Meta-analysis of the effect of KCNQ1 gene polymorphism on the risk of type 2 diabetes

Molecular Biology Reports

Volumn 40, Issue 5, 2013, Pages 3557-3567

  Liu, Jun ^a   Wang, Fang ^a   Wu, Yueyue ^a   Huang, Xinmei ^a   Sheng, Li ^a   Xu, Jiong ^a   Zha, Bingbing ^a   Ding, Heyuan ^a   Chen, Zaoping ^a   Sun, Tiange ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

KCNQ1; Meta analysis; Polymorphism; Susceptibility; Type 2 diabetes

Indexed keywords

POTASSIUM CHANNEL KCNQ1; SODIUM CHLORIDE;

ARTICLE; ASIAN; CASE CONTROL STUDY; DISEASE PREDISPOSITION; ETHNICITY; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC RISK; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HUMAN; ION TRANSPORT; META ANALYSIS (TOPIC); NON INSULIN DEPENDENT DIABETES MELLITUS; SAMPLE SIZE; SINGLE NUCLEOTIDE POLYMORPHISM; WATER TRANSPORT;

DIABETES MELLITUS, TYPE 2; ETHNIC GROUPS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KCNQ1 POTASSIUM CHANNEL; ODDS RATIO; POLYMORPHISM, GENETIC; PUBLICATION BIAS; RISK;

MAMMALIA;

EID: 84878416943     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-2429-7     Document Type: Article

References (52)

1. Zimmet P, Alberti KG, Shaw J (2001) Global and societal implications of the diabetes epidemic. Nature 414:782-787
2. O'Rahilly S, Barroso I, Wareham NJ (2005) Genetic factors in type 2 diabetes: the end of the beginning? Science 307:370-373
3. Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A et al (2006) Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38:320-323
4. Nielsen EM, Hansen L, Carstensen B, Echwald SM, Drivsholm T et al (2003) The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes. Diabetes 52:573-577
5. Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl MC et al (2000) The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26:76-80
6. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y et al (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341-1345
7. Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H et al (2008) Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 40:1092-1097
8. Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447:661-678
9. Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI et al (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331-1336
10. Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS et al (2007) Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316:1336-1341
11. Barhanin J, Lesage F, Guillemare E, Fink M, Lazdunski M, Romey G (1996) K(V)LQT1 and IsK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature 384:78-80
12. Wang Q, Curran ME, Splawski I, Burn TC, Millholland JM et al (1996) Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet 12:17-23
13. Neyroud N, Tesson F, Denjoy I, Leibovici M, Donger C et al (1997) A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome. Nat Genet 15:186-189
14. Chen YH, Xu SJ, Bendahhou S, Wang XL, Wang Y et al (2003) KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science 299:251-254
15. Lee MP, Ravenel JD, Hu RJ, Lustig LR, Tomaselli G et al (2000) Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice. J Clin Invest 106:1447-1455
16. Casimiro MC, Knollmann BC, Ebert SN, Vary JC Jr, Greene AE et al (2001) Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange-Nielsen syndrome. Proc Natl Acad Sci USA 98:2526-2531
17. Demolombe S, Franco D, de Boer P, Kuperschmidt S, Roden D et al (2001) Differential expression of KvLQT1 and its regulator IsK in mouse epithelia. Am J Physiol Cell Physiol 280:C359-C372
18. Ullrich S, Su J, Ranta F, Wittekindt OH, Ris F et al (2005) Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cells. Pflugers Arch 451:428-436
19. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177-188
20. Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22:719-748
21. Harbord RM, Egger M, Sterne JA (2006) A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints. Stat Med 25:3443-3457
22. Lee YH, Kang ES, Kim SH, Han SJ, Kim CH et al (2008) Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population. J Hum Genet 53:991-998
23. Unoki H, Takahashi A, Kawaguchi T, Hara K, Horikoshi M et al (2008) SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet 40:1098-1102
24. Hu C, Wang C, Zhang R, Ma X, Wang J et al (2009) Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population. Diabetologia 52:1322-1325
25. Jonsson A, Isomaa B, Tuomi T, Taneera J, Salehi A et al (2009) A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion. Diabetes 58:2409-2413
26. Liu Y, Zhou DZ, Zhang D, Chen Z, Zhao T et al (2009) Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China. Diabetologia 52:1315-1321
27. Qi Q, Li H, Loos RJ, Liu C, Wu Y et al (2009) Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Hum Mol Genet 18:3508-3515
28. Takeuchi F, Serizawa M, Yamamoto K, Fujisawa T, Nakashima E et al (2009) Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes 58:1690-1699
29. Chen Z, Zhang X, Ma G, Qian Q, Yao Y (2010) Association study of four variants in KCNQ1 with type 2 diabetes mellitus and premature coronary artery disease in a Chinese population. Mol Biol Rep 37:207-212
30. Grallert H, Herder C, Marzi C, Meisinger C, Wichmann HE et al (2010) Association of genetic variation in KCNQ1 with type 2 diabetes in the KORA surveys. Horm Metab Res 42:149-151
31. Han X, Luo Y, Ren Q, Zhang X, Wang F et al (2010) Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population. BMC Med Genet 11:81
32. Shu XO, Long J, Cai Q, Qi L, Xiang YB et al (2010) Identification of new genetic risk variants for type 2 diabetes. PLoS Genet 6
33. Tan JT, Ng DP, Nurbaya S, Ye S, Lim XL et al (2010) Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore. J Clin Endocrinol Metab 95:390-397
34. Tsai FJ, Yang CF, Chen CC, Chuang LM, Lu CH et al (2010) A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet 6:e1000847
35. Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C et al (2010) Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 42:579-589
36. Xu M, Bi Y, Xu Y, Yu B, Huang Y et al (2010) Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies. PLoS One 5:e14022
37. Yamauchi T, Hara K, Maeda S, Yasuda K, Takahashi A et al (2010) A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet 42:864-868
38. Zhou JB, Yang JK, Zhao L, Xin Z (2010) Variants in KCNQ1, AP3S1, MAN2A1, and ALDH7A1 and the risk of type 2 diabetes in the Chinese Northern Han population: a case-control study and meta-analysis. Med Sci Monit 16:BR179-BR183
39. Been LF, Ralhan S, Wander GS, Mehra NK, Singh J et al (2011) Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: a study of 3,310 subjects from India and the US. BMC Med Genet 12:18
40. Ohshige T, Iwata M, Omori S, Tanaka Y, Hirose H et al (2011) Association of new Loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese. PLoS One 6:e26911
41. Rees SD, Hydrie MZ, Shera AS, Kumar S, O'Hare JP et al (2011) Replication of 13 genome-wide association (GWA)-validated risk variants for type 2 diabetes in Pakistani populations. Diabetologia 54:1368-1374
42. Saif-Ali R, Ismail IS, Al-Hamodi Z, Al-Mekhlafi HM, Siang LC et al (2011) KCNQ1 haplotypes associate with type 2 diabetes in Malaysian Chinese subjects. Int J Mol Sci 12:5705-5718
43. Saif-Ali R, Muniandy S, Al-Hamodi Z, Lee CS, Ahmed KA et al (2011) KCNQ1 variants associate with type 2 diabetes in Malaysian Malay subjects. Ann Acad Med Singapore 40:488-492
44. Tabara Y, Osawa H, Kawamoto R, Onuma H, Shimizu I et al (2011) Genotype risk score of common susceptible variants for prediction of type 2 diabetes mellitus in Japanese: the Shimanami Health Promoting Program (J-SHIPP study). Development of type 2 diabetes mellitus and genotype risk score. Metabolism 60:1634-1640
45. Campbell DD, Parra MV, Duque C, Gallego N, Franco L et al (2012) Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a colombian population. PLoS One 7:e33570
46. Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L et al (2012) European genetic variants associated with type 2 diabetes in North African Arabs. Diabetes Metab 38(4):316-323
47. Odgerel ZLH, Erdenebileg N, Gandbold S, Luvsanjamba M, Sambuughin N, Sonomtseren S, Sharavdorj P, Jodov E, Altaisaikhan K, Goldfarb LG (2012) Genetic variants in potassium channels are associated with type 2 diabetes in Mongolian population. J Diabetes 4:238-242
48. van Vliet-Ostaptchouk JV, van Haeften TW, Landman GW, Reiling E, Kleefstra N et al (2012) Common variants in the type 2 diabetes KCNQ1 gene are associated with impairments in insulin secretion during hyperglycaemic glucose clamp. PLoS One 7:e32148
49. Yu W, Ma RC, Hu C et al (2012) Association between KCNQ1 genetic variants and obesity in Chinese patients with type 2 diabetes. Diabetologia. doi: 10.1007/s00125-012-2636-8
50. Gamboa-Meléndez MA, Huerta-Chagoya A, Moreno-Macías H et al (2012) Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population. Diabetes. doi: 10.2337/db11-0550
51. Wild S, Roglic G, Green A, Sicree R, King H (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27:1047-1053
52. Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL et al (2008) Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40:638-645