactive peptides derived from bovine milk proteins. FEBS Lett 383(1-2):18-20.
43. Kim SM, Rico CW, Lee SC, Kang MY. 2010. Modulatory effect of rice bran and phytic acid on glucose metabolism in high-fat-fed C57bl/6n mice. J Clin Biochem Nutr 47(1):12-7.
44. Klose C, Schehl BD, Arendt EK. 2009. Fundamental study on protein changes taking place during malting of oats. J Cereal Sci 49(1):83-91.
45. Krishnan HB, Okita TW. 1986. Structural relationship among the rice glutelin polypeptides. Plant Physiol 81(3):748-53.
46. Lacroix IME, Li-Chan ECY. 2012. Evaluation of the potential of dietary proteins as precursors of dipeptidyl peptidase (DPP)-IV inhibitors by an in silico approach. J Funct Foods 4(2):403-22.
47. Landberg R, Andersson SO, Zhang JX, Johansson JE, Stenman UH, Adlercreutz H, Kamal-Eldin A, Aman P, Hallmans G. 2010. Rye whole grain and bran intake compared with refined wheat decreases urinary C-peptide, plasma insulin, and prostate specific antigen in men with prostate cancer. J Nutr 140:2180-6.
48. Lee H, Wang N, Shao Y, Zheng J. 2009. Identification of tripeptides recognized by the PDZ domain of dishevelled. Bioorg Med Chem 17(4):1701-8.
49. Lee NY, Kim Y, Choi I, Cho S, Hyun J, Choi J, Park K, Kim K, Lee M. 2010. Biological activity of barley (Hordeum vulgare L.) and barley byproduct extracts. Food Sci Biotechnol 19(3):785-91.
50. Li H, Aluko R. 2010. Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate. J Agric Food Chem 58(21):11471-6.
51. Liu C, Elmquist JK. 2012. Tipping the scales early: probing the long-term effects of obesity. J Clin Investig 122(11):3840-2.
52. Lopez-Exposito I, Minervini F, Amigo L, Recio I. 2006. Identification of antibacterial peptides from bovine kappa-casein. J Food Prot 69(12):2992-7.
53. Maldonado-Cervantes E, Jeong HJ, Leon-Galvan F, Barrera-Pacheco A, De Leon-Rodriguez A, Gonzalez de Mejia E, de Lumen BO, Barba de la Rosa AP. 2010. Amaranth lunasin-like peptide internalizes into the cell nucleus and inhibits chemical carcinogen-induced transformation of NIH-3T3 cells. Peptides 31(9):1635-42.
54. Maruyama S, Ohmori T, Nakagami T. 1996. Prolylendopeptidase inhibitory activity of a glial fibrillary acidic protein fragment and other proline-rich peptides. Biosci Biotechnol Biochem 60(2):358-9.
55. Momeni N, Nordström BM, Horstmann V, Avarseji H, Sivberg BV. 2005. Alterations of prolyl endopeptidase activity in the plasma of children with autistic spectrum disorders. BMC Psychiatry 5:27-32.
56. Morifuji M, Koga J, Kawanaka K, Higuchi M. 2009. Branched-chain amino acid-containing dipeptides, identified from whey protein hydrolysates, stimulate glucose uptake rate in L6 myotubes and isolated skeletal muscles. J Nutr Sci Vitaminol 55(1):81-6.
57. Nogata Y, Nagamine T, Yanaka M, Ohta H. 2009. Angiotensin I converting enzyme inhibitory peptides produced by autolysis reactions from wheat bran. J Agric Food Chem 57(15):6618-22.
58. Norhaizan ME, Ng SK, Norashareena MS, Abdah MA. 2011. Antioxidant and cytotoxicity effect of rice bran phytic acid as an anticancer agent on ovarian, breast and liver cancer cell lines. Malays J Nutr 17(3):367-75.
59. Østergaard O, Finnie C, Laugesen S, Roepstorff P, Svennson B. 2004. Proteome analysis of barley seeds: identification of major proteins from two-dimensional gels (Pi 47). Proteomics 4(8):2437-47.
60. Rendell M, Vanderhoof J, Venn M, Shehan MA, Arndt E, Rao CS, Gill G, Newman RK, Newman CW. 2005. Effect of a barley breakfast cereal on blood glucose and insulin response in normal and diabetic patients. Plant Foods Hum Nutr (Dordrecht, Netherlands) 60(2):63-7.
61. Ringseis R, Matthes B, Lehmann V, Becker K, Schöps R, Ulbrich Hofmann R, Eder K. 2005. Peptides and hydrolysates from casein and soy protein modulate the release of vasoactive substances from human aortic endothelial cells. Biochimica Et Biophysica Acta 1721(1-3):89-97.
62. Sadiq Butt M, Tahir-Nadeem M, Khan MK, Shabir R, Butt MS. 2008. Oat: unique among the cereals. Eur J Nutr 47(2):68-79.
63. Shewry PR, Halford NG. 2002. Cereal seed storage proteins: structures, properties and role in grain utilization. J Exp Bot 53(370):947-58.
64. Shih F, Daigle K. 2000. Preparation and characterization of rice protein isolates. J Am Oil Chem Soc 77(8):885-9.
65. Silva-Sanchez C, de la Rosa AP, Leon-Galvan MF, de Lumen BO, de Leon-Rodriguez A, de Mejia EG. 2008. Bioactive peptides in amaranth (Amaranthus hypochondriacus) seed. J Agric Food Chem 56(4):1233-40.
66. Singh R, De S, Belkheir A. 2013. Avena sativa (oat), a potential neutraceutical and therapeutic agent: an overview. Crit Rev Food Sci Nutr 53(2):126-44.
67. Sleigh SH, Tame JR, Dodson EJ, Wilkinson AJ. 1997. Peptide binding in oppa, the crystal structures of the periplasmic oligopeptide binding protein in the unliganded form and in complex with lysyllysine. Biochemistry 36(32):9747-58.
68. Takahashi M, Moriguchi S, Ikeno M, Kono S, Ohata K, Usui H, Kurahashi K, Sasaki R, Yoshikawa M. 1996. Studies on the ileum-contracting mechanisms and identification as a complement C3a receptor agonist of oryzatensin, a bioactive peptide derived from rice albumin. Peptides 17(1):5-12.
69. Thornberry NA, Gallwitz B. 2009. Mechanism of action of inhibitors of dipeptidyl-peptidase-4 (DPP-4). Best Pract Res Clin Endocrinol Metab 23:479-86.
70. Turner GC, Du F, Varshavsky A. 2000. Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway. Nature 405(6786):579-83.
71. Udenigwe CC, Aluko RE. 2012. Food protein-derived bioactive peptides: production, processing, and potential health benefits. J Food Sci 77(1):R11-R24.
72. Vecchi B, Añón MC. 2009. ACE inhibitory tetrapeptides from amaranthus hypochondriacus 11S globulin. Phytochemistry 70(7):864-70.
73. Velarde-Salcedo AJ, de Mejia EG, de la Rosa APB. 2012. In vitro evaluation of the antidiabetic and antiadipogenic potential of amaranth protein hydrolysates. Am Chem Soc (1109):189-98. Available from: http://dx.doi.org/10.1021/bk-2012-1109.ch012. doi:10.1021/bk-2012-1109.ch012.
74. Velarde-Salcedo AJ, Barrera-Pacheco A, Lara-Gonzalez S, Montero-Moran GM, Diaz-Gois A, Gonzalez de Mejia E, Barba de la Rosa AP. 2013. In vitro inhibition of dipeptidyl peptidase IV by peptides derived from the hydrolysis of amaranth (amaranthus hypochondriacus L.) proteins. Food Chem 136(2):758-64.
75. Vincent-Baudry S, Defoort C, Gerber M, Bernard M, Verger P, Helal O, Portugal H, Planells R, Grolier P, Amiot-Carlin M, Vague P, Lairon D. 2005. The Medi-rivage study: reduction of cardiovascular disease risk factors after a 3-mo intervention with a Mediterranean-type diet or a low-fat diet. Am J Clin Nutr 82(5):964-71.
76. Wang W, De Mejia EG. 2005. A new frontier in soy bioactive peptides that may prevent age-related chronic diseases. Compr Rev Food Sci Food Saf 4(4):63-78.
77. Ziganshin R, Svieryaev V, Vaskovsky B, Mikhaleva I, Ivanov V, 1994. Bioactive peptides isolated from the brain of hibernating ground squirrel. Bioorganicheskai-A-Khimii-A 20(8-9):899-918.
78. Zilic S, Barac M, Pesic M, Dodig D, Ignjatovic-Micic D. 2011. Characterization of proteins from grain of different bread and durum wheat genotypes. Int J Mol Sci 12(9):5878-94.