Rho as a mediator of G protein-coupled receptor signaling

Molecular Pharmacology

Volumn 55, Issue 6, 1999, Pages 949-956

  Seasholtz, Tammy M ^a   Majumdar, Mousumi ^a   Brown, Joan Heller ^a  

^a San Diego   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; GUANINE NUCLEOTIDE BINDING PROTEIN; RHO FACTOR;

CALCIUM TRANSPORT; CELL GROWTH; GENETIC TRANSCRIPTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SHORT SURVEY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTION; TRANSCRIPTION REGULATION;

EID: 0032977036     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.55.6.949     Document Type: Short Survey

References (100)

1. Amano M, Ito M, Kimura K, Fukata Y, Chihara K, Nakano T, Matsuura Y and Kaibuchi K (1996) Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J Biol Chem 271:20246-20249.
2. Aoki H, Izumo S and Sadoshima J (1998) Angiotensin II activates RhoA in cardiac myocytes. A critical role of RhoA in angiotensin II-induced premyofibril formation. Circ Res 82:666-676.
3. Barr AJ, Brass LF and Manning DR (1997) Reconstitution of receptors and GTP-binding regulatory proteins (G proteins) in Sf9 cells. A direct evaluation of selectivity in receptor-G protein coupling. J Biol Chem 272:2223-2229.
4. Barrett K, Leptin M and Settleman J (1997) The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation. Cell 91:905-915.
5. q-protein α-subunit. Nature (London) 389:296-299.
6. rhoA in preadipocytes. J Biol Chem 273:15804-15810.
7. Brown HA, Gutowski S, Moomaw CR, Slaughter C and Sternweis PC (1993) ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity. Cell 75:1137-1144.
8. 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly. J Biol Chem 270:24631-24634.
9. Cachero TG, Morielli AD and Peralta E (1998) The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel. Cell 93:1077-1085.
10. Cazaubon S, Chaverot N, Romero IA, Girault JA, Adamson P, Strosberg AD and Couraud PO (1997) Growth factor activity of endothelin-1 in primary astrocytes mediated by adhesion-dependent and -independent pathways. J Neurosci Methods 17:6203-6212.
11. Chihara K, Amano M, Nakamura N, Yano T, Shibata M, Tokui T, Ichikawa H, Ikebe R, Ikebe M and Kaibuchi K (1997) Cytoskeletal rearrangements and transcriptional activation of c-fos serum response element by Rho-kinase. J Biol Chem 272:25121-25127.
12. Chong LD, Traynor-Kaplan A, Bokoch GM and Schwartz MA (1994) The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell 79:507-513.
13. Chrzanowska-Wodnicka M and Burridge K (1996) Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J Cell Biol 133:1403-1415.
14. 2+ sensitization of tracheal smooth muscle. Am J Physiol 275:L748-L755.
15. de Rooij J, Zwartkruis FJT, Verheijen MHG, Cool RH, Nijman SMB, Wittinghofer A and Bos JL (1998) Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature (London) 396:474-477.
16. Dong J-M, Leung T, Manser E and Lim L (1998) cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKα. J Biol Chem 273:22554-22562.
17. Donovan FM, Pike CJ, Cotman CW and Cunningham DD (1997) Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. J Neurosci 17:5316-5326.
18. Essler M, Amano M, Kruse H-J, Kaibuchi K, Weber PC and Aepfelbacher M (1998) Thrombin inactivates myosin light chain phosphatase via Rho and its target Rho kinase in human endothelial cells. J Biol Chem 273:21867-21874.
19. Fiorentini C, Fabbri A, Flatau G, Donelli G, Matarrese P, Lemichez E, Falzano L and Boquet P (1997) Escherichia coli cytotoxic necrotizing factor 1 (CNF1), a toxin that activates the Rho GTPase. J Biol Chem 272:19532-19537.
20. Flatau G, Lemichez E, Gauthier M, Chardin P, Paris S, Fiorentini C and Boquet P (1997) Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine. Nature (London) 387:729-733.
21. Fleming IN, Elliot CM and Exton JH (1996) Differential translocation of Rho family GTPases by lysophosphatidic acid, endothelin-1, and platelet-derived growth factor. J Biol Chem 271:33067-33073.
22. Fleming IN, Elliott CM, Collard JG and Exton JH (1997) Lysophosphatidic acid induces threonine phosphorylation of Tiam1 in Swiss 3T3 fibroblasts via activation of protein kinase C. J Biol Chem 272:33105-33110.
23. 12 to the serum response element and to cellular transformation. Proc Natl Acad Sci USA 91: 10098-10103.
24. Fukata Y, Kimura K, Oshiro N, Saya HMY and Kaibuchi K (1998) Association of the myosin-binding subunit of myosin phosphatase and moesin: Dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphatase. J Cell Biol 141:409-418
25. Fukuhara S, Murga C, Zohar M, Igishi T and Gutkind JS (1999) A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. J Biol Chem 274:5868-5879.
26. Glaven JA, Whitehead IP, Nomanbhoy T, Kay R and Cerione RA (1996) Lfc and Lsc oncoproteins represent two new guanine nucleotide exchange factors for the Rho GTP-binding protein. J Biol Chem 271:27374-27381.
27. 12 mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho. J Biol Chem 273:4653-4659.
28. 2+ sensitization of smooth muscle. J Biol Chem 272:10704-10709.
29. Harhammer R, Gohla A and Schultz G (1996) Interaction of G protein G-betagamma dimers with small GTP-binding proteins of the Rho family. FEBS Lett 399:211-214.
30. 13. Science (Wash DC) 280:2112-2114.
31. Hart MJ, Sharma S, elMasry N, Qiu R-G, McCabe P, Polakis P and Bollag G (1996) Identification of a novel guanine nucleotide exchange factor for the Rho GTPase. J Biol Chem 271:25452-25458.
32. Hill CS and Treisman R (1995a) Transcriptional regulation by extracellular signals: Mechanisms and specificity. Cell 80:199-211.
33. Hill CS, Wynne J and Treisman R (1995b) The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell 81:1159-1170.
34. Hirata K-I, Kikuchi A, Sasaki T, Kuroda S, Kaibuchi K, Matsuura Y, Seki H, Saida K and Takai Y (1992) Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction. J Biol Chem 267:8719-8722.
35. Hirose M, Ishizaki T, Watanabe N, Uehata M, Kranenburg O, Moolenaar WH, Matsumura F, Maekawa M, Bito H and Narumiya S (1998) Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells. J Cell Biol 141:1625-1636.
36. Hodson EAM, Ashley CC, Hughes AD and Lymn JS (1998) Regulation of phospholipase C-delta by GTP-binding proteins-RhoA as an inhibitory modulator. Biochim Biophys Acta 1403:97-101.
37. Homma Y and Emori Y (1995) A dual functional signal mediator showing RhoGAP and phospholipase C-δ stimulating activities. EMBO J 14:286-291.
38. + exchange through distinct Cdc42-dependent and RhoA-dependent pathways. J Biol Chem 271:6152-6158.
39. Hoshijima M, Sah VP, Wang Y, Chien KR and Brown JH (1998) The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase. J Biol Chem 273:7725-7730.
40. Huang X-Y, Morielli AD and Peralta E (1993) Tyrosine kinase-dependent suppression of a potassium channel by the G protein-coupled m1 muscarinic acetylcholine receptor. Cell 75:1145-1156.
41. Jalink K and Moolenaar WH (1992) Thrombin receptor activation causes rapid neural cell rounding and neurite retraction independent of classic second messengers. J Cell Biol 118:411-419.
42. Jalink K, van Corven EJ, Hengeveld T, Morii N, Narumiya S and Moolenaar WH (1994) Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho. J Cell Biol 126:801-810.
43. Kai T, Jones KA and Warner DO (1998) Halothane attenuates calcium sensitization in airway smooth muscle by inhibiting G-proteins. Anesthesiology 89:1543-1552.
44. q induce Rho-dependent neurite retraction through different signaling pathways. J Biol Chem 273:28700-28707.
45. Katoh H, Negishi M and Ichikawa A (1996) Prostaglandin E receptor EP3 subtype induces neunte retraction via small GTPase Rho. J Biol Chem 271:29780-29784.
46. Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, Housman DE and Graybiel AM (1998) A family of cAMP-binding proteins that directly activate Rap1. Science (Wash DC) 282:2275-2279.
47. Keller J, Schmidt M, Hussein B, Rumenapp U and Jakobs KH (1997) Muscarinic receptor-stimulated cytosol-membrane translocation of RhoA. FEBS Lett 403: 299-302.
48. Kim J-H, Cho Y-S, Kim B-C, Kim Y-S and Lee G-S (1997) Role of Rho GTPase in the endothelin-1-induced nuclear signaling. Biochem Biophys Res Commun 232:223-226.
49. Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, Yamamori B, Feng J, Nakano T, Okawa K, Iwamatsu A and Kaibuchi K (1996) Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science (Wash DC) 273:245-248.
50. 2+. J Biol Chem 264:5339-5342.
51. 13 results in shape change and Rho/Rho kinase-mediated myosin light chain phosphorylation in mouse platelets. J Cell Biol 144:745-754.
52. 2+-sensitization. Eur J Pharmacol 290:19-27.
53. Koyama Y and Baba A (1996) Endothelin-induced cytoskeletal actin reorganization in cultured astrocytes: Inhibition by C3 ADP-ribosyltransferase. Glia 16:342-350.
54. βγ. J Biol Chem 271:12562-12567.
55. 13. Science (Wash DC) 280:2109-2111.
56. Kumagai N, Morii N, Fujisawa K, Nemoto Y and Narumiya S (1993) ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells. J Biol Chem 268:24535-24538.
57. Kureishi Y, Kobayashi S, Amano M, Kimura K, Nakano T, Kaibuchi K and Ito M (1997) Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J Biol Chem 272:12257-12260.
58. Lang P, Gesbert F, Delespine-Carmagnat M, Stancou R, Pouchelet M and Bertoglio J (1996) Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes. EMBO J 15:510-519.
59. Laudanna C, Campbell JJ and Butcher EC (1996) Role of Rho in chemoattractant-activated leukocyte adhesion through integrins. Science (Wash DC) 271:981-983.
60. Laudanna C, Campbell JJ and Butcher EC (1997) Elevation of intracellular cAMP inhibits RhoA activation and integral-dependent leukocyte adhesion induced by chemoattractants. J Biol Chem 272:24141-24144.
61. Levitzki A and Gazit A (1995) Tyrosine kinase inhibition: An approach to drug development. Science (Wash DC) 267:1782-1788.
62. + exchanger isoforms. J Biol Chem 271: 22604-22610.
63. Majumdar M, Seasholtz TM, Goldstein D, de Lanerolle P and Brown JH (1998) Requirement for Rho-mediated myosin light chain phosphorylation in thrombin-stimulated cell rounding and its dissociation from mitogenesis. J Biol Chem 273:10099-10106.
64. Malcolm KC, Elliott CM and Exton JH (1996) Evidence for Rho-mediated agonist stimulation of phospholipase D in Ratl fibroblasts. Effects of Clostridium botulinum C3 exoenzyme. J Biol Chem 271:13135-13139.
65. Malcolm KC, Ross AH, Qiu R-G, Symons M and Exton JH (1994) Activation of rat liver phospholipase D by the small GTP-binding protein RhoA. J Biol Chem 269:25951-25954.
66. Mao J, Yuan H and Wu D (1998) Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein α subunit Gα13. Proc Natl Acad Sci USA 95:12973-12976.
67. Mitchell R, McCulloch D, Lutz E, Johnson M, MacKenzie C, Fennell M, Fink G, Zhou W and Sealfon SC (1998) Rhodopsin-family receptors associate with small G proteins to activate phospholipase D. Nature (London) 392:411-414.
68. 13 stimulate Rho-dependent tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130 Crk-associated substrate. J Biol Chem 273:14626-14632.
69. Nishiki T, Narumiya S, Morii N, Yamamoto M, Fujiwara M, Kamata Y, Sakaguchi G and Kozaki S (1990) ADP-ribosylation of the rho/rac proteins induces growth inhibition, neurite outgrowth and acetylcholine esterase in cultured PC-12 cells. Biochem Biophys Res Commun 167:265-272.
70. 2+ sensitivity in α-toxin permeabilized arterial smooth muscle. Biochem Biophys Res Commun 157:677-683.
71. Nobes CD, Hawkins P, Stephens L, Hall A (1995) Activation of the small GTP-binding proteins rho and rac by growth factor receptors. J Cell Sci 108:225-233.
72. 13 are phosphorylated during platelet activation. J Biol Chem 271:26044-26048.
73. 2 and thrombin receptors in human platelets. Proc Natl Acad Sci USA 91:504-508.
74. Postma FR, Jalink K, Hengeveld T and Moolenaar WH (1996) Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: Action through a specific cell surface receptor. EMBO J 15:2388-2395.
75. Rankin S, Morii N, Narumiya S and Rozengurt E (1994) Botulinum C3 exoenzyme blocks the tyrosine phosphorylation of p125FAK and paxillin induced by bombesin and endothelin. FEBS Lett 354:315-319.
76. Ren X-D, Kiosses WB and Schwartz MA (1999) Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J 18:578-685.
77. Ridley AJ and Hall A (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70:389-399.
78. Ridley AJ and Hall A (1994) Signal transduction pathways regulating Rho-mediated stress fibre formation: Requirement for a tyrosine kinase. EMBO J 13:2600-2610.
79. 1-adrenergic receptor signaling in cardiomyocytes: Dissociation of Ras and Rho pathways. J Biol Chem 271:31185-31195.
80. Sahai E, Alberts AS and Treisman R (1998) RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transforma tion. EMBO J 17:1350-1361.
81. Sasaki T and Takai Y (1998) The Rho small G protein family-Rho GDI system as a temporal and spatial determinant for cytoskeletal control. Biochem Biophys Res Commun 245:641-645.
82. Schmidt G, Sehr P, Wilm M, Selzer J, Mann M and Aktories K (1997) Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1. Nature (London) 387:725-729.
83. Seasholtz TM, Majumdar M, Kaplan DD and Brown JH (1999) Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration. Circ Res, in press.
84. FAK and paxillin in permeabilized Swiss 3T3 cells. J Biol Chem 270:6984-6990.
85. Sekine A, Motohatsu F and Narumiya S (1989) Asparagine residue in the rho gene product is the modification site for botulinum ADP-ribosyltransferase. J Biol Chem 264:8602-8605.
86. Rho in the signaling pathway. J Biol Chem 270:24343-24351.
87. Taylor JM, Hildebrand JD, Mack CP, Cox ME and Parsons JT (1998) Characterization of Graf, the GTPase-activating protein for Rho associated with focal adhesion kinase. Phosphorylation and possible regulation by mitogen-activated protein kinase. J Biol Chem 273:8063-8070.
88. Tigyi G, Fischer DJ, Sebok A, Marshall F, Dyer DL and Miledi R (1996a) Lysophosphatidic acid-induced neunte retraction in PC12 cells: Neurite-protective effects of cyclic AMP signaling. J Neurochem 66:1-10.
89. 2+ signaling and Rho. J Neurochem 66:537-548.
90. i activation of Rho in human airway smooth muscle cells. Am J Physiol 274:L803-L809.
91. Toksoz D and Williams DA (1994) Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products. Oncogene 9:621-628.
92. Tominaga T, Ishizaki T, Narumiya S and Barber DL (1998) p160ROCK mediates RhoA activation of Na-H exchange. EMBO J 17:4712-4722.
93. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M and Narumiya S (1997) Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature (London) 389:990-994.
94. + exchange is necessary for RhoA-induced stress fiber formation. J Biol Chem 271:22281-22284.
95. Wang F, Nobes CD, Hall A and Spiegel S (1997) Sphingosine 1-phosphate stimulates Rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts. Biochem J 324:481-488.
96. Wang S-M, Tsai Y-J, Jiang M-J and Tseng Y-Z (1997) Studies on the function of RhoA protein in cardiac myofibrillogeneeis. J Cell Biochem 68:43-53.
97. Wei L, Zhou W, Croissant JD, Johansen F-E, Prywes R, Balasubramanayam A and Schwartz RJ (1998) RhoA signaling via serum response factor plays an obligatory role in myogenic differentiation. J Biol Chem 273:30287-30294.
98. Yamamoto M, Marui N, Sakai T, Mori N, Kozaki S, Ikai K, Imamura S and Narumiya S (1993) ADP-ribosylation of the RhoA gene product by botulimun C3 exotoxin causes Swiss 3T3 cells to accumulate in the G1 phase of the cell cycle. Oncogene 8:1449-1455.
99. Yoshioka K, Matsumura F, Akedo H and Itoh K (1998) Small GTP-binding protein Rho stimulates the actomyosin system, leading to invasion of tumor cells. J Biol Chem 273:5146-5154
100. Zheng Y, Olson MF, Hall A, Cerione RA and Toksoz D (1995) Direct involvement of the small GTP-binding protein Rho in lbc oncogene function. J Biol Chem 270: 9031-9034.