Role of caspase-1 and interleukin-1β in acetaminophen-induced hepatic inflammation and liver injury

Toxicology and Applied Pharmacology

Volumn 247, Issue 3, 2010, Pages 169-178

  Williams, C David ^a   Farhood, Anwar ^b   Jaeschke, Hartmut ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b Brackenridge Hospital   (United States)

Author keywords

Acetaminophen; Hepatotoxicity; Inflammasome; Inflammation; Interleukin 1; Neutrophils

Indexed keywords

CASPASE INHIBITOR; INFLAMMASOME; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PARACETAMOL; UNCLASSIFIED DRUG; Z VD FMK;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DRUG OVERDOSE; ENZYME INHIBITION; GENETIC TRANSCRIPTION; HEPATITIS; LEUKOCYTE ACTIVATION; LIVER INJURY; LIVER TOXICITY; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; WILD TYPE;

ACETAMINOPHEN; ANIMALS; ANTIGENS, CD11B; CASPASE 1; CASPASE 3; DRUG-INDUCED LIVER INJURY; ENZYME INHIBITORS; FLOW CYTOMETRY; INTERLEUKIN-1BETA; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; REACTIVE OXYGEN SPECIES;

ANIMALIA; MUS;

EID: 77955922658     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.07.004     Document Type: Article

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