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Volumn 7, Issue 1, 2010, Pages 74-80

Substance P Antagonists as a Therapeutic Approach to Improving Outcome Following Traumatic Brain Injury

Author keywords

edema; inflammation; Neurotrauma; substance P; tachykinins

Indexed keywords

2 [1 IMINO 2 (2 METHOXYPHENYL)ETHYL] 7,7 DIPHENYLPERHYDROISOINDOL 4 ONE; CALCITONIN GENE RELATED PEPTIDE; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ A; SUBSTANCE P; SUBSTANCE P ANTAGONIST; TACHYKININ;

EID: 72949094390     PISSN: 19337213     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nurt.2009.10.018     Document Type: Article
Times cited : (47)

References (70)
  • 3
    • 0030045798 scopus 로고    scopus 로고
    • Neuropathological sequelae of traumatic brain injury: relationship to neurochemical and biomechanical mechanisms
    • McIntosh T.K., Smith D.H., Meaney D.F., Kotapka M.J., Gennarelli T.A., and Graham D.I. Neuropathological sequelae of traumatic brain injury: relationship to neurochemical and biomechanical mechanisms. Lab Invest 74 (1996) 315-342
    • (1996) Lab Invest , vol.74 , pp. 315-342
    • McIntosh, T.K.1    Smith, D.H.2    Meaney, D.F.3    Kotapka, M.J.4    Gennarelli, T.A.5    Graham, D.I.6
  • 4
    • 0032807430 scopus 로고    scopus 로고
    • Severe head injury in children: impact of risk factors on outcome
    • Feickert H.J., Drommer S., and Heyer R. Severe head injury in children: impact of risk factors on outcome. J Trauma 47 (1999) 33-38
    • (1999) J Trauma , vol.47 , pp. 33-38
    • Feickert, H.J.1    Drommer, S.2    Heyer, R.3
  • 5
    • 0033855240 scopus 로고    scopus 로고
    • Contribution of edema and cerebral blood volume to traumatic brain swelling in head-injured patients
    • Marmarou A., Fatouros P.P., Barzó P., et al. Contribution of edema and cerebral blood volume to traumatic brain swelling in head-injured patients. J Neurosurg 93 (2000) 183-193
    • (2000) J Neurosurg , vol.93 , pp. 183-193
    • Marmarou, A.1    Fatouros, P.P.2    Barzó, P.3
  • 6
    • 0034202511 scopus 로고    scopus 로고
    • Initial management
    • Brain Trauma Foundation; American Association of Neurological Surgeons, Joint Section on Neurotrauma and Critical Care
    • Brain Trauma Foundation; American Association of Neurological Surgeons, Joint Section on Neurotrauma and Critical Care. Initial management. J Neurotrauma 17 (2000) 463-469
    • (2000) J Neurotrauma , vol.17 , pp. 463-469
  • 7
    • 1642305688 scopus 로고    scopus 로고
    • Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats
    • Nimmo A.J., Cernak I., Heath D.L., Hu X., Bennett C.J., and Vink R. Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats. Neuropeptides 38 (2004) 40-47
    • (2004) Neuropeptides , vol.38 , pp. 40-47
    • Nimmo, A.J.1    Cernak, I.2    Heath, D.L.3    Hu, X.4    Bennett, C.J.5    Vink, R.6
  • 10
    • 84944496221 scopus 로고
    • An unidentified depressor substance in certain tissue extracts
    • von Euler U.S., and Gaddum J.H. An unidentified depressor substance in certain tissue extracts. J Physiol 72 (1931) 74-87
    • (1931) J Physiol , vol.72 , pp. 74-87
    • von Euler, U.S.1    Gaddum, J.H.2
  • 11
    • 34250948792 scopus 로고
    • Central transmission of afferent impulses: III. Incidence and significance of the substance P in the dorsal roots of the spinal cord [In German]
    • Lembeck F. Central transmission of afferent impulses: III. Incidence and significance of the substance P in the dorsal roots of the spinal cord [In German]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol 219 (1953) 197-213
    • (1953) Naunyn Schmiedebergs Arch Exp Pathol Pharmakol , vol.219 , pp. 197-213
    • Lembeck, F.1
  • 12
    • 0027523466 scopus 로고
    • Neurotransmitter functions of mammalian tachykinins
    • Otsuka M., and Yoshioka K. Neurotransmitter functions of mammalian tachykinins. Physiol Rev 73 (1993) 229-308
    • (1993) Physiol Rev , vol.73 , pp. 229-308
    • Otsuka, M.1    Yoshioka, K.2
  • 13
    • 0036674858 scopus 로고    scopus 로고
    • 2 receptor antagonist, reduces brain edema and improves long-term neurological function recovery after closed head trauma in rats
    • 2 receptor antagonist, reduces brain edema and improves long-term neurological function recovery after closed head trauma in rats. J Neurotrauma 19 (2002) 953-964
    • (2002) J Neurotrauma , vol.19 , pp. 953-964
    • Kaplanski, J.1    Pruneau, D.2    Asa, I.3
  • 14
    • 12244260771 scopus 로고    scopus 로고
    • 2 receptor antagonist, decreases ex vivo brain tissue prostaglandin E2 synthesis after closed head trauma in rats
    • 2 receptor antagonist, decreases ex vivo brain tissue prostaglandin E2 synthesis after closed head trauma in rats. Resuscitation 56 (2003) 207-213
    • (2003) Resuscitation , vol.56 , pp. 207-213
    • Kaplanski, J.1    Asa, I.2    Artru, A.A.3
  • 15
    • 0033034999 scopus 로고    scopus 로고
    • Effects of the bradykinin antagonist Bradycor (deltibant, CP-1027) in severe traumatic brain injury: results of a multi-center, randomized, placebo-controlled trial
    • Marmarou A., Nichols J., Burgess J., et al. Effects of the bradykinin antagonist Bradycor (deltibant, CP-1027) in severe traumatic brain injury: results of a multi-center, randomized, placebo-controlled trial. J Neurotrauma 16 (1999) 431-444
    • (1999) J Neurotrauma , vol.16 , pp. 431-444
    • Marmarou, A.1    Nichols, J.2    Burgess, J.3
  • 16
    • 62949096976 scopus 로고    scopus 로고
    • 2 receptor antagonist, reduces intracranial hypertension and histopathological damage after experimental traumatic brain injury
    • 2 receptor antagonist, reduces intracranial hypertension and histopathological damage after experimental traumatic brain injury. Neurosci Lett 454 (2009) 115-117
    • (2009) Neurosci Lett , vol.454 , pp. 115-117
    • Zweckberger, K.1    Plesnila, N.2
  • 17
    • 16244385015 scopus 로고    scopus 로고
    • Targeting kinin receptors for the treatment of neurological diseases
    • Rodi D., Couture R., Ongali B., and Simonato M. Targeting kinin receptors for the treatment of neurological diseases. Curr Pharm Des 11 (2005) 1313-1326
    • (2005) Curr Pharm Des , vol.11 , pp. 1313-1326
    • Rodi, D.1    Couture, R.2    Ongali, B.3    Simonato, M.4
  • 18
    • 33749051394 scopus 로고    scopus 로고
    • 2 receptor aggravates reactive oxygen species generation and renal damage in ischemia/reperfusion injury
    • 2 receptor aggravates reactive oxygen species generation and renal damage in ischemia/reperfusion injury. Free Radic Biol Med 41 (2006) 1304-1314
    • (2006) Free Radic Biol Med , vol.41 , pp. 1304-1314
    • Chiang, W.C.1    Chien, C.T.2    Lin, W.W.3
  • 19
    • 34047164038 scopus 로고    scopus 로고
    • Neuroprotective role of bradykinin because of the attenuation of pro-inflammatory cytokine release from activated microglia
    • Noda M., Kariura Y., Pannasch U., et al. Neuroprotective role of bradykinin because of the attenuation of pro-inflammatory cytokine release from activated microglia. J Neurochem 101 (2007) 397-410
    • (2007) J Neurochem , vol.101 , pp. 397-410
    • Noda, M.1    Kariura, Y.2    Pannasch, U.3
  • 20
    • 0345342970 scopus 로고
    • On the origin from the spinal cord of the vaso-dilator fibres of the hind-limb, and on the nature of these fibres
    • Bayliss W.M. On the origin from the spinal cord of the vaso-dilator fibres of the hind-limb, and on the nature of these fibres. J Physiol 26 (1901) 173-209
    • (1901) J Physiol , vol.26 , pp. 173-209
    • Bayliss, W.M.1
  • 21
    • 0036911319 scopus 로고    scopus 로고
    • Stress and the inflammatory response: a review of neurogenic inflammation
    • Black P.H. Stress and the inflammatory response: a review of neurogenic inflammation. Brain Behav Immun 16 (2002) 622-653
    • (2002) Brain Behav Immun , vol.16 , pp. 622-653
    • Black, P.H.1
  • 23
    • 0032481904 scopus 로고    scopus 로고
    • Migraine
    • Ferrari M.D. Migraine. Lancet 351 (1998) 1043-1051
    • (1998) Lancet , vol.351 , pp. 1043-1051
    • Ferrari, M.D.1
  • 24
    • 0032970173 scopus 로고    scopus 로고
    • Vanilloid (capsaicin) receptors and mechanisms
    • Szallasi A., and Blumberg P.M. Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev 51 (1999) 159-212
    • (1999) Pharmacol Rev , vol.51 , pp. 159-212
    • Szallasi, A.1    Blumberg, P.M.2
  • 25
    • 0030777012 scopus 로고    scopus 로고
    • The capsaicin receptor: a heat-activated ion channel in the pain pathway
    • Caterina M.J., Schumacher M.A., Tominaga M., et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389 (1997) 816-824
    • (1997) Nature , vol.389 , pp. 816-824
    • Caterina, M.J.1    Schumacher, M.A.2    Tominaga, M.3
  • 26
    • 0021670203 scopus 로고
    • Effects of capsaicin on the development of gastric mucosal damage by different necrotizing agents and of gastric cytoprotection by PGI2 atropine and cimetidine on rats
    • Szolcsányi J., and Mózsik G. Effects of capsaicin on the development of gastric mucosal damage by different necrotizing agents and of gastric cytoprotection by PGI2 atropine and cimetidine on rats. Acta Physiol Hung 64 (1984) 287-291
    • (1984) Acta Physiol Hung , vol.64 , pp. 287-291
    • Szolcsányi, J.1    Mózsik, G.2
  • 27
    • 34547819270 scopus 로고    scopus 로고
    • A review of progress in understanding the pathophysiology and treatment of brain edema
    • Marmarou A. A review of progress in understanding the pathophysiology and treatment of brain edema. Neurosurg Focus 22 5 (2007) E1
    • (2007) Neurosurg Focus , vol.22 , Issue.5
    • Marmarou, A.1
  • 28
    • 67650602106 scopus 로고    scopus 로고
    • Pathology and new players in the pathogenesis of brain edema
    • Nag S., Manias J.L., and Stewart D.J. Pathology and new players in the pathogenesis of brain edema. Acta Neuropathol 118 (2009) 197-217
    • (2009) Acta Neuropathol , vol.118 , pp. 197-217
    • Nag, S.1    Manias, J.L.2    Stewart, D.J.3
  • 29
    • 33846216899 scopus 로고    scopus 로고
    • Changes in blood-brain barrier permeability to large and small molecules following traumatic brain injury in mice
    • Habgood M.D., Bye N., Dziegielewska K.M., et al. Changes in blood-brain barrier permeability to large and small molecules following traumatic brain injury in mice. Eur J Neurosci 25 (2007) 231-238
    • (2007) Eur J Neurosci , vol.25 , pp. 231-238
    • Habgood, M.D.1    Bye, N.2    Dziegielewska, K.M.3
  • 30
    • 0034570505 scopus 로고    scopus 로고
    • Distinguishing between cellular and vasogenic edema in head injured patients with focal lesions using magnetic resonance imaging
    • Marmarou A., Portella G., Barzo P., et al. Distinguishing between cellular and vasogenic edema in head injured patients with focal lesions using magnetic resonance imaging. Acta Neurochir Suppl (Wien) 76 (2000) 349-351
    • (2000) Acta Neurochir Suppl (Wien) , vol.76 , pp. 349-351
    • Marmarou, A.1    Portella, G.2    Barzo, P.3
  • 31
    • 0034570501 scopus 로고    scopus 로고
    • The permissive nature of blood brain barrier (BBB) opening in edema formation following traumatic brain injury
    • Beaumont A., Marmarou A., Hayasaki K., et al. The permissive nature of blood brain barrier (BBB) opening in edema formation following traumatic brain injury. Acta Neurochir Suppl (Wien) 76 (2000) 125-129
    • (2000) Acta Neurochir Suppl (Wien) , vol.76 , pp. 125-129
    • Beaumont, A.1    Marmarou, A.2    Hayasaki, K.3
  • 34
    • 0021336616 scopus 로고
    • Substance P in sensory nerve fibres contributes to the development of oedema in the rat hind paw after thermal injury
    • Saria A. Substance P in sensory nerve fibres contributes to the development of oedema in the rat hind paw after thermal injury. Br J Pharmacol 82 (1984) 217-222
    • (1984) Br J Pharmacol , vol.82 , pp. 217-222
    • Saria, A.1
  • 35
    • 0023619092 scopus 로고
    • Contribution of substance P to heat-induced edema in rat paw
    • Yonehara N., Shibutani T., and Inoki R. Contribution of substance P to heat-induced edema in rat paw. J Pharmacol Exp Ther 242 (1987) 1071-1076
    • (1987) J Pharmacol Exp Ther , vol.242 , pp. 1071-1076
    • Yonehara, N.1    Shibutani, T.2    Inoki, R.3
  • 36
    • 0025188833 scopus 로고
    • Inflammatory responses induced by substance P in rat paw
    • De A.K., and Ghosh J.J. Inflammatory responses induced by substance P in rat paw. Indian J Exp Biol 28 (1990) 946-948
    • (1990) Indian J Exp Biol , vol.28 , pp. 946-948
    • De, A.K.1    Ghosh, J.J.2
  • 37
    • 72949086320 scopus 로고    scopus 로고
    • Mild concussive head injury results in increased brain substance P immunoreactivity
    • Medimond International Proceedings, Bologna
    • Donkin J.J., Cernak I., Rodgers K.M., and Vink R. Mild concussive head injury results in increased brain substance P immunoreactivity. 7th International Neurotrauma Symposium (2004), Medimond International Proceedings, Bologna 75-78
    • (2004) 7th International Neurotrauma Symposium , pp. 75-78
    • Donkin, J.J.1    Cernak, I.2    Rodgers, K.M.3    Vink, R.4
  • 39
    • 0022373842 scopus 로고
    • Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability
    • Brain S.D., and Williams T.J. Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability. Br J Pharmacol 86 (1985) 855-860
    • (1985) Br J Pharmacol , vol.86 , pp. 855-860
    • Brain, S.D.1    Williams, T.J.2
  • 40
    • 0035137002 scopus 로고    scopus 로고
    • Substance P: a pioneer amongst neuropeptides
    • Hökfelt T., Pernow B., and Wahren J. Substance P: a pioneer amongst neuropeptides. J Intern Med 249 (2001) 27-40
    • (2001) J Intern Med , vol.249 , pp. 27-40
    • Hökfelt, T.1    Pernow, B.2    Wahren, J.3
  • 41
    • 0033983432 scopus 로고    scopus 로고
    • Abnormal substance P release from the spinal cord following injury to primary sensory neurons
    • Malcangio M., Ramer M.S., Jones M.G., and McMahon S.B. Abnormal substance P release from the spinal cord following injury to primary sensory neurons. Eur J Neurosci 12 (2000) 397-399
    • (2000) Eur J Neurosci , vol.12 , pp. 397-399
    • Malcangio, M.1    Ramer, M.S.2    Jones, M.G.3    McMahon, S.B.4
  • 42
    • 0025130804 scopus 로고
    • Alteration of substance P after trauma to the spinal cord: an experimental study in the rat
    • Sharma H.S., Nyberg F., Olsson Y., and Dey P.K. Alteration of substance P after trauma to the spinal cord: an experimental study in the rat. Neuroscience 38 (1990) 205-212
    • (1990) Neuroscience , vol.38 , pp. 205-212
    • Sharma, H.S.1    Nyberg, F.2    Olsson, Y.3    Dey, P.K.4
  • 43
    • 0036792090 scopus 로고    scopus 로고
    • Substance P antagonist blocks leakage and reduces activation of cytokine-stimulated rat brain endothelium
    • Annunziata P., Cioni C., Santonini R., and Paccagnini E. Substance P antagonist blocks leakage and reduces activation of cytokine-stimulated rat brain endothelium. J Neuroimmunol 131 (2002) 41-49
    • (2002) J Neuroimmunol , vol.131 , pp. 41-49
    • Annunziata, P.1    Cioni, C.2    Santonini, R.3    Paccagnini, E.4
  • 44
    • 0035112614 scopus 로고    scopus 로고
    • Adaptive plasticity in tachykinin and tachykinin receptor expression after focal cerebral ischemia is differentially linked to GABAergic and glutamatergic cerebrocortical circuits and cerebrovenular endothelium
    • Stumm R., Culmsee C., Schafer M.K., Krieglstein J., and Weihe E. Adaptive plasticity in tachykinin and tachykinin receptor expression after focal cerebral ischemia is differentially linked to GABAergic and glutamatergic cerebrocortical circuits and cerebrovenular endothelium. J Neurosci 21 (2001) 798-811
    • (2001) J Neurosci , vol.21 , pp. 798-811
    • Stumm, R.1    Culmsee, C.2    Schafer, M.K.3    Krieglstein, J.4    Weihe, E.5
  • 47
    • 0024413505 scopus 로고
    • Substance P receptor binding sites are expressed by glia in vivo after neuronal injury
    • Mantyh P.W., Johnson D.J., Boehmer C.G., et al. Substance P receptor binding sites are expressed by glia in vivo after neuronal injury. Proc Natl Acad Sci U S A 86 (1989) 5193-5197
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 5193-5197
    • Mantyh, P.W.1    Johnson, D.J.2    Boehmer, C.G.3
  • 48
    • 0029549476 scopus 로고
    • Reactive astrocytes express substance-P immunoreactivity in the adult forebrain after injury
    • Lin R.C. Reactive astrocytes express substance-P immunoreactivity in the adult forebrain after injury. Neuroreport 7 (1995) 310-312
    • (1995) Neuroreport , vol.7 , pp. 310-312
    • Lin, R.C.1
  • 49
    • 2342440109 scopus 로고    scopus 로고
    • Alternative, nonapoptotic programmed cell death: mediation by arrestin-2, ERK2 and Nur77
    • Castro-Obregón S., Rao R.V., del Rio G., et al. Alternative, nonapoptotic programmed cell death: mediation by arrestin-2, ERK2 and Nur77. J Biol Chem 279 (2004) 17543-17553
    • (2004) J Biol Chem , vol.279 , pp. 17543-17553
    • Castro-Obregón, S.1    Rao, R.V.2    del Rio, G.3
  • 50
    • 34548436586 scopus 로고    scopus 로고
    • Neurokinin 1 receptor antagonists: current prospects
    • Alvaro G., and Di Fabio R. Neurokinin 1 receptor antagonists: current prospects. Curr Opin Drug Discov Devel 10 (2007) 613-621
    • (2007) Curr Opin Drug Discov Devel , vol.10 , pp. 613-621
    • Alvaro, G.1    Di Fabio, R.2
  • 51
    • 0033609015 scopus 로고    scopus 로고
    • Substance P is expressed in hippocampal principal neurons during status epilepticus and plays a critical role in the maintenance of status epilepticus
    • Liu H., Mazarati A.M., Katsumori H., Sankar R., and Wasterlain C.G. Substance P is expressed in hippocampal principal neurons during status epilepticus and plays a critical role in the maintenance of status epilepticus. Proc Natl Acad Sci U S A 96 (1999) 5286-5291
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 5286-5291
    • Liu, H.1    Mazarati, A.M.2    Katsumori, H.3    Sankar, R.4    Wasterlain, C.G.5
  • 52
    • 0018556566 scopus 로고
    • Synthesis of substance P analogs and agonistic and antagonistic activities
    • Leban J., Rackur G., Yamaguchi I., et al. Synthesis of substance P analogs and agonistic and antagonistic activities. Acta Chem Scand B 33 (1979) 664-668
    • (1979) Acta Chem Scand B , vol.33 , pp. 664-668
    • Leban, J.1    Rackur, G.2    Yamaguchi, I.3
  • 54
    • 0019795057 scopus 로고
    • A synthetic peptide as an antagonist of substance P
    • Engberg G., Svensson T.H., Rosell S., and Folkers K. A synthetic peptide as an antagonist of substance P. Nature 293 (1981) 222-223
    • (1981) Nature , vol.293 , pp. 222-223
    • Engberg, G.1    Svensson, T.H.2    Rosell, S.3    Folkers, K.4
  • 55
    • 0025721939 scopus 로고
    • Effect of CP-96,345, a nonpeptide substance P receptor antagonist, on salivation in rats
    • Snider R.M., Longo K.P., Drozda S.E., Lowe III J.A., and Leeman S.E. Effect of CP-96,345, a nonpeptide substance P receptor antagonist, on salivation in rats. Proc Natl Acad Sci U S A 88 (1991) 10042-10044
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 10042-10044
    • Snider, R.M.1    Longo, K.P.2    Drozda, S.E.3    Lowe III, J.A.4    Leeman, S.E.5
  • 56
    • 0028933748 scopus 로고
    • Synthesis and biological evaluation of NK1 antagonists derived from l-tryptophan
    • MacLeod A.M., Cascieri M.A., Merchant K.J., et al. Synthesis and biological evaluation of NK1 antagonists derived from l-tryptophan. J Med Chem 38 (1995) 934-941
    • (1995) J Med Chem , vol.38 , pp. 934-941
    • MacLeod, A.M.1    Cascieri, M.A.2    Merchant, K.J.3
  • 57
    • 0033457351 scopus 로고    scopus 로고
    • Discovery of the antidepressant and anti-emetic efficacy of substance P receptor (NK1) antagonists
    • Rupniak N.M., and Kramer M.S. Discovery of the antidepressant and anti-emetic efficacy of substance P receptor (NK1) antagonists. Trends Pharmacol Sci 20 (1999) 485-490
    • (1999) Trends Pharmacol Sci , vol.20 , pp. 485-490
    • Rupniak, N.M.1    Kramer, M.S.2
  • 58
    • 0035852719 scopus 로고    scopus 로고
    • Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function
    • Santarelli L., Gobbi G., Debs P.C., et al. Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function. Proc Natl Acad Sci U S A 98 (2001) 1912-1917
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 1912-1917
    • Santarelli, L.1    Gobbi, G.2    Debs, P.C.3
  • 59
    • 0036452950 scopus 로고    scopus 로고
    • Clinical experience with substance P receptor (NK1) antagonists in depression
    • Ranga K., and Krishnan R. Clinical experience with substance P receptor (NK1) antagonists in depression. J Clin Psychiatry 63 Suppl 11 (2002) 25-29
    • (2002) J Clin Psychiatry , vol.63 , Issue.SUPPL. 11 , pp. 25-29
    • Ranga, K.1    Krishnan, R.2
  • 60
    • 16644368140 scopus 로고    scopus 로고
    • A substance P antagonist increases brain intracellular free magnesium concentration after diffuse traumatic brain injury in rats
    • Vink R., Donkin J.J., Cruz M.I., Nimmo A.J., and Cernak I. A substance P antagonist increases brain intracellular free magnesium concentration after diffuse traumatic brain injury in rats. J Am Coll Nutr 23 (2004) 538S-540S
    • (2004) J Am Coll Nutr , vol.23
    • Vink, R.1    Donkin, J.J.2    Cruz, M.I.3    Nimmo, A.J.4    Cernak, I.5
  • 61
    • 0027243791 scopus 로고
    • Nuclear magnetic resonance characterization of secondary mechanisms following traumatic brain injury
    • Vink R. Nuclear magnetic resonance characterization of secondary mechanisms following traumatic brain injury. Mol Chem Neuropathol 18 (1993) 279-297
    • (1993) Mol Chem Neuropathol , vol.18 , pp. 279-297
    • Vink, R.1
  • 62
    • 0037426714 scopus 로고    scopus 로고
    • Magnesium attenuates persistent functional deficits following diffuse traumatic brain injury in rats
    • Vink R., O'Connor C.A., Nimmo A.J., and Heath D.L. Magnesium attenuates persistent functional deficits following diffuse traumatic brain injury in rats. Neurosci Lett 336 (2003) 41-44
    • (2003) Neurosci Lett , vol.336 , pp. 41-44
    • Vink, R.1    O'Connor, C.A.2    Nimmo, A.J.3    Heath, D.L.4
  • 63
    • 57849136110 scopus 로고    scopus 로고
    • Multifunctional drugs for head injury
    • Vink R., and Nimmo A.J. Multifunctional drugs for head injury. Neurotherapeutics 6 (2009) 28-42
    • (2009) Neurotherapeutics , vol.6 , pp. 28-42
    • Vink, R.1    Nimmo, A.J.2
  • 64
    • 0030790069 scopus 로고    scopus 로고
    • Neurokinin-1 receptor antagonist SR140333: a novel type of drug to treat cerebral ischemia
    • Yu Z., Cheng G., Huang X., Li K., and Cao X. Neurokinin-1 receptor antagonist SR140333: a novel type of drug to treat cerebral ischemia. Neuroreport 8 (1997) 2117-2119
    • (1997) Neuroreport , vol.8 , pp. 2117-2119
    • Yu, Z.1    Cheng, G.2    Huang, X.3    Li, K.4    Cao, X.5
  • 65
    • 34547793705 scopus 로고    scopus 로고
    • Inhibition of neurogenic inflammation as a novel treatment for ischemic stroke
    • Turner R., and Vink R. Inhibition of neurogenic inflammation as a novel treatment for ischemic stroke. Drug News Perspect 20 (2007) 221-226
    • (2007) Drug News Perspect , vol.20 , pp. 221-226
    • Turner, R.1    Vink, R.2
  • 66
    • 0036181169 scopus 로고    scopus 로고
    • Role of tachykinin NK receptors on the local and remote injuries following ischaemia and reperfusion of the superior mesenteric artery in the rat
    • Souza D.G., Mendonça V.A., de A Castro M.S., Poole S., and Teixeira M.M. Role of tachykinin NK receptors on the local and remote injuries following ischaemia and reperfusion of the superior mesenteric artery in the rat. Br J Pharmacol 135 (2002) 303-312
    • (2002) Br J Pharmacol , vol.135 , pp. 303-312
    • Souza, D.G.1    Mendonça, V.A.2    de A Castro, M.S.3    Poole, S.4    Teixeira, M.M.5
  • 67
    • 0030971879 scopus 로고    scopus 로고
    • Magnesium deficiency enhanced post-ischemic myocardial injury is reduced by substance P receptor blockade
    • Kramer J.H., Phillips T.M., and Weglicki W.B. Magnesium deficiency enhanced post-ischemic myocardial injury is reduced by substance P receptor blockade. J Cardiol 29 (1997) 97-110
    • (1997) J Cardiol , vol.29 , pp. 97-110
    • Kramer, J.H.1    Phillips, T.M.2    Weglicki, W.B.3
  • 68
    • 0030605171 scopus 로고    scopus 로고
    • Traumatic brain axonal injury produces sustained decline in intracellular free magnesium concentration
    • Heath D.L., and Vink R. Traumatic brain axonal injury produces sustained decline in intracellular free magnesium concentration. Brain Res 738 (1996) 150-153
    • (1996) Brain Res , vol.738 , pp. 150-153
    • Heath, D.L.1    Vink, R.2
  • 69
    • 0033753580 scopus 로고    scopus 로고
    • Neurokinin mediation of edema and inflammation
    • Campos M.M., and Calixto J.B. Neurokinin mediation of edema and inflammation. Neuropeptides 34 (2000) 314-322
    • (2000) Neuropeptides , vol.34 , pp. 314-322
    • Campos, M.M.1    Calixto, J.B.2
  • 70
    • 0030571610 scopus 로고    scopus 로고
    • Systemic capsaicin in the adult rat differentially affects gene expression for neuropeptides and neurotrophin receptors in primary sensory neurons
    • Kashiba H., Ueda Y., and Senba E. Systemic capsaicin in the adult rat differentially affects gene expression for neuropeptides and neurotrophin receptors in primary sensory neurons. Neuroscience 76 (1997) 299-312
    • (1997) Neuroscience , vol.76 , pp. 299-312
    • Kashiba, H.1    Ueda, Y.2    Senba, E.3


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