Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population

Human Molecular Genetics

Volumn 18, Issue 18, 2009, Pages 3508-3515

  Qi, Qibin ^a   Li, Huaixing ^a   Loos, Ruth J F ^b   Liu, Chen ^a   Wu, Ying ^a   Hu, Frank B ^c   Wu, Hongyu ^a   Lu, Ling ^a   Yu, Zhijie ^a   Lin, Xu ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL KCNQ1;

ADULT; AGED; ARTICLE; CELL FUNCTION; CHINESE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; FASTING; FEMALE; HUMANS; KCNQ1 POTASSIUM CHANNEL; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 69449108010     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddp294     Document Type: Article

References (20)

1. Yoon, K.H., Lee, J.H., Kim, J.W., Cho, J.H., Choi, Y.H., Ko, S.H., Zimmet, P. and Son, H.Y. (2006) Epidemic obesity and type 2 diabetes in Asia. Lancet, 368, 1681-1688.
2. Gu, D., Reynolds, K., Duan, X., Xin, X., Chen, J., Wu, X., Mo, J., Whelton, P.K. and He, J. (2003) Prevalence of diabetes and impaired fasting glucose in the Chinese adult population: International Collaborative Study of Cardiovascular Disease in Asia (InterASIA). Diabetologia, 46, 1190-1198.
3. Chen, K.W., Boyko, E.J., Bergstrom, R.W., Leonetti, D.L., Newell-Morris, L., Wahl, P.W. and Fujimoto, W.Y. (1995) Earlier appearance of impaired insulin secretion than of visceral adiposity in the pathogenesis of NIDDM. 5-Year follow-up of initially nondiabetic Japanese-American men. Diabetes Care, 18, 747-753.
4. Park, Y.W., Allison, D.B., Heymsfield, S.B. and Gallagher, D. (2001) Larger amounts of visceral adipose tissue in Asian Americans. Obes. Res., 9, 381-387.
5. Barhanin, J., Lesage, F., Guillemare, E., Fink, M., Lazdunski, M. and Romey, G. (1996) K(V)LQT1 and IsK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature, 384, 78-80.
6. Wang, Q., Curran, M.E., Splawski, I., Burn, T.C., Millholland, J.M., VanRaay, T.J., Shen, J., Timothy, K.W., Vincent, G.M., de Jager, T. et al. (1996) Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat. Genet., 12, 17-23.
7. Neyroud, N., Tesson, F., Denjoy, I., Leibovici, M., Donger, C., Barhanin, J., Faure, S., Gary, F., Coumel, P., Petit, C. et al. (1997) A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome. Nat. Genet., 15, 186-189.
8. Chen, Y.-H., Xu, S.-J., Bendahhou, S., Wang, X.-L., Wang, Y., Xu, W.-Y., Jin, H.-W., Sun, H., Su, X.-Y., Zhuang, Q.-N. et al. (2003) KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science 299, 251-254.
9. Lee, M.P., Ravenel, J.D., Hu, R.J., Lustig, L.R., Tomaselli, G., Berger, R.D., Brandenburg, S.A., Litzi, T.J., Bunton, T.E., Limb, C. et al. (2000) Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice. J. Clin. Invest., 106, 1447-1455.
10. Casimiro, M.C., Knollmann, B.C., Ebert, S.N., Vary, J.C. Jr, Greene, A.E., Franz, M.R., Grinberg, A., Huang, S.P. and Pfeifer, K. (2001) Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange-Nielsen syndrome. Proc. Natl Acad. Sci. USA, 98, 2526-2531.
11. Demolombe, S., Franco, D., de Boer, P., Kuperschmidt, S., Roden, D., Pereon, Y., Jarry, A., Moorman, A.F. and Escande, D. (2001) Differential expression of KvLQT1 and its regulator IsK in mouse epithelia. Am. J. Physiol. Cell Physiol., 280, C359-C372.
12. Ullrich, S., Su, J., Ranta, F., Wittekindt, O.H., Ris, F., Rosler, M., Gerlach, U., Heitzmann, D., Warth, R. and Lang, F. (2005) Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cells. Pflugers Arch., 451, 428-436.
13. Unoki, H., Takahashi, A.,Kawaguchi, T., Hara, K., Horikoshi, M., Andersen, G., Ng, D.P.K., Holmkvist, J., Borch-Johnsen, K., Jorgensen, T. et al. (2008) SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat. Genet., 40, 1098-1102.
14. Yasuda, K., Miyake, K., Horikawa, Y., Hara, K., Osawa, H., Furuta, H., Hirota, Y., Mori, H., Jonsson, A., Sato, Y. et al. (2008) Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat. Genet., 40, 1092-1097.
15. Tan, J.T., Nurbaya, S., Gardner, D., Sandra, Y., Tai, E.S. and Ng, D.P.K. (2009) Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: A study of 3734 subjects comprising three ethnicities living in Singapore. Diabetes, 58, 1445-1449.
16. Hu, C., Wang, C., Zhang, R., Ma, X., Wang, J., Lu, J., Qin, W., Bao, Y., Xiang, K. and Jia, W. Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population. Diabetologia 52, 1322-1325.
17. Wu, Y., Li, H., Loos, R.J., Yu, Z., Ye, X., Chen, L., Pan, A., Hu, F.B. and Lin, X. (2008) Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Diabetes, 57, 2834-2842.
18. Grant, S.F., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Manolescu, A., Sainz, J., Helgason, A., Stefansson, H., Emilsson, V., Helgadottir, A. et al. (2006) Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat. Genet. 38, 320-323.
19. Ye, X., Yu, Z., Li, H., Franco, O.H., Liu, Y. and Lin, X. (2007) Distributions of C-reactive protein and its association with metabolic syndrome in middle-aged and older Chinese people. J. Am. Coll. Cardiol., 49, 1798-1805.
20. Levy, J.C., Matthews, D.R. and Hermans, M.P. (1998) Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care, 21, 2191-2192.