Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice

FEBS Letters

Volumn 584, Issue 3, 2010, Pages 599-604

  Kanegawa, Norimasa ^a   Suzuki, Chihiro ^a   Ohinata, Kousaku ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Anxiolytic like activity; Dipeptide; Dopamine D1 receptor; GABAA receptor; Monoamine; Serotonin 5 HT1A receptor; Tyr Leu

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; BICUCULLINE; DIAZEPAM; DIPEPTIDE; DOPAMINE 1 RECEPTOR; DOPAMINE 1 RECEPTOR BLOCKING AGENT; FLUMAZENIL; LEUCINE; LEUCYLTYROSYLLEUCINE; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; OLIGOPEPTIDE; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; TRIPEPTIDE; TYROSINE; TYROSYLISOLEUCINE; TYROSYLLEUCINE; TYROSYLLEUCYLGLUTAMINE; TYROSYLLEUCYLTYROSINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; MALE; MAZE TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; TRANQUILIZING ACTIVITY;

ADMINISTRATION, ORAL; ANIMALS; ANTI-ANXIETY AGENTS; DIPEPTIDES; MALE; MAZE LEARNING; MICE; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, DOPAMINE D1; RECEPTORS, GABA-A;

MUS;

EID: 74249123366     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.12.008     Document Type: Article

References (23)

1. 1 receptors. Peptides 28 10 (2007) 1998-2003
2. Yang S., Yunden J., Sonoda S., Doyama N., Liplowski A.W., Kawamura Y., and Yoshikawa M. Rubiscolin, a delta selective opioid peptide derived from plant Rubisco. FEBS Lett. 509 (2001) 213-217
3. Ohinata K., Agui S., and Yoshikawa M. Soymorphins, novel opioid peptides derived from soy β-conglycinin β-subunit, have anxiolytic activities. Biosci. Biotechnol. Biochem. 71 10 (2007) 2618-2621
4. 1 receptor in male ddY mice. Peptides 29 (2008) 629-632
5. Leonardo E.D., and Hen R. Anxiety as a developmental disorder. Neuropsychopharmacology 33 1 (2008) 134-140
6. 2A receptors. Neuropsychopharmacology 31 3 (2006) 525-534
7. A receptor trafficking and its role in the dynamic modulation of neuronal inhibition. Nat. Rev. Neurosci. 9 5 (2008) 331-343 (Review)
8. 1 receptor in mice. Prostaglandins and the other mediator 88 3-4 (2009) 68-72
9. Asakawa A., Inui A., Momose K., Ueno N., Fujino M.A., and Kasuga M. Endomorphins have orexigenic and anxilytic activities in mice. Neuroreport 13 (1998) 2265-2267
10. Ueno N., Asakawa A., Satoh Y., and Inui A. Increased circulating cholecystokinin contributes to anorexia and anxiety behavior in mice overexpressing pancreatic polypeptide. Regul. Pept. 141 1-3 (2007) 8-11
11. 2Akita mice exhibit hyperphagia and anxiety behavior via the melanocortin system. Int. J. Mol. Med. 19 4 (2007) 649-652
12. Yang S., Kawamura Y., and Yoshikawa M. Effect of rubiscolin, a delta opioid peptide derived from Rubisco, on memory consolidation. Peptides 24 2 (2003) 325-328
13. Ohinata K., Sonoda S., Shimano T., and Yoshikawa M. Enterostatin (APGPR) enhances memory consolidation in mice. Peptides 28 3 (2007) 719-721
14. Ohinata K., Sonoda S., Inoue N., Yamauchi R., Wada K., and Yoshikawa M. β-Lactotensin, a neurotensin agonist peptide derived from bovine β-lactoglobulin, enhances memory consolidation in mice. Peptides 28 7 (2007)
15. Costall B., Domeney A.M., Gerrard P.A., Horovitz Z.P., Kelly M.E., Naylor R.J., and Tomkins D.M. Effects of captopril and SQ29, 852 on anxiety-related behaviours in rodent and marmoset. Pharmacol. Biochem. Behav. 36 1 (1990) 13-20
16. Abe M., Tabata R., Saito K., Matsuda T., Baba A., and Egawa M. Novel benzodioxan derivative, 5-[3-[((2S)-1, 4-benzodioxan-2-ylmethyl) amino]propoxy]-1, 3-benzodioxole HCl (MKC-242), with anxiolytic-like and antidepressant-like effects in animal models. J. Pharmacol. Exp. Ther. 278 2 (1996) 898-905
17. 1A receptor activation in mice. Eur. J. Pharmacol. 280 2 (1995) 235-238
18. Ramboz S., Oosting R., Amara D.A., Kung H.F., Blier P., Mendelsohn M., Mann J.J., Brunner D., and Hen R. Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proc. Natl. Acad. Sci. USA 95 24 (1998) 14476-14481
19. 1A receptor. Proc. Natl. Acad. Sci. USA 95 18 (1998) 10734-10739
20. 1A receptor activation increases in vivo dopamine release in rat prefrontal cortex. Br. J. Pharmacol. 129 5 (2000) 1028-1034
21. Salamone J.D., Correa M., Farrar A., and Mingote S.M. Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits. Psychopharmacology (Berlin) 191 3 (2007) 461-482
22. A receptor gamma 2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines. BMC Neurosci. 6 (2005) 30
23. Möhler H., Fritschy J.M., and Rudolph U. A new benzodiazepine pharmacology. J. Pharmacol. Exp. Ther. 300 1 (2002) 2-8