Neuroimaging of the vesicular acetylcholine transporter by a novel 4-[18F]fluoro-benzoyl derivative of 7-hydroxy-6-(4-phenyl-piperidin-1-yl)-octahydro-benzo[1,4]oxazines

Nuclear Medicine and Biology

Volumn 36, Issue 1, 2009, Pages 17-27

  Sorger, Dietlind ^a   Scheunemann, Matthias ^b   Vercouillie, Johnny ^b   Großmann, Udo ^a   Fischer, Steffen ^b   Hiller, Achim ^b   Wenzel, Barbara ^b   Roghani, Ali ^c   Schliebs, Reinhard ^a   Steinbach, Jörg ^b   Brust, Peter ^b   Sabri, Osama ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b Institute of Interdisciplinary Isotope Research   (Germany)

^c TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

Affinity; Biodistribution; Cholinergic deficiency; Radiosynthesis; Rat brain; Selectivity; VAChT; Vesamicol derivatives

Indexed keywords

4 (4 FLUOROBENZOYL) 7 HYDROXY 6 (4 PHENYLPIPERIDIN 1 YL)OCTAHYDROBENZO[1,4]OXAZINE F 18; 4 FLUOROBENZOYL DERIVATIVE F 18; 7 HYDROXY 6 (4 PHENYLPIPERIDIN 1 YL)OCTAHYDRO BENZO[1,4]OXAZINE DERIVATIVE; FLUORINE 18; UNCLASSIFIED DRUG; VESAMICOL DERIVATIVE; VESICULAR ACETYLCHOLINE TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRAIN; CONTROLLED STUDY; DRUG STRUCTURE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; NEUROIMAGING; NONHUMAN; RADIOCHEMISTRY; RAT; SWINE;

ANIMALS; AUTORADIOGRAPHY; BENZOIC ACID; BRAIN; FEMALE; FLUORINE RADIOISOTOPES; OXAZINES; PC12 CELLS; POSITRON-EMISSION TOMOGRAPHY; RADIOCHEMISTRY; RATS; SUBSTRATE SPECIFICITY; TISSUE DISTRIBUTION; VESICULAR ACETYLCHOLINE TRANSPORT PROTEINS;

EID: 58749114601     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2008.10.006     Document Type: Article

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