메뉴 건너뛰기




Volumn 195, Issue 1, 2007, Pages 131-138

Receptor occupancy of mirtazapine determined by PET in healthy volunteers

Author keywords

Anti depressant; Binding potential; Mirtazapine; PET; Receptor occupancy

Indexed keywords

MIRTAZAPINE; MIRTAZAPINE C 11; PLACEBO; UNCLASSIFIED DRUG;

EID: 35248852880     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-007-0877-x     Document Type: Article
Times cited : (9)

References (48)
  • 2
    • 0028007226 scopus 로고
    • Neurochemical studies of human narcolepsy: Alpha-adrenergic receptor autoradiography of human narcoleptic brain and brainstem
    • Aldrich MS, Prokopowicz G, Ockert K, Hollingsworth Z, Penney JB, Albin RL (1994) Neurochemical studies of human narcolepsy: alpha-adrenergic receptor autoradiography of human narcoleptic brain and brainstem. Sleep 17:598-608
    • (1994) Sleep , vol.17 , pp. 598-608
    • Aldrich, M.S.1    Prokopowicz, G.2    Ockert, K.3    Hollingsworth, Z.4    Penney, J.B.5    Albin, R.L.6
  • 4
    • 0028287162 scopus 로고
    • Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space
    • Collins DL, Neelin P, Peter TM, Evans AC (1994) Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. J Comput Assist Tomogr 18:192-205
    • (1994) J Comput Assist Tomogr , vol.18 , pp. 192-205
    • Collins, D.L.1    Neelin, P.2    Peter, T.M.3    Evans, A.C.4
  • 5
    • 0029888880 scopus 로고    scopus 로고
    • The pharmacologic profile of mirtazapine
    • de Boer T (1996) The pharmacologic profile of mirtazapine. J Clin Psychiatry 57(Suppl 4):19-25
    • (1996) J Clin Psychiatry , vol.57 , Issue.SUPPL. 4 , pp. 19-25
    • De Boer, T.1
  • 6
    • 0023929271 scopus 로고
    • Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers
    • de Boer TH, Maura G, Raiteri M, de Vos CJ, Wieringa J, Pinder RM (1988) Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers. Neuropharmacology 27:399-408
    • (1988) Neuropharmacology , vol.27 , pp. 399-408
    • De Boer, T.H.1    Maura, G.2    Raiteri, M.3    De Vos, C.J.4    Wieringa, J.5    Pinder, R.M.6
  • 7
    • 0028214582 scopus 로고
    • Imidazoline receptors, non-adrenergic idazoxan binding sites and alpha2-adrenoceptors in the human central nervous system
    • De Vos H, Bricca G, De Keyser J, De Backer JP, Bousquet P, Vauquelin G (1994) Imidazoline receptors, non-adrenergic idazoxan binding sites and alpha2-adrenoceptors in the human central nervous system. Neuroscience 59:589-598
    • (1994) Neuroscience , vol.59 , pp. 589-598
    • De Vos, H.1    Bricca, G.2    De Keyser, J.3    De Backer, J.P.4    Bousquet, P.5    Vauquelin, G.6
  • 8
    • 0034589078 scopus 로고    scopus 로고
    • Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression
    • Drevets WC (2000) Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression. Prog Brain Res 126:413-431
    • (2000) Prog Brain Res , vol.126 , pp. 413-431
    • Drevets, W.C.1
  • 9
    • 0026718710 scopus 로고
    • Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects
    • Farde L, Nordstrom AL, Wiesel FA, Pauli S, Halldin C, Sedvall G (1992) Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects. Arch Gen Psychiatry 49:538-544
    • (1992) Arch Gen Psychiatry , vol.49 , pp. 538-544
    • Farde, L.1    Nordstrom, A.L.2    Wiesel, F.A.3    Pauli, S.4    Halldin, C.5    Sedvall, G.6
  • 10
    • 0034894282 scopus 로고    scopus 로고
    • Efficacy and safety of mirtazapine in major depressive disorder patients after SSRI treatment failure: An open-label trial
    • Fava M, Dunner DL, Greist JH, Preskorn SH, Trivedi MH, Zajecka J, Cohen M (2001) Efficacy and safety of mirtazapine in major depressive disorder patients after SSRI treatment failure: an open-label trial. J Clin Psychiatry 62:413-420
    • (2001) J Clin Psychiatry , vol.62 , pp. 413-420
    • Fava, M.1    Dunner, D.L.2    Greist, J.H.3    Preskorn, S.H.4    Trivedi, M.H.5    Zajecka, J.6    Cohen, M.7
  • 12
    • 0016823810 scopus 로고
    • "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician
    • Folstein MF, Folstein SE, McHugh PR (1975) "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198
    • (1975) J Psychiatr Res , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 13
    • 0033400901 scopus 로고    scopus 로고
    • Imaging strategies in depression
    • Grasby PM (1999) Imaging strategies in depression. J Psychopharmacol 13:346-351
    • (1999) J Psychopharmacol , vol.13 , pp. 346-351
    • Grasby, P.M.1
  • 14
    • 0037430754 scopus 로고    scopus 로고
    • Regional distribution of alpha(2C)-adrenoceptors in brain and spinal cord of control mice and transgenic mice overexpressing the alpha2C-subtype: An autoradiographic study with [3H]RX821002 and [3H]rauwolscine
    • Holmberg M, Fagerholm V, Scheinin M (2003) Regional distribution of alpha(2C)-adrenoceptors in brain and spinal cord of control mice and transgenic mice overexpressing the alpha2C-subtype: an autoradiographic study with [3H]RX821002 and [3H]rauwolscine. Neuroscience 117:875-898
    • (2003) Neuroscience , vol.117 , pp. 875-898
    • Holmberg, M.1    Fagerholm, V.2    Scheinin, M.3
  • 15
  • 17
    • 0034635825 scopus 로고    scopus 로고
    • SNaRIs, NaSSAs, and NaRIs: New agents for the treatment of depression
    • Kent JM (2003) SNaRIs, NaSSAs, and NaRIs: new agents for the treatment of depression. Lancet 355:911-918
    • (2003) Lancet , vol.355 , pp. 911-918
    • Kent, J.M.1
  • 18
    • 0030468875 scopus 로고    scopus 로고
    • Simplified reference tissue model for PET receptor studies
    • Lammertsma AA, Hume SP (1996) Simplified reference tissue model for PET receptor studies. Neuroimage 4:153-158
    • (1996) Neuroimage , vol.4 , pp. 153-158
    • Lammertsma, A.A.1    Hume, S.P.2
  • 19
    • 0036392074 scopus 로고    scopus 로고
    • Positron emission tomography: Imaging and quantification of neurotransporter availability
    • Laruelle M, Slifstein M, Huang Y (2002) Positron emission tomography: imaging and quantification of neurotransporter availability. Methods 27:287-299
    • (2002) Methods , vol.27 , pp. 287-299
    • Laruelle, M.1    Slifstein, M.2    Huang, Y.3
  • 21
    • 0036771734 scopus 로고    scopus 로고
    • [11C]Mirtazapine for PET neuroimaging: Radiosynthesis and initial evaluation in the living porcine brain
    • Marthi K, Bender D, Gjedde A, Smith D (2002a) [11C]Mirtazapine for PET neuroimaging: radiosynthesis and initial evaluation in the living porcine brain. Eur Neuropsychopharmacol 12:427-432
    • (2002) Eur Neuropsychopharmacol , vol.12 , pp. 427-432
    • Marthi, K.1    Bender, D.2    Gjedde, A.3    Smith, D.4
  • 22
    • 0036202713 scopus 로고    scopus 로고
    • PET evaluation of a tetracyclic, atypical antidepressant, [N-methyl-11C]mianserin, in the living porcine brain
    • Marthi K, Bender D, Watanabe H, Smith DF (2002b) PET evaluation of a tetracyclic, atypical antidepressant, [N-methyl-11C]mianserin, in the living porcine brain. Nucl Med Biol 29:317-319
    • (2002) Nucl Med Biol , vol.29 , pp. 317-319
    • Marthi, K.1    Bender, D.2    Watanabe, H.3    Smith, D.F.4
  • 23
  • 25
    • 0036895694 scopus 로고    scopus 로고
    • Depression, II: Localization of pathophysiology
    • Mayberg H (2002) Depression, II: localization of pathophysiology. Am J Psychiatry 159:1979
    • (2002) Am J Psychiatry , vol.159 , pp. 1979
    • Mayberg, H.1
  • 27
    • 0035157572 scopus 로고    scopus 로고
    • Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: A [11C]DASB PET imaging study
    • Meyer JH, Wilson AA, Ginovart N, Goulding V, Hussey D, Hood K, Houle S (2001) Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [11C]DASB PET imaging study. Am J Psychiatry158:1843-1849
    • (2001) Am J Psychiatry , vol.158 , pp. 1843-1849
    • Meyer, J.H.1    Wilson, A.A.2    Ginovart, N.3    Goulding, V.4    Hussey, D.5    Hood, K.6    Houle, S.7
  • 29
    • 33645452696 scopus 로고    scopus 로고
    • Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application
    • Millan MJ (2006) Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application. Pharmacol Ther 110:135-370
    • (2006) Pharmacol Ther , vol.110 , pp. 135-370
    • Millan, M.J.1
  • 30
    • 0034026318 scopus 로고    scopus 로고
    • Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha2-adrenergic and serotonin2C receptors: A comparison with citalopram
    • Millan MJ, Gobert A, Rivet JM, Adhumeau-Auclair A, Cussac D, Newman-Tancredi A, Dekeyne A, Nicolas JP, Lejeune F (2000) Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha2-adrenergic and serotonin2C receptors: a comparison with citalopram. Eur J Neurosci 12:1079-1095
    • (2000) Eur J Neurosci , vol.12 , pp. 1079-1095
    • Millan, M.J.1    Gobert, A.2    Rivet, J.M.3    Adhumeau-Auclair, A.4    Cussac, D.5    Newman-Tancredi, A.6    Dekeyne, A.7    Nicolas, J.P.8    Lejeune, F.9
  • 31
    • 23244463878 scopus 로고    scopus 로고
    • Inter- and intraindividual pharmacokinetic variations of mirtazapine and its N-demethyl metabolite in patients treated for major depressive disorder: A 6-month therapeutic drug monitoring study
    • Reis M, Prochazka J, Sitsen A, Ahlner J, Bengtsson F (2005) Inter- and intraindividual pharmacokinetic variations of mirtazapine and its N-demethyl metabolite in patients treated for major depressive disorder: a 6-month therapeutic drug monitoring study. Ther Drug Monit 27:469-477
    • (2005) Ther Drug Monit , vol.27 , pp. 469-477
    • Reis, M.1    Prochazka, J.2    Sitsen, A.3    Ahlner, J.4    Bengtsson, F.5
  • 34
    • 33646037988 scopus 로고    scopus 로고
    • Inhibition of [11C]mirtazapine binding by alpha2-adrenoceptor antagonists studied by positron emission tomography in living porcine brain
    • Smith DF, Dyve S, Minuzzi L, Jakobsen S, Munk OL, Marthi K, Cumming P (2006) Inhibition of [11C]mirtazapine binding by alpha2-adrenoceptor antagonists studied by positron emission tomography in living porcine brain. Synapse 59:463-471
    • (2006) Synapse , vol.59 , pp. 463-471
    • Smith, D.F.1    Dyve, S.2    Minuzzi, L.3    Jakobsen, S.4    Munk, O.L.5    Marthi, K.6    Cumming, P.7
  • 36
    • 0031029632 scopus 로고    scopus 로고
    • Mirtazapine: An antidepressant with noradrenergic and specific serotonergic effects
    • Stimmel GL, Dopheide JA, Stahl SM (1997) Mirtazapine: an antidepressant with noradrenergic and specific serotonergic effects. Pharmacotherapy 17:10-21
    • (1997) Pharmacotherapy , vol.17 , pp. 10-21
    • Stimmel, G.L.1    Dopheide, J.A.2    Stahl, S.M.3
  • 37
    • 0032870413 scopus 로고    scopus 로고
    • Regional brain distribution of noradrenaline uptake sites, and of alpha1-alpha2- and beta-adrenergic receptors in PCD mutant mice: A quantitative autoradiographic study
    • Strazielle C, Lalonde R, Hebert C, Reader TA (1999) Regional brain distribution of noradrenaline uptake sites, and of alpha1-alpha2- and beta-adrenergic receptors in PCD mutant mice: a quantitative autoradiographic study. Neuroscience 94:287-304
    • (1999) Neuroscience , vol.94 , pp. 287-304
    • Strazielle, C.1    Lalonde, R.2    Hebert, C.3    Reader, T.A.4
  • 38
    • 18144372418 scopus 로고    scopus 로고
    • Mirtazapine: A review of its clinical efficacy and tolerability
    • Szegedi A, Schwertfeger N (2005) Mirtazapine: a review of its clinical efficacy and tolerability. Expert Opin Pharmacother 6:631-641
    • (2005) Expert Opin Pharmacother , vol.6 , pp. 631-641
    • Szegedi, A.1    Schwertfeger, N.2
  • 39
    • 17944374941 scopus 로고    scopus 로고
    • Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): A comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine
    • Tagawa M, Kano M, Okamura N, Higuchi M, Matsuda M, Mizuki Y, Arai H, Iwata R, Fujii T, Komemushi S, Ido T, Itoh M, Sasaki H, Watanabe T, Yanai K (2001) Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): a comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine. Br J Clin Pharmacol 52:501-509
    • (2001) Br J Clin Pharmacol , vol.52 , pp. 501-509
    • Tagawa, M.1    Kano, M.2    Okamura, N.3    Higuchi, M.4    Matsuda, M.5    Mizuki, Y.6    Arai, H.7    Iwata, R.8    Fujii, T.9    Komemushi, S.10    Ido, T.11    Itoh, M.12    Sasaki, H.13    Watanabe, T.14    Yanai, K.15
  • 41
    • 0036895218 scopus 로고    scopus 로고
    • The role of in vivo molecular imaging with PET and SPECT in the elucidation of psychiatric drug action and new drug development
    • Talbot PS, Laruelle M (2002) The role of in vivo molecular imaging with PET and SPECT in the elucidation of psychiatric drug action and new drug development. Eur Neuropsychopharmacol 12:503-511
    • (2002) Eur Neuropsychopharmacol , vol.12 , pp. 503-511
    • Talbot, P.S.1    Laruelle, M.2
  • 42
    • 0030460935 scopus 로고    scopus 로고
    • Pharmacokinetics of mirtazapine from orally administered tablets: Influence of gender, age and treatment regimen
    • Timmer CJ, Paanakker JE, van Hal HJM (1996) Pharmacokinetics of mirtazapine from orally administered tablets: influence of gender, age and treatment regimen. Human Psychopharmacology 11:497-509
    • (1996) Human Psychopharmacology , vol.11 , pp. 497-509
    • Timmer, C.J.1    Paanakker, J.E.2    Van Hal, H.J.M.3
  • 44
    • 14644404328 scopus 로고    scopus 로고
    • Comparison of the effects of mirtazapine and fluoxetine in severely depressed patients
    • Versiani M, Moreno R, Ramakers-van Moorsel CJ, Schutte AJ (2005) Comparison of the effects of mirtazapine and fluoxetine in severely depressed patients. CNS Drugs 19:137-146
    • (2005) CNS Drugs , vol.19 , pp. 137-146
    • Versiani, M.1    Moreno, R.2    Ramakers-Van Moorsel, C.J.3    Schutte, A.J.4
  • 48
    • 0027222039 scopus 로고
    • Regional distribution and heterogeneity of alpha-adrenoceptors in the rat and human central nervous system
    • Zilles K, Qu M, Schleicher A (1993) Regional distribution and heterogeneity of alpha-adrenoceptors in the rat and human central nervous system. J Hirnforsch 34:123-132
    • (1993) J Hirnforsch , vol.34 , pp. 123-132
    • Zilles, K.1    Qu, M.2    Schleicher, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.