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Volumn 62, Issue 7, 2013, Pages 2450-2459

Human Pancreatic β-Cell G1/S Molecule Cell Cycle Atlas

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; CYCLIN D; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 1C; CYCLIN E; PROTEIN P21; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; CYCLIN DEPENDENT KINASE; CYCLINE;

EID: 85047688974     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-0777     Document Type: Article
Times cited : (62)

References (50)
  • 1
    • 77957787230 scopus 로고    scopus 로고
    • Significant human β-cells turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating
    • Perl S, Kushner JA, Buchholz BA, et al. Significant human β-cells turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating. J Clin Endocrinol Metab 2010;95:E234-E239
    • (2010) J Clin Endocrinol Metab , vol.95
    • Perl, S.1    Kushner, J.A.2    Buchholz, B.A.3
  • 4
    • 67650239579 scopus 로고    scopus 로고
    • Functional assessment of pancreatic beta-cell area in humans
    • Meier JJ, Menge BA, Breuer TGK, et al. Functional assessment of pancreatic beta-cell area in humans. Diabetes 2009;58:1595-1603
    • (2009) Diabetes , vol.58 , pp. 1595-1603
    • Meier, J.J.1    Menge, B.A.2    Breuer, T.G.K.3
  • 6
    • 77958040076 scopus 로고    scopus 로고
    • Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy
    • Butler AE, Cao-Minh L, Galasso R, et al. Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy. Diabetologia 2010;53:2167-2176
    • (2010) Diabetologia , vol.53 , pp. 2167-2176
    • Butler, A.E.1    Cao-Minh, L.2    Galasso, R.3
  • 7
    • 38449086256 scopus 로고    scopus 로고
    • Partial pancreatectomy in adult humans does not provoke beta-cell regeneration
    • Menge BA, Tannapfel A, Belyaev O, et al. Partial pancreatectomy in adult humans does not provoke beta-cell regeneration. Diabetes 2008;57:142-149
    • (2008) Diabetes , vol.57 , pp. 142-149
    • Menge, B.A.1    Tannapfel, A.2    Belyaev, O.3
  • 8
    • 36649000083 scopus 로고    scopus 로고
    • Proliferation of sorted human and rat beta cells
    • Parnaud G, Bosco D, Berney T, et al. Proliferation of sorted human and rat beta cells. Diabetologia 2008;51:91-100
    • (2008) Diabetologia , vol.51 , pp. 91-100
    • Parnaud, G.1    Bosco, D.2    Berney, T.3
  • 9
    • 62749083679 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets
    • Liu H, Remedi MS, Pappan KL, et al. Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets. Diabetes 2009;58: 663-672
    • (2009) Diabetes , vol.58 , pp. 663-672
    • Liu, H.1    Remedi, M.S.2    Pappan, K.L.3
  • 10
    • 33750577223 scopus 로고    scopus 로고
    • Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: A potential role for Fas and pancreatic duodenal homeobox-1
    • Maedler K, Schumann DM, Schulthess F, et al. Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1. Diabetes 2006;55:2455-2462
    • (2006) Diabetes , vol.55 , pp. 2455-2462
    • Maedler, K.1    Schumann, D.M.2    Schulthess, F.3
  • 11
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic β-cellss are formed by self-duplication rather than stem-cell differentiation
    • Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic β-cellss are formed by self-duplication rather than stem-cell differentiation. Nature 2004;429:41-46
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 12
    • 77956102457 scopus 로고    scopus 로고
    • FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation
    • Davis DB, Lavine JA, Suhonen JI, et al. FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation. Mol Endocrinol 2010;24:1822-1834
    • (2010) Mol Endocrinol , vol.24 , pp. 1822-1834
    • Davis, D.B.1    Lavine, J.A.2    Suhonen, J.I.3
  • 13
    • 44749088201 scopus 로고    scopus 로고
    • Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans
    • Meier JJ, Butler AE, Saisho Y, et al. Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. Diabetes 2008;57:1584-1594
    • (2008) Diabetes , vol.57 , pp. 1584-1594
    • Meier, J.J.1    Butler, A.E.2    Saisho, Y.3
  • 15
    • 0033853921 scopus 로고    scopus 로고
    • Beta-cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy
    • Kassem SA, Ariel I, Thornton PS, Scheimberg I, Glaser B. Beta-cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy. Diabetes 2000;49:1325-1333
    • (2000) Diabetes , vol.49 , pp. 1325-1333
    • Kassem, S.A.1    Ariel, I.2    Thornton, P.S.3    Scheimberg, I.4    Glaser, B.5
  • 16
    • 80054991835 scopus 로고    scopus 로고
    • PDGF signalling controls age-dependent proliferation in pancreatic β-cells
    • Chen H, Gu X, Liu Y, et al. PDGF signalling controls age-dependent proliferation in pancreatic β-cells. Nature 2011;478:349-355
    • (2011) Nature , vol.478 , pp. 349-355
    • Chen, H.1    Gu, X.2    Liu, Y.3
  • 17
    • 33748935803 scopus 로고    scopus 로고
    • Intrinsic regulators of pancreatic beta-cell proliferation
    • Heit JJ, Karnik SK, Kim SK. Intrinsic regulators of pancreatic beta-cell proliferation. Annu Rev Cell Dev Biol 2006;22:311-338
    • (2006) Annu Rev Cell Dev Biol , vol.22 , pp. 311-338
    • Heit, J.J.1    Karnik, S.K.2    Kim, S.K.3
  • 18
    • 33744920617 scopus 로고    scopus 로고
    • Molecular control of cell cycle progression in the pancreatic beta-cell
    • Cozar-Castellano I, Fiaschi-Taesch N, Bigatel TA, et al. Molecular control of cell cycle progression in the pancreatic beta-cell. Endocr Rev 2006;27: 356-370
    • (2006) Endocr Rev , vol.27 , pp. 356-370
    • Cozar-Castellano, I.1    Fiaschi-Taesch, N.2    Bigatel, T.A.3
  • 19
    • 0033919390 scopus 로고    scopus 로고
    • Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro
    • Halvorsen TL, Beattie GM, Lopez AD, Hayek A, Levine F. Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro. J Endocrinol 2000;166:103-109
    • (2000) J Endocrinol , vol.166 , pp. 103-109
    • Halvorsen, T.L.1    Beattie, G.M.2    Lopez, A.D.3    Hayek, A.4    Levine, F.5
  • 20
    • 33749187810 scopus 로고    scopus 로고
    • P16INK4a induces an agedependent decline in islet regenerative potential
    • Krishnamurthy J, Ramsey MR, Ligon KL, et al. p16INK4a induces an agedependent decline in islet regenerative potential. Nature 2006;443:453-457
    • (2006) Nature , vol.443 , pp. 453-457
    • Krishnamurthy, J.1    Ramsey, M.R.2    Ligon, K.L.3
  • 21
    • 64649104150 scopus 로고    scopus 로고
    • Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo
    • Fiaschi-Taesch NM, Bigatel TA, Sicari BM, et al. Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo. Diabetes 2009;58:882-893
    • (2009) Diabetes , vol.58 , pp. 882-893
    • Fiaschi-Taesch, N.M.1    Bigatel, T.A.2    Sicari, B.M.3
  • 22
    • 77955357730 scopus 로고    scopus 로고
    • Induction of human betacell proliferation and engraftment using a single G1/S regulatory molecule, cdk6
    • Fiaschi-Taesch NM, Salim F, Kleinberger J, et al. Induction of human betacell proliferation and engraftment using a single G1/S regulatory molecule, cdk6. Diabetes 2010;59:1926-1936
    • (2010) Diabetes , vol.59 , pp. 1926-1936
    • Fiaschi-Taesch, N.M.1    Salim, F.2    Kleinberger, J.3
  • 23
    • 78650073823 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein enhances human ß-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin e expression
    • Guthalu Kondegowda N, Joshi-Gokhale S, Harb G, et al. Parathyroid hormone-related protein enhances human ß-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression. Diabetes 2010;59:3131-3138
    • (2010) Diabetes , vol.59 , pp. 3131-3138
    • Guthalu Kondegowda, N.1    Joshi-Gokhale, S.2    Harb, G.3
  • 24
    • 56749105741 scopus 로고    scopus 로고
    • Overexpression of pre-procholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function
    • Lavine JA, Raess PW, Davis DB, et al. Overexpression of pre-procholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function. Mol Endocrinol 2008;22:2716-2728
    • (2008) Mol Endocrinol , vol.22 , pp. 2716-2728
    • Lavine, J.A.1    Raess, P.W.2    Davis, D.B.3
  • 25
    • 79953752183 scopus 로고    scopus 로고
    • Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-severe combined immunodeficiency (SCID) mice
    • Levitt HE, Cyphert TJ, Pascoe JL, et al. Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-severe combined immunodeficiency (SCID) mice. Diabetologia 2011;54:572-582
    • (2011) Diabetologia , vol.54 , pp. 572-582
    • Levitt, H.E.1    Cyphert, T.J.2    Pascoe, J.L.3
  • 26
    • 80053345327 scopus 로고    scopus 로고
    • CMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication
    • Karslioglu E, Kleinberger JW, Salim FG, et al. cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication. Mol Endocrinol 2011;25:1760-1772
    • (2011) Mol Endocrinol , vol.25 , pp. 1760-1772
    • Karslioglu, E.1    Kleinberger, J.W.2    Salim, F.G.3
  • 27
    • 34948821871 scopus 로고    scopus 로고
    • Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells
    • Zhong L, Georgia S, Tschen SI, Nakayama K, Nakayama K, Bhushan A. Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells. J Clin Invest 2007;117:2869-2876
    • (2007) J Clin Invest , vol.117 , pp. 2869-2876
    • Zhong, L.1    Georgia, S.2    Tschen, S.I.3    Nakayama, K.4    Nakayama, K.5    Bhushan, A.6
  • 29
    • 33644754585 scopus 로고    scopus 로고
    • Akt induces β-cells proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity
    • Fatrai S, Elghazi L, Balcazar N, et al. Akt induces β-cells proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity. Diabetes 2006;55:318-325
    • (2006) Diabetes , vol.55 , pp. 318-325
    • Fatrai, S.1    Elghazi, L.2    Balcazar, N.3
  • 31
    • 24344459011 scopus 로고    scopus 로고
    • Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy
    • Brissova M, Fowler MJ, Nicholson WE, et al. Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy. J Histochem Cytochem 2005;53:1087-1097
    • (2005) J Histochem Cytochem , vol.53 , pp. 1087-1097
    • Brissova, M.1    Fowler, M.J.2    Nicholson, W.E.3
  • 32
    • 0347990598 scopus 로고    scopus 로고
    • Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1
    • Cozar-Castellano I, Takane KK, Bottino R, Balamurugan AN, Stewart AF. Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1. Diabetes 2004;53:149-159
    • (2004) Diabetes , vol.53 , pp. 149-159
    • Cozar-Castellano, I.1    Takane, K.K.2    Bottino, R.3    Balamurugan, A.N.4    Stewart, A.F.5
  • 33
    • 81455139491 scopus 로고    scopus 로고
    • Human islet distribution program for basic research at a single center
    • Kin T, O'Gorman D, Schroeder A, et al. Human islet distribution program for basic research at a single center. Transplant Proc 2011;43: 3195-3197
    • (2011) Transplant Proc , vol.43 , pp. 3195-3197
    • Kin, T.1    O'Gorman, D.2    Schroeder, A.3
  • 34
    • 85047688791 scopus 로고    scopus 로고
    • Cytoplasmic-nuclear trafficking of G1/S cell cycle molecules and adult human β-cells replication: A revised model of human β-cells G1/S control
    • Fiaschi-Taesch NM, Kleinberger JW, Salim FG, et al. Cytoplasmic-nuclear trafficking of G1/S cell cycle molecules and adult human β-cells replication: a revised model of human β-cells G1/S control. Diabetes 2013;62:2460-2470
    • (2013) Diabetes , vol.62 , pp. 2460-2470
    • Fiaschi-Taesch, N.M.1    Kleinberger, J.W.2    Salim, F.G.3
  • 35
    • 0035654182 scopus 로고    scopus 로고
    • P57(KIP2) expression in normal islet cells and in hyperinsulinism of infancy
    • Kassem SA, Ariel I, Thornton PS, et al. p57(KIP2) expression in normal islet cells and in hyperinsulinism of infancy. Diabetes 2001;50:2763-2769
    • (2001) Diabetes , vol.50 , pp. 2763-2769
    • Kassem, S.A.1    Ariel, I.2    Thornton, P.S.3
  • 36
    • 18344383345 scopus 로고    scopus 로고
    • Pocket proteins and cell cycle control
    • Cobrinik D. Pocket proteins and cell cycle control. Oncogene 2005;24: 2796-2809
    • (2005) Oncogene , vol.24 , pp. 2796-2809
    • Cobrinik, D.1
  • 37
    • 8644219655 scopus 로고    scopus 로고
    • Living with or without cyclins and cyclin-dependent kinases
    • Sherr CJ, Roberts JM. Living with or without cyclins and cyclin-dependent kinases. Genes Dev 2004;18:2699-2711
    • (2004) Genes Dev , vol.18 , pp. 2699-2711
    • Sherr, C.J.1    Roberts, J.M.2
  • 38
    • 0037819443 scopus 로고    scopus 로고
    • Tumour suppressors: Timing will tell
    • Berns A. Tumour suppressors: timing will tell. Nature 2003;424:140-141
    • (2003) Nature , vol.424 , pp. 140-141
    • Berns, A.1
  • 39
  • 40
    • 69249230769 scopus 로고    scopus 로고
    • Mammalian cell-cycle regulation: Several Cdks, numerous cyclins and diverse compensatory mechanisms
    • Satyanarayana A, Kaldis P. Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms. Oncogene 2009; 28:2925-2939
    • (2009) Oncogene , vol.28 , pp. 2925-2939
    • Satyanarayana, A.1    Kaldis, P.2
  • 41
    • 0346496026 scopus 로고    scopus 로고
    • High expression of active CDK6 in the cytoplasm of CD8 memory cells favors rapid division
    • Veiga-Fernandes H, Rocha B. High expression of active CDK6 in the cytoplasm of CD8 memory cells favors rapid division. Nat Immunol 2004;5:31-37
    • (2004) Nat Immunol , vol.5 , pp. 31-37
    • Veiga-Fernandes, H.1    Rocha, B.2
  • 42
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 1999;13:1501-1512
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 43
    • 70350445980 scopus 로고    scopus 로고
    • Cyclin D2 protein stability is regulated in pancreatic beta-cells
    • He LM, Sartori DJ, Teta M, et al. Cyclin D2 protein stability is regulated in pancreatic beta-cells. Mol Endocrinol 2009;23:1865-1875
    • (2009) Mol Endocrinol , vol.23 , pp. 1865-1875
    • He, L.M.1    Sartori, D.J.2    Teta, M.3
  • 44
    • 34347392646 scopus 로고    scopus 로고
    • Glucose infusion in mice: A new model to induce beta-cell replication
    • Alonso LC, Yokoe T, Zhang P, et al. Glucose infusion in mice: a new model to induce beta-cell replication. Diabetes 2007;56:1792-1801
    • (2007) Diabetes , vol.56 , pp. 1792-1801
    • Alonso, L.C.1    Yokoe, T.2    Zhang, P.3
  • 45
    • 34548853393 scopus 로고    scopus 로고
    • A novel mechanism of E2F1 regulation via nucleocytoplasmic shuttling: Determinants of nuclear import and export
    • Ivanova IA, Vespa A, Dagnino L. A novel mechanism of E2F1 regulation via nucleocytoplasmic shuttling: determinants of nuclear import and export. Cell Cycle 2007;6:2186-2195
    • (2007) Cell Cycle , vol.6 , pp. 2186-2195
    • Ivanova, I.A.1    Vespa, A.2    Dagnino, L.3
  • 46
    • 0034689001 scopus 로고    scopus 로고
    • Subcellular compartmentalization of E2F family members is required for maintenance of the postmitotic state in terminally differentiated muscle
    • Gill RM, Hamel PA. Subcellular compartmentalization of E2F family members is required for maintenance of the postmitotic state in terminally differentiated muscle. J Cell Biol 2000;148:1187-1201
    • (2000) J Cell Biol , vol.148 , pp. 1187-1201
    • Gill, R.M.1    Hamel, P.A.2
  • 47
    • 0036285205 scopus 로고    scopus 로고
    • Expression of cell-cycleregulated proteins pRb2/p130, p107, p27(kip1), p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinoma
    • Claudio PP, Zamparelli A, Garcia FU, et al. Expression of cell-cycleregulated proteins pRb2/p130, p107, p27(kip1), p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinoma. Clin Cancer Res 2002;8:1808-1815
    • (2002) Clin Cancer Res , vol.8 , pp. 1808-1815
    • Claudio, P.P.1    Zamparelli, A.2    Garcia, F.U.3
  • 48
    • 0842278331 scopus 로고    scopus 로고
    • Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
    • Chipuk JE, Kuwana T, Bouchier-Hayes L, et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 2004;303:1010-1014
    • (2004) Science , vol.303 , pp. 1010-1014
    • Chipuk, J.E.1    Kuwana, T.2    Bouchier-Hayes, L.3
  • 50
    • 0036201059 scopus 로고    scopus 로고
    • Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm
    • Jackman M, Kubota Y, den Elzen N, Hagting A, Pines J. Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm. Mol Biol Cell 2002;13:1030-1045
    • (2002) Mol Biol Cell , vol.13 , pp. 1030-1045
    • Jackman, M.1    Kubota, Y.2    Den Elzen, N.3    Hagting, A.4    Pines, J.5


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