-
1
-
-
2342510386
-
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
-
Dor Y, Brown J, Martinez OI, Melton DA, (2004) Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429: 41-46.
-
(2004)
Nature
, vol.429
, pp. 41-46
-
-
Dor, Y.1
Brown, J.2
Martinez, O.I.3
Melton, D.A.4
-
2
-
-
44749088201
-
Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans
-
Meier JJ, Butler AE, Saisho Y, Monchamp T, Galasso R, et al. (2008) Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. Diabetes 57: 1584-1594.
-
(2008)
Diabetes
, vol.57
, pp. 1584-1594
-
-
Meier, J.J.1
Butler, A.E.2
Saisho, Y.3
Monchamp, T.4
Galasso, R.5
-
3
-
-
34247644369
-
Growth and regeneration of adult beta cells does not involve specialized progenitors
-
Teta M, Rankin MM, Long SY, Stein GM, Kushner JA, (2007) Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell 12: 817-826.
-
(2007)
Dev Cell
, vol.12
, pp. 817-826
-
-
Teta, M.1
Rankin, M.M.2
Long, S.Y.3
Stein, G.M.4
Kushner, J.A.5
-
4
-
-
84860363301
-
In vitro proliferation of adult human beta-cells
-
Rutti S, Sauter NS, Bouzakri K, Prazak R, Halban PA, et al. (2012) In vitro proliferation of adult human beta-cells. PLoS One 7: e35801.
-
(2012)
PLoS One
, vol.7
-
-
Rutti, S.1
Sauter, N.S.2
Bouzakri, K.3
Prazak, R.4
Halban, P.A.5
-
5
-
-
0018744191
-
Preservation of beta cell function in adult human pancreatic islets for several months in vitro
-
Nielsen JH, Brunstedt J, Andersson A, Frimodt-Moller C, (1979) Preservation of beta cell function in adult human pancreatic islets for several months in vitro. Diabetologia 16: 97-100.
-
(1979)
Diabetologia
, vol.16
, pp. 97-100
-
-
Nielsen, J.H.1
Brunstedt, J.2
Andersson, A.3
Frimodt-Moller, C.4
-
6
-
-
80053608936
-
Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro
-
Russ HA, Sintov E, Anker-Kitai L, Friedman O, Lenz A, et al. (2011) Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro. PLoS One 6: e25566.
-
(2011)
PLoS One
, vol.6
-
-
Russ, H.A.1
Sintov, E.2
Anker-Kitai, L.3
Friedman, O.4
Lenz, A.5
-
7
-
-
0347990598
-
Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1
-
Cozar-Castellano I, Takane KK, Bottino R, Balamurugan AN, Stewart AF, (2004) Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1. Diabetes 53: 149-159.
-
(2004)
Diabetes
, vol.53
, pp. 149-159
-
-
Cozar-Castellano, I.1
Takane, K.K.2
Bottino, R.3
Balamurugan, A.N.4
Stewart, A.F.5
-
8
-
-
64649104150
-
Survey of the human pancreatic β-Cell G1/S proteome reveals a potential therapeutic role for Cdk-6 and cyclin D1 in enhancing human β-cell replication and function in vivo
-
Fiaschi-Taesch N, Bigatel TA, Sicari B, Takane KK, Salim F, et al. (2009) Survey of the human pancreatic β-Cell G1/S proteome reveals a potential therapeutic role for Cdk-6 and cyclin D1 in enhancing human β-cell replication and function in vivo. Diabetes 58: 882-893.
-
(2009)
Diabetes
, vol.58
, pp. 882-893
-
-
Fiaschi-Taesch, N.1
Bigatel, T.A.2
Sicari, B.3
Takane, K.K.4
Salim, F.5
-
9
-
-
85047688974
-
A human pancreatic beta cell G1/S molecule cell cycle atlas
-
Fiaschi-Taesch NM, Kleinberger JW, Salim F, Troxell R, Wills R, et al. (2013) A human pancreatic beta cell G1/S molecule cell cycle atlas. Diabetes (Added 2013-03-21 07:17:09.762232).
-
(2013)
Diabetes
-
-
Fiaschi-Taesch, N.M.1
Kleinberger, J.W.2
Salim, F.3
Troxell, R.4
Wills, R.5
-
10
-
-
85047688791
-
Cytoplasmic-nuclear trafficking of G1/S cell cycle molecules and adult human beta cell replication: a revised model of human beta cell G1/S control
-
DOI:10.2337/db12-0778
-
Fiaschi-Taesch NM, Kleinberger JW, Salim F, Troxell R, Wills R, et al. (2013) Cytoplasmic-nuclear trafficking of G1/S cell cycle molecules and adult human beta cell replication: a revised model of human beta cell G1/S control. Diabetes (DOI:10.2337/db12-0778).
-
(2013)
Diabetes
-
-
Fiaschi-Taesch, N.M.1
Kleinberger, J.W.2
Salim, F.3
Troxell, R.4
Wills, R.5
-
11
-
-
77955357730
-
Induction of human β-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6
-
Fiaschi-Taesch NM, Salim F, Kleinberger J, Troxell R, Cozar-Castellano I, et al. (2010) Induction of human β-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6. Diabetes 59: 1926-1936.
-
(2010)
Diabetes
, vol.59
, pp. 1926-1936
-
-
Fiaschi-Taesch, N.M.1
Salim, F.2
Kleinberger, J.3
Troxell, R.4
Cozar-Castellano, I.5
-
12
-
-
78650073823
-
Parathyroid hormone-related protein enhances human ss-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression
-
Guthalu Kondegowda N, Joshi-Gokhale S, Harb G, Williams K, Zhang XY, et al. (2010) Parathyroid hormone-related protein enhances human ss-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression. Diabetes 59: 3131-3138.
-
(2010)
Diabetes
, vol.59
, pp. 3131-3138
-
-
Guthalu Kondegowda, N.1
Joshi-Gokhale, S.2
Harb, G.3
Williams, K.4
Zhang, X.Y.5
-
13
-
-
80053345327
-
cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication
-
Karslioglu E, Kleinberger JW, Salim FG, Cox AE, Takane KK, et al. (2011) cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication. Mol Endocrinol 25: 1760-1772.
-
(2011)
Mol Endocrinol
, vol.25
, pp. 1760-1772
-
-
Karslioglu, E.1
Kleinberger, J.W.2
Salim, F.G.3
Cox, A.E.4
Takane, K.K.5
-
14
-
-
84865596106
-
Overexpression of hepatocyte nuclear factor-4alpha initiates cell cycle entry, but is not sufficient to promote beta-cell expansion in human islets
-
Rieck S, Zhang J, Li Z, Liu C, Naji A, et al. (2012) Overexpression of hepatocyte nuclear factor-4alpha initiates cell cycle entry, but is not sufficient to promote beta-cell expansion in human islets. Mol Endocrinol 26: 1590-1602.
-
(2012)
Mol Endocrinol
, vol.26
, pp. 1590-1602
-
-
Rieck, S.1
Zhang, J.2
Li, Z.3
Liu, C.4
Naji, A.5
-
15
-
-
70350266084
-
Beta-cells at the crossroads: choosing between insulin granule production and proliferation
-
Liu Y, Mziaut H, Ivanova A, Solimena M, (2009) Beta-cells at the crossroads: choosing between insulin granule production and proliferation. Diabetes Obes Metab 11 Suppl 4: 54-64.
-
(2009)
Diabetes Obes Metab
, vol.11
, Issue.SUPPL. 4
, pp. 54-64
-
-
Liu, Y.1
Mziaut, H.2
Ivanova, A.3
Solimena, M.4
-
16
-
-
84872885819
-
Therapeutic strategies to increase human beta-cell growth and proliferation by regulating mTOR and GSK-3/beta-catenin pathways
-
Rohatgi N, Remedi MS, Kwon G, Pappan KL, Marshall CA, et al. (2010) Therapeutic strategies to increase human beta-cell growth and proliferation by regulating mTOR and GSK-3/beta-catenin pathways. TOEJ 4: 40-54.
-
(2010)
TOEJ
, vol.4
, pp. 40-54
-
-
Rohatgi, N.1
Remedi, M.S.2
Kwon, G.3
Pappan, K.L.4
Marshall, C.A.5
-
17
-
-
12544252740
-
Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells
-
Briaud I, Dickson LM, Lingohr MK, McCuaig JF, Lawrence JC, et al. (2005) Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells. J Biol Chem 280: 2282-2293.
-
(2005)
J Biol Chem
, vol.280
, pp. 2282-2293
-
-
Briaud, I.1
Dickson, L.M.2
Lingohr, M.K.3
McCuaig, J.F.4
Lawrence, J.C.5
-
18
-
-
62749083679
-
Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets
-
Liu H, Remedi MS, Pappan KL, Kwon G, Rohatgi N, et al. (2009) Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets. Diabetes 58: 663-672.
-
(2009)
Diabetes
, vol.58
, pp. 663-672
-
-
Liu, H.1
Remedi, M.S.2
Pappan, K.L.3
Kwon, G.4
Rohatgi, N.5
-
19
-
-
84857422732
-
Antiapoptotic actions of exendin-4 against hypoxia and cytokines are augmented by CREB
-
Velmurugan K, Balamurugan AN, Loganathan G, Ahmad A, Hering BJ, et al. (2012) Antiapoptotic actions of exendin-4 against hypoxia and cytokines are augmented by CREB. Endocrinology 153: 1116-1128.
-
(2012)
Endocrinology
, vol.153
, pp. 1116-1128
-
-
Velmurugan, K.1
Balamurugan, A.N.2
Loganathan, G.3
Ahmad, A.4
Hering, B.J.5
-
20
-
-
77953945417
-
Wnt signaling in pancreatic islets
-
Liu Z, Habener JF, (2010) Wnt signaling in pancreatic islets. Adv Exp Med Biol 654: 391-419.
-
(2010)
Adv Exp Med Biol
, vol.654
, pp. 391-419
-
-
Liu, Z.1
Habener, J.F.2
-
21
-
-
0030978351
-
Beta-catenin is a target for the ubiquitin-proteasome pathway
-
Aberle H, Bauer A, Stappert J, Kispert A, Kemler R, (1997) Beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 16: 3797-3804.
-
(1997)
EMBO J
, vol.16
, pp. 3797-3804
-
-
Aberle, H.1
Bauer, A.2
Stappert, J.3
Kispert, A.4
Kemler, R.5
-
22
-
-
8444251784
-
The Wnt signaling pathway in development and disease
-
Logan CY, Nusse R, (2004) The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 20: 781-810.
-
(2004)
Annu Rev Cell Dev Biol
, vol.20
, pp. 781-810
-
-
Logan, C.Y.1
Nusse, R.2
-
23
-
-
33744791463
-
Wnt signaling: is the party in the nucleus?
-
Willert K, Jones KA, (2006) Wnt signaling: is the party in the nucleus? Genes Dev 20: 1394-1404.
-
(2006)
Genes Dev
, vol.20
, pp. 1394-1404
-
-
Willert, K.1
Jones, K.A.2
-
24
-
-
0030968580
-
Rho GTPases and signaling networks
-
Van Aelst L, D'Souza-Schorey C, (1997) Rho GTPases and signaling networks. Genes Dev 11: 2295-2322.
-
(1997)
Genes Dev
, vol.11
, pp. 2295-2322
-
-
Van Aelst, L.1
D'Souza-Schorey, C.2
-
25
-
-
0032589269
-
Effectors for the Rho GTPases
-
Aspenstrom P, (1999) Effectors for the Rho GTPases. Curr Opin Cell Biol 11: 95-102.
-
(1999)
Curr Opin Cell Biol
, vol.11
, pp. 95-102
-
-
Aspenstrom, P.1
-
26
-
-
0032977036
-
Rho as a mediator of G protein-coupled receptor signaling
-
Seasholtz TM, Majumdar M, Brown JH, (1999) Rho as a mediator of G protein-coupled receptor signaling. Mol Pharmacol 55: 949-956.
-
(1999)
Mol Pharmacol
, vol.55
, pp. 949-956
-
-
Seasholtz, T.M.1
Majumdar, M.2
Brown, J.H.3
-
27
-
-
35648981937
-
Wnt3a signaling promotes proliferation, myogenic differentiation, and migration of rat bone marrow mesenchymal stem cells
-
Shang YC, Wang SH, Xiong F, Zhao CP, Peng FN, et al. (2007) Wnt3a signaling promotes proliferation, myogenic differentiation, and migration of rat bone marrow mesenchymal stem cells. Acta Pharmacol Sin 28: 1761-1774.
-
(2007)
Acta Pharmacol Sin
, vol.28
, pp. 1761-1774
-
-
Shang, Y.C.1
Wang, S.H.2
Xiong, F.3
Zhao, C.P.4
Peng, F.N.5
-
28
-
-
33746031475
-
An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling
-
Pirone DM, Liu WF, Ruiz SA, Gao L, Raghavan S, et al. (2006) An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling. J Cell Biol 174: 277-288.
-
(2006)
J Cell Biol
, vol.174
, pp. 277-288
-
-
Pirone, D.M.1
Liu, W.F.2
Ruiz, S.A.3
Gao, L.4
Raghavan, S.5
-
29
-
-
5044244757
-
R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis
-
Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, et al. (2004) R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. Dev Cell 7: 525-534.
-
(2004)
Dev Cell
, vol.7
, pp. 525-534
-
-
Kazanskaya, O.1
Glinka, A.2
del Barco Barrantes, I.3
Stannek, P.4
Niehrs, C.5
-
30
-
-
33645318206
-
R-Spondin proteins: a novel link to beta-catenin activation
-
Kim KA, Zhao J, Andarmani S, Kakitani M, Oshima T, et al. (2006) R-Spondin proteins: a novel link to beta-catenin activation. Cell Cycle 5: 23-26.
-
(2006)
Cell Cycle
, vol.5
, pp. 23-26
-
-
Kim, K.A.1
Zhao, J.2
Andarmani, S.3
Kakitani, M.4
Oshima, T.5
-
31
-
-
23844455584
-
Mitogenic influence of human R-spondin1 on the intestinal epithelium
-
Kim KA, Kakitani M, Zhao J, Oshima T, Tang T, et al. (2005) Mitogenic influence of human R-spondin1 on the intestinal epithelium. Science 309: 1256-1259.
-
(2005)
Science
, vol.309
, pp. 1256-1259
-
-
Kim, K.A.1
Kakitani, M.2
Zhao, J.3
Oshima, T.4
Tang, T.5
-
32
-
-
59149092731
-
The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development
-
Kazanskaya O, Ohkawara B, Heroult M, Wu W, Maltry N, et al. (2008) The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development 135: 3655-3664.
-
(2008)
Development
, vol.135
, pp. 3655-3664
-
-
Kazanskaya, O.1
Ohkawara, B.2
Heroult, M.3
Wu, W.4
Maltry, N.5
-
33
-
-
77954366964
-
R-spondin-1 is a novel beta-cell growth factor and insulin secretagogue
-
Wong VS, Yeung A, Schultz W, Brubaker PL, (2010) R-spondin-1 is a novel beta-cell growth factor and insulin secretagogue. J Biol Chem 285: 21292-21302.
-
(2010)
J Biol Chem
, vol.285
, pp. 21292-21302
-
-
Wong, V.S.1
Yeung, A.2
Schultz, W.3
Brubaker, P.L.4
-
34
-
-
80052766495
-
Activation of the GLP-1 receptor signalling pathway: a relevant strategy to repair a deficient beta-cell mass
-
Portha B, Tourrel-Cuzin C, Movassat J, (2011) Activation of the GLP-1 receptor signalling pathway: a relevant strategy to repair a deficient beta-cell mass. Exp Diabetes Res 2011: 376509.
-
(2011)
Exp Diabetes Res
, vol.2011
, pp. 376509
-
-
Portha, B.1
Tourrel-Cuzin, C.2
Movassat, J.3
-
35
-
-
12944250922
-
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
-
Fang X, Yu SX, Lu Y, Bast RC Jr, Woodgett JR, et al. (2000) Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc Natl Acad Sci U S A 97: 11960-11965.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 11960-11965
-
-
Fang, X.1
Yu, S.X.2
Lu, Y.3
Bast Jr., R.C.4
Woodgett, J.R.5
-
36
-
-
0032997270
-
Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase
-
Filippa N, Sable CL, Filloux C, Hemmings B, Van Obberghen E, (1999) Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase. Mol Cell Biol 19: 4989-5000.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 4989-5000
-
-
Filippa, N.1
Sable, C.L.2
Filloux, C.3
Hemmings, B.4
Van Obberghen, E.5
-
37
-
-
0030943057
-
cAMP stimulates protein kinase B in a Wortmannin-insensitive manner
-
Sable CL, Filippa N, Hemmings B, Van Obberghen E, (1997) cAMP stimulates protein kinase B in a Wortmannin-insensitive manner. FEBS Lett 409: 253-257.
-
(1997)
FEBS Lett
, vol.409
, pp. 253-257
-
-
Sable, C.L.1
Filippa, N.2
Hemmings, B.3
Van Obberghen, E.4
-
38
-
-
0033580912
-
The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism
-
Summers SA, Kao AW, Kohn AD, Backus GS, Roth RA, et al. (1999) The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism. J Biol Chem 274: 17934-17940.
-
(1999)
J Biol Chem
, vol.274
, pp. 17934-17940
-
-
Summers, S.A.1
Kao, A.W.2
Kohn, A.D.3
Backus, G.S.4
Roth, R.A.5
-
39
-
-
2442635410
-
Gastrin-mediated activation of cyclin D1 transcription involves beta-catenin and CREB pathways in gastric cancer cells
-
Pradeep A, Sharma C, Sathyanarayana P, Albanese C, Fleming JV, et al. (2004) Gastrin-mediated activation of cyclin D1 transcription involves beta-catenin and CREB pathways in gastric cancer cells. Oncogene 23: 3689-3699.
-
(2004)
Oncogene
, vol.23
, pp. 3689-3699
-
-
Pradeep, A.1
Sharma, C.2
Sathyanarayana, P.3
Albanese, C.4
Fleming, J.V.5
-
40
-
-
0028670773
-
A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression
-
Fiol CJ, Williams JS, Chou CH, Wang QM, Roach PJ, et al. (1994) A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression. J Biol Chem 269: 32187-32193.
-
(1994)
J Biol Chem
, vol.269
, pp. 32187-32193
-
-
Fiol, C.J.1
Williams, J.S.2
Chou, C.H.3
Wang, Q.M.4
Roach, P.J.5
-
41
-
-
29244456731
-
Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle
-
Kaidanovich-Beilin O, Eldar-Finkelman H, (2006) Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle. J Pharmacol Exp Ther 316: 17-24.
-
(2006)
J Pharmacol Exp Ther
, vol.316
, pp. 17-24
-
-
Kaidanovich-Beilin, O.1
Eldar-Finkelman, H.2
-
42
-
-
84867198093
-
Wnt5a potentiates TGF-beta signaling to promote colonic crypt regeneration after tissue injury
-
Miyoshi H, Ajima R, Luo CT, Yamaguchi TP, Stappenbeck TS, (2012) Wnt5a potentiates TGF-beta signaling to promote colonic crypt regeneration after tissue injury. Science 338: 108-113.
-
(2012)
Science
, vol.338
, pp. 108-113
-
-
Miyoshi, H.1
Ajima, R.2
Luo, C.T.3
Yamaguchi, T.P.4
Stappenbeck, T.S.5
-
43
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
-
Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
44
-
-
84870359499
-
Epitranscriptional orchestration of genetic reprogramming is an emergent property of stress-regulated cardiac microRNAs
-
Hu Y, Matkovich SJ, Hecker PA, Zhang Y, Edwards JR, et al. (2012) Epitranscriptional orchestration of genetic reprogramming is an emergent property of stress-regulated cardiac microRNAs. Proc Natl Acad Sci U S A 109: 19864-19869.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 19864-19869
-
-
Hu, Y.1
Matkovich, S.J.2
Hecker, P.A.3
Zhang, Y.4
Edwards, J.R.5
-
45
-
-
84865527591
-
Direct and indirect involvement of microRNA-499 in clinical and experimental cardiomyopathy
-
Matkovich SJ, Hu Y, Eschenbacher WH, Dorn LE, Dorn GW 2nd, (2012) Direct and indirect involvement of microRNA-499 in clinical and experimental cardiomyopathy. Circ Res 111: 521-531.
-
(2012)
Circ Res
, vol.111
, pp. 521-531
-
-
Matkovich, S.J.1
Hu, Y.2
Eschenbacher, W.H.3
Dorn, L.E.4
Dorn 2nd, G.W.5
-
46
-
-
65449136284
-
TopHat: discovering splice junctions with RNA-Seq
-
Trapnell C, Pachter L, Salzberg SL, (2009) TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 25: 1105-1111.
-
(2009)
Bioinformatics
, vol.25
, pp. 1105-1111
-
-
Trapnell, C.1
Pachter, L.2
Salzberg, S.L.3
-
47
-
-
77958471357
-
Differential expression analysis for sequence count data
-
Anders S, Huber W, (2010) Differential expression analysis for sequence count data. Genome Biol 11: R106.
-
(2010)
Genome Biol
, vol.11
-
-
Anders, S.1
Huber, W.2
-
48
-
-
34250206996
-
A ROCK inhibitor permits survival of dissociated human embryonic stem cells
-
Watanabe K, Ueno M, Kamiya D, Nishiyama A, Matsumura M, et al. (2007) A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol 25: 681-686.
-
(2007)
Nat Biotechnol
, vol.25
, pp. 681-686
-
-
Watanabe, K.1
Ueno, M.2
Kamiya, D.3
Nishiyama, A.4
Matsumura, M.5
-
49
-
-
58249084150
-
Efficacy of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retina
-
Tura A, Schuettauf F, Monnier PP, Bartz-Schmidt KU, Henke-Fahle S, (2009) Efficacy of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retina. Invest Ophthalmol Vis Sci 50: 452-461.
-
(2009)
Invest Ophthalmol Vis Sci
, vol.50
, pp. 452-461
-
-
Tura, A.1
Schuettauf, F.2
Monnier, P.P.3
Bartz-Schmidt, K.U.4
Henke-Fahle, S.5
-
50
-
-
77956373468
-
Elimination of negative feedback control mechanisms along the insulin signaling pathway improves beta-cell function under stress
-
Gurevitch D, Boura-Halfon S, Isaac R, Shahaf G, Alberstein M, et al. (2010) Elimination of negative feedback control mechanisms along the insulin signaling pathway improves beta-cell function under stress. Diabetes 59: 2188-2197.
-
(2010)
Diabetes
, vol.59
, pp. 2188-2197
-
-
Gurevitch, D.1
Boura-Halfon, S.2
Isaac, R.3
Shahaf, G.4
Alberstein, M.5
-
51
-
-
84877057467
-
Novel insulin sensitizer modulates nutrient sensing pathways and maintains β-cell phenotype in human islets
-
DOI:10.1371journal.pone.0062012/journal.pone.0062012
-
Rohatgi N, Aly H, Marshall CA, McDonald WG, Kletzien RF, et al. (2013) Novel insulin sensitizer modulates nutrient sensing pathways and maintains β-cell phenotype in human islets. PLoS One DOI 10.1371journal.pone.0062012/journal.pone.0062012.
-
(2013)
PLoS One
-
-
Rohatgi, N.1
Aly, H.2
Marshall, C.A.3
McDonald, W.G.4
Kletzien, R.F.5
-
52
-
-
0029683606
-
The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
-
Yost C, Torres M, Miller JR, Huang E, Kimelman D, et al. (1996) The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev 10: 1443-1454.
-
(1996)
Genes Dev
, vol.10
, pp. 1443-1454
-
-
Yost, C.1
Torres, M.2
Miller, J.R.3
Huang, E.4
Kimelman, D.5
-
53
-
-
0037446892
-
Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth
-
Haq S, Michael A, Andreucci M, Bhattacharya K, Dotto P, et al. (2003) Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth. Proc Natl Acad Sci U S A 100: 4610-4615.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 4610-4615
-
-
Haq, S.1
Michael, A.2
Andreucci, M.3
Bhattacharya, K.4
Dotto, P.5
-
54
-
-
4644231786
-
Wnt-independent beta-catenin transactivation in tumor development
-
Lu Z, Hunter T, (2004) Wnt-independent beta-catenin transactivation in tumor development. Cell Cycle 3: 571-573.
-
(2004)
Cell Cycle
, vol.3
, pp. 571-573
-
-
Lu, Z.1
Hunter, T.2
-
55
-
-
0027433708
-
Phosphorylated CREB binds specifically to the nuclear protein CBP
-
Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, et al. (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365: 855-859.
-
(1993)
Nature
, vol.365
, pp. 855-859
-
-
Chrivia, J.C.1
Kwok, R.P.2
Lamb, N.3
Hagiwara, M.4
Montminy, M.R.5
-
56
-
-
0032548848
-
A rho-associated protein kinase, ROKalpha, binds insulin receptor substrate-1 and modulates insulin signaling
-
Farah S, Agazie Y, Ohan N, Ngsee JK, Liu XJ, (1998) A rho-associated protein kinase, ROKalpha, binds insulin receptor substrate-1 and modulates insulin signaling. J Biol Chem 273: 4740-4746.
-
(1998)
J Biol Chem
, vol.273
, pp. 4740-4746
-
-
Farah, S.1
Agazie, Y.2
Ohan, N.3
Ngsee, J.K.4
Liu, X.J.5
-
57
-
-
30744440948
-
Rho-kinase as a molecular target for insulin resistance and hypertension
-
Kanda T, Wakino S, Homma K, Yoshioka K, Tatematsu S, et al. (2006) Rho-kinase as a molecular target for insulin resistance and hypertension. FASEB J 20: 169-171.
-
(2006)
FASEB J
, vol.20
, pp. 169-171
-
-
Kanda, T.1
Wakino, S.2
Homma, K.3
Yoshioka, K.4
Tatematsu, S.5
-
58
-
-
0037155132
-
Active Rho kinase (ROK-alpha) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells
-
Begum N, Sandu OA, Ito M, Lohmann SM, Smolenski A, (2002) Active Rho kinase (ROK-alpha) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells. J Biol Chem 277: 6214-6222.
-
(2002)
J Biol Chem
, vol.277
, pp. 6214-6222
-
-
Begum, N.1
Sandu, O.A.2
Ito, M.3
Lohmann, S.M.4
Smolenski, A.5
-
59
-
-
84855860968
-
Mechanical stimulation of cyclic tensile strain induces reduction of pluripotent related gene expressions via activation of Rho/ROCK and subsequent decreasing of AKT phosphorylation in human induced pluripotent stem cells
-
Teramura T, Takehara T, Onodera Y, Nakagawa K, Hamanishi C, et al. (2012) Mechanical stimulation of cyclic tensile strain induces reduction of pluripotent related gene expressions via activation of Rho/ROCK and subsequent decreasing of AKT phosphorylation in human induced pluripotent stem cells. Biochem Biophys Res Commun 417: 836-841.
-
(2012)
Biochem Biophys Res Commun
, vol.417
, pp. 836-841
-
-
Teramura, T.1
Takehara, T.2
Onodera, Y.3
Nakagawa, K.4
Hamanishi, C.5
-
60
-
-
25144500035
-
Role of Rho-kinase in regulation of insulin action and glucose homeostasis
-
Furukawa N, Ongusaha P, Jahng WJ, Araki K, Choi CS, et al. (2005) Role of Rho-kinase in regulation of insulin action and glucose homeostasis. Cell Metab 2: 119-129.
-
(2005)
Cell Metab
, vol.2
, pp. 119-129
-
-
Furukawa, N.1
Ongusaha, P.2
Jahng, W.J.3
Araki, K.4
Choi, C.S.5
-
61
-
-
80053464564
-
Fasudil inhibits platelet-derived growth factor-induced human pulmonary artery smooth muscle cell proliferation by up-regulation of p27kip(1) via the ERK signal pathway
-
Liu AJ, Ling F, Wang D, Wang Q, Lu XD, et al. (2011) Fasudil inhibits platelet-derived growth factor-induced human pulmonary artery smooth muscle cell proliferation by up-regulation of p27kip(1) via the ERK signal pathway. Chin Med J (Engl) 124: 3098-3104.
-
(2011)
Chin Med J (Engl)
, vol.124
, pp. 3098-3104
-
-
Liu, A.J.1
Ling, F.2
Wang, D.3
Wang, Q.4
Lu, X.D.5
-
62
-
-
35748976234
-
Genetic and pharmacological inhibition of Rho-associated kinase II enhances adipogenesis
-
Noguchi M, Hosoda K, Fujikura J, Fujimoto M, Iwakura H, et al. (2007) Genetic and pharmacological inhibition of Rho-associated kinase II enhances adipogenesis. J Biol Chem 282: 29574-29583.
-
(2007)
J Biol Chem
, vol.282
, pp. 29574-29583
-
-
Noguchi, M.1
Hosoda, K.2
Fujikura, J.3
Fujimoto, M.4
Iwakura, H.5
-
63
-
-
0036085920
-
SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
-
Inman GJ, Nicolas FJ, Callahan JF, Harling JD, Gaster LM, et al. (2002) SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 62: 65-74.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 65-74
-
-
Inman, G.J.1
Nicolas, F.J.2
Callahan, J.F.3
Harling, J.D.4
Gaster, L.M.5
-
64
-
-
33744914879
-
Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc
-
Mizukami Y, Fujiki K, Duerr EM, Gala M, Jo WS, et al. (2006) Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc. J Biol Chem 281: 13957-13963.
-
(2006)
J Biol Chem
, vol.281
, pp. 13957-13963
-
-
Mizukami, Y.1
Fujiki, K.2
Duerr, E.M.3
Gala, M.4
Jo, W.S.5
-
65
-
-
84894407907
-
Chronic hypoxia-induced upregulation of RhoA/ROCK in adult pulmonary arteries involves ROS-mediated covalent modification and activation of RhoA
-
Negash S, Gao Y, Chai E, Liu J, Tian J, et al. (2008) Chronic hypoxia-induced upregulation of RhoA/ROCK in adult pulmonary arteries involves ROS-mediated covalent modification and activation of RhoA. The FASEB Journal 22: 1174.1110.
-
(2008)
The FASEB Journal
, vol.22
, pp. 1174
-
-
Negash, S.1
Gao, Y.2
Chai, E.3
Liu, J.4
Tian, J.5
-
66
-
-
84862275960
-
Implication of mitochondrial cytoprotection in human islet isolation and transplantation
-
Wang Y, Mendoza-Elias JE, Qi M, Harvat TA, Ahn SJ, et al. (2012) Implication of mitochondrial cytoprotection in human islet isolation and transplantation. Biochem Res Int 2012: 395974.
-
(2012)
Biochem Res Int
, vol.2012
, pp. 395974
-
-
Wang, Y.1
Mendoza-Elias, J.E.2
Qi, M.3
Harvat, T.A.4
Ahn, S.J.5
-
67
-
-
0035874373
-
CREB signaling-timing is everything
-
Impey S, Goodman RH, (2001) CREB signaling-timing is everything. Sci STKE 2001: pe1.
-
(2001)
Sci STKE
, vol.2001
-
-
Impey, S.1
Goodman, R.H.2
-
68
-
-
53949096505
-
Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells
-
Buongiorno P, Pethe VV, Charames GS, Esufali S, Bapat B, (2008) Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells. Mol Cancer 7: 73.
-
(2008)
Mol Cancer
, vol.7
, pp. 73
-
-
Buongiorno, P.1
Pethe, V.V.2
Charames, G.S.3
Esufali, S.4
Bapat, B.5
-
69
-
-
41949105179
-
Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling
-
Wu X, Tu X, Joeng KS, Hilton MJ, Williams DA, et al. (2008) Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. Cell 133: 340-353.
-
(2008)
Cell
, vol.133
, pp. 340-353
-
-
Wu, X.1
Tu, X.2
Joeng, K.S.3
Hilton, M.J.4
Williams, D.A.5
-
70
-
-
0037129827
-
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
-
Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, et al. (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3: RESEARCH0034.
-
(2002)
Genome Biol
, vol.3
-
-
Vandesompele, J.1
De Preter, K.2
Pattyn, F.3
Poppe, B.4
Van Roy, N.5
|