Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates

Journal of Medicinal Chemistry

Volumn 49, Issue 18, 2006, Pages 5442-5461

  Wells, Geoff ^a   Martin, Christopher R H ^b,c   Howard, Philip W ^a,b   Sands, Zara A ^d   Laughton, Charles A ^d   Tiberghien, Arnaud ^a,b   Woo, Chi Kit ^b   Masterson, Luke A ^a,b   Stephenson, Marissa J ^b   Hartley, John A ^b,e   Jenkins, Terence C ^f,h   Shnyder, Steven D ^g   Loadman, Paul M ^g   Waring, Michael J ^c   Thurston, David E ^a,b  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f UNIVERSITY OF MANCHESTER   (United Kingdom)

^g UNIVERSITY OF BRADFORD   (United Kingdom)

^h Morvus Technology Limited   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAMYCIN; BENZODIAZEPINE DERIVATIVE; CONGOCIDINE; DISTAMYCIN A; METHYL 4 [4 (7 METHOXY 5 OXO 2,3,5,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 8 YLOXY)BUTYRYLAMINO] 1 METHYL 1H PYRROLE 2 CARBOXYLATE; METHYL 4 [[4 [4 (7 METHOXY 5 OXO 2,3,5,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 8 YLOXY)BUTYRYLAMINO] 1 METHYL 1H PYRROLE 2 CARBONYL]AMINO] 1 METHYL 1H PYRROLE 2 CARBOXYLATE; METHYL GROUP; PYRROLE DERIVATIVE; PYRROLOBENZODIAZEPINE POLY(N METHYLPYRROLE); SJG 136; TOMAYMYCIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL STRAIN K 562; CELL STRAIN MCF 7; CONJUGATE; DNA FOOTPRINTING; DNA SEQUENCE; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DNA BINDING; DRUG PENETRATION; DRUG SYNTHESIS; DRUG UPTAKE; HUMAN; HUMAN CELL; PROTEIN DNA INTERACTION; PROTEIN MOTIF; TRANSCRIPTION TERMINATION;

EID: 33748537069     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm051199z     Document Type: Article

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