Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: A study of 3,310 subjects from India and the US

BMC Medical Genetics

Volumn 12, Issue , 2011, Pages

  Been, Latonya F ^a   Ralhan, Sarju ^b   Wander, Gurpreet S ^b   Mehra, Narinder K ^c   Singh, JaiRup ^d   Mulvihill, John J ^a   Aston, Christopher E ^a   Sanghera, Dharambir K ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b DAYANAND MEDICAL COLLEGE AND HOSPITAL   (India)

^c ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^d CENTRAL UNIVERSITY OF PUNJAB   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE DERIVATIVE; GLYCYLCYSTEINYLCYSTEINE; POTASSIUM CHANNEL KCNQ1; UNCLASSIFIED DRUG; KCNQ1 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CASE CONTROL STUDY; CLINICAL ASSESSMENT TOOL; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE MUTATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HAPLOTYPE; HETEROZYGOTE; HOMEOSTASIS MODEL ASSESSMENT FOR BETA CELL FUNCTION; HUMAN; INDIA; INDIAN; MAJOR CLINICAL STUDY; MALE; META ANALYSIS; MIGRATION; MULTICENTER STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; QUANTITATIVE TRAIT LOCUS; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SOUTH ASIA; UNITED STATES; COMPARATIVE STUDY; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; MIDDLE AGED;

CASE-CONTROL STUDIES; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; INDIA; KCNQ1 POTASSIUM CHANNEL; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; UNITED STATES;

EID: 78751647900     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-12-18     Document Type: Article

References (20)

1. Neyroud N, Tesson F, Denjoy I, Leibovici M, Donger C, Barhanin J, Faure S, Gary F, Coumel P, Petit C, et al. A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome. Nat Genet 1997, 15(2):186-189. 10.1038/ng0297-186, 9020846.
2. Ullrich S, Su J, Ranta F, Wittekindt OH, Ris F, Rosler M, Gerlach U, Heitzmann D, Warth R, Lang F. Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cells. Pflugers Arch 2005, 451(3):428-436. 10.1007/s00424-005-1479-2, 16133261.
3. MacDonald PE, Wheeler MB. Voltage-dependent K(+) channels in pancreatic beta cells: role, regulation and potential as therapeutic targets. Diabetologia 2003, 46(8):1046-1062. 10.1007/s00125-003-1159-8, 12830383.
4. Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, Furuta H, Hirota Y, Mori H, Jonsson A, Sato Y, et al. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 2008, 40(9):1092-1097. 10.1038/ng.207, 18711367.
5. Unoki H, Takahashi A, Kawaguchi T, Hara K, Horikoshi M, Andersen G, Ng DP, Holmkvist J, Borch-Johnsen K, Jorgensen T, et al. SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet 2008, 40(9):1098-1102. 10.1038/ng.208, 18711366.
6. Hu C, Wang C, Zhang R, Ma X, Wang J, Lu J, Qin W, Bao Y, Xiang K, Jia W. Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population. Diabetologia 2009, 52(7):1322-1325. 10.1007/s00125-009-1335-6, 19308350.
7. Liu Y, Zhou DZ, Zhang D, Chen Z, Zhao T, Zhang Z, Ning M, Hu X, Yang YF, Zhang ZF, et al. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China. Diabetologia 2009, 52(7):1315-1321. 10.1007/s00125-009-1375-y, 2688614, 19448982.
8. Tan JT, Nurbaya S, Gardner D, Ye S, Tai ES, Ng DP. Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore. Diabetes 2009, 58(6):1445-1449. 10.2337/db08-1138, 2682664, 19252135.
9. Holmkvist J, Banasik K, Andersen G, Unoki H, Jensen TS, Pisinger C, Borch-Johnsen K, Sandbaek A, Lauritzen T, Brunak S, et al. The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load. PLoS One 2009, 4(6):e5872. 10.1371/journal.pone.0005872, 2689931, 19516902.
10. Jonsson A, Isomaa B, Tuomi T, Taneera J, Salehi A, Nilsson P, Groop L, Lyssenko V. A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion. Diabetes 2009, 58(10):2409-2413. 10.2337/db09-0246, 2750226, 19584308.
11. Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010, 42(7):579-589. Epub, 10.1038/ng.609, 20581827.
12. Sanghera DK, Ortega L, Han S, Singh J, Ralhan SK, Wander GS, Mehra NK, Mulvihill JJ, Ferrell RE, Nath SK, et al. Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. BMC Med Genet 2008, 9:59. 10.1186/1471-2350-9-59, 2481250, 18598350.
13. Diagnosis and classification of diabetes mellitus. Diabetes Care 2004, 27(Suppl 1):S5-S10.
14. Sanghera DK, Been L, Ortega L, Wander GS, Mehra NK, Aston CE, Mulvihill JJ, Ralhan S. Testing the association of novel meta-analysis-derived diabetes risk genes with type II diabetes and related metabolic traits in Asian Indian Sikhs. J Hum Genet 2009, 54(3):162-168. 10.1038/jhg.2009.7, 19247373.
15. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28(7):412-419. 10.1007/BF00280883, 3899825.
16. Purcell SCS, Sham PC. Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 2003, 19(1):149-150. 10.1093/bioinformatics/19.1.149, 12499305.
17. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007, 316(5829):1341-1345. 10.1126/science.1142382, 17463248.
18. Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, Boutin P, Vincent D, Belisle A, Hadjadj S, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007, 445(7130):881-885. 10.1038/nature05616, 17293876.
19. Frayling TM. Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet 2007, 8(9):657-662. 10.1038/nrg2178, 17703236.
20. Chang YC, Chang TJ, Jiang YD, Kuo SS, Lee KC, Chiu KC, Chuang LM. Association study of the genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population. Diabetes 2007, 56(10):2631-2637. 10.2337/db07-0421, 17579206.