Association between KCNQ1 genetic variants and obesity in Chinese patients with type 2 diabetes

Diabetologia

Volumn 55, Issue 10, 2012, Pages 2655-2659

  Yu, W ^a   Ma, R C ^b   Hu, C ^a   So, W Y ^b   Zhang, R ^a   Wang, C ^a   Tam, C H ^b   Ho, J S ^b   Lu, J ^a   Jiang, F ^a   Tang, S ^a   Ng, M C ^b,c   Bao, Y ^a   Xiang, K ^a   Jia, W ^a   Chan, J C N ^b  

^a SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Genetic variants; Han Chinese; KCNQ1; Obesity; Type 2 diabetes

Indexed keywords

ALLELE; ANTHROPOMETRY; ARTICLE; BODY MASS; CASE CONTROL STUDY; CHINESE; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC VARIABILITY; GENOTYPE; HONG KONG; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; PROVOCATION TEST; QUANTITATIVE TRAIT; SINGLE NUCLEOTIDE POLYMORPHISM; WAIST CIRCUMFERENCE;

ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; BODY MASS INDEX; CASE-CONTROL STUDIES; CHINA; COMORBIDITY; DIABETES MELLITUS, TYPE 2; GENOTYPE; HUMANS; INCIDENCE; KCNQ1 POTASSIUM CHANNEL; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84866073328     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2636-8     Document Type: Article

References (10)

1. McCarthy MI (2010) Genomics, type 2 diabetes, and obesity. N Engl J Med 363:2339-2350
2. Frayling TM, Timpson NJ, Weedon MN et al (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316:889-894 (Pubitemid 46764279)
3. Cauchi S, Meyre D, Dina C et al (2006) Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes. Diabetes 55:2903-2908 (Pubitemid 44923694)
4. Yasuda K, Miyake K, Horikawa Y et al (2008) Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 40:1092-1097
5. Unoki H, Takahashi A, Kawaguchi T et al (2008) SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet 40:1098-1102
6. Hu C, Wang C, Zhang R et al (2009) Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population. Diabetologia 52:1322-1325
7. Liu Y, Zhou DZ, Zhang D et al (2009) Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China. Diabetologia 52:1315-1321
8. Hu C, Zhang R, Wang C et al (2010) Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion. PLoS One 5:e11761
9. Ng MC, Tam CH, So WY et al (2010) Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. J Clin Endocrinol Metab 95:2418-2425
10. Boini KM, Graf D, Hennige AM et al (2009) Enhanced insulin sensitivity of gene-targeted mice lacking functional KCNQ1. Am J Physiol Regul Integr Comp Physiol 296:R1695-R1701