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Volumn 5, Issue 11, 2010, Pages

Combined effects of 19 common variations on type 2 diabetes in Chinese: Results from two community-based studies

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; POTASSIUM CHANNEL KCNQ1;

EID: 78649526616     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014022     Document Type: Article
Times cited : (79)

References (42)
  • 1
    • 77950263954 scopus 로고    scopus 로고
    • China National Diabetes and Metabolic Disorders Study Group. Prevalence of diabetes among men and women in China
    • Yang W, Lu J, Weng J, Jia W, Ji L, et al. (2010) China National Diabetes and Metabolic Disorders Study Group. Prevalence of diabetes among men and women in China. N Engl J Med 362: 1090-1101.
    • (2010) N Engl J Med , vol.362 , pp. 1090-1101
    • Yang, W.1    Lu, J.2    Weng, J.3    Jia, W.4    Ji, L.5
  • 2
    • 34249885875 scopus 로고    scopus 로고
    • A genomewide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    • Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, et al. (2007) A genomewide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316: 1341-1345.
    • (2007) Science , vol.316 , pp. 1341-1345
    • Scott, L.J.1    Mohlke, K.L.2    Bonnycastle, L.L.3    Willer, C.J.4    Li, Y.5
  • 4
    • 34249888775 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    • Diabetes Genetics Initiative of Broad Institute of Harvard and MIT LU, and Novartis Institutes for BioMedical Research
    • Diabetes Genetics Initiative of Broad Institute of Harvard and MIT LU, and Novartis Institutes for BioMedical Research (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316: 1331-1336.
    • (2007) Science , vol.316 , pp. 1331-1336
  • 5
    • 34249895023 scopus 로고    scopus 로고
    • Replication of genome-wide association signals in U.K. samples reveals risk loci for type 2 diabetes
    • Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, et al. (2007) Replication of genome-wide association signals in U.K. samples reveals risk loci for type 2 diabetes. Science 316: 1336-1341.
    • (2007) Science , vol.316 , pp. 1336-1341
    • Zeggini, E.1    Weedon, M.N.2    Lindgren, C.M.3    Frayling, T.M.4    Elliott, K.S.5
  • 6
    • 33847176604 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel risk loci for type 2 diabetes
    • Slaked R, Rocheleau G, Rung J, Dina C, Sheen L, et al. (2007) A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445: 828-830.
    • (2007) Nature , vol.445 , pp. 828-830
    • Slaked, R.1    Rocheleau, G.2    Rung, J.3    Dina, C.4    Sheen, L.5
  • 7
    • 38849129636 scopus 로고    scopus 로고
    • Polymorphisms within novel risk loci for type 2 Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function
    • Staiger H, Machicao F, Stefan N, Tschritter O, Thamer C, et al. (2007) Polymorphisms within novel risk loci for type 2 Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function. PLoSONE 2: e832.
    • (2007) PLoSONE , vol.2
    • Staiger, H.1    Machicao, F.2    Stefan, N.3    Tschritter, O.4    Thamer, C.5
  • 8
    • 42449159284 scopus 로고    scopus 로고
    • Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study
    • Palmer ND, Goodarzi MO, Langefeld CD, Ziegler J, Norris JM, et al. (2008) Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study. Diabetes 57: 1093-1100.
    • (2008) Diabetes , vol.57 , pp. 1093-1100
    • Palmer, N.D.1    Goodarzi, M.O.2    Langefeld, C.D.3    Ziegler, J.4    Norris, J.M.5
  • 9
    • 35649024167 scopus 로고    scopus 로고
    • Annual incidence and relative risk of diabetes in people with various categories of dysglycemia: A systematic overview and meta-analysis of prospective studies
    • Gerstein HC, Santaguida P, Raina P, Morrison KM, Balion C, et al. (2007) Annual incidence and relative risk of diabetes in people with various categories of dysglycemia: a systematic overview and meta-analysis of prospective studies. Diabetes Res Clin Pract 78: 305-312.
    • (2007) Diabetes Res Clin Pract , vol.78 , pp. 305-312
    • Gerstein, H.C.1    Santaguida, P.2    Raina, P.3    Morrison, K.M.4    Balion, C.5
  • 10
    • 0024215846 scopus 로고
    • The natural history of impaired glucose tolerance in the Pima Indians
    • Saad MF, Knowler WC, Pettitt DJ, Nelson RG, Mott DM, et al. (1988) The natural history of impaired glucose tolerance in the Pima Indians. N Engl J Med 319: 1500-1506.
    • (1988) N Engl J Med , vol.319 , pp. 1500-1506
    • Saad, M.F.1    Knowler, W.C.2    Pettitt, D.J.3    Nelson, R.G.4    Mott, D.M.5
  • 11
    • 34247855851 scopus 로고    scopus 로고
    • Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion
    • Wang J, Kuusisto J, Vänttinen M, Kuulasmaa T, Lindström J, et al. (2007) Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion. Diabetologia 50: 1192-1200.
    • (2007) Diabetologia , vol.50 , pp. 1192-1200
    • Wang, J.1    Kuusisto, J.2    Vänttinen, M.3    Kuulasmaa, T.4    Lindström, J.5
  • 12
    • 20944446045 scopus 로고    scopus 로고
    • Leu7Pro polymorphism in the neuropeptide Y (NPY) gene is associated with impaired glucose tolerance and type 2 diabetes in Swedish men
    • Nordman S, Ding B, Ostenson CG, Kä rvestedt L, Brismar K, et al. (2005) Leu7Pro polymorphism in the neuropeptide Y (NPY) gene is associated with impaired glucose tolerance and type 2 diabetes in Swedish men. Exp Clin Endocrinol Diabetes 113: 282-287.
    • (2005) Exp Clin Endocrinol Diabetes , vol.113 , pp. 282-287
    • Nordman, S.1    Ding, B.2    Ostenson, C.G.3    Kä, R.L.4    Brismar, K.5
  • 13
    • 65949099120 scopus 로고    scopus 로고
    • Genetic risk prediction-are we there yet?
    • Kraft P, Hunter DJ (2009) Genetic risk prediction-are we there yet? N Engl J Med 360: 1701-1703.
    • (2009) N Engl J Med , vol.360 , pp. 1701-1703
    • Kraft, P.1    Hunter, D.J.2
  • 14
    • 58149333712 scopus 로고    scopus 로고
    • Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: A population-based study
    • van Hoek M, Dehghan A, Witteman JC, van Duijn CM, Uitterlinden AG, et al. (2008) Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study. Diabetes 57: 3122-3128.
    • (2008) Diabetes , vol.57 , pp. 3122-3128
    • van Hoek, M.1    Dehghan, A.2    Witteman, J.C.3    van Duijn, C.M.4    Uitterlinden, A.G.5
  • 15
    • 56749101779 scopus 로고    scopus 로고
    • Genotype score in addition to common risk factors for prediction of type 2 diabetes
    • Meigs JB, Shrader P, Sullivan LM, McAteer JB, Fox CS, et al. (2008) Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med 359: 208-219.
    • (2008) N Engl J Med , vol.359 , pp. 208-219
    • Meigs, J.B.1    Shrader, P.2    Sullivan, L.M.3    McAteer, J.B.4    Fox, C.S.5
  • 16
    • 55649105963 scopus 로고    scopus 로고
    • Clinical risk factors, DNA variants, and the development of type 2 diabetes
    • Lyssenko V, Jonsson A, Almgren P, Pulizzi N, Isomaa B, et al. (2008) Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med 359: 2220-2232.
    • (2008) N Engl J Med , vol.359 , pp. 2220-2232
    • Lyssenko, V.1    Jonsson, A.2    Almgren, P.3    Pulizzi, N.4    Isomaa, B.5
  • 17
    • 56349096931 scopus 로고    scopus 로고
    • Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk
    • Lango H, UK Type 2 Diabetes Genetics Consortium, Palmer CN, Morris AD, Zeggini E, et al. (2008) Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes 57: 3129-3135.
    • (2008) Diabetes , vol.57 , pp. 3129-3135
    • Lango, H.1    Palmer, C.N.2    Morris, A.D.3    Zeggini, E.4
  • 18
    • 33750876203 scopus 로고    scopus 로고
    • Combining information from common type 2 diabetes risk polymorphisms improves disease prediction
    • Weedon MN, McCarthy MI, Hitman G, Walker M, Groves CJ, et al. (2006) Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. PLoS Med 3: e374.
    • (2006) PLoS Med , vol.3
    • Weedon, M.N.1    McCarthy, M.I.2    Hitman, G.3    Walker, M.4    Groves, C.J.5
  • 19
    • 71149105110 scopus 로고    scopus 로고
    • Genetic Structure of the Han Chinese Population Revealed by Genome-wide SNP Variation
    • Chen J, Zheng H, Bei JX, Sun L, Jia WH, et al. (2009) Genetic Structure of the Han Chinese Population Revealed by Genome-wide SNP Variation. Am J Hum Genet 85: 775-785.
    • (2009) Am J Hum Genet , vol.85 , pp. 775-785
    • Chen, J.1    Zheng, H.2    Bei, J.X.3    Sun, L.4    Jia, W.H.5
  • 20
    • 63149192854 scopus 로고    scopus 로고
    • Serum CRP and microalbuminuria in relation to fasting and 2-h post-load plasma glucose in a Chinese population
    • Li XY, Xu M, Wang JG, Wang XJ, Huang Y, et al. (2009) Serum CRP and microalbuminuria in relation to fasting and 2-h post-load plasma glucose in a Chinese population. Clin Endocrinol (Oxf) 70: 691-697.
    • (2009) Clin Endocrinol (Oxf) , vol.70 , pp. 691-697
    • Li, X.Y.1    Xu, M.2    Wang, J.G.3    Wang, X.J.4    Huang, Y.5
  • 21
    • 67650649404 scopus 로고    scopus 로고
    • Retinol-binding protein 4 is associated with impaired glucose regulation and microalbuminuria in a Chinese population
    • Xu M, Li XY, Wang JG, Wang XJ, Huang Y, et al. (2009) Retinol-binding protein 4 is associated with impaired glucose regulation and microalbuminuria in a Chinese population. Diabetologia 52: 1511-1519.
    • (2009) Diabetologia , vol.52 , pp. 1511-1519
    • Xu, M.1    Li, X.Y.2    Wang, J.G.3    Wang, X.J.4    Huang, Y.5
  • 22
    • 50449085998 scopus 로고    scopus 로고
    • Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
    • Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, et al. (2008) Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 40: 1092-1097.
    • (2008) Nat Genet , vol.40 , pp. 1092-1097
    • Yasuda, K.1    Miyake, K.2    Horikawa, Y.3    Hara, K.4    Osawa, H.5
  • 24
    • 58149175143 scopus 로고    scopus 로고
    • A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
    • Bouatia-Naji N, Bonnefond A, Cavalcanti-Proença C, Sparsø T, Holmkvist J, et al. (2009) A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet 41: 89-94.
    • (2009) Nat Genet , vol.41 , pp. 89-94
    • Bouatia-Naji, N.1    Bonnefond, A.2    Cavalcanti-Proença, C.3    Sparsø, T.4    Holmkvist, J.5
  • 25
    • 34547510624 scopus 로고    scopus 로고
    • Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
    • Gudmundsson J, Sulem P, Steinthorsdottir V, Bergthorsson JT, Thorleifsson G, et al. (2007) Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet 39: 977-983.
    • (2007) Nat Genet , vol.39 , pp. 977-983
    • Gudmundsson, J.1    Sulem, P.2    Steinthorsdottir, V.3    Bergthorsson, J.T.4    Thorleifsson, G.5
  • 26
    • 42349106044 scopus 로고    scopus 로고
    • Metaanalysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    • Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, et al. (2008) Metaanalysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40: 638-645.
    • (2008) Nat Genet , vol.40 , pp. 638-645
    • Zeggini, E.1    Scott, L.J.2    Saxena, R.3    Voight, B.F.4    Marchini, J.L.5
  • 27
    • 38449097877 scopus 로고    scopus 로고
    • Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population
    • Li H, Wu Y, Loos RJ, Hu FB, Liu Y, et al. (2008) Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes 57: 264-268.
    • (2008) Diabetes , vol.57 , pp. 264-268
    • Li, H.1    Wu, Y.2    Loos, R.J.3    Hu, F.B.4    Liu, Y.5
  • 28
    • 33748804424 scopus 로고    scopus 로고
    • A tutorial on statistical methods for population association studies
    • Balding DJ (2006) A tutorial on statistical methods for population association studies. Nat Rev Genet 7: 781-791.
    • (2006) Nat Rev Genet , vol.7 , pp. 781-791
    • Balding, D.J.1
  • 29
    • 3242770671 scopus 로고    scopus 로고
    • Overall C as a measure of discrimination in survival analysis: Model specific population value and confidence interval estimation
    • Pencina MJ, D'Agostino RB (2004) Overall C as a measure of discrimination in survival analysis: model specific population value and confidence interval estimation. Stat Med 23: 2109-2123.
    • (2004) Stat Med , vol.23 , pp. 2109-2123
    • Pencina, M.J.1    D'agostino, R.B.2
  • 30
    • 53749086159 scopus 로고    scopus 로고
    • Zinc transporter-8 gene (SLC30A8) is associated with type 2 diabetes in Chinese
    • Xiang J, Li XY, Xu M, Hong J, Huang Y, et al. (2008) Zinc transporter-8 gene (SLC30A8) is associated with type 2 diabetes in Chinese. J Clin Endocrinol Metab 93: 4107-4112.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4107-4112
    • Xiang, J.1    Li, X.Y.2    Xu, M.3    Hong, J.4    Huang, Y.5
  • 31
    • 36849011549 scopus 로고    scopus 로고
    • Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: Validation and extension of genome-wide association studies
    • Grarup N, Rose CS, Andersson EA, Andersen G, Nielsen AL, et al. (2007) Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies. Diabetes 56: 3105-3111.
    • (2007) Diabetes , vol.56 , pp. 3105-3111
    • Grarup, N.1    Rose, C.S.2    Andersson, E.A.3    Andersen, G.4    Nielsen, A.L.5
  • 32
    • 35848945259 scopus 로고    scopus 로고
    • Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population
    • Horikoshi M, Hara K, Ito C, Shojima N, Nagai R, et al. (2007) Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. Diabetologia 50: 2461-2466.
    • (2007) Diabetologia , vol.50 , pp. 2461-2466
    • Horikoshi, M.1    Hara, K.2    Ito, C.3    Shojima, N.4    Nagai, R.5
  • 33
    • 50449104632 scopus 로고    scopus 로고
    • Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians
    • Ng MCY, Park KS, Oh B, Tam CHT, Cho YM, et al. (2008) Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. Diabetes 57: 2226-2233.
    • (2008) Diabetes , vol.57 , pp. 2226-2233
    • Ng, M.C.Y.1    Park, K.S.2    Oh, B.3    Tam, C.H.T.4    Cho, Y.M.5
  • 34
    • 40949087723 scopus 로고    scopus 로고
    • Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population
    • Omori S, Tanaka Y, Takahashi A, Hirose H, Kashiwagi A, et al. (2008) Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. Diabetes 57: 791-795.
    • (2008) Diabetes , vol.57 , pp. 791-795
    • Omori, S.1    Tanaka, Y.2    Takahashi, A.3    Hirose, H.4    Kashiwagi, A.5
  • 35
    • 70349113136 scopus 로고    scopus 로고
    • Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants
    • Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, et al. (2009) Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes. 58: 2070-2083.
    • (2009) Diabetes , vol.58 , pp. 2070-2083
    • Nicolson, T.J.1    Bellomo, E.A.2    Wijesekara, N.3    Loder, M.K.4    Baldwin, J.M.5
  • 36
    • 77955514154 scopus 로고    scopus 로고
    • Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion
    • Wijesekara N, Dai FF, Hardy AB, Giglou PR, Bhattacharjee A, et al. (2010) Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion. Diabetologia 53: 1656-1668.
    • (2010) Diabetologia , vol.53 , pp. 1656-1668
    • Wijesekara, N.1    Dai, F.F.2    Hardy, A.B.3    Giglou, P.R.4    Bhattacharjee, A.5
  • 37
    • 0032937751 scopus 로고    scopus 로고
    • Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in b-islet cell hyperplasia
    • Rane SG, Dubus P, Mettus RV, Galbreath EJ, Boden G, et al. (1999) Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in b-islet cell hyperplasia. Nat Genet 22: 44-52.
    • (1999) Nat Genet , vol.22 , pp. 44-52
    • Rane, S.G.1    Dubus, P.2    Mettus, R.V.3    Galbreath, E.J.4    Boden, G.5
  • 38
    • 33749187810 scopus 로고    scopus 로고
    • P16INK4a induces an age-dependent decline in islet regenerative potential
    • Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, et al. (2006) P16INK4a induces an age-dependent decline in islet regenerative potential. Nature 443: 453-57.
    • (2006) Nature , vol.443 , pp. 453-457
    • Krishnamurthy, J.1    Ramsey, M.R.2    Ligon, K.L.3    Torrice, C.4    Koh, A.5
  • 39
    • 67349205597 scopus 로고    scopus 로고
    • Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population
    • Hu C, Wang C, Zhang R, Ma X, Wang J, et al. (2009) Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population. Diabetologia 52: 1322-1325.
    • (2009) Diabetologia , vol.52 , pp. 1322-1325
    • Hu, C.1    Wang, C.2    Zhang, R.3    Ma, X.4    Wang, J.5
  • 40
    • 69449108010 scopus 로고    scopus 로고
    • Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population
    • 3508-3015
    • Qi Q, Li H, Loos RJ, Liu C, Wu Y, et al. (2009) Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Hum Mol Genet 18: 3508-3015.
    • (2009) Hum Mol Genet , vol.18
    • Qi, Q.1    Li, H.2    Loos, R.J.3    Liu, C.4    Wu, Y.5
  • 41
    • 75749086085 scopus 로고    scopus 로고
    • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    • Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, et al. (2010) New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2: 105-116.
    • (2010) Nat Genet , vol.2 , pp. 105-116
    • Dupuis, J.1    Langenberg, C.2    Prokopenko, I.3    Saxena, R.4    Soranzo, N.5
  • 42
    • 75749091912 scopus 로고    scopus 로고
    • Nat Genet. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
    • Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, et al. (2010) Nat Genet. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 42: 142-148.
    • (2010) Nat Genet , vol.42 , pp. 142-148
    • Saxena, R.1    Hivert, M.F.2    Langenberg, C.3    Tanaka, T.4    Pankow, J.S.5


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