Individual cerebellar Purkinje cells express different cGMP phosphodiesterases (PDEs): In vivo phosphorylation of cGMP-specific PDE (PDE5) as an indicator of cGMP-dependent protein kinase (PKG) activation

Journal of Neuroscience

Volumn 23, Issue 16, 2003, Pages 6452-6459

  Shimizu Albergine, Masami ^a   Rybalkin, Sergei D ^a   Rybalkina, Irina G ^a   Feil, Robert ^b   Wolfsgruber, Wiebke ^b   Hofmann, Franz ^b   Beavo, Joseph A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Calmodulin stimulated cyclic nucleotide phosphodiesterase; Cerebellum; cGMP specific phosphodiesterase; Cyclic GMP dependent protein kinase; Cyclic nudeotide phosphodiesterase; Long term depression; PDE1B; PDE5; PDEs; Phosphorylation; PKG; Purkinje cells

Indexed keywords

CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP PHOSPHODIESTERASE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; GUANYLATE CYCLASE; ISOBUTYLMETHYLXANTHINE; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PHOSPHODIESTERASE I; PHOSPHODIESTERASE V; SILDENAFIL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN LATERAL VENTRICLE; CENTRAL NERVOUS SYSTEM DEPRESSION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HYDROLYSIS; IMMUNOCYTOCHEMISTRY; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURKINJE CELL; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 0042844737     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-16-06452.2003     Document Type: Article

References (30)

1. Aguado F, Sanchez-Franco F, Rodrigo J, Cacicedo L, Martinez-Murillo R (1994) Insulin-like growth factor I-immunoreactive peptide in adult human cerebellar Purkinje cells: co-localization with low-affinity nerve growth factor receptor. Neuroscience 59:641-650.
2. Ariano MA, Lewicki JA, Brandwein HJ, Murad F (1982) Immunohistochemical localization of guanylate cyclase within neurons of rat brain. Proc Natl Acad Sci USA 79:1316-1320.
3. Calabresi P, Gubellini P, Centonze D, Sancesario G, Morello M, Giorgi M, Pisani A, Bernardi G (1999) A critical role of the nitric oxide/cGMP pathway in corticostriatal long-term depression. J Neurosci 19:2489-2499.
4. Crepel F, Jaillard D (1990) Protein kinases, nitric oxide and long-term depression of synapses in the cerebellum. NeuroReport 1:133-136.
5. Daniel H, Hemart N, Jaillard D, Crepel F (1993) Long-term depression requires nitric oxide and guanosine 3′:5′ cyclic monophosphate production in rat cerebellar Purkinje cells. Eur J Neurosci 5:1079-1082.
6. de Vente J, Steinbusch HW (1992) On the stimulation of soluble and particulate guanylate cyclase in the rat brain and the involvement of nitric oxide as studied by cGMP immunocytochemistry. Acta Histochem 92:13-38.
7. de Vente J, Bol JG, Steinbusch HW (1989) Localization of cGMP in the cerebellum of the adult rat: an immunohistochemical study. Brain Res 504:332-337.
8. Detre JA, Nairn AC, Aswad DW, Greengard P (1984) Localization in mammallan brain of G-substrate, a specific substrate for guanosine 3′, 5′-cyclic monophosphate-dependent protein kinase. J Neurosci 4:2843-2849.
9. Dusart I, Morel MP, Sotelo C (1994) Parasagittal compartmentation of adult rat Purkinje cells expressing the low-affinity nerve growth factor receptor: changes of pattern expression after a traumatic lesion. Neuroscience 63:351-356.
10. Endo S, Suzuki M, Sumi M, Nairn AC, Morita R, Yamakawa K, Greengard P, Ito M (1999) Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells. Proc Natl Acad Sci USA 96:2467-2472.
11. Giuili G, Luzi A, Poyard M, Guellaen G (1994) Expression of mouse brain soluble guanylyl cyclase and NO synthase during ontogeny. Brain Res Dev Brain Res 81:269-283.
12. Hartell NA (1994) cGMP acts within cerebellar Purkinje cells to produce long term depression via mechanisms involving PKC and PKG. NeuroReport 5:833-836.
13. Hartell NA (1996) Inhibition of cGMP breakdown promotes the induction of cerebellar long-term depression. J Neurosci 16:2881-2890.
14. Hartell NA, Furuya S, Jacoby S, Okada D (2001) Intercellular action of nitric oxide increases cGMP in cerebellar Purkinje cells. NeuroReport 12:25-28.
15. Haug LS, Jensen V, Hvalby O, Walaas SI, Ostvold AC (1999) Phosphorylation of the inositol 1, 4, 5-trisphosphate receptor by cyclic nucleotide-dependent kinases in vitro and in rat cerebellar slices in situ. J Biol Chem 274:7467-7473.
16. Honda A, Adams SR, Sawyer CL, Lev-Ram V, Tsien RY, Dostmann WR (2001) Spatiotemporal dynamics of guanosine 3′, 5′-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator. Proc Natl Acad Sci USA 98:2437-2442.
17. Ito M (2000) Mechanisms of motor learning in the cerebellum. Brain Res 886:237-245.
18. Ito M (2001) Cerebellar long-term depression: characterization, signal transduction, and functional roles. Physiol Rev 81:1143-1195.
19. Ito M, Karachot L (1992) Protein kinases and phosphatase inhibitors mediating long-term desensitization of glutamate receptors in cerebellar Purkinje cells. Neurosci Res 14:27-38.
20. Juilfs DM, Soderling S, Burns F, Beavo JA (1999) Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs). Rev Physiol Biochem Pharmacol 135:67-104.
21. Kotera J, Yanaka N, Fujishige K, Imai Y, Akatsuka H, Ishizuka T, Kawashima K, Omori K (1997) Expression of rat cGMP-binding cGMP-specific phosphodiesterase mRNA in Purkinje cell layers during postnatal neuronal development. Eur J Biochem 249:434-442.
22. 2+ in the induction of cerebellar long-term depression. Neuron 18:1025-1038.
23. Lohmann SM, Walter U, Miller PE, Greengard P, De Camilli P (1981) Immunohistochemical localization of cyclic GMP-dependent protein kinase in mammalian brain. Proc Natl Acad Sci USA 78:653-657.
24. Nakagawa S, Watanabe M, Inoue Y (1996) Altered gene expression of the N-methyl-D-aspartate receptor channel subunits in Purkinje cells of the staggerer mutant mouse. Eur J Neurosci 8:2644-2651.
25. Nakazawa K, Mikawa S, Hashikawa T, Ito M (1995) Transient and persistent phosphorylation of AMPA-type glutamate receptor subunits in cerebellar Purkinje cells. Neuron 15:697-709.
26. Rybalkin SD, Bornfeldt KE, Sonnenburg WK, Rybalkina IG, Kwak KS, Hanson K, Krebs EG, Beavo JA (1997) Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype. J Clin Invest 100:2611-2621.
27. Rybalkin SD, Rybalkina IG, Feil R, Hofmann F, Beavo JA (2002) Regulation ofcGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells. J Biol Chem 277:3310-3317.
28. Rybalkin SD, Rybalkina IG, Shimizu-Albergine M, Tang XB, Beavo JA (2003) PDE5 is converted to an activated state upon cGMP binding to the GAF A domain. EMBO J 22:469-478.
29. Wang YT, Linden DJ (2000) Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis. Neuron 25:635-647.
30. Yan C, Zhao AZ, Bentley JK, Beavo JA (1996) The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue-specific manner. J Biol Chem 271:25699-25706.