Mechanical stimulation of cyclic tensile strain induces reduction of pluripotent related gene expressions via activation of Rho/ROCK and subsequent decreasing of AKT phosphorylation in human induced pluripotent stem cells

Biochemical and Biophysical Research Communications

Volumn 417, Issue 2, 2012, Pages 836-841

  Teramura, Takeshi ^a   Takehara, Toshiyuki ^a   Onodera, Yuta ^a   Nakagawa, Koichi ^a   Hamanishi, Chiaki ^a   Fukuda, Kanji ^a  

^a KINKI UNIVERSITY   (Japan)

Author keywords

Cyclic strain; IPS cells; Mechanical stress; Pluripotency; Rho ROCK; Small GTPase Rho

Indexed keywords

ACTIN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN KINASE B; RHO KINASE; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVATION; FIBER; GENE EXPRESSION; HUMAN; HUMAN CELL; MECHANICAL STRESS; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

CELLS, CULTURED; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MECHANOTRANSDUCTION, CELLULAR; OCTAMER TRANSCRIPTION FACTOR-3; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RHO-ASSOCIATED KINASES; SOXB1 TRANSCRIPTION FACTORS; TENSILE STRENGTH;

IPS; MAMMALIA;

EID: 84855860968     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.12.052     Document Type: Article

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