Fas receptor-deficient lpr mice are protected against acetaminophen hepatotoxicity due to higher glutathione synthesis and enhanced detoxification of oxidant stress

Food and Chemical Toxicology

Volumn 58, Issue , 2013, Pages 228-235

  Williams, C David ^a   McGill, Mitchell R ^a   Farhood, Anwar ^b   Jaeschke, Hartmut ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b St David's South Austin Medical Center   (United States)

Author keywords

Acetaminophen; Drug hepatotoxicity; Fas receptor; Heat shock protein70; Oxidant stress; Protein adducts

Indexed keywords

3 NITROTYROSINE; ALANINE AMINOTRANSFERASE; CYTOCHROME P450 2E1; FAS ANTIGEN; GLUTAMATE CYSTEINE LIGASE; GLUTAMATE DEHYDROGENASE; GLUTATHIONE; HEAT SHOCK PROTEIN 70; HEME OXYGENASE 1; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; METALLOTHIONEIN; PARACETAMOL; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG DETOXIFICATION; DRUG METABOLISM; DRUG OVERDOSE; GENE EXPRESSION; HEAT SHOCK PROTEIN 70 GENE; HEME OXYGENASE 1 GENE; IN VIVO STUDY; LIVER INJURY; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; MALE; METALLOTHIONEIN GENE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; TOXIC HEPATITIS; WILD TYPE;

ACETAMINOPHEN; ALANINE AMINOTRANSFERASE; ALT; APAP; DRUG HEPATOTOXICITY; FAS RECEPTOR; GCLC; GDH; GLUTAMATE DEHYDROGENASE; GLUTAMATE-CYSTEINE LIGASE, CATALYTIC SUBUNIT; GLUTATHIONE; GLUTATHIONE DISULFIDE; GSH; GSSG; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN70; HEME OXYGENASE 1; HO-1; HSP; INDUCIBLE NITRIC OXIDE SYNTHASE; INOS; LPR; LYMPHOPROLIFERATION, RECESSIVE (FAS DEFECTIVE MOUSE); METALLOTHIONEIN; MT; N-ACETYL-P-BENZOQUINONE IMINE; NAPQI; OXIDANT STRESS; PROTEIN ADDUCTS; REACTIVE OXYGEN SPECIES; ROS;

ACETAMINOPHEN; ANIMALS; ANTIGENS, CD95; GLUTATHIONE; LIVER; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS;

EID: 84878116795     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.04.031     Document Type: Article

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