-
1
-
-
0029807115
-
Flavopiridol (L86 8275; NSC 649890): A new kinase inhibitor for tumor therapy
-
Sedlacek, H. H., Czech, J., Naik, R., Kaut, G., Worland, P., Losiewicz, M., Parker, B., Carlson, B., Smith, A., Senderowicz, A., and Sausville, E. Flavopiridol (L86 8275; NSC 649890): a new kinase inhibitor for tumor therapy. Int. J. Oncol., 9: 1143-1168, 1996.
-
(1996)
Int. J. Oncol.
, vol.9
, pp. 1143-1168
-
-
Sedlacek, H.H.1
Czech, J.2
Naik, R.3
Kaut, G.4
Worland, P.5
Losiewicz, M.6
Parker, B.7
Carlson, B.8
Smith, A.9
Senderowicz, A.10
Sausville, E.11
-
2
-
-
0031670668
-
Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms
-
Senderowicz, A. M., Headlee, D., Stinson, S. F., Lush, R. M., Kalil, N., Villalba, L., Hill, K., Steinberg, S. M., Figg, W. D., Tompkins, A., Arbuck, S. G., and Sausville, E. A. Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms. J. Clin. Oncol., 16, 2986-2999, 1998.
-
(1998)
J. Clin. Oncol.
, vol.16
, pp. 2986-2999
-
-
Senderowicz, A.M.1
Headlee, D.2
Stinson, S.F.3
Lush, R.M.4
Kalil, N.5
Villalba, L.6
Hill, K.7
Steinberg, S.M.8
Figg, W.D.9
Tompkins, A.10
Arbuck, S.G.11
Sausville, E.A.12
-
3
-
-
0005751758
-
Clinical trials of flavopiridol
-
Wright, J., Blatner, G. L., and Cheson, B. D. Clinical trials of flavopiridol. Oncology, 12: 1018-1024, 1998.
-
(1998)
Oncology
, vol.12
, pp. 1018-1024
-
-
Wright, J.1
Blatner, G.L.2
Cheson, B.D.3
-
4
-
-
0028917771
-
Antitumoral activity of flavone L86-8275
-
Czech, J., Hoffmann, D., Naik, R., and Sedlacek, H-H. Antitumoral activity of flavone L86-8275. Int. J. Oncol., 6: 31-36, 1995.
-
(1995)
Int. J. Oncol.
, vol.6
, pp. 31-36
-
-
Czech, J.1
Hoffmann, D.2
Naik, R.3
Sedlacek, H.-H.4
-
6
-
-
0031019034
-
Flavopiridol (L86-8275): Selective antitumor in vitro and activity in vivo for prostate carcinoma cells
-
Drees, M., Dengler, W. A., Roth, T., Labonte, H., Mayo, J., Malspeis, L., Grever, M., Sausville, E. A., and Fiebig, H. H. Flavopiridol (L86-8275): selective antitumor in vitro and activity in vivo for prostate carcinoma cells. Clin. Cancer Res., 3: 273-279, 1997.
-
(1997)
Clin. Cancer Res.
, vol.3
, pp. 273-279
-
-
Drees, M.1
Dengler, W.A.2
Roth, T.3
Labonte, H.4
Mayo, J.5
Malspeis, L.6
Grever, M.7
Sausville, E.A.8
Fiebig, H.H.9
-
7
-
-
0029904810
-
Flavopiridol (NSC 649890, L86-8275): A cytotoxic flavone that induces cell death in human lung carcinoma cells
-
Bible, K. C., and Kaufmann, S. H. Flavopiridol (NSC 649890, L86-8275): a cytotoxic flavone that induces cell death in human lung carcinoma cells. Cancer Res., 56: 4856-4861, 1996.
-
(1996)
Cancer Res.
, vol.56
, pp. 4856-4861
-
-
Bible, K.C.1
Kaufmann, S.H.2
-
8
-
-
0032533599
-
Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence upon functional p53
-
Byrd, J. C., Shinn, C., Waselenko, J. K., Fuchs, E. J., Lehman, T. A., Nguyen, P. L., Flinn, I. W., Diehl, L. F., Sausville, E., and Grever, M. R. Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence upon functional p53. Blood, 92: 3804-3816, 1998.
-
(1998)
Blood
, vol.92
, pp. 3804-3816
-
-
Byrd, J.C.1
Shinn, C.2
Waselenko, J.K.3
Fuchs, E.J.4
Lehman, T.A.5
Nguyen, P.L.6
Flinn, I.W.7
Diehl, L.F.8
Sausville, E.9
Grever, M.R.10
-
9
-
-
0030824869
-
Potentiation of apoptosis by flavopiridol in mitomycin-C-treated gastric and breast cancer cells
-
Schwartz, G. K., Farsi, K., Maslak, P., Kelsen, D. P., and Spriggs, D. Potentiation of apoptosis by flavopiridol in mitomycin-C-treated gastric and breast cancer cells. Clin. Cancer Res., 3: 1467-1472, 1997.
-
(1997)
Clin. Cancer Res.
, vol.3
, pp. 1467-1472
-
-
Schwartz, G.K.1
Farsi, K.2
Maslak, P.3
Kelsen, D.P.4
Spriggs, D.5
-
10
-
-
0040932434
-
The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines
-
König, A., Schwartz, G. K., Mohammad, R. M., Al-Katib, A., and Gabrilove, J. L. The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines. Blood, 90: 4307-4312, 1997.
-
(1997)
Blood
, vol.90
, pp. 4307-4312
-
-
König, A.1
Schwartz, G.K.2
Mohammad, R.M.3
Al-Katib, A.4
Gabrilove, J.L.5
-
11
-
-
0032055497
-
Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity in vivo against human leukemia and lymphoma xenografts
-
Arguello, F., Alexander, M., Sterry, J. A., Tudor, G., Smith, E. M., Kalavar, N. T., Greene, J. F., Jr., Koss, W., Morgan, C. D., Stinson, S. F., Siford, T. J., Alvord, W. G., Klabansky, R. L., and Sausville, E. A. Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity in vivo against human leukemia and lymphoma xenografts. Blood, 91: 2482-2490, 1998.
-
(1998)
Blood
, vol.91
, pp. 2482-2490
-
-
Arguello, F.1
Alexander, M.2
Sterry, J.A.3
Tudor, G.4
Smith, E.M.5
Kalavar, N.T.6
Greene J.F., Jr.7
Koss, W.8
Morgan, C.D.9
Stinson, S.F.10
Siford, T.J.11
Alvord, W.G.12
Klabansky, R.L.13
Sausville, E.A.14
-
12
-
-
0032212885
-
Flavopiridol, a novel cyclin dependent kinase inhibitor, suppresses the growth of squamous cell carcinomas of the head and neck by inducing apoptosis
-
Patel, V., Senderowicz, A. M., Pinto, D., Jr., Igishi, T., Raffeld, M., Quintanilla-Martinez, L., Ensley, J. F., Sausville, E. A., and Gutkind, J. S. Flavopiridol, a novel cyclin dependent kinase inhibitor, suppresses the growth of squamous cell carcinomas of the head and neck by inducing apoptosis. J. Clin. Invest., 102: 1674-1681, 1998.
-
(1998)
J. Clin. Invest.
, vol.102
, pp. 1674-1681
-
-
Patel, V.1
Senderowicz, A.M.2
Pinto D., Jr.3
Igishi, T.4
Raffeld, M.5
Quintanilla-Martinez, L.6
Ensley, J.F.7
Sausville, E.A.8
Gutkind, J.S.9
-
13
-
-
0040379168
-
Cell cycle-independent induction of apoptosis by the anti-tumor drug flavopiridol in endothelial cells
-
Brüsselbach, S., Nettelbeck, D. M., Sedlacek, H-H., and Müller, R. Cell cycle-independent induction of apoptosis by the anti-tumor drug flavopiridol in endothelial cells. Int. J. Cancer, 77: 146-152, 1998.
-
(1998)
Int. J. Cancer
, vol.77
, pp. 146-152
-
-
Brüsselbach, S.1
Nettelbeck, D.M.2
Sedlacek, H.-H.3
Müller, R.4
-
14
-
-
0031963058
-
Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol
-
Parker, B. W., Kaur, G., Nieves-Neira, W., Taimi, M., Kohlhagen, G., Shimizu, T., Losiewicz, M. D., Pommier, Y., Sausville, E. A., and Senderowicz, A. M. Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol. Blood, 91: 458-465, 1998.
-
(1998)
Blood
, vol.91
, pp. 458-465
-
-
Parker, B.W.1
Kaur, G.2
Nieves-Neira, W.3
Taimi, M.4
Kohlhagen, G.5
Shimizu, T.6
Losiewicz, M.D.7
Pommier, Y.8
Sausville, E.A.9
Senderowicz, A.M.10
-
15
-
-
0028176485
-
Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275
-
Losiewicz, M. D., Carlson, B. A., Kaur, G., Sausville, E. A., and Worland, P. J. Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275. Biochem. Biophys. Res. Commun., 201: 589-595, 1994.
-
(1994)
Biochem. Biophys. Res. Commun.
, vol.201
, pp. 589-595
-
-
Losiewicz, M.D.1
Carlson, B.A.2
Kaur, G.3
Sausville, E.A.4
Worland, P.J.5
-
16
-
-
0029993339
-
Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase
-
de Azevedo, W. F., Mueller-Dieckmann, H-J., Schulze-Gahmen, U., Worland, P. J., Sausville, E., and Kim, S-H. Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase. Proc. Natl. Acad. Sci. USA, 93: 2735-2740, 1996.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 2735-2740
-
-
De Azevedo, W.F.1
Mueller-Dieckmann, H.-J.2
Schulze-Gahmen, U.3
Worland, P.J.4
Sausville, E.5
Kim, S.-H.6
-
17
-
-
0032563315
-
Exploiting chemical libraries, structures, and genomics in the search for kinase inhibitors
-
Washington DC
-
Gray, N. S., Wodicka, L., Thunnissen, A. M., Norman, T. C., Kwon, S., Espinoza, F. H., Morgan, D. O., Barnes, G., LeClerc, S., Meijer, L., Kim, S. H., Lockhart, D. J., and Schultz, P. G. Exploiting chemical libraries, structures, and genomics in the search for kinase inhibitors. Science (Washington DC), 281: 533-538, 1998.
-
(1998)
Science
, vol.281
, pp. 533-538
-
-
Gray, N.S.1
Wodicka, L.2
Thunnissen, A.M.3
Norman, T.C.4
Kwon, S.5
Espinoza, F.H.6
Morgan, D.O.7
Barnes, G.8
LeClerc, S.9
Meijer, L.10
Kim, S.H.11
Lockhart, D.J.12
Schultz, P.G.13
-
18
-
-
0019515510
-
Differential killing efficacy of twenty antitumor drugs on proliferating and nonproliferating human tumor cells
-
Drewinko, B., Patchen, M., Yang, L-Y., and Barlogie, B. Differential killing efficacy of twenty antitumor drugs on proliferating and nonproliferating human tumor cells. Cancer Res., 41: 2328-2333, 1981.
-
(1981)
Cancer Res.
, vol.41
, pp. 2328-2333
-
-
Drewinko, B.1
Patchen, M.2
Yang, L.-Y.3
Barlogie, B.4
-
19
-
-
0030031184
-
Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I
-
Boege, F., Straub, T., Kehr, A., Boesenberg, C., Christiansen, K., Andersen, A., Jakob, F., and Kohrle, J. Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I. J. Biol. Chem., 271: 2262-2270, 1996.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 2262-2270
-
-
Boege, F.1
Straub, T.2
Kehr, A.3
Boesenberg, C.4
Christiansen, K.5
Andersen, A.6
Jakob, F.7
Kohrle, J.8
-
20
-
-
0030812207
-
Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: Importance of sequence of administration
-
Bible, K. C., and Kaufmann, S. H. Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: importance of sequence of administration. Cancer Res., 57: 3375-3380, 1997.
-
(1997)
Cancer Res.
, vol.57
, pp. 3375-3380
-
-
Bible, K.C.1
Kaufmann, S.H.2
-
21
-
-
0030970983
-
Cytotoxic synergy between pyrazoloacridine (NSC 366140) and cisplatin in vitro: Inhibition of platinum-DNA adduct removal
-
Adjei, A. A., Budihardjo, I., Rowinsky, E. K., Kottke, T. J., Svingen, P. A., Buckwalter, C. A., Grochow, L. B., Donehower, R. C., and Kaufmann, S. H. Cytotoxic synergy between pyrazoloacridine (NSC 366140) and cisplatin in vitro: inhibition of platinum-DNA adduct removal. Clin. Cancer Res., 3: 761-770, 1997.
-
(1997)
Clin. Cancer Res.
, vol.3
, pp. 761-770
-
-
Adjei, A.A.1
Budihardjo, I.2
Rowinsky, E.K.3
Kottke, T.J.4
Svingen, P.A.5
Buckwalter, C.A.6
Grochow, L.B.7
Donehower, R.C.8
Kaufmann, S.H.9
-
22
-
-
0030933933
-
Altered formation of topotecan-stabilized topoisomerase 1-DNA adducts in human leukemia cells
-
Kaufmann, S. H., Svingen, P. A., Gore, S. D., Armstrong, D. K., Cheng, Y-C., and Rowinsky, E. K. Altered formation of topotecan-stabilized topoisomerase 1-DNA adducts in human leukemia cells. Blood, 89: 2098-2104, 1997.
-
(1997)
Blood
, vol.89
, pp. 2098-2104
-
-
Kaufmann, S.H.1
Svingen, P.A.2
Gore, S.D.3
Armstrong, D.K.4
Cheng, Y.-C.5
Rowinsky, E.K.6
-
23
-
-
0025970972
-
Principles, and practice of DNA filter elution
-
Kohn, K. W. Principles, and practice of DNA filter elution. Pharmacol. Ther., 49: 55-77, 1991.
-
(1991)
Pharmacol. Ther.
, vol.49
, pp. 55-77
-
-
Kohn, K.W.1
-
24
-
-
0030701895
-
Comparison of caspase activation and subcellular localization in HL-60 and K562 cells undergoing etoposide-induced apoptosis
-
Martins, L. M., Mesner, P. W., Kottke, T. J., Basi, G. S., Sinha, S., Tung, J. S., Svingen, P. A., Madden, B. J., Takahashi, A., McCormick, D. J., Earnshaw, W. C., and Kaufmann, S. H. Comparison of caspase activation and subcellular localization in HL-60 and K562 cells undergoing etoposide-induced apoptosis. Blood, 90: 4283-4296, 1997.
-
(1997)
Blood
, vol.90
, pp. 4283-4296
-
-
Martins, L.M.1
Mesner, P.W.2
Kottke, T.J.3
Basi, G.S.4
Sinha, S.5
Tung, J.S.6
Svingen, P.A.7
Madden, B.J.8
Takahashi, A.9
McCormick, D.J.10
Earnshaw, W.C.11
Kaufmann, S.H.12
-
25
-
-
0031948557
-
Effect of pyrazoloacridine (NSC 366140) on DNA topoisomerases I and II: Prevention of cleavable complex formation
-
Adjei, A. A., Charron, M., Rowinsky, E. K., Svingen, P. A., Miller, J., Reid, J. C., Sebolt-Leopold, J., Ames, M. M., and Kaufmann, S. H. Effect of pyrazoloacridine (NSC 366140) on DNA topoisomerases I and II: prevention of cleavable complex formation. Clin. Cancer Res., 4: 683-691, 1998.
-
(1998)
Clin. Cancer Res.
, vol.4
, pp. 683-691
-
-
Adjei, A.A.1
Charron, M.2
Rowinsky, E.K.3
Svingen, P.A.4
Miller, J.5
Reid, J.C.6
Sebolt-Leopold, J.7
Ames, M.M.8
Kaufmann, S.H.9
-
26
-
-
0030996962
-
An HPLC method for the measurement of polyamines and lipidic amines binding DNA
-
Karikas, G. A., Constantinou-Kokotou, V., and Kokotos, G. An HPLC method for the measurement of polyamines and lipidic amines binding DNA. J. Liq. Chromatogr. Relat. Technol., 20: 1789-1796, 1997.
-
(1997)
J. Liq. Chromatogr. Relat. Technol.
, vol.20
, pp. 1789-1796
-
-
Karikas, G.A.1
Constantinou-Kokotou, V.2
Kokotos, G.3
-
27
-
-
0028906786
-
Some practical considerations and applications of the national cancer institute in vitro anticancer drug discovery screen
-
Boyd, M. R., and Paull, K. D. Some practical considerations and applications of the national cancer institute in vitro anticancer drug discovery screen. Drug Dev. Res., 34: 91-109, 1995.
-
(1995)
Drug Dev. Res.
, vol.34
, pp. 91-109
-
-
Boyd, M.R.1
Paull, K.D.2
-
28
-
-
84961985847
-
Quantum calculation of molecular energies and energy gradients in solution by a conductor solvent model
-
Barone, V., and Cossi, M. Quantum calculation of molecular energies and energy gradients in solution by a conductor solvent model. J. Phys. Chem., 102: 1995-2001, 1998.
-
(1998)
J. Phys. Chem.
, vol.102
, pp. 1995-2001
-
-
Barone, V.1
Cossi, M.2
-
29
-
-
0026452974
-
Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275
-
Kaur, G., Stetler-Stevenson, M., Sebers, S., Worland, P., Sedlacek, H., Myers, C., Czech, J., Naik, R., and Sausville, E. Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275. J. Natl. Cancer Inst., 84: 1736-1740, 1992.
-
(1992)
J. Natl. Cancer Inst.
, vol.84
, pp. 1736-1740
-
-
Kaur, G.1
Stetler-Stevenson, M.2
Sebers, S.3
Worland, P.4
Sedlacek, H.5
Myers, C.6
Czech, J.7
Naik, R.8
Sausville, E.9
-
30
-
-
0026465665
-
ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes
-
Troelstra, C., van Gool, A., de Wit, J., Vermeulen, W., Bootsma, D., and Hoeijmakers, J. H. J. ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes. Cell, 71: 939-953, 1992.
-
(1992)
Cell
, vol.71
, pp. 939-953
-
-
Troelstra, C.1
Van Gool, A.2
De Wit, J.3
Vermeulen, W.4
Bootsma, D.5
Hoeijmakers, J.H.J.6
-
31
-
-
0015150039
-
Studies on camptothecin. I. Effects of nucleic acid and protein synthesis
-
Horwitz, S. B., Chang, C. K., and Grollman, A. P. Studies on camptothecin. I. Effects of nucleic acid and protein synthesis. Mol. Pharmacol., 7: 632-644, 1971.
-
(1971)
Mol. Pharmacol.
, vol.7
, pp. 632-644
-
-
Horwitz, S.B.1
Chang, C.K.2
Grollman, A.P.3
-
32
-
-
0025893984
-
Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line
-
Kaufmann, S. H. Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line. Cancer Res., 51: 1129-1136, 1991.
-
(1991)
Cancer Res.
, vol.51
, pp. 1129-1136
-
-
Kaufmann, S.H.1
-
33
-
-
0027528789
-
Retinoblastoma protein and the cell cycle
-
Hollingsworth, R. E., Jr., Hensey, C. E., and Lee, W. H. Retinoblastoma protein and the cell cycle. Curr. Opin. Genet. Dev., 3: 55-62, 1993.
-
(1993)
Curr. Opin. Genet. Dev.
, vol.3
, pp. 55-62
-
-
Hollingsworth R.E., Jr.1
Hensey, C.E.2
Lee, W.H.3
-
34
-
-
0026318356
-
Participation of p53 protein in the cellular response to DNA damage
-
Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B., and Craig, R. W. Participation of p53 protein in the cellular response to DNA damage. Cancer Res., 51: 6304-6311, 1991.
-
(1991)
Cancer Res.
, vol.51
, pp. 6304-6311
-
-
Kastan, M.B.1
Onyekwere, O.2
Sidransky, D.3
Vogelstein, B.4
Craig, R.W.5
-
35
-
-
0028204160
-
DNA strand breaks: The DNA template alterations that trigger p53-dependent DNA damage response pathways
-
Nelson, W. G., and Kastan, M. B. DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol. Cell. Biol., 14: 1815-1823, 1994.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 1815-1823
-
-
Nelson, W.G.1
Kastan, M.B.2
-
36
-
-
0025289360
-
The interaction with DNA of unfused aromatic systems containing terminal piperazino substituents
-
Wilson, W. D., Barton, H. J., Tanious, F. A., Kong, S-B., and Strekowski, L. The interaction with DNA of unfused aromatic systems containing terminal piperazino substituents. Biophys. Chem., 35: 227-243, 1990.
-
(1990)
Biophys. Chem.
, vol.35
, pp. 227-243
-
-
Wilson, W.D.1
Barton, H.J.2
Tanious, F.A.3
Kong, S.-B.4
Strekowski, L.5
-
37
-
-
0000741486
-
Topography of nucleic acid helices in solutions: Steric requirements for interactions
-
Gabbay, E. J., and DePaolis, A. Topography of nucleic acid helices in solutions: steric requirements for interactions. J. Am. Chem. Soc., 93: 562-564, 1971.
-
(1971)
J. Am. Chem. Soc.
, vol.93
, pp. 562-564
-
-
Gabbay, E.J.1
DePaolis, A.2
-
38
-
-
0015923304
-
Steric effects on the intercalation of aromatic cations to deoxyribonucleic acid
-
Gabbay, E. J., Scofield, R. E., and Baxter, C. S. Steric effects on the intercalation of aromatic cations to deoxyribonucleic acid. J. Am. Chem. Soc., 95: 7850-7857, 1973.
-
(1973)
J. Am. Chem. Soc.
, vol.95
, pp. 7850-7857
-
-
Gabbay, E.J.1
Scofield, R.E.2
Baxter, C.S.3
-
39
-
-
0019990978
-
Mechanism of interaction of CC-1065 (NSC 298223) with DNA
-
Swenson, D. H., Li, L. H., Hurley, L. H., Rokem, J. S., Petzold, G. L., Dayton, B. D., Wallace, T. L., Lin, A. H., and Krueger, W. C. Mechanism of interaction of CC-1065 (NSC 298223) with DNA. Cancer Res., 42: 2821-2828, 1982.
-
(1982)
Cancer Res.
, vol.42
, pp. 2821-2828
-
-
Swenson, D.H.1
Li, L.H.2
Hurley, L.H.3
Rokem, J.S.4
Petzold, G.L.5
Dayton, B.D.6
Wallace, T.L.7
Lin, A.H.8
Krueger, W.C.9
-
40
-
-
0001631414
-
1H NMR
-
1H NMR. Proc. Natl. Acad. Sci. USA, 84: 2155-2159, 1987.
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 2155-2159
-
-
Delbarre, A.1
Delepierre, M.2
Garbay, C.3
Igolen, J.4
Le Pecq, J.-B.5
Roques, B.P.6
-
43
-
-
0028863869
-
Calicheamicin-DNA complexes: Warhead alignment and saccharide recognition of the minor groove
-
Ikemoto, N., Kumar, R. A., Ling, T-T., Ellestad, G. A., Danishefsky, S. J., and Patel, D. J. Calicheamicin-DNA complexes: warhead alignment and saccharide recognition of the minor groove. Proc. Natl. Acad. Sci. USA, 92: 10506-10510, 1995.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 10506-10510
-
-
Ikemoto, N.1
Kumar, R.A.2
Ling, T.-T.3
Ellestad, G.A.4
Danishefsky, S.J.5
Patel, D.J.6
-
44
-
-
0028818564
-
NMR studies of drug-DNA complexes
-
Keniry, M. A., and Shafer, R. H. NMR studies of drug-DNA complexes. Methods Enzymol., 261: 575-603, 1995.
-
(1995)
Methods Enzymol.
, vol.261
, pp. 575-603
-
-
Keniry, M.A.1
Shafer, R.H.2
-
45
-
-
0029013864
-
Solution structure of a DNA complex with the florescent bis-intercalator TOTO determined by NMR spectroscopy
-
Spielmann, H. P., Wemmer, D. E., and Jacobsen, J. P. Solution structure of a DNA complex with the florescent bis-intercalator TOTO determined by NMR spectroscopy. Biochemistry, 34: 8542-8553, 1995.
-
(1995)
Biochemistry
, vol.34
, pp. 8542-8553
-
-
Spielmann, H.P.1
Wemmer, D.E.2
Jacobsen, J.P.3
-
46
-
-
0023218399
-
Pyrazoloacridine, a new class of antitumor agents with selectivity against solid tumors in vitro
-
Sebolt, J. S., Scavone, S. V., Pinter, C. D., Hemelehle, K. L., Von Hoff, D. D., and Jackson, R. C. Pyrazoloacridine, a new class of antitumor agents with selectivity against solid tumors in vitro. Cancer Res., 47: 4299-4304, 1987.
-
(1987)
Cancer Res.
, vol.47
, pp. 4299-4304
-
-
Sebolt, J.S.1
Scavone, S.V.2
Pinter, C.D.3
Hemelehle, K.L.4
Von Hoff, D.D.5
Jackson, R.C.6
-
47
-
-
0029682993
-
Preclinical pharmacology of ecteinascidin 729, a marine natural product with potent antitumor activity
-
Reid, J. M., Walker, D. L., and Ames, M. M. Preclinical pharmacology of ecteinascidin 729, a marine natural product with potent antitumor activity. Cancer Chemother. Pharmacol., 38: 329-334, 1996.
-
(1996)
Cancer Chemother. Pharmacol.
, vol.38
, pp. 329-334
-
-
Reid, J.M.1
Walker, D.L.2
Ames, M.M.3
-
48
-
-
0028211340
-
Oligonucleotide studies of sequence-specific binding of chromomycin A3 to DNA
-
Liu, C., and Chen, F. M. Oligonucleotide studies of sequence-specific binding of chromomycin A3 to DNA. Biochemistry, 33: 1419-1424, 1994.
-
(1994)
Biochemistry
, vol.33
, pp. 1419-1424
-
-
Liu, C.1
Chen, F.M.2
-
49
-
-
0028057566
-
Formation of multiple complexes between actinomycin D and a DNA hairpin: Structural characterization by multinuclear NMR
-
Brown, D. R., Kurz, M., Kearns, D. R., and Hsu, V. L. Formation of multiple complexes between actinomycin D and a DNA hairpin: structural characterization by multinuclear NMR. Biochemistry, 33: 651-664, 1994.
-
(1994)
Biochemistry
, vol.33
, pp. 651-664
-
-
Brown, D.R.1
Kurz, M.2
Kearns, D.R.3
Hsu, V.L.4
-
50
-
-
0030271304
-
Chemical inhibitors of cyclin-dependent kinases
-
Meijer, L. Chemical inhibitors of cyclin-dependent kinases. Trends Cell Biol., 6: 393-397, 1996.
-
(1996)
Trends Cell Biol.
, vol.6
, pp. 393-397
-
-
Meijer, L.1
-
51
-
-
0026656853
-
Wild-type p53 is a cell cycle checkpoint determinant following irradiation
-
Kuerbitz, S. J., Plunkett, B. S., Walsh, W. V., and Kastan, M. B. Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl. Acad. Sci. USA, 89: 7491-7495, 1992.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 7491-7495
-
-
Kuerbitz, S.J.1
Plunkett, B.S.2
Walsh, W.V.3
Kastan, M.B.4
-
52
-
-
0032553485
-
2 arrest after DNA damage
-
Washington DC
-
2 arrest after DNA damage. Science (Washington DC), 282: 1497-1501, 1998.
-
(1998)
Science
, vol.282
, pp. 1497-1501
-
-
Bunz, F.1
Dutriaux, A.2
Lengauer, C.3
Waldman, T.4
Zhou, S.5
Brown, J.P.6
Sedivy, J.M.7
Kinzler, K.W.8
Vogelstein, B.9
-
53
-
-
0024316466
-
DNA topoisomerase poisons as antitumor drugs
-
Liu, L. F. DNA topoisomerase poisons as antitumor drugs. Annu. Rev. Biochem., 58: 351-375, 1989.
-
(1989)
Annu. Rev. Biochem.
, vol.58
, pp. 351-375
-
-
Liu, L.F.1
|