-
1
-
-
0026682657
-
Transcription factors: Structural families and principles of DNA recognition
-
Pabo CO, Sauer RT. Transcription factors: Structural families and principles of DNA recognition. Annu Rev Biochem 1992;61(1):1053-1095.
-
(1992)
Annu Rev Biochem
, vol.61
, Issue.1
, pp. 1053-1095
-
-
Pabo, C.O.1
Sauer, R.T.2
-
2
-
-
43249128626
-
Nuclear receptors and inflammatory diseases
-
Wang K, Wan Y-JY. Nuclear receptors and inflammatory diseases. Exp Biol Med 2008;233(5):496-506.
-
(2008)
Exp Biol Med
, vol.233
, Issue.5
, pp. 496-506
-
-
Wang, K.1
Wan, Y.-J.2
-
3
-
-
0030568155
-
Transcription-factor mutations and disease
-
Latchman DS. Transcription-factor mutations and disease. New Engl J Med 1996;334(1):28-33.
-
(1996)
New Engl J Med
, vol.334
, Issue.1
, pp. 28-33
-
-
Latchman, D.S.1
-
4
-
-
2942606066
-
Structure and evolution of transcriptional regulatory networks
-
Babu MM, Luscombe NM, Aravind L, Gerstein M, Teichmann SA. Structure and evolution of transcriptional regulatory networks. Curr Opin Struct Biol 2004;14(3):283-291.
-
(2004)
Curr Opin Struct Biol
, vol.14
, Issue.3
, pp. 283-291
-
-
Babu, M.M.1
Luscombe, N.M.2
Aravind, L.3
Gerstein, M.4
Teichmann, S.A.5
-
5
-
-
0036782706
-
Transcription factors as targets for cancer therapy
-
Darnell JE. Transcription factors as targets for cancer therapy. Nat Rev Cancer 2002;2(10):740-749.
-
(2002)
Nat Rev Cancer
, vol.2
, Issue.10
, pp. 740-749
-
-
Darnell, J.E.1
-
6
-
-
27544515095
-
ETS transcription factors and their emerging roles in human cancer
-
Seth A, Watson DK. ETS transcription factors and their emerging roles in human cancer. Eur J Cancer 2005;41(16):2462-2478.
-
(2005)
Eur J Cancer
, vol.41
, Issue.16
, pp. 2462-2478
-
-
Seth, A.1
Watson, D.K.2
-
7
-
-
78650307699
-
Metastatic bone disease: Role of transcription factors and future targets
-
Pratap J, Lian JB, Stein GS. Metastatic bone disease: Role of transcription factors and future targets. Bone 2011;48(1):30-36.
-
(2011)
Bone
, vol.48
, Issue.1
, pp. 30-36
-
-
Pratap, J.1
Lian, J.B.2
Stein, G.S.3
-
8
-
-
77955460021
-
The ups and downs of transcription factors in melanoma
-
Santiago-Walker A, Herlyn M. The ups and downs of transcription factors in melanoma. J Natl Cancer Inst 2010;102(15):1103-1104.
-
(2010)
J Natl Cancer Inst
, vol.102
, Issue.15
, pp. 1103-1104
-
-
Santiago-Walker, A.1
Herlyn, M.2
-
9
-
-
0035131812
-
The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome
-
Crisponi L, Deiana M, Loi A, Chiappe F, Uda M, Amati P, Bisceglia L, Zelante L, Nagaraja R, Porcu S, Serafina Ristaldi M, Marzella R, Rocchi M, Nicolino M, Lienhardt-Roussie A, Nivelon A, Verloes A, Schlessinger D, Gasparini P, Bonneau D, Cao A, Pilia G. The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome. Nat Genet 2001;27(2):159-166.
-
(2001)
Nat Genet
, vol.27
, Issue.2
, pp. 159-166
-
-
Crisponi, L.1
Deiana, M.2
Loi, A.3
Chiappe, F.4
Uda, M.5
Amati, P.6
Bisceglia, L.7
Zelante, L.8
Nagaraja, R.9
Porcu, S.10
Serafina Ristaldi, M.11
Marzella, R.12
Rocchi, M.13
Nicolino, M.14
Lienhardt-Roussie, A.15
Nivelon, A.16
Verloes, A.17
Schlessinger, D.18
Gasparini, P.19
Bonneau, D.20
Cao, A.21
Pilia, G.22
more..
-
10
-
-
0034284545
-
Variation in residual PITX2 activity underlies the phenotypic spectrum of anterior segment developmental disorders
-
Kozlowski K, Walter MA. Variation in residual PITX2 activity underlies the phenotypic spectrum of anterior segment developmental disorders. Hum Mol Genet 2000;9(14):2131-2139.
-
(2000)
Hum Mol Genet
, vol.9
, Issue.14
, pp. 2131-2139
-
-
Kozlowski, K.1
Walter, M.A.2
-
11
-
-
0034056505
-
The molecular basis for developmental disorders of the pituitary gland in man
-
Dattani M, Robinson I. The molecular basis for developmental disorders of the pituitary gland in man. Clin Genet 2000;57(5):337-346.
-
(2000)
Clin Genet
, vol.57
, Issue.5
, pp. 337-346
-
-
Dattani, M.1
Robinson, I.2
-
12
-
-
77952584843
-
The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation
-
Chang H-C, Sehra S, Goswami R, Yao W, Yu Q, Stritesky GL, Jabeen R, McKinley C, Ahyi A-N, Han L, Nguyen ET, Robertson MJ, Perumal NB, Tepper RS, Nutt SL, Kaplan MH. The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat Immunol 2010;11(6):527-534.
-
(2010)
Nat Immunol
, vol.11
, Issue.6
, pp. 527-534
-
-
Chang, H.-C.1
Sehra, S.2
Goswami, R.3
Yao, W.4
Yu, Q.5
Stritesky, G.L.6
Jabeen, R.7
McKinley, C.8
Ahyi, A.-N.9
Han, L.10
Nguyen, E.T.11
Robertson, M.J.12
Perumal, N.B.13
Tepper, R.S.14
Nutt, S.L.15
Kaplan, M.H.16
-
13
-
-
65749103365
-
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
-
Koch MA, Tucker-Heard Gs, Perdue NR, Killebrew JR, Urdahl KB, Campbell DJ. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol 2009;10(6):595-602.
-
(2009)
Nat Immunol
, vol.10
, Issue.6
, pp. 595-602
-
-
Koch, M.A.1
Tucker-Heard, G.2
Perdue, N.R.3
Killebrew, J.R.4
Urdahl, K.B.5
Campbell, D.J.6
-
14
-
-
80052014052
-
Inflammation meets cancer, with NF-[kappa]B as the matchmaker
-
Ben-Neriah Y, Karin M. Inflammation meets cancer, with NF-[kappa]B as the matchmaker. Nat Immunol 2011;12(8):715-723.
-
(2011)
Nat Immunol
, vol.12
, Issue.8
, pp. 715-723
-
-
Ben-Neriah, Y.1
Karin, M.2
-
15
-
-
80053539605
-
NF-[kappa]B controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration
-
Mauro C, Leow SC, Anso E, Rocha S, Thotakura AK, Tornatore L, Moretti M, De Smaele E, Beg AA, Tergaonkar V, Chandel NS, Franzoso G. NF-[kappa]B controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration. Nat Cell Biol 2011;13(10):1272-1279.
-
(2011)
Nat Cell Biol
, vol.13
, Issue.10
, pp. 1272-1279
-
-
Mauro, C.1
Leow, S.C.2
Anso, E.3
Rocha, S.4
Thotakura, A.K.5
Tornatore, L.6
Moretti, M.7
De Smaele, E.8
Beg, A.A.9
Tergaonkar, V.10
Chandel, N.S.11
Franzoso, G.12
-
16
-
-
0034507632
-
Transcription of eukaryotic protein-coding genes
-
Lee TI, Young RA. Transcription of eukaryotic protein-coding genes. Annu Rev Genet 2000;34(1):77-137.
-
(2000)
Annu Rev Genet
, vol.34
, Issue.1
, pp. 77-137
-
-
Lee, T.I.1
Young, R.A.2
-
17
-
-
34548801789
-
The molecular basis of eukaryotic transcription
-
Kornberg RD. The molecular basis of eukaryotic transcription. Proc Natl Acad Sci USA 2007;104(32):12955-12961.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.32
, pp. 12955-12961
-
-
Kornberg, R.D.1
-
18
-
-
2942610696
-
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II
-
Bourbon H-M, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ, Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M, Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP, Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch AG, Holmberg S, Holstege FC, Jaehning JA, Kim Y-J, Kuras L, Leutz A, Lis JT, Meisterernest M, Naar AM, Nasmyth K, Parvin JD, Ptashne M, Reinberg D, Ronne H, Sadowski I, Sakurai H, Sipiczki M, Sternberg PW, Stillman DJ, Strich R, Struhl K, Svejstrup JQ, Tuck S, Winston F, Roeder RG, Kornberg RD. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol cell 2004;14(5):553-557.
-
(2004)
Mol cell
, vol.14
, Issue.5
, pp. 553-557
-
-
Bourbon, H.-M.1
Aguilera, A.2
Ansari, A.Z.3
Asturias, F.J.4
Berk, A.J.5
Bjorklund, S.6
Blackwell, T.K.7
Borggrefe, T.8
Carey, M.9
Carlson, M.10
Conaway, J.W.11
Conaway, R.C.12
Emmons, S.W.13
Fondell, J.D.14
Freedman, L.P.15
Fukasawa, T.16
Gustafsson, C.M.17
Han, M.18
He, X.19
Herman, P.K.20
Hinnebusch, A.G.21
Holmberg, S.22
Holstege, F.C.23
Jaehning, J.A.24
Kim, Y.-J.25
Kuras, L.26
Leutz, A.27
Lis, J.T.28
Meisterernest, M.29
Naar, A.M.30
Nasmyth, K.31
Parvin, J.D.32
Ptashne, M.33
Reinberg, D.34
Ronne, H.35
Sadowski, I.36
Sakurai, H.37
Sipiczki, M.38
Sternberg, P.W.39
Stillman, D.J.40
Strich, R.41
Struhl, K.42
Svejstrup, J.Q.43
Tuck, S.44
Winston, F.45
Roeder, R.G.46
Kornberg, R.D.47
more..
-
19
-
-
18844451820
-
Mediator and the mechanism of transcriptional activation
-
Kornberg RD. Mediator and the mechanism of transcriptional activation. Trends Biochem Sci 2005;30(5):235-239.
-
(2005)
Trends Biochem Sci
, vol.30
, Issue.5
, pp. 235-239
-
-
Kornberg, R.D.1
-
20
-
-
73249129425
-
Drug effects viewed from a signal transduction network perspective
-
Fliri AF, Loging WT, Volkmann RA. Drug effects viewed from a signal transduction network perspective. J Med Chem 2009;52(24):8038-8046.
-
(2009)
J Med Chem
, vol.52
, Issue.24
, pp. 8038-8046
-
-
Fliri, A.F.1
Loging, W.T.2
Volkmann, R.A.3
-
21
-
-
50249186849
-
Inhibition of transcription factors with small organic molecules
-
Thorsten B. Inhibition of transcription factors with small organic molecules. Curr Opin Chem Biol 2008;12(4):464-471.
-
(2008)
Curr Opin Chem Biol
, vol.12
, Issue.4
, pp. 464-471
-
-
Thorsten, B.1
-
22
-
-
25144452721
-
Chemical approaches to transcriptional regulation
-
Majmudar CY, Mapp AK. Chemical approaches to transcriptional regulation. Curr Opin Chem Biol 2005;9(5):467-474.
-
(2005)
Curr Opin Chem Biol
, vol.9
, Issue.5
, pp. 467-474
-
-
Majmudar, C.Y.1
Mapp, A.K.2
-
23
-
-
33746288394
-
Small molecule modulators of transcription
-
Arndt H-D. Small molecule modulators of transcription. Angew Chem Int Ed 2006;45(28):4552-4560.
-
(2006)
Angew Chem Int Ed
, vol.45
, Issue.28
, pp. 4552-4560
-
-
Arndt, H.-D.1
-
24
-
-
77952545553
-
A complex task? Direct modulation of transcription factors with small molecules
-
Koehler AN. A complex task? Direct modulation of transcription factors with small molecules. Curr Opin Chem Biol 2010;14(3):331-340.
-
(2010)
Curr Opin Chem Biol
, vol.14
, Issue.3
, pp. 331-340
-
-
Koehler, A.N.1
-
25
-
-
0037440734
-
Evolution of transcription factors and the gene regulatory network in Escherichia coli
-
Madan Babu M, Teichmann SA. Evolution of transcription factors and the gene regulatory network in Escherichia coli. Nucleic Acids Res 2003;31(4):1234-1244.
-
(2003)
Nucleic Acids Res
, vol.31
, Issue.4
, pp. 1234-1244
-
-
Madan Babu, M.1
Teichmann, S.A.2
-
26
-
-
37249004920
-
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
-
Wells JA, McClendon CL. Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature 2007;450(7172):1001-1009.
-
(2007)
Nature
, vol.450
, Issue.7172
, pp. 1001-1009
-
-
Wells, J.A.1
McClendon, C.L.2
-
27
-
-
22144454687
-
Strategies for targeting protein-protein interactions with synthetic agents
-
Yin H, Hamilton AD. Strategies for targeting protein-protein interactions with synthetic agents. Angew Chem Int Ed 2005;44(27):4130-4163.
-
(2005)
Angew Chem Int Ed
, vol.44
, Issue.27
, pp. 4130-4163
-
-
Yin, H.1
Hamilton, A.D.2
-
28
-
-
0037648966
-
Transcription factors as targets for DNA-interacting drugs
-
Gniazdowski M, Denny WA, Nelson SM, Czyz M. Transcription factors as targets for DNA-interacting drugs. Curr Med Chem 2003;10(11):909-924.
-
(2003)
Curr Med Chem
, vol.10
, Issue.11
, pp. 909-924
-
-
Gniazdowski, M.1
Denny, W.A.2
Nelson, S.M.3
Czyz, M.4
-
29
-
-
21244481362
-
Effects of anticancer drugs on transcription factor-DNA interactions
-
Gniazdowski M, Denny WA, Nelson SM, Czyz M. Effects of anticancer drugs on transcription factor-DNA interactions. Expert Opin Ther Targets 2005;9(3):471-489.
-
(2005)
Expert Opin Ther Targets
, vol.9
, Issue.3
, pp. 471-489
-
-
Gniazdowski, M.1
Denny, W.A.2
Nelson, S.M.3
Czyz, M.4
-
30
-
-
34548169696
-
Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactions
-
Hellman LM, Fried MG. Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactions. Nat Protocols 2007;2(8):1849-1861.
-
(2007)
Nat Protocols
, vol.2
, Issue.8
, pp. 1849-1861
-
-
Hellman, L.M.1
Fried, M.G.2
-
31
-
-
0024554911
-
Physical studies of protein-DNA complexes by footprinting
-
Tullius TD. Physical studies of protein-DNA complexes by footprinting. Annu Rev Biophys Biophys Chem 1989; 18(1):213-217.
-
(1989)
Annu Rev Biophys Biophys Chem
, vol.18
, Issue.1
, pp. 213-217
-
-
Tullius, T.D.1
-
32
-
-
0029008592
-
Sequence-dependent drug binding to the minor groove of DNA: Crystal structure of the DNA dodecamer d(CGCAAATTTGCG)2 complexed with propamidine
-
Nunn CM, Neidle S. Sequence-dependent drug binding to the minor groove of DNA: Crystal structure of the DNA dodecamer d(CGCAAATTTGCG)2 complexed with propamidine. J Med Chem 1995;38(13):2317-2325.
-
(1995)
J Med Chem
, vol.38
, Issue.13
, pp. 2317-2325
-
-
Nunn, C.M.1
Neidle, S.2
-
33
-
-
0029026601
-
Criteria for the mode of binding of DNA binding agents
-
Suh D, Chaires JB. Criteria for the mode of binding of DNA binding agents. Bioorg Med Chem 1995;3(6):723-728.
-
(1995)
Bioorg Med Chem
, vol.3
, Issue.6
, pp. 723-728
-
-
Suh, D.1
Chaires, J.B.2
-
34
-
-
84857924168
-
Determination of the drug-DNA binding modes using fluorescence-based assays
-
Williams AK, Dasilva SC, Bhatta A, Rawal B, Liu M, Korobkova EA. Determination of the drug-DNA binding modes using fluorescence-based assays. Anal Biochem 2012;422(2):66-73.
-
(2012)
Anal Biochem
, vol.422
, Issue.2
, pp. 66-73
-
-
Williams, A.K.1
Dasilva, S.C.2
Bhatta, A.3
Rawal, B.4
Liu, M.5
Korobkova, E.A.6
-
35
-
-
0000528608
-
A 1H NMR study of the DNA binding of ruthenium(II) polypyridyl complexes
-
Collins JG, Sleeman AD, Aldrich-Wright JR, Greguric I, Hambley TW. A 1H NMR study of the DNA binding of ruthenium(II) polypyridyl complexes. Inorg Chem 1998;37(13):3133-3141.
-
(1998)
Inorg Chem
, vol.37
, Issue.13
, pp. 3133-3141
-
-
Collins, J.G.1
Sleeman, A.D.2
Aldrich-Wright, J.R.3
Greguric, I.4
Hambley, T.W.5
-
36
-
-
79960327383
-
In vitro DNA-binding profile of transcription factors: Methods and new insights
-
Wang J, Lu J, Gu G, Liu Y. In vitro DNA-binding profile of transcription factors: Methods and new insights. J Endocrinol 2011;210(1):15-27.
-
(2011)
J Endocrinol
, vol.210
, Issue.1
, pp. 15-27
-
-
Wang, J.1
Lu, J.2
Gu, G.3
Liu, Y.4
-
38
-
-
79960918868
-
The Interactions of Small Molecules with DNA and RNA
-
Mayer G, editor. . Chichester, UK: John Wiley & Sons, Ltd;
-
Xie Y, Tam VK, Tor Y. The Interactions of Small Molecules with DNA and RNA. In: Mayer G, editor. The Chemical Biology of Nucleic Acids. Chichester, UK: John Wiley & Sons, Ltd; 2010. p 115-140.
-
(2010)
The Chemical Biology of Nucleic Acids
, pp. 115-140
-
-
Xie, Y.1
Tam, V.K.2
Tor, Y.3
-
39
-
-
0032102816
-
Drug-DNA interactions
-
Jonathan B C. Drug-DNA interactions. Curr Opin Struct Biol 1998;8(3):314-320.
-
(1998)
Curr Opin Struct Biol
, vol.8
, Issue.3
, pp. 314-320
-
-
Jonathan, B.C.1
-
40
-
-
79951679219
-
Reversible Small Molecule-Nucleic Acid Interactions
-
Blackburn GM, Gait MJ, Loakes D, Williams DM, editors. . 3rd ed. Cambridge, UK: RSC publishing
-
Reversible Small Molecule-Nucleic Acid Interactions. In: Blackburn GM, Gait MJ, Loakes D, Williams DM, editors. Nucleic Acids in Chemistry and Biology. 3rd ed. Cambridge, UK: RSC publishing; 2006. p 341-382.
-
(2006)
Nucleic Acids in Chemistry and Biology
, pp. 341-382
-
-
-
41
-
-
8544273289
-
Novel DNA bis-intercalation by MLN944, a potent clinical bisphenazine anticancer drug
-
Dai J, Punchihewa C, Mistry P, Ooi AT, Yang D. Novel DNA bis-intercalation by MLN944, a potent clinical bisphenazine anticancer drug. J Biol Chem 2004;279(44):46096-46103.
-
(2004)
J Biol Chem
, vol.279
, Issue.44
, pp. 46096-46103
-
-
Dai, J.1
Punchihewa, C.2
Mistry, P.3
Ooi, A.T.4
Yang, D.5
-
42
-
-
0035017573
-
Antitumor activity of XR5944, a novel and potent topoisomerase poison
-
Stewart AJ, Mistry P, Dangerfield W, Bootle D, Baker M, Kofler B, Okiji S, Baguley BC, Denny WA, Charlton PA. Antitumor activity of XR5944, a novel and potent topoisomerase poison. Anti-Cancer Drugs 2001;12(4):359-367.
-
(2001)
Anti-Cancer Drugs
, vol.12
, Issue.4
, pp. 359-367
-
-
Stewart, A.J.1
Mistry, P.2
Dangerfield, W.3
Bootle, D.4
Baker, M.5
Kofler, B.6
Okiji, S.7
Baguley, B.C.8
Denny, W.A.9
Charlton, P.A.10
-
43
-
-
0035953323
-
Dicationic bis(9-methylphenazine-1-carboxamides): Relationships between biological activity and linker chain structure for a series of potent topoisomerase targeted anticancer drugs
-
Gamage SA, Spicer JA, Finlay GJ, Stewart AJ, Charlton P, Baguley BC, Denny WA. Dicationic bis(9-methylphenazine-1-carboxamides): Relationships between biological activity and linker chain structure for a series of potent topoisomerase targeted anticancer drugs. J Med Chem 2001;44(9):1407-1415.
-
(2001)
J Med Chem
, vol.44
, Issue.9
, pp. 1407-1415
-
-
Gamage, S.A.1
Spicer, J.A.2
Finlay, G.J.3
Stewart, A.J.4
Charlton, P.5
Baguley, B.C.6
Denny, W.A.7
-
44
-
-
0242691046
-
AP-1: A double-edged sword in tumorigenesis
-
Eferl R, Wagner EF. AP-1: A double-edged sword in tumorigenesis. Nat Rev Cancer 2003;3(11):859-868.
-
(2003)
Nat Rev Cancer
, vol.3
, Issue.11
, pp. 859-868
-
-
Eferl, R.1
Wagner, E.F.2
-
45
-
-
33846048058
-
Transcription factors control invasion: AP-1 the first among equals
-
Ozanne BW, Spence HJ, McGarry LC, Hennigan RF. Transcription factors control invasion: AP-1 the first among equals. Oncogene 2006;26(1):1-10.
-
(2006)
Oncogene
, vol.26
, Issue.1
, pp. 1-10
-
-
Ozanne, B.W.1
Spence, H.J.2
McGarry, L.C.3
Hennigan, R.F.4
-
46
-
-
35148828429
-
Hypoxia-inducible factor 1 (HIF-1) pathway
-
Semenza GL. Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE 2007;407:cm8.
-
(2007)
Sci STKE
, vol.407
-
-
Semenza, G.L.1
-
47
-
-
26244438912
-
Hypoxia inducible factor-1: A novel target for cancer therapy
-
Belozerov VE, Van Meir EG. Hypoxia inducible factor-1: A novel target for cancer therapy. Anti-Cancer Drugs 2005;16(9):901-909.
-
(2005)
Anti-Cancer Drugs
, vol.16
, Issue.9
, pp. 901-909
-
-
Belozerov, V.E.1
Van Meir, E.G.2
-
48
-
-
60549083256
-
Regulation of cancer cell metabolism by hypoxia-inducible factor 1
-
Semenza GL. Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Semin Cancer Biol 2009;19(1):12-16.
-
(2009)
Semin Cancer Biol
, vol.19
, Issue.1
, pp. 12-16
-
-
Semenza, G.L.1
-
49
-
-
76349095132
-
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
-
Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 2009;29(5):625-634.
-
(2009)
Oncogene
, vol.29
, Issue.5
, pp. 625-634
-
-
Semenza, G.L.1
-
50
-
-
25444523184
-
Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity
-
Kong D, Park EJ, Stephen AG, Calvani M, Cardellina JH, Monks A, Fisher RJ, Shoemaker RH, Melillo G. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res 2005;65(19):9047-9055.
-
(2005)
Cancer Res
, vol.65
, Issue.19
, pp. 9047-9055
-
-
Kong, D.1
Park, E.J.2
Stephen, A.G.3
Calvani, M.4
Cardellina, J.H.5
Monks, A.6
Fisher, R.J.7
Shoemaker, R.H.8
Melillo, G.9
-
51
-
-
0021192920
-
Echinomycin binding sites on DNA
-
Van Dyke M, Dervan P. Echinomycin binding sites on DNA. Science 1984;225(4667):1122-1127.
-
(1984)
Science
, vol.225
, Issue.4667
, pp. 1122-1127
-
-
Van Dyke, M.1
Dervan, P.2
-
52
-
-
0028341460
-
Phase II trial of echinomycin in patients with advanced or recurrent colorectal cancer
-
Wadler S, Tenteromano L, Cazenave L, Sparano JA, Greenwald ES, Rozenblit A, Kaleya R, Wiernik PH. Phase II trial of echinomycin in patients with advanced or recurrent colorectal cancer. Cancer Chemother Pharmacol 1994;34(3):266-269.
-
(1994)
Cancer Chemother Pharmacol
, vol.34
, Issue.3
, pp. 266-269
-
-
Wadler, S.1
Tenteromano, L.2
Cazenave, L.3
Sparano, J.A.4
Greenwald, E.S.5
Rozenblit, A.6
Kaleya, R.7
Wiernik, P.H.8
-
53
-
-
0028844387
-
A phase II clinical trial of echinomycin in metastatic soft tissue sarcoma
-
Gradishar WJ, Vogelzang NJ, Kilton LJ, Leibach SJ, Rademaker AW, French S, Benson AB. A phase II clinical trial of echinomycin in metastatic soft tissue sarcoma. Invest New Drugs 1995;13(2):171-174.
-
(1995)
Invest New Drugs
, vol.13
, Issue.2
, pp. 171-174
-
-
Gradishar, W.J.1
Vogelzang, N.J.2
Kilton, L.J.3
Leibach, S.J.4
Rademaker, A.W.5
French, S.6
Benson, A.B.7
-
54
-
-
78649465565
-
Transcription factors: MYC matters
-
Swami M. Transcription factors: MYC matters. Nat Rev Cancer 2010;10(12):812-813.
-
(2010)
Nat Rev Cancer
, vol.10
, Issue.12
, pp. 812-813
-
-
Swami, M.1
-
55
-
-
33847643631
-
Drug insight: VEGF as a therapeutic target for breast cancer
-
Schneider BP, Sledge GW. Drug insight: VEGF as a therapeutic target for breast cancer. Nat Clin Prac Oncol 2007;4(3):181-189.
-
(2007)
Nat Clin Prac Oncol
, vol.4
, Issue.3
, pp. 181-189
-
-
Schneider, B.P.1
Sledge, G.W.2
-
56
-
-
33644857142
-
Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy
-
Lee YK, Isham CR, Kaufman SH, Bible KC. Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy. Mol Cancer Ther 2006;5(1):138-148.
-
(2006)
Mol Cancer Ther
, vol.5
, Issue.1
, pp. 138-148
-
-
Lee, Y.K.1
Isham, C.R.2
Kaufman, S.H.3
Bible, K.C.4
-
57
-
-
0037204953
-
A road map for those who don't know JAK-STAT
-
Aaronson DS, Horvath CM. A road map for those who don't know JAK-STAT. Science 2002;296(5573):1653-1655.
-
(2002)
Science
, vol.296
, Issue.5573
, pp. 1653-1655
-
-
Aaronson, D.S.1
Horvath, C.M.2
-
58
-
-
1042302005
-
The STATs of cancer-new molecular targets come of age
-
Yu H, Jove R. The STATs of cancer-new molecular targets come of age. Nat Rev Cancer 2004;4(2):97-105.
-
(2004)
Nat Rev Cancer
, vol.4
, Issue.2
, pp. 97-105
-
-
Yu, H.1
Jove, R.2
-
59
-
-
70350500225
-
STATs in cancer inflammation and immunity: A leading role for STAT3
-
Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: A leading role for STAT3. Nat Rev Cancer 2009;9(11):798-809.
-
(2009)
Nat Rev Cancer
, vol.9
, Issue.11
, pp. 798-809
-
-
Yu, H.1
Pardoll, D.2
Jove, R.3
-
60
-
-
0034194254
-
Flavopiridol binds to duplex DNA
-
Bible KC, Bible RH, Kottke TJ, Svingen PA, Xu K, Pang Y-P, Hajdu E, Kaufmann SH. Flavopiridol binds to duplex DNA. Cancer Res 2000;60(9):2419-2428.
-
(2000)
Cancer Res
, vol.60
, Issue.9
, pp. 2419-2428
-
-
Bible, K.C.1
Bible, R.H.2
Kottke, T.J.3
Svingen, P.A.4
Xu, K.5
Pang, Y.-P.6
Hajdu, E.7
Kaufmann, S.H.8
-
61
-
-
13344295097
-
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor
-
Meydan N, Grunberger T, Dadi H, Shahar M, Arpaia E, Lapidot Z, Leeder JS, Freedman M, Cohen A, Gazit A, Levitzki A, Roifman CM. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature 1996;379(6566):645-648.
-
(1996)
Nature
, vol.379
, Issue.6566
, pp. 645-648
-
-
Meydan, N.1
Grunberger, T.2
Dadi, H.3
Shahar, M.4
Arpaia, E.5
Lapidot, Z.6
Leeder, J.S.7
Freedman, M.8
Cohen, A.9
Gazit, A.10
Levitzki, A.11
Roifman, C.M.12
-
62
-
-
0023628351
-
The formation, isolation and characterization of DNA adducts produced by anticancer platinum complexes
-
Eastman A. The formation, isolation and characterization of DNA adducts produced by anticancer platinum complexes. Pharmacol Ther 1987;34(2):155-166.
-
(1987)
Pharmacol Ther
, vol.34
, Issue.2
, pp. 155-166
-
-
Eastman, A.1
-
63
-
-
0033586725
-
Site-specific inhibition of transcription factor binding to DNA by a metallointercalator
-
Odom DT, Parker CS, Barton JK. Site-specific inhibition of transcription factor binding to DNA by a metallointercalator. Biochemistry 1999;38(16):5155-5163.
-
(1999)
Biochemistry
, vol.38
, Issue.16
, pp. 5155-5163
-
-
Odom, D.T.1
Parker, C.S.2
Barton, J.K.3
-
64
-
-
70349267679
-
A mass spectrometric investigation of the ability of metal complexes to modulate transcription factor activity
-
Talib J, Beck JL, Urathamakul T, Nguyen CD, Aldrich-Wright JR, Mackay JP, Ralph SF. A mass spectrometric investigation of the ability of metal complexes to modulate transcription factor activity. Chem Commun 2009(37):5546-5548.
-
Chem Commun
, vol.2009
, Issue.37
, pp. 5546-5548
-
-
Talib, J.1
Beck, J.L.2
Urathamakul, T.3
Nguyen, C.D.4
Aldrich-Wright, J.R.5
Mackay, J.P.6
Ralph, S.F.7
-
65
-
-
0028136726
-
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
-
Scott E, Simon M, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 1994;265(5178):1573-1577.
-
(1994)
Science
, vol.265
, Issue.5178
, pp. 1573-1577
-
-
Scott, E.1
Simon, M.2
Anastasi, J.3
Singh, H.4
-
66
-
-
8844220158
-
Evaluation of the DNA-Binding Properties of Cationic Dyes by Absorption and Emission Spectroscopy
-
Schmuck C, Wennemers H, editors. . Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA
-
Ihmels H, Faulhaber K, Viola G, Schmuck C. Evaluation of the DNA-Binding Properties of Cationic Dyes by Absorption and Emission Spectroscopy. In: Schmuck C, Wennemers H, editors. Highlights in Bioorganic Chemistry. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA; 2005. p 172-190.
-
(2005)
Highlights in Bioorganic Chemistry
, pp. 172-190
-
-
Ihmels, H.1
Faulhaber, K.2
Viola, G.3
Schmuck, C.4
-
67
-
-
3042662220
-
DNA minor groove binders as potential antitumor and antimicrobial agents
-
Baraldi PG, Bovero A, Fruttarolo F, Preti D, Tabrizi MA, Pavani MG, Romagnoli R. DNA minor groove binders as potential antitumor and antimicrobial agents. Med Res Rev 2004;24(4):475-528.
-
(2004)
Med Res Rev
, vol.24
, Issue.4
, pp. 475-528
-
-
Baraldi, P.G.1
Bovero, A.2
Fruttarolo, F.3
Preti, D.4
Tabrizi, M.A.5
Pavani, M.G.6
Romagnoli, R.7
-
68
-
-
0034951136
-
DNA minor-groove recognition by small molecules
-
Neidle S. DNA minor-groove recognition by small molecules. Nat Prod Rep 2001;18(3):291-309.
-
(2001)
Nat Prod Rep
, vol.18
, Issue.3
, pp. 291-309
-
-
Neidle, S.1
-
70
-
-
0034231581
-
The genome as a drug target: Sequence specific minor groove binding ligands
-
Turner PR, Denny WA. The genome as a drug target: Sequence specific minor groove binding ligands. Curr Drug Targets 2000;1(1):1-14.
-
(2000)
Curr Drug Targets
, vol.1
, Issue.1
, pp. 1-14
-
-
Turner, P.R.1
Denny, W.A.2
-
71
-
-
0034830898
-
Molecular recognition of DNA by small molecules
-
Dervan PB. Molecular recognition of DNA by small molecules. Bioorg Med Chem 2001;9(9):2215-2235.
-
(2001)
Bioorg Med Chem
, vol.9
, Issue.9
, pp. 2215-2235
-
-
Dervan, P.B.1
-
72
-
-
0342987251
-
Design of peptides that bind in the minor groove of DNA at 5′-(A,T)G(A,T)C(A,T)-3′ sequences by a dimeric side-by-side motif
-
Wade WS, Mrksich M, Dervan PB. Design of peptides that bind in the minor groove of DNA at 5′-(A, T)G(A, T)C(A, T)-3′ sequences by a dimeric side-by-side motif. J Am Chem Soc 1992;114(23):8783-8794.
-
(1992)
J Am Chem Soc
, vol.114
, Issue.23
, pp. 8783-8794
-
-
Wade, W.S.1
Mrksich, M.2
Dervan, P.B.3
-
73
-
-
69449087887
-
Allosteric modulation of DNA by small molecules
-
Chenoweth DM, Dervan PB. Allosteric modulation of DNA by small molecules. Proc Natl Acad Sci USA 2009;106(32):13175-13179.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.32
, pp. 13175-13179
-
-
Chenoweth, D.M.1
Dervan, P.B.2
-
74
-
-
0001015292
-
Structural characterization of a 2:1 distamycin A.d(CGCAAATTGGC) complex by two-dimensional NMR
-
Pelton JG, Wemmer DE. Structural characterization of a 2:1 distamycin A.d(CGCAAATTGGC) complex by two-dimensional NMR. Proc Natl Acad Sci USA 1989;86(15):5723-5727.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, Issue.15
, pp. 5723-5727
-
-
Pelton, J.G.1
Wemmer, D.E.2
-
75
-
-
0026661689
-
Antiparallel side-by-side dimeric motif for sequence-specific recognition in the minor groove of DNA by the designed peptide 1-methylimidazole-2-carboxamide netropsin
-
Mrksich M, Wade WS, Dwyer TJ, Geierstanger BH, Wemmer DE, Dervan PB. Antiparallel side-by-side dimeric motif for sequence-specific recognition in the minor groove of DNA by the designed peptide 1-methylimidazole-2-carboxamide netropsin. Proc Natl Acad Sci USA 1992;89(16):7586-7590.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, Issue.16
, pp. 7586-7590
-
-
Mrksich, M.1
Wade, W.S.2
Dwyer, T.J.3
Geierstanger, B.H.4
Wemmer, D.E.5
Dervan, P.B.6
-
76
-
-
0029786013
-
Recognition of DNA by designed ligands at subnanomolar concentrations
-
Trauger JW, Baird EE, Dervan PB. Recognition of DNA by designed ligands at subnanomolar concentrations. Nature 1996;382(6591):559-561.
-
(1996)
Nature
, vol.382
, Issue.6591
, pp. 559-561
-
-
Trauger, J.W.1
Baird, E.E.2
Dervan, P.B.3
-
77
-
-
0033577001
-
Effects of γ-turn and β-tail amino acids on sequence-specific recognition of DNA by hairpin polyamides
-
Swalley SE, Baird EE, Dervan PB. Effects of γ-turn and β-tail amino acids on sequence-specific recognition of DNA by hairpin polyamides. J Am Chem Soc 1999;121(6):1113-1120.
-
(1999)
J Am Chem Soc
, vol.121
, Issue.6
, pp. 1113-1120
-
-
Swalley, S.E.1
Baird, E.E.2
Dervan, P.B.3
-
78
-
-
0035105078
-
Expanding the recognition of the minor groove of DNA by incorporation of β-alanine in hairpin polyamides
-
Wang CCC, Ellervik U, Dervan PB. Expanding the recognition of the minor groove of DNA by incorporation of β-alanine in hairpin polyamides. Bioorg Med Chem 2001;9(3):653-657.
-
(2001)
Bioorg Med Chem
, vol.9
, Issue.3
, pp. 653-657
-
-
Wang, C.C.C.1
Ellervik, U.2
Dervan, P.B.3
-
79
-
-
34249058968
-
Completion of a programmable DNA-binding small molecule library
-
Hsu CF, Phillips JW, Trauger JW, Farkas ME, Belitsky JM, Heckel A, Olenyuk BZ, Puckett JW, Wang CCC, Dervan PB. Completion of a programmable DNA-binding small molecule library. Tetrahedron 2007;63(27):6146-6151.
-
(2007)
Tetrahedron
, vol.63
, Issue.27
, pp. 6146-6151
-
-
Hsu, C.F.1
Phillips, J.W.2
Trauger, J.W.3
Farkas, M.E.4
Belitsky, J.M.5
Heckel, A.6
Olenyuk, B.Z.7
Puckett, J.W.8
Wang, C.C.C.9
Dervan, P.B.10
-
80
-
-
0037832279
-
Recognition of the DNA minor groove by pyrrole-imidazole polyamides
-
Dervan PB, Edelson BS. Recognition of the DNA minor groove by pyrrole-imidazole polyamides. Curr Opin Struct Biol 2003;13(3):284-299.
-
(2003)
Curr Opin Struct Biol
, vol.13
, Issue.3
, pp. 284-299
-
-
Dervan, P.B.1
Edelson, B.S.2
-
81
-
-
0038375540
-
Allosteric inhibition of protein-DNA complexes by polyamide-intercalator conjugates
-
Fechter EJ, Dervan PB. Allosteric inhibition of protein-DNA complexes by polyamide-intercalator conjugates. J Am Chem Soc 2003;125(28):8476-8485.
-
(2003)
J Am Chem Soc
, vol.125
, Issue.28
, pp. 8476-8485
-
-
Fechter, E.J.1
Dervan, P.B.2
-
82
-
-
1942425075
-
Sequence-specific gene silencing in mammalian cells by alkylating pyrrole-imidazole polyamides
-
Shinohara K-i, Narita A, Oyoshi T, Bando T, Teraoka H, Sugiyama H. Sequence-specific gene silencing in mammalian cells by alkylating pyrrole-imidazole polyamides. J Am Chem Soc 2004;126(16):5113-5118.
-
(2004)
J Am Chem Soc
, vol.126
, Issue.16
, pp. 5113-5118
-
-
Shinohara, K.-I.1
Narita, A.2
Oyoshi, T.3
Bando, T.4
Teraoka, H.5
Sugiyama, H.6
-
83
-
-
55249093393
-
Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells
-
Hsu CF, Dervan PB. Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells. Bioorg Med Chem let 2008;18(22):5851-5855.
-
(2008)
Bioorg Med Chem let
, vol.18
, Issue.22
, pp. 5851-5855
-
-
Hsu, C.F.1
Dervan, P.B.2
-
84
-
-
33846937087
-
Improved nuclear localization of DNA-binding polyamides
-
Nickols NG, Jacobs CS, Farkas ME, Dervan PB. Improved nuclear localization of DNA-binding polyamides. Nucleic Acids Res 2007;35(2):363-370.
-
(2007)
Nucleic Acids Res
, vol.35
, Issue.2
, pp. 363-370
-
-
Nickols, N.G.1
Jacobs, C.S.2
Farkas, M.E.3
Dervan, P.B.4
-
85
-
-
10044258467
-
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist
-
Olenyuk BZ, Zhang G-J, Klco JM, Nickols NG, Kaelin WG, Dervan PB. Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist. Proc Natl Acad Sci USA 2004;101(48):16768-16773.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.48
, pp. 16768-16773
-
-
Olenyuk, B.Z.1
Zhang, G.-J.2
Klco, J.M.3
Nickols, N.G.4
Kaelin, W.G.5
Dervan, P.B.6
-
86
-
-
33750503786
-
Exploring the limits of benzimidazole DNA-binding oligomers for the hypoxia inducible factor (HIF) site
-
Viger A, Dervan PB. Exploring the limits of benzimidazole DNA-binding oligomers for the hypoxia inducible factor (HIF) site. Bioorg Med Chem 2006;14(24):8539-8549.
-
(2006)
Bioorg Med Chem
, vol.14
, Issue.24
, pp. 8539-8549
-
-
Viger, A.1
Dervan, P.B.2
-
87
-
-
33646402602
-
Suppression of VEGF transcription in renal cell carcinoma cells by pyrrole-imidazole hairpin polyamides targeting the hypoxia responsive element
-
Kageyama Y, Sugiyama H, Ayame H, Iwai A, Fujii Y, Eric Huang L, Kizaka-Kondoh S, Hiraoka M, Kihara K. Suppression of VEGF transcription in renal cell carcinoma cells by pyrrole-imidazole hairpin polyamides targeting the hypoxia responsive element. Acta Oncol 2006;45(3):317-324.
-
(2006)
Acta Oncol
, vol.45
, Issue.3
, pp. 317-324
-
-
Kageyama, Y.1
Sugiyama, H.2
Ayame, H.3
Iwai, A.4
Fujii, Y.5
Eric Huang, L.6
Kizaka-Kondoh, S.7
Hiraoka, M.8
Kihara, K.9
-
88
-
-
0034604110
-
Role of transforming growth factor β in human disease
-
Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor β in human disease. New Engl J Med 2000;342(18):1350-1358.
-
(2000)
New Engl J Med
, vol.342
, Issue.18
, pp. 1350-1358
-
-
Blobe, G.C.1
Schiemann, W.P.2
Lodish, H.F.3
-
89
-
-
33645457692
-
Development of gene silencing pyrrole-imidazole polyamide targeting the TGF-β1 promoter for treatment of progressive renal diseases
-
Matsuda H, Fukuda N, Ueno T, Tahira Y, Ayame H, Zhang W, Bando T, Sugiyama H, Saito S, Matsumoto K, Mugishima H, Serie K. Development of gene silencing pyrrole-imidazole polyamide targeting the TGF-β1 promoter for treatment of progressive renal diseases. J Am Soc Nephrol 2006;17(2):422-432.
-
(2006)
J Am Soc Nephrol
, vol.17
, Issue.2
, pp. 422-432
-
-
Matsuda, H.1
Fukuda, N.2
Ueno, T.3
Tahira, Y.4
Ayame, H.5
Zhang, W.6
Bando, T.7
Sugiyama, H.8
Saito, S.9
Matsumoto, K.10
Mugishima, H.11
Serie, K.12
-
90
-
-
78650264127
-
Transcriptional inhibition of progressive renal disease by gene silencing pyrrole-imidazole polyamide targeting of the transforming growth factor-[beta]1 promoter
-
Matsuda H, Fukuda N, Ueno T, Katakawa M, Wang X, Watanabe T, Matsui S-I, Aoyama T, Saito K, Bando T, Matsumoto Y, Nagase H, Matsumoto K, Sugiyama H. Transcriptional inhibition of progressive renal disease by gene silencing pyrrole-imidazole polyamide targeting of the transforming growth factor-[beta]1 promoter. Kidney Int 2011;79(1):46-56.
-
(2011)
Kidney Int
, vol.79
, Issue.1
, pp. 46-56
-
-
Matsuda, H.1
Fukuda, N.2
Ueno, T.3
Katakawa, M.4
Wang, X.5
Watanabe, T.6
Matsui, S.-I.7
Aoyama, T.8
Saito, K.9
Bando, T.10
Matsumoto, Y.11
Nagase, H.12
Matsumoto, K.13
Sugiyama, H.14
-
91
-
-
46449128573
-
Novel gene silencer pyrrole-imidazole polyamide targeting lectin-like oxidized low-density lipoprotein receptor-1 attenuates restenosis of the artery after injury
-
Yao E-H, Fukuda N, Ueno T, Matsuda H, Matsumoto K, Nagase H, Matsumoto Y, Takasaka A, Serie K, Sugiyama H, Sawamura T. Novel gene silencer pyrrole-imidazole polyamide targeting lectin-like oxidized low-density lipoprotein receptor-1 attenuates restenosis of the artery after injury. Hypertension 2008;52(1):86-92.
-
(2008)
Hypertension
, vol.52
, Issue.1
, pp. 86-92
-
-
Yao, E.-H.1
Fukuda, N.2
Ueno, T.3
Matsuda, H.4
Matsumoto, K.5
Nagase, H.6
Matsumoto, Y.7
Takasaka, A.8
Serie, K.9
Sugiyama, H.10
Sawamura, T.11
-
92
-
-
0035993485
-
LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis
-
Chen M, Masaki T, Sawamura T. LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis. Pharmacol Ther 2002;95(1):89-100.
-
(2002)
Pharmacol Ther
, vol.95
, Issue.1
, pp. 89-100
-
-
Chen, M.1
Masaki, T.2
Sawamura, T.3
-
93
-
-
33846847632
-
Modulation of topoisomerase IIα expression by a DNA sequence-specific polyamide
-
Hochhauser D, Kotecha M, O'Hare C, Morris PJ, Hartley JM, Taherbhai Z, Harris D, Forni C, Mantovani R, Lee M, Hartley JA. Modulation of topoisomerase IIα expression by a DNA sequence-specific polyamide. Mol Cancer Ther 2007;6(1):346-354.
-
(2007)
Mol Cancer Ther
, vol.6
, Issue.1
, pp. 346-354
-
-
Hochhauser, D.1
Kotecha, M.2
O'Hare, C.3
Morris, P.J.4
Hartley, J.M.5
Taherbhai, Z.6
Harris, D.7
Forni, C.8
Mantovani, R.9
Lee, M.10
Hartley, J.A.11
-
94
-
-
33748211158
-
Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation
-
Di Agostino S, Strano S, Emiliozzi V, Zerbini V, Mottolese M, Sacchi A, Blandino G, Piaggio G. Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation. Cancer Cell 2006;10(3):191-202.
-
(2006)
Cancer Cell
, vol.10
, Issue.3
, pp. 191-202
-
-
Di Agostino, S.1
Strano, S.2
Emiliozzi, V.3
Zerbini, V.4
Mottolese, M.5
Sacchi, A.6
Blandino, G.7
Piaggio, G.8
-
95
-
-
2342558431
-
Androgen receptor in prostate cancer
-
Heinlein CA, Chang C. Androgen receptor in prostate cancer. Endocr Rev 2004;25(2):276-308.
-
(2004)
Endocr Rev
, vol.25
, Issue.2
, pp. 276-308
-
-
Heinlein, C.A.1
Chang, C.2
-
96
-
-
35548958147
-
New androgen receptor genomic targets show an interaction with the ETS1 transcription factor
-
Massie CE, Adryan B, Barbosa-Morais NL, Lynch AG, Tran MG, Neal DE, Mills IG. New androgen receptor genomic targets show an interaction with the ETS1 transcription factor. EMBO Rep 2007;8(9):871-878.
-
(2007)
EMBO Rep
, vol.8
, Issue.9
, pp. 871-878
-
-
Massie, C.E.1
Adryan, B.2
Barbosa-Morais, N.L.3
Lynch, A.G.4
Tran, M.G.5
Neal, D.E.6
Mills, I.G.7
-
97
-
-
34547496561
-
Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide
-
Nickols NG, Dervan PB. Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide. Proc Natl Acad Sci USA 2007;104(25):10418-10423.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.25
, pp. 10418-10423
-
-
Nickols, N.G.1
Dervan, P.B.2
-
98
-
-
69449104508
-
The androgen receptor in hormone-refractory prostate cancer
-
Mao H-L, Zhu Z-Q, Chen CD. The androgen receptor in hormone-refractory prostate cancer. Asian J Androl 2008;11(1):69-73.
-
(2008)
Asian J Androl
, vol.11
, Issue.1
, pp. 69-73
-
-
Mao, H.-L.1
Zhu, Z.-Q.2
Chen, C.D.3
-
99
-
-
82455175405
-
Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide
-
Zhang Y, Sicot G, Cui X, Vogel M, Wuertzer CA, Lezon-Geyda K, Wheeler J, Harki DA, Muzikar KA, Stolper DA, Dervan PB, Perkins AS. Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide. Biochemistry 2011;50(48):10431-10441.
-
(2011)
Biochemistry
, vol.50
, Issue.48
, pp. 10431-10441
-
-
Zhang, Y.1
Sicot, G.2
Cui, X.3
Vogel, M.4
Wuertzer, C.A.5
Lezon-Geyda, K.6
Wheeler, J.7
Harki, D.A.8
Muzikar, K.A.9
Stolper, D.A.10
Dervan, P.B.11
Perkins, A.S.12
-
100
-
-
0026342692
-
Evi-1, a murine zinc finger proto-oncogene, encodes a sequence-specific DNA-binding protein
-
Perkins AS, Fishel R, Jenkins NA, Copeland NG. Evi-1, a murine zinc finger proto-oncogene, encodes a sequence-specific DNA-binding protein. Mol Cell Biol 1991;11(5):2665-2674.
-
(1991)
Mol Cell Biol
, vol.11
, Issue.5
, pp. 2665-2674
-
-
Perkins, A.S.1
Fishel, R.2
Jenkins, N.A.3
Copeland, N.G.4
-
101
-
-
33845191515
-
Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites
-
Lee T-J, Jung EM, Lee JT, Kim S, Park J-W, Choi KS, Kwon TK. Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites. Mol Cancer Ther 2006;5(11):2737-2746.
-
(2006)
Mol Cancer Ther
, vol.5
, Issue.11
, pp. 2737-2746
-
-
Lee, T.-J.1
Jung, E.M.2
Lee, J.T.3
Kim, S.4
Park, J.-W.5
Choi, K.S.6
Kwon, T.K.7
-
102
-
-
0027168887
-
Solution structure of the mithramycin dimer-DNA complex
-
Sastry M, Patel DJ. Solution structure of the mithramycin dimer-DNA complex. Biochemistry 1993;32(26):6588-6604.
-
(1993)
Biochemistry
, vol.32
, Issue.26
, pp. 6588-6604
-
-
Sastry, M.1
Patel, D.J.2
-
103
-
-
49849084303
-
Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78
-
Kotecha M, Kluza J, Wells G, O'Hare CC, Forni C, Mantovani R, Howard PW, Morris P, Thurston DE, Hartley JA, Hochhauser D. Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78. Mol Cancer Ther 2008;7(5):1319-1328.
-
(2008)
Mol Cancer Ther
, vol.7
, Issue.5
, pp. 1319-1328
-
-
Kotecha, M.1
Kluza, J.2
Wells, G.3
O'Hare, C.C.4
Forni, C.5
Mantovani, R.6
Howard, P.W.7
Morris, P.8
Thurston, D.E.9
Hartley, J.A.10
Hochhauser, D.11
-
104
-
-
33748537069
-
Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates
-
Wells G, Martin CRH, Howard PW, Sands ZA, Laughton CA, Tiberghien A, Woo CK, Masterson LA, Stephenson MJ, Hartley JA, Jenkins TC, Shnyder SD, Loadman PM, Waring MJ, Thurston DE. Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates. J Med Chem 2006;49(18):5442-5461.
-
(2006)
J Med Chem
, vol.49
, Issue.18
, pp. 5442-5461
-
-
Wells, G.1
Martin, C.R.H.2
Howard, P.W.3
Sands, Z.A.4
Laughton, C.A.5
Tiberghien, A.6
Woo, C.K.7
Masterson, L.A.8
Stephenson, M.J.9
Hartley, J.A.10
Jenkins, T.C.11
Shnyder, S.D.12
Loadman, P.M.13
Waring, M.J.14
Thurston, D.E.15
-
105
-
-
45549100438
-
Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dication
-
Peixoto P, Liu Y, Depauw S, Hildebrand M-P, Boykin DW, Bailly C, Wilson WD, David-Cordonnier M-H. Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dication. Nucleic Acids Res 2008;36(10):3341-3353.
-
(2008)
Nucleic Acids Res
, vol.36
, Issue.10
, pp. 3341-3353
-
-
Peixoto, P.1
Liu, Y.2
Depauw, S.3
Hildebrand, M.-P.4
Boykin, D.W.5
Bailly, C.6
Wilson, W.D.7
David-Cordonnier, M.-H.8
-
106
-
-
23844482513
-
Pit-1 is expressed in normal and tumorous human breast and regulates GH secretion and cell proliferation
-
Gil-Puig C, Seoane S, Blanco M, Macia M, Garcia-Caballero T, Segura C, Perez-Fernandez R. Pit-1 is expressed in normal and tumorous human breast and regulates GH secretion and cell proliferation. Eur J Endocrinol 2005;153(2):335-344.
-
(2005)
Eur J Endocrinol
, vol.153
, Issue.2
, pp. 335-344
-
-
Gil-Puig, C.1
Seoane, S.2
Blanco, M.3
Macia, M.4
Garcia-Caballero, T.5
Segura, C.6
Perez-Fernandez, R.7
-
107
-
-
56249083567
-
POU domain transcription factors: BRN2 as a regulator of melanocytic growth and tumourigenesis
-
Cook AL, Sturm RA. POU domain transcription factors: BRN2 as a regulator of melanocytic growth and tumourigenesis. Pigment Cell Melanoma Res 2008;21(6):611-626.
-
(2008)
Pigment Cell Melanoma Res
, vol.21
, Issue.6
, pp. 611-626
-
-
Cook, A.L.1
Sturm, R.A.2
-
108
-
-
0035928819
-
Recognition of ATGA sequences by the unfused aromatic dication DB293 forming stacked dimers in the DNA minor groove
-
Bailly C, Tardy C, Wang L, Armitage B, Hopkins K, Kumar A, Schuster GB, Boykin DW, Wilson WD. Recognition of ATGA sequences by the unfused aromatic dication DB293 forming stacked dimers in the DNA minor groove. Biochemistry 2001;40(33):9770-9779.
-
(2001)
Biochemistry
, vol.40
, Issue.33
, pp. 9770-9779
-
-
Bailly, C.1
Tardy, C.2
Wang, L.3
Armitage, B.4
Hopkins, K.5
Kumar, A.6
Schuster, G.B.7
Boykin, D.W.8
Wilson, W.D.9
-
109
-
-
0023619361
-
Sequence-specific cleavage of double helical DNA by triple helix formation
-
Moser H, Dervan P. Sequence-specific cleavage of double helical DNA by triple helix formation. Science 1987;238(4827):645-650.
-
(1987)
Science
, vol.238
, Issue.4827
, pp. 645-650
-
-
Moser, H.1
Dervan, P.2
-
110
-
-
33748577758
-
Sequence-specific recognition and modification of double-helical DNA by oligonucleotides
-
Thuong NT, Hélène C. Sequence-specific recognition and modification of double-helical DNA by oligonucleotides. Angew Chem Int Ed 1993;32(5):666-690.
-
(1993)
Angew Chem Int Ed
, vol.32
, Issue.5
, pp. 666-690
-
-
Thuong, N.T.1
Hélène, C.2
-
111
-
-
0026595218
-
Specific inhibition of transcription by triple helix-forming oligonucleotides
-
Duval-Valentin G, Thuong NT, Hélène C. Specific inhibition of transcription by triple helix-forming oligonucleotides. Proc Natl Acad Sci USA 1992;89(2):504-508.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, Issue.2
, pp. 504-508
-
-
Duval-Valentin, G.1
Thuong, N.T.2
Hélène, C.3
-
112
-
-
0035404317
-
Triplex-forming molecules: From concepts to applications
-
Faria M, Giovannangeli C. Triplex-forming molecules: From concepts to applications. J Gene Med 2001;3(4):299-310.
-
(2001)
J Gene Med
, vol.3
, Issue.4
, pp. 299-310
-
-
Faria, M.1
Giovannangeli, C.2
-
113
-
-
79959377187
-
DNA triplex-mediated inhibition of MET leads to cell death and tumor regression in hepatoma
-
Singhal G, Akhter MZ, Stern DF, Gupta SD, Ahuja A, Sharma U, Jagannathan NR, Rajeswari MR. DNA triplex-mediated inhibition of MET leads to cell death and tumor regression in hepatoma. Cancer Gene Ther 2011;18(7):520-530.
-
(2011)
Cancer Gene Ther
, vol.18
, Issue.7
, pp. 520-530
-
-
Singhal, G.1
Akhter, M.Z.2
Stern, D.F.3
Gupta, S.D.4
Ahuja, A.5
Sharma, U.6
Jagannathan, N.R.7
Rajeswari, M.R.8
-
114
-
-
0035475787
-
Triplex forming oligonucleotides: Sequence-specific tools for gene targeting
-
Knauert MP, Glazer PM. Triplex forming oligonucleotides: Sequence-specific tools for gene targeting. Hum Mol Genet 2001;10(20):2243-2251.
-
(2001)
Hum Mol Genet
, vol.10
, Issue.20
, pp. 2243-2251
-
-
Knauert, M.P.1
Glazer, P.M.2
-
115
-
-
47649089968
-
Targeting DNA with triplex-forming oligonucleotides to modify gene sequence
-
Simon P, Cannata F, Concordet J-P, Giovannangeli C. Targeting DNA with triplex-forming oligonucleotides to modify gene sequence. Biochimie 2008;90(8):1109-1116.
-
(2008)
Biochimie
, vol.90
, Issue.8
, pp. 1109-1116
-
-
Simon, P.1
Cannata, F.2
Concordet, J.-P.3
Giovannangeli, C.4
-
116
-
-
50449090659
-
Chromium(III) complexes inhibit transcription factors binding to DNA and associated gene expression
-
Raja NS, Nair BU. Chromium(III) complexes inhibit transcription factors binding to DNA and associated gene expression. Toxicology 2008;251(1-3):61-65.
-
(2008)
Toxicology
, vol.251
, Issue.1-3
, pp. 61-65
-
-
Raja, N.S.1
Nair, B.U.2
-
117
-
-
41849147879
-
Chemical properties and toxicity of chromium(III) nutritional supplements
-
Levina A, Lay PA. Chemical properties and toxicity of chromium(III) nutritional supplements. Chem Res Toxicol 2008;21(3):563-571.
-
(2008)
Chem Res Toxicol
, vol.21
, Issue.3
, pp. 563-571
-
-
Levina, A.1
Lay, P.A.2
-
118
-
-
79952263626
-
Specific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes
-
Wang P, Leung C-H, Ma D-L, Sun RW-Y, Yan S-C, Chen Q-S, Che C-M. Specific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes. Angew Chem Int Ed 2011;50(11):2554-2558.
-
(2011)
Angew Chem Int Ed
, vol.50
, Issue.11
, pp. 2554-2558
-
-
Wang, P.1
Leung, C.-H.2
Ma, D.-L.3
Sun, R.-Y.4
Yan, S.-C.5
Chen, Q.-S.6
Che, C.-M.7
-
119
-
-
24344482544
-
CREB: The unindicted cancer co-conspirator
-
Conkright MD, Montminy M. CREB: The unindicted cancer co-conspirator. Trends Cell Biol 2005;15(9):457-459.
-
(2005)
Trends Cell Biol
, vol.15
, Issue.9
, pp. 457-459
-
-
Conkright, M.D.1
Montminy, M.2
-
120
-
-
65249140538
-
CREB in the pathophysiology of cancer: Implications for targeting transcription factors for cancer therapy
-
Sakamoto KM, Frank DA. CREB in the pathophysiology of cancer: Implications for targeting transcription factors for cancer therapy. Clin Cancer Res 2009;15(8):2583-2587.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.8
, pp. 2583-2587
-
-
Sakamoto, K.M.1
Frank, D.A.2
-
121
-
-
34548581017
-
Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interface
-
Nickols NG, Jacobs CS, Farkas ME, Dervan PB. Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interface. ACS Chem Biol 2007;2(8):561-571.
-
(2007)
ACS Chem Biol
, vol.2
, Issue.8
, pp. 561-571
-
-
Nickols, N.G.1
Jacobs, C.S.2
Farkas, M.E.3
Dervan, P.B.4
|