Dicationic bis(9-methylphenazine-1-carboxamides): Relationships between biological activity and linker chain structure for a series of potent topoisomerase targeted anticancer drugs

Journal of Medicinal Chemistry

Volumn 44, Issue 9, 2001, Pages 1407-1415

  Gamage, S A ^a   Spicer, J A ^a   Finlay, G J ^a   Stewart, A J ^b   Charlton, P ^b   Baguley, B C ^a   Denny, W A ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b Cantab Pharmaceuticals Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; ANTINEOPLASTIC AGENT; BIS(9 METHYLPHENAZINE 1 CARBOXAMIDE); BISNAFIDE MESYLATE; CYTOTOXIN; DNA TOPOISOMERASE; GLYCOPROTEIN P; INTERCALATING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CRYSTALLIZATION; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; GENE TARGETING; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEWIS CARCINOMA; NONHUMAN; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; TUMOR GROWTH;

AMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; CATIONS, DIVALENT; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DNA, SUPERHELICAL; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MICE, INBRED C57BL; MICE, NUDE; PHENAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0035953323     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0003283     Document Type: Article

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