PET neuroimaging in pigs

Scandinavian Journal of Laboratory Animal Science

Volumn 39, Issue 1, 2012, Pages 25-45

  Alstrup, Aage Kristian Olsen ^a   Smith, Donald F ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; BENZODIAZEPINE RECEPTOR; BUTANOL; CARBON 11; DOPA; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; FLUORINE 18; FLUORODEOXYGLUCOSE F 18; GLYCINE TRANSPORTER 1; HISTAMINE H3 RECEPTOR; MIANSERIN; MIRTAZAPINE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; NEUROKININ; NEUROKININ 1 RECEPTOR; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE V; RADIOLIGAND; ROLIPRAM; SEROTONIN; SEROTONIN 1 RECEPTOR; SEROTONIN 4 RECEPTOR; VENLAFAXINE; YOHIMBINE;

ANESTHESIA; ARTICLE; BRAIN BLOOD FLOW; BRAIN BLOOD VOLUME; BRAIN METABOLISM; CHOLINERGIC TRANSMISSION; DOPAMINERGIC TRANSMISSION; EXPERIMENTAL PIG; NEUROCHEMISTRY; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY;

EID: 84877943779     PISSN: 09013393     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (118)

1. Abi-Dargham A, D Martinez, O Mawlawi, N Simpson, DR Hwang, M Slifstein, S Anjilvel, J Pidcock, NN Guo, I Lombardo, JJ Mann, R van Heertum, C Foged, C Halldin & M Lamelle: Measurement of striatal and extrastriatal dopamine D1 receptor binding potential with [11C] NNC 112 in humans: validation and reproducibility. J Cereb Blood Flow Metab, 2000, 20, 225-243.
2. Alstrup AKO: Anesthesia and analgesia in Ellegaard Göttingen minipigs. Ellegaard, Dalmose, DK, 2000.
3. Alstrup AKO, S Jakobsen, G Wegener, A Gjedde, AK Hansen, DJ Doudet & AM Landau: Differential effects of propofol and isoflurane anesthesia on dopamine receptor 1 availability in minipig brain. 2011 (in preparation).
4. Alstrup AKO & M Winterdahl: Imaging techniques in large animals. Scand J Lab Animal Sci, 2009, 36, 55-66.
5. Andersen F, H Watanabe, C Bjarkam, EH Danielsen & P Cumming: Pig brain stereotaxic standard space: mapping of cerebral blood flow normative values and effect of MPTP-lesioning. Brain Res Bull, 2005, 66, 17-29.
6. Anichtchik OV, N Peitsaro, JO Rinne, H Kalimo & P Panula: Distribution and modulation of histamine H(3) receptors in basal ganglia and frontal cortex of healthy controls and patients with Parkinson's disease. Neurobiol Dis, 2001, 5, 707-716.
7. Bailey DL, DW Townsend, PE Valk & MN Maisey: Positron Emission Tomography: Basic Sciences, Springer-Verlag, London, UK, 2005.
8. Bauer R, P Brust, B Walter, G Vorwieger, R Bergmann, E Elhalag, A Fritz, J Steinbach, F Fuchtner, R Hinz, U Zwiener & B Johannsen: Effect of hypoxia/hypercapnia on metabolism of 6-[(18)F]fluoro-L-DOPA in newborn piglets. Brain Res, 2002, 934, 23-33.
9. Bauer R, P Brust, B Walte, G Vorwieger, R Bergmann, F Fuchtner, J Steinbach, E el Hallag, A Fritz, B Johannsen & U Zwiener: Relation between brain tissue pO2 and dopamine synthesis of basal ganglia - a 18FDOPA-PET study in newborn piglets. J Perinat Med, 2000, 28, 54-60.
10. Bender AT & JA Beavo: Specific localized expression of cGMP PDEs in Purkinje neurons and macrophages. Neurochem Int, 2004, 45, 853-857.
11. Bender D, AK Olsen, MK Marthi, DF Smith & P Cumming: PET evaluation of the uptake of N-[11C]methyl CP-643, 051, an NK1 receptor antagonist, in the living porcine brain. Nucl Med Biol, 2004, 31, 699-704.
12. Benevenga NJ: Amino acid metabolism in swine: applicability to normal and altered amino acid metabolism in humans. In: Tumbleson, M.E. (Ed.), Swine in Biomedical Research. Volume 2., Plenum Press, New York, 1986, pp. 1017-1030.
13. Betz H, J Gomeza, W Armsen, P Scholze & V Eulen-burg: Glycine transporters: essential regulators of synaptic transmission. Biochem Soc Trans, 2006, 34, 55-58.
14. Bjarkam CR, MS Nielsen, AN Glud, F Rosendal, P Mogensen, D Bender, D Doudet, A Moller & JC Sorensen: Neuromodulation in a minipig MPTP model of Parkinson disease. Br J Neurosurg, 2008, 22, Suppl 1, S9-12.
15. Blaizot X, B Landeau, JC Baron & C Chavoix: Mapping the visual recognition memory network with PET in the behaving baboon. J Cereb Blood Flow Metab, 2000, 20, 213-219.
16. Bollen PJA, AK Hansen & AKO Alstrup: The laboratory swine. CRC Press, Boca Raton, Fl. 2010.
17. Brust P, R Hinz, H Kuwabara, S Hesse, J Zessin, B Pawelke, H Stephan, R Bergmann, J Steinbach & O Sabril In vivo measurement of the serotonin transporter with (S)-([18F]fluoromethyl)-(+)-McN5652. Neuropsychopharmacology, 2003a, 25, 2010-2019.
18. Brust P, JT Patt, W Deuther-Conrad, G Becker, M Patt, A Schildern, D Sorger, K Kendziorra, P Meyer, J Steinbach & O Sabri: In vivo measurement of nicotinic acetylcholine receptors with [18F]norchloro-fluoro-homoepibatidine. Synapse, 2008, 62, 205-218.
19. Brust P, G Vorwieger, B Walter, F Fuchtner, H Stark, H Kuwabara, M Herzau, T Opfermann, J Stein-bach, V Ganapathy & R Bauer. The influx of neutral amino acids into the porcine brain during development: a positron emission tomography study. Brain Res Dev Brain Res 2004a, 152, 241-253.
20. Brust P, B Walter, R Hinz, F Fuchtner, M Muller, J Steinbach & R Bauer: Developmental changes in the activities of aromatic amino acid decarboxylase and catechol-O-methyl transferase in the porcine brain: a positron emission tomography study. Neurosci Lett, 2004b, 364, 159-163.
21. Brust P, J Zessin, H Kuwabara, B Pawelke, M Kretzschmar, R Hinz, J Bergman, O Eskola, O Solin, J Steinbach & B Johannsen: Positron emission tomography imaging of the serotonin transporter in the pig brain using [11C](+)-McN5652 and S-([18F]fluoromethyl)-(+)-McN5652. Synapse 2003a, 47, 143-151.
22. Buck A, PM Gucker, RD Schonbachler, M Arigoni, S Kneifel, FX Vollenweider, SM Ametamey & C Burger. Evaluation of serotonergic transporters using PET and [11 C](+)McN-5652: assessment of methods. J Cereb Blood Flow Metab, 2000, 20, 253-262.
23. Carter AJ, WD Bechtel, M Grauert, P Harrison, H Merz & W Stransky: Bill 277 CL is a potent and specific ion-channel blocker of the NMDA receptor-channel complex. J Pharmacol Exp Ther, 1995, 275, 1382-1389.
24. Chalon S, H Hall, W Saba, L Garreau, F Dolle, C Halldin, P Emond, M Bottlaender, JB Deloye, J Helfenbein, JC Madelmon, S Bodard, Z Mincheva, JC Besnard & D Guilloteau: Pharmacological characterization of (E)-N-(4-fluorobut-2-enyl)-2beta-carbomethoxy-3beta-(4'-tolyl) nortropane (LBT-999) as a highly promising fluorinated ligand for the dopamine transporter. J Pharmacol Exp Ther, 2006, 317, 147-152.
25. Cumming P, EH Danielsen, M Vafaee, L Falborg, E Steffensen, JC Sorensen, N Gillings, D Bender, K Marthi, F Andersen, O Munk, D Smith, A Moller & A Gjedde: Normalization of markers for dopamine innervation in striatum of MPTP-lesioned miniature pigs with intrastriatal grafts. Acta Neurol Scand 2001, 103, 309-315.
26. Cumming P, NM Gillings, SB Jensen, C Bjarkam & A Gjedde: Kinetics of the uptake and distribution of the dopamine D(2, 3) agonist (R)-N-[1-(11)C]n- propylnorapomorphine in brain of healthy and MPTP-treated Gottingen miniature pigs. Nucl Med Biol, 2003a, 30, 547-553.
27. Cumming P, M Moller, K Benda, L Minuzzi, S Jakobsen, SB Jensen, B Pakkenberg, AK Stark, JB Gramsbergen, MF Andreasen & AK Olsen: A PET study of effects of chronic 3, 4-methylene-dioxymethamphetamine (MDMA, "ecstasy") on serotonin markers in Gottingen minipig brain. Synapse, 2007, 61, 478-487.
28. Cumming P, MD Pedersen, L Minuzzi, K Mezzomo, EH Danielsen, P Iversen, D Aagaard, S Keiding, OL Munk & B Finsen: Distribution of PK 11195 binding sites in porcine brain studied by autoradiography in vitro and by positron emission tomography. Synapse, 2006, 59, 418-426.
29. Cumming P, P Rosa-Neto, H Watanabe, D Smith, D Bender, PB Clarke & A Gjedde: Effects of acute nicotine on hemodynamics and binding of [11C]raclopride to dopamine D2, 3 receptors in pig brain. Neurolmage, 2003b, 19, 1127-1136.
30. Dagal A & AM Lam: Cerebral autoregulation and anesthesia. Curr Opin Anaesthesiol, 2009, 22, 547-552.
31. Dall AM, EH Danielsen, JC Sorensen, F Andersen, A Moller, J Zimmer, AH Gjedde & P Cumming: Quantitative [18F]fluorodopa/PET and histology of fetal mesencephalic dopaminergic grafts to the striatum of MPTP-poisoned minipigs. Cell Transplant, 2002, 11, 733-746.
32. Danielsen EH, P Cumming, F Andersen, D Bender, T Brevig, L Falborg, A Gee, NM Gillings, SB Hansen, F Hermansen, J Johansen, TE Johansen, A Dahl-Jorgensen, HA Jorgensen, M Meyer, O Munk, EB Pedersen, PH Poulsen, AB Rodell, M Sakoh, CZ Simonsen, DF Smith, JC Sorensen, L Ostergard, J Zimmer, A Gjedde & A Moller: The DaNeX study of embryonic mesencephalic, dopaminergic tissue grafted to a minipig model of Parkinson's disease: preliminary findings of effect of MPTP poisoning on striatal dopaminergic markers. Cell Transplant, 2000, 9, 247-259.
33. Danielsen EH, D Smith, F Hermansen, A Gjedde & P Cumming: Acute neuroleptic stimulates DOPA decarboxylase in porcine brain in vivo. Synapse, 2001a, 41, 172-175.
34. Danielsen EH, DF Smith, F Andersen, AD Gee, D Bender, SB Hansen, F Hermansen, L Ostergaard, P Cumming & A Gjedde: FDOPA metabolism in the adult porcine brain: influence of tracer circulation time and VOI selection on estimates of striatal DOPA decarboxylation. J Neurosci Methods, 2001b, 111, 157-168.
35. Deuther-Conrad W, JT Patt, D Feuerbach, F Wegner, P Brust & J Steinbach: Norchloro-fluoro-homoepibatidine: specificity to neuronal nicotinic acetylcholine receptor subtypes in vitro. Farmaco, 2004, 59, 785-792.
36. Diehl KH, R Hull, D Morton, R Pfister, Y Rabemam-pianina, D Smith, JM Vidal van: A good practice guide to the administration of substances and removal of blood, including routes and volumes. J Appl Toxicol, 2001, 21, 15-23.
37. Doorduin J, EF de Vries, RA Dierckx & HC Klein: PET imaging of the peripheral benzodiazepine receptor: monitoring disease progression and therapy response in neurodegenerative disorders. Curr Pharm Des, 2008, 14, 3297-3315.
38. Egerton A, A Demjaha, P McGuire, MA Mehta & OD Howes: The test-retest reliability of 18F-DOPA PET in assessing striatal and extrastriatal presynaptic dopaminergic function. Neurolmage, 2010, 50, 524-531.
39. Egerton A, MA Mehta, AJ Montgomery, JM Lappin, OD Howes, SJ Reeves, VJ Cunningham & PM Grasby: The dopaminergic basis of human behaviors: A review of molecular imaging studies. Neurosci Biobehav Rev, 2009, 33, 1109-1132.
40. Farde L, E Ehrin, L Eriksson, T Greitz, H Hall, CG Hedstrom, JE Litton & G Sedvall: Substituted benzamides as ligands for visualization of dopamine receptor binding in the human brain by positron emission tomography. Proc Natl Acad Sci USA, 1985, 82, 3863-3867.
41. Félix B, M-E Léger & D Albe-Fessard: Stereotaxic Atlas of the Pig Brain, Elsevier, Amsterdam, Holland, 1999.
42. Ginovart N, JH Meyer, A Boovariwala, D Hussey, EA Rabiner, S Houle, AA Wilson: Positron emission tomography quantification of [11C]-harmine binding to monoamine oxidase-A in the human brain. J Cereb Blood Flow Metab, 2006, 26, 330-344.
43. Ginovart N, AA Wilson, JH Meyer, D Hussey & S Houle: Positron emission tomography quantification of [(1)C]-DASB binding to the human serotonin transporter: modeling strategies. J Cereb Blood Row Metab, 2001, 21, 1342-1353.
44. Hall H, C Halldin, D Guilloteau, S Chalon, P Emond, J Besnard, L Farde & G Sedvall: Visualization of the dopamine transporter in the human brain postmortem with the new selective ligand [125I]PE2I. Neurolmage, 1999, 9, 108-116.
45. Hardingham GE: Coupling of the NMDA receptor to neuroprotective and neurodestructive events. Biochem Soc Trans, 1999, 37, 1147-1160.
46. Hardingham GE & H Bading: The Yin and Yang of NMDA receptor signalling. Trends Neurosci, 2003, 26, 81-89.
47. Hartvig P, H Agren, L Reibring, J Tedroff, P Bjurling, T Kihlberg & B Langstrom: Brain kinetics of L-[beta-11C]dopa in humans studied by positron emission tomography. J Neural Transm Gen Sect, 1991, 86, 25-41.
48. Herscovitch P, ME Raichle, MR Kilbourn & MJ Welch: Positron emission tomographic measurement of cerebral blood flow and permeability-surface area product of water using [15O]water and [11C]butanol. J Cereb Blood Row Metab 1987, 7, 527-542.
49. Holm IE & FA Geneser: Histochemical demonstration of zinc in the hippocampal region of the domestic pig: I. Entorhinal area, parasubiculum, and presubiculum. J Comp Neurol, 1989, 287, 145-163.
50. Holm IE, FA Geneser & J Zimmer: Somatostatin- and neuropeptide Y-like immunoreactivity in the dentate area, hippocampus, and subiculum of the domestic pig. J Comp Neurol, 1992, 322, 390-408.
51. Hudson AL, ES Robinson, MD Lalies, RJ Tyacke, HC Jackson & DJ Nutt: In vitro and in vivo approaches to the characterization of the alpha2-adrenoceptor. J Auton Pharmacol, 1999, 19, 311-320.
52. Ishizu K, DF Smith, D Bender, E Danielsen, SB Hansen, DF Wong, P Cumming & A Gjedde: Positron emission tomography of radioligand binding in porcine striatum in vivo: haloperidol inhibition linked to endogenous ligand release. Synapse, 2000, 58, 87-101.
53. Ito C: The role of brain histamine in acute and chronic stresses. Biomed Pharmacother 2000, 54, 263-267.
54. Jakobsen S, GM Kodahl, AK Olsen & P Cumming: Synthesis, radiolabeling and in vivo evaluation of [11C]RAL-01, a potential phosphodiesterase 5 radioligand. Nucl Med Biol, 2006a, 33, 593-597.
55. Jakobsen S, K Pedersen, DF Smith, SB Jensen, OL Munk & P Cumming: Detection of alpha2-adrenergic receptors in brain of living pig with 11C-yohimbine. J Nucl Med, 2006b, 47, 2008-2015.
56. Jelsing J, R Nielsen, AK Olsen, N Grand, R Hemmingsen & B Pakkenberg: The postnatal development of neocortical neurons and glial cells in the Gottingen minipig and the domestic pig brain. J Exp Biol, 2006, 209, 1454-1462.
57. Jensen SB, R Di Santo, AK Olsen, K Pedersen, R Costi, R Cirilli & P Cumming: Synthesis and cerebral uptake of 1-(1-[(1 l)C]methyl-1H-pyr-rol-2-yl)- 2-phenyl-2-(1-pyrrolidinyl)ethanone, a novel tracer for positron emission tomography studies of monoamine oxidase type A. J Med Chem, 2008, 51, 1617-1622.
58. Jensen SB, AK Olsen, K Pedersen & P Cumming: Effect of monoamine oxidase inhibition on amphetamine-evoked changes in dopamine receptor availability in the living pig: a dual tracer PET study with [11C]harmine and [11C]raclo-pride. Synapse, 2006, 59, 427-434.
59. Jensen SB, DF Smith, D Bender, S Jakobsen, D Peters, EO Nielsen, GM Olsen, J Scheel-Kruger, A Wilson & P dimming: [11C]-NS 4194 versus [11C]-DASB for PET imaging of serotonin transporters in living porcine brain. Synapse, 2003, 49, 170-177.
60. Kimes AS, AG Horti, ED London, SI Chefer, C Contoreggi, M Ernst, P Friello, AO Koren, V Kurian, JA Matochik, O Pavlova, DB Vaupel & AG Mukhin: 2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans. FASEB J, 2003, 17, 1331-1333.
61. Kimme P, T Ledin, & F Sjoberg: Dose effect of sevoflurane and isoflurane anesthetics on cortical blood flow during controlled hypotension in the pig. Acta Anaesthesiol Scand, 2007, 57, 607-613.
62. King MV, CA Marsden, KC Fone: A role for the 5-HT(1A), 5-HT4 and 5-HT6 receptors in learning and memory. Trends Pharmacol Sci, 2008, 29, 482-492.
63. Kleppisch T: Phosphodiesterases in the central nervous system. Handb Exp Pharmacol, 2009, 191, 71-92.
64. Kokic M, M Honer, LJ Kessler, M Grauert, PA Schubiger & SM Ametamey: Synthesis and in vitro and in vivo evaluation of [11C]methyl-BIII277CL for imaging the PCP-binding site of the NMDA receptor by PET. J Recept Signal Transduct Res, 2002, 22, 123-139.
65. Kornum BR, NM Lind, N Gillings, L Marner, F Andersen & GM Knudsen: Evaluation of the novel 5-HT4 receptor PET ligand [11C]SB207145 in the Gottingen minipig. J Cereb Blood Flow Metab 2009, 29, 186-196.
66. Kretzschmar M, P Brust, J Zessin, P Cumming, R Bergmann & B Johannsen: Autoradiographic imaging of the serotonin transporter in the brain of rats and pigs using S-([18F]fluoromefhyl)-(+)-McN5652. Eur Neuropsychopharmacol, 2003, 13, 387-397.
67. Lamelle M: Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review. J Cereb Blood Flow Metab, 2000, 20, 423-451.
68. Lind NM, A Gjedde, A Moustgaard, AK Olsen, SB Jensen, S Jakobsen, SM Arnfred, AK Hansen, RP Hemmingsen & P Cumming: Behavioral response to novelty correlates with dopamine receptor availability in striatum of Gottingen minipigs. Behav Brain Res, 2005, 164, 172-177.
69. Makrides V, R Bauer, W Weber, HJ Wester, S Fischer, R Hinz, K Huggel, T Opfermann, M Herzau, V Ganapathy, F Verrey & P Brust:. Preferred transport of 0-(2-[18F]fluoroethyl)-D-tyrosine (D-FET) into the porcine brain. Brain Res, 2007, 1147, 25-33.
70. Marthi K, D Bender, A Gjedde & D Smith: [11C] Mirtazapine for PET neuroimaging: radiosyn-thesis and initial evaluation in the living porcine brain. Eur Neuropsychopharmacol, 2004a, 12, 427-432.
71. Marthi K, D Bender, H Watanabe & D F Smith: PET evaluation of a tetracyclic, atypical antidepressant, [N-methyl-11C]mianserin, in the living porcine brain. Nucl Med Biol, 2004b, 29, 317-319.
72. Marthi K, SB Hansen, S Jakobsen, D Bender, SB Smith & DF Smith: Biodistribution and radiation dosimetry of [N-methyl-11 C]mirtazapine, an antidepressant affecting adrenoceptors. Applied Radiation Isotopes, 2003, 59, 175-179.
73. Marthi K. S, Jakobsen, D Bender, SB Hansen, SB Smith, F Hermansen, R Rosenberg & DF Smith: [N-methyl-11C]Mirtazapine for positron emission tomography neuroimaging of antidepressant actions in humans. Psychopharmacology (Berl), 2004, 174, 260-265.
74. Meyer JH, N Ginovart, A Boovariwala, S Sagrati, D Hussey, A Garcia, T Young, N Praschak-Rieder, AA Wilson & S Houle: Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression. Arch Gen Psychiatry, 2006, 63, 1209-1216.
75. Meyer JH, AA Wilson, N Ginovart, V Goulding, D Hussey, K Hood & S Houle: Occupancy of serotonin transporters by paroxetine and Citalopram during treatment of depression: a [(11)C]DASB PET imaging study. Am J Psychiatry, 2001, 158, 1843-1849.
76. Millan MJ: Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application. Pharmacol Ther, 2006, 110, 135-370.
77. Minuzzi L, GG Nomikos, MR Wade, SB Jensen, AK Olsen & P Camming: Interaction between LSD and dopamine D2/3 binding sites in pig brain. Synapse, 2005, 56, 198-204.
78. Minuzzi L, AK Olsen, D Bender, S Arnfred, R Grant, EH Danielsen, & P Cumming: Quantitative autoradiography of ligands for dopamine receptors and transporters in brain of Gottingen minipig: comparison with results in vivo. Synapse, 2006, 59, 211-219.
79. Olsen AK, S Keiding & OL Munk: Effect of hyper-capnia on cerebral blood flow and blood volume in pigs studied by positron emission tomography. Comp Med, 2006, 56, 416-420.
80. Olsen AK, D Zeidler, K Pedersen, M Sørensen, SB Jensen & O Munk: Imaging techniques: CT, MRI, and PET scanning. Swine in the laboratory. Surgery, anesthesia, imaging, and experimental techniques., CRC Press, Boca Raton, FL, USA, 2007, pp. 387-395.
81. Ostergaard K, IE Holm & J Zimmer: Tyrosine hydroxylase and acetylcholinesterase in the domestic pig mesencephalon: an immunocy-tochemical and histochemical study. J Comp Neurol, 1992, 322, 149-166.
82. Parker CA, JC Matthews, RN Gunn, L Martarello, VJ Cunningham, D Dommett, ST Knibb, D Bender, S Jakobsen, J Brown & AD Gee: Behaviour of [11C]R(-)- and [11C]S(+)-rolipram in vitro and in vivo, and their use as PET radiotracers for the quantificative assay of PDE4. Synapse, 2005, 55, 270-279.
83. Passchier J, G Gentile, R Porter, H Herdon, C Salinas, S Jakobsen, H Audrain, M Laruelle & RN Gunn: Identification and evaluation of [11C] GSK931145 as a novel ligand for imaging the type 1 glycine transporter with positron emission tomography. Synapse, 2010, 64, 542-549.
84. Patt JT, JE Spang, A Buck, H Cristina, M Arras, PA Schubiger & G Western: Synthesis and in vivo studies of the stereoisomers of N-[11C]methyl-homoepibatidine. Nucl Med Biol, 2001, 28, 645-655.
85. Plisson C, RN Gunn, VJ Cunningham, D Bender, CA Salinas, AD Medhurst, JC Roberts, M Laruelle, & AD Gee: 11C-GSK189254: a selective radioligand for in vivo central nervous system imaging of histamine H3 receptors by PET. J Nucl Med, 2009, 50, 2064-2072.
86. Poulsen PH, DF Smith, L Ostergaard, EH Danielsen, A Gee, SB Hansen, J Astrup & A Gjedde: In vivo estimation of cerebral blood flow, oxygen consumption and glucose metabolism in the pig by [150]water injection, [150]oxygen inhalation and dual injections of [18F]fluoro-deoxyglucose. J Neurosci Methods, 1997, 77, 199-209.
87. Rasmussen M, PH Poulsen, A Treiber, S Delahaye, A Tankisi, GE Cold, K Therkelsen, A Gjedde & J Astrup: No influence of the endothelin receptor antagonist bosentan on basal and indomethacin-induced reduction of cerebral blood flow in pigs. Acta Anaesthesiol Scand, 2003, 47, 200-207.
88. Rosa-Neto P, DJ Doudet & P Cumming: Gradients of dopamine Dl- and D2/3-binding sites in the basal ganglia of pig and monkey measured by PET. Neuro Image, 2004a, 22, 1076-1083.
89. Rosa-Neto P, A Gjedde, AK Olsen, SB Jensen, OL Munk, H Watanabe & P Cumming: MDMA-evoked changes in [11C]raclopride and [11C] NMSP binding in living pig brain. Synapse, 2004b, 53, 222-233.
90. Rosa-Neto P, AK Olsen, A Gjedde, H Watanabe & P Cumming: MDMA-evoked changes in cerebral blood flow in living porcine brain: correlation with hyperthermia. Synapse, 2004c, 53, 214-221.
91. Sakoh M & A Gjedde: Neuroprotection in hypothermia linked to redistribution of oxygen in brain. Am J Physiol Heart Circ Physiol, 2003, 285, H17-H25.
92. Sakoh M, T Ohnishi, L Ostergaard & A Gjedde: Prediction of tissue survival after stroke based on changes in the apparent diffusion of water (cytotoxic edema). Acta Neurochir Suppl, 2003, 86, 137-140.
93. Sakoh M, L Ostergaard, A Gjedde, L Rohl, P Vestergaard-Poulsen, DF Smith, D Le Bihan, S Sakaki & C Gyldensted: Prediction of tissue survival after middle cerebral artery occlusion based on changes in the apparent diffusion of water. J Neurosurg, 2001, 95, 450-458.
94. Sakoh M, L Rohl, C Gyldensted, A Gjedde & L Ostergaard: Cerebral blood flow and blood volume measured by magnetic resonance imaging bolus tracking after acute stroke in pigs: comparison with t(15)O]H(2)O positron emission tomography. Stroke, 2000, 31, 1958-1964.
95. Shimizu-Albergine M, SD Rybalkin, IG Rybalkina, R Feil, W Wolfsgruber, F Hofmann & JA Beavo: Individual cerebellar Purkinje cells express different cGMP phosphodiesterases (PDEs): in vivo phosphorylation of cGMP-specific PDE (PDE5) as an indicator of cGMP-dependent protein kinase (PKG) activation. J Neurosci, 2003, 23, 6452-6459.
96. Smith DF, D Bender, K Marthi, P Cumming, SB Hansen, D Peters, NE Ostergaard, J Scheel-Kruger & A Gjedde: Synthesis and evaluation of racemic (11C)NS2456 and its enantiomers as selective serotonin reuptake radiotracers for PET. Nucl Med Biol, 2001a, 28, 265-270.
97. Smith DF, S Dyve, L Minuzzi, S Jakobsen, OL Munk, K Marthi & P Cumming: Inhibition of [11C] mirtazapine binding by alpha2-adrenoceptor antagonists studied by positron emission tomography in living porcine brain. Synapse, 2006a, 59, 463-471.
98. Smith DF, SB Hansen, S Jakobsen, D Bender, H Audrain, M Ashkanian, BS Stork, L Minuzzi, H Hall & R Rosenberg: Neuroimaging of mirtazapine enantiomers in humans. Psychopharmacology (Berl), 2008, 200, 273-279.
99. Smith DF, SB Hansen, L Ostergaard, AD Gee, E Danielsen, K Ishizu, D Bender, PH Poulsen & A Gjedde: [14C] Serotonin uptake and [O-methyl-11C]venlafaxine kinetics in porcine brain. Nucl Med Biol, 2001b, 28, 633-638.
100. Smith DF & S Jakobsen,: Stereoselective neuroimaging in vivo. Eur Neuropsychopharmacol, 2007, 17, 507-522.
101. Smith DF, PN Jensen, AD Gee, SB Hansen, E Danielsen, F Andersen, PA Saiz & A Gjedde: PET neuroimaging with [11C]venlafaxine: serotonin uptake inhibition, biodistribution and binding in living pig brain. Eur Neuropsychopharmacol, 1997, 7, 195-200.
102. Smith DF, K Marthi, OL Munk, P Cumming, SB Hansen & S Jakobsen: PET neuroimaging of [11C]mirtazapine enantiomers in pigs. Eur Neuropsychopharmacol, 2006b, 16, 350-357.
103. Smith DF, BS Stork, G Wegener, M Ashkanian, S Jakobsen, D Bender, H Audrain, KH Vase, SB Hansen, P Videbech & R Rosenberg: [11C]Mir-tazapine binding in depressed antidepressant nonresponders studied by PET neuroimaging. Psychopharmacology (Berl), 2009, 206, 133-140.
104. Smith DF, BS Stork, G Wegener, S Jakobsen, D Bender, H Audrain, SB Jensen, SB Hansen, A Rodell & R Rosenberg: Receptor occupancy of mirtazapine determined by PET in healthy volunteers. Psychopharmacology (Berl), 2007, 195, 131-138.
105. Sorger D, M Scheunemann, J Vercouillie, U Grossmann, S Fischer, A Hiller, B Wenzel, A Roghani, R Schliebs, J Steinbach, P Brust & O Sabri: Neuroimaging of the vesicular acetylcholine transporter by a novel 4-[18F]fluoro-benzoyl derivative of 7-hydroxy-6-(4-phenyl-piperidinl-yl)- octahydro-benzo[1,4]oxazines. Nucl Med Biol, 2009, 36, 17-27.
106. Stahl SM & A Felker. Monoamine oxidase inhibitors: a modern guide to an unrequited class of antidepressants. CNS Spectr, 2008, 13, 855-870.
107. Szabo Z, PF Kao, U Scheffel, M Suehiro, WB Mathews, HT Ravert, JL Musachio, S Marenco, SE Kim & GA Ricaurte: Positron emission tomography imaging of serotonin transporters in the human brain using [1 1C](+)MCN5652. Synapse, 1995a, 20, 37-43.
108. Szabo Z, U Scheffel, WB Mathews, HT Ravert, K Szabo, M Kraut, S Palmon, GA Ricaurte & RF Dannals: Kinetic analysis of [1 1C]MCN5652: a serotonin transporter radioligand. J Cereb Blood Flow Metab, 1999, 19, 967-981.
109. Szabo Z, U Scheffel, M Suehiro, RF Dannals, SE Kim, HT Ravert, GA Ricaurte & HN Wagner J: Positron emission tomography of 5-HT transporter sites in the baboon brain with [11C] McN5652. J Cereb Blood Flow Metab, 1995b, 15, 798-805.
110. Tsukada H, S Nishiyama, T Kakiuchi, H Ohba, K Sato, N Harada & S Nakanishi: Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR 12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain. Brain Res, 1999, 849, 85-96.
111. Tumbleson ME & LB Schook: Advances in Swine in Biomedical Research, Plenum Press, New York, N.Y, USA, 1996.
112. Tumbleson ME: Swine in Biomedical Research., Plenum Press, New York, USA, 1986.
113. Vink R & v.d. C Heuvel: Substance P antagonists as a therapeutic approach to improving outcome following traumatic brain injury. Neurothera-peutics, 2010, 7, 74-80.
114. Volkow ND, JS Fowler, YS Ding, GJ Wang & SJ Gatley: Positron emission tomography radioligands for dopamine transporters and studies in human and nonhuman primates. Adv Pharmacol, 1998, 42, 211-214.
115. Walter B, P Brust, F Fuchtner, M Muller, R Hinz, H Kuwabara, H Fritz, U Zwiener & R Bauer. Age-dependent effects of severe traumatic brain injury on cerebral dopaminergic activity in newborn and juvenile pigs. J Neurotrauma, 2004, 27, 1076-1089.
116. Watanabe H, F Andersen, CZ Simonsen, SM Evans, A Gjedde & P Cumming: MR-Based Statistical Atlas of the Gottingen Minipig Brain. Neurolmage, 2001, 14, 1089-1096.
117. Watanabe H, M Sakoh, F Andersen, A Rodell, JC Sorensen, L Ostergaard, K Mouridsen & P Cumming: Statistical mapping of effects of middle cerebral artery occlusion (MCAO) on blood flow and oxygen consumption in porcine brain. J Neurosci Methods, 2007, 160, 109-115.
118. Yoshikawa T: Atlas of the brains of domestic animals. The brain of the pig., Pennsylvania State University Press, University Park, Pennsylvania, USA, 1968.