Common variants in the type 2 diabetes KCNQ1 gene are associated with impairments in insulin secretion during hyperglycaemic glucose clamp

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  van Vliet Ostaptchouk, Jana V ^a   van Haeften, Timon W ^b   Landman, Gijs W D ^c   Reiling, Erwin ^d   Kleefstra, Nanne ^a,c,e   Bilo, Henk J G ^a,c   Klungel, Olaf H ^f   de Boer, Anthonius ^f   van Diemen, Cleo C ^a   Wijmenga, Cisca ^a   Boezen, H Marike ^a   Dekker, Jacqueline M ^g   van 't Riet, Esther ^g   Nijpels, Giel ^g   Welschen, Laura M C ^g   Zavrelova, Hata ^g   Bruin, Elinda J ^a   Elbers, Clara C ^b   Bauer, Florianne ^b   Onland Moret, N Charlotte ^b   van der Schouw, Yvonne T ^b   Grobbee, Diederick E ^b   Spijkerman, Annemieke M W ^h   van der A, Daphne L ^h   Simonis Bik, Annemarie M ^g   Eekhoff, Elisabeth M W ^g   Diamant, Michaela ^g   Kramer, Mark H H ^g   Boomsma, Dorret I ^g,i   de Geus, Eco J ^g,i   Willemsen, Gonneke ^g,i   Slagboom, P Eline ^d,j   Hofker, Marten H ^a   't Hart, Leen M ^c,d   more..

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c ISALA HOSPITAL   (Netherlands)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e Medical Research Group Langerhans   (Netherlands)

^f UTRECHT UNIVERSITY   (Netherlands)

^g VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^h NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

ⁱ VU UNIVERSITY AMSTERDAM   (Netherlands)

^j University Medical Center Utrecht ^*  (Netherlands)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GLUCOSE; HEMOGLOBIN A1C; INSULIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; POTASSIUM CHANNEL KCNQ1;

ADULT; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DIABETIC RETINOPATHY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; GLUCOSE CLAMP TECHNIQUE; HETEROZYGOTE; HUMAN; INSULIN RELEASE; KCNQ1 GENE; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; METABOLIC REGULATION; MORTALITY; NETHERLANDS; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; CASE CONTROL STUDY; DIABETES MELLITUS; GENETIC PREDISPOSITION; GENETICS; HYPERGLYCEMIA; METABOLISM; MIDDLE AGED; SECRETION;

CASE-CONTROL STUDIES; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GLUCOSE CLAMP TECHNIQUE; HUMANS; HYPERGLYCEMIA; INSULIN; KCNQ1 POTASSIUM CHANNEL; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84857709224     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032148     Document Type: Article

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