Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc

Journal of Biological Chemistry

Volumn 281, Issue 20, 2006, Pages 13957-13963

  Mizukami, Yusuke ^a   Fujiki, Kotoyo ^a   Duerr, Eva Maria ^a   Gala, Manish ^a   Jo, Won Seok ^a   Zhang, Xiaobo ^a   Chung, Daniel C ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGRAPHY; ASSAYS; ENZYME KINETICS; MOLECULAR BIOLOGY; MUTAGENESIS; RNA; TUMORS;

ELECTROPHORETIC MOBILITY; HYPOXIC INDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF);

CELL CULTURE;

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; HYPOXIA INDUCIBLE FACTOR 1; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; RAS PROTEIN; RHO FACTOR; SMALL INTERFERING RNA; VASCULOTROPIN;

ARTICLE; CANCER CELL; COLON CANCER; COMPLEX FORMATION; CONTROLLED STUDY; DRUG INHIBITION; EFFECTOR CELL; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; HYPOXIA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANOXIA; BASE SEQUENCE; COLONIC NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-MYC; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33744914879     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M511763200     Document Type: Article

References (42)

1. Hanahan, D., and Folkman, J. (1996) Cell 86, 353-364
2. Bergers, G., and Benjamin, L. E. (2003) Nat. Rev. Cancer 3, 401-410
3. Kerbel, R. S. (2000) Carcinogenesis 21, 505-515
4. Ferrara, N. (2002) Semin. Oncol. 29, 10-14
5. Hurwitz, H., Fehrenbacher, L., Novotny, W., Cartwright, T., Hainsworth, J., Heim, W., Berlin, J., Baron, A., Griffing, S., Holmgren, E., Ferrara, N., Fyfe, G., Rogers, B., Ross, R., and Kabbinavar, F. (2004) N. Engl. J. Med. 350, 2335-2342
6. Zhang, X., Gaspard, J. P., and Chung, D. C. (2001) Cancer Res. 61, 6050-6054
7. Forsythe, J. A., Jiang, B. H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., and Semenza, G. L. (1996) Mol. Cell. Biol. 16, 4604-4613
8. Bruick, R. K., and McKnight, S. L. (2001) Science 294, 1337-1340
9. Lando, D., Peet, D. J., Whelan, D. A., Gorman, J. J., and Whitelaw, M. L. (2002) Science 295, 858-861
10. Wang, G. L., Jiang, B. H., Rue, E. A., and Semenza, G. L. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 5510-5514
11. Mizukami, Y., Li, J., Zhang, X., Zimmer, M. A., Iliopoulos, O., and Chung, D. C. (2004) Cancer Res. 64, 1765-1772
12. Kotch, L. E., Iyer, N. V., Laughner, E., and Semenza, G. L. (1999) Dev. Biol. 209, 254-267
13. Ryan, H. E., Poloni, M., McNulty, W., Elson, D., Gassmann, M., Arbeit, J. M., and Johnson, R. S. (2000) Cancer Res. 60, 4010-4015
14. Ryan, H. E., Lo, J., and Johnson, R. S. (1998) EMBO J. 17, 3005-3015
15. von Marschall, Z., Cramer, T., Hocker, M., Finkenzeller, G., Wiedenmann, B., and Rosewicz, S. (2001) Gut 48, 87-96
16. Pore, N., Liu, S., Shu, H. K., Li, B., Haas-Kogan, D., Stokoe, D., Milanini-Mongiat, J., Pages, G., O'Rourke, D. M., Bernhard, E., and Maity, A. (2004) Mol. Biol. Cell 15, 4841-4853
17. Khokhlatchev, A., Rabizadeh, S., Xavier, R., Nedwidek, M., Chen, T., Zhang, X. F., Seed, B., and Avruch, J. (2002) Curr. Biol. 12, 253-265
18. Robbins, D. J., Zhen, E., Owaki, H., Vanderbilt, C. A., Ebert, D., Geppert, T. D., and Cobb, M. H. (1993) J. Biol. Chem. 268, 5097-5106
19. Hara, K., Yonezawa, K., Sakaue, H., Ando, A., Kotani, K., Kitamura, T., Kitamura, Y., Ueda, H., Stephens, L., Jackson, T. R., Hawkins, P. T., Dhand, R., Clark, A. E., Holman, G. D., Waterfield, M. D., and Kasuga, M. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 7415-7419
20. Cong, L. N., Chen, H., Li, Y., Zhou, L., McGibbon, M. A., Taylor, S. I., and Quon, M. J. (1997) Mol. Endocrinol. 11, 1881-1890
21. Lynch, M., Chen, L., Ravitz, M. J., Mehtani, S., Korenblat, K., Pazin, M. J., and Schmidt, E. V. (2005) Mol. Cell. Biol. 25, 6436-6453
22. Behre, G., Smith, L. T., and Tenen, D. G. (1999) BioTechniques 26, 24-26, 28
23. Williams, N. S., Gaynor, R. B., Scoggin, S., Verma, U., Gokaslan, T., Simmang, C., Fleming, J., Tavana, D., Frenkel, E., and Becerra, C. (2003) Clin. Cancer Res. 9, 931-946
24. Chen, E. Y., Mazure, N. M., Cooper, J. A., and Giaccia, A. J. (2001) Cancer Res. 61, 2429-2433
25. Matsui, T., Amano, M., Yamamoto, T., Chihara, K., Nakafuku, M., Ito, M., Nakano, T., Okawa, K., Iwamatsu, A., and Kaibuchi, K. (1996) EMBO J. 15, 2208-2216
26. Sahai, E., Ishizaki, T., Narumiya, S., and Treisman, R. (1999) Curr. Biol. 9, 136-145
27. Watnick, R. S., Cheng, Y. N., Rangarajan, A., Ince, T. A., and Weinberg, R. A. (2003) Cancer Cell 3, 219-231
28. Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., and Semenza, G. L. (1998) Genes Dev. 12, 149-162
29. Kaluz, S., Kaluzova, M., and Stanbridge, E. J. (2003) Cancer Res. 63, 917-922
30. Minet, E., Michel, G., Mottet, D., Piret, J. P., Barbieux, A., Raes, M., and Michiels, C. (2001) Exp. Cell Res. 265, 114-124
31. Koong, A. C., Chen, E. Y., Mivechi, N. F., Denko, N. C., Stambrook, P., and Giaccia, A. J. (1994) Cancer Res. 54, 5273-5279
32. Yan, S. F., Fujita, T., Lu, J., Okada, K., Shan Zou, Y., Mackman, N., Pinsky, D. J., and Stern, D. M. (2000) Nat. Med. 6, 1355-1361
33. Kamakura, S., Moriguchi, T., and Nishida, E. (1999) J. Biol. Chem. 274, 26563-26571
34. Sohn, S. J., Sarvis, B. K., Cado, D., and Winoto, A. (2002) J. Biol. Chem. 277, 43344-43351
35. Vanhaesebroeck, B., Waterfield, M. D. (1999) Exp. Cell Res. 253, 239-254
36. Baudino, T. A., McKay, C., Pendeville-Samain, H., Nilsson, J. A., Maclean, K. H., White, E. L., Davis, A. C., Ihle, J. N., and Cleveland, J. L. (2002) Genes Dev. 16, 2530-2543
37. Mezquita, P., Parghi, S. S., Brandvold, K. A., and Ruddell, A. (2005) Oncogene 24, 889-901
38. Knies-Bamforth, U. E., Fox, S. B., Poulsom, R., Evan, G. I., and Harris, A. L. (2004) Cancer Res. 64, 6563-6570
39. Barr, L. F., Campbell, S. E., Diette, G. B., Gabrielson, E. W., Kim, S., Shim, H., and Dang, C. V. (2000) Cancer Res. 60, 143-149
40. Kamaraju, A. K., and Roberts, A. B. (2005) J. Biol. Chem. 280, 1024-1036
41. Ngo, C. V., Gee, M., Akhtar, N., Yu, D., Volpert, O., Auerbach, R., and Thomas-Tikhonenko, A. (2000) Cell Growth & Differ. 11, 201-210
42. Erisman, M. D., Rothberg, P. G., Diehl, R. E., Morse, C. C., Spandorfer, J. M., and Astrin, S. M. (1985) Mol. Cell. Biol. 5, 1969-1976