Novel DNA bis-intercalation by MLN944, a potent clinical bisphenazine anticancer drug

Journal of Biological Chemistry

Volumn 279, Issue 44, 2004, Pages 46096-46103

  Dai, Jixun ^a   Punchihewa, Chandanamalie ^a   Mistry, Prakash ^b   Ooi, Aik Teong ^a   Yang, Danzhou ^a,c  

^a UNIVERSITY OF ARIZONA   (United States)

^b Cantab Pharmaceuticals Ltd   (United Kingdom)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; ASSAYS; CHROMOPHORES; DNA; DRUG PRODUCTS; ELECTROPHORESIS; GELS; HYDROGEN BONDS; MATHEMATICAL MODELS; MEDICAL IMAGING; NUCLEAR MAGNETIC RESONANCE;

ANTICANCER COMPOUNDS; BIOLOGICAL ACTIVITY; ELECTROPHORETIC GEL; PHENAZINE RINGS;

TUMORS;

ACRIDINE DERIVATIVE; AMIDE; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DOUBLE STRANDED DNA; MLN 576; MLN 944; PHENAZINE DERIVATIVE; PROTEIN C JUN; THYMINE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; XR 11576; XR 5944;

ARTICLE; BASE PAIRING; BINDING SITE; CHROMATOPHORE; DNA SEQUENCE; DNA TRANSCRIPTION; DRUG CONFORMATION; DRUG DNA BINDING; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; HYDROGEN BOND; PH; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ANTINEOPLASTIC AGENTS; BINDING SITES; DNA; ELECTROPHORETIC MOBILITY SHIFT ASSAY; INTERCALATING AGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; NUCLEIC ACID CONFORMATION; PHENAZINES; PROTO-ONCOGENE PROTEINS C-JUN; TRANSCRIPTION FACTOR AP-1;

MURINAE;

EID: 8544273289     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M404053200     Document Type: Article

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