Distribution of PK11195 binding sites in porcine brain studied by autoradiography in vitro and by positron emission tomography

Synapse

Volumn 59, Issue 7, 2006, Pages 418-426

  Cumming, Paul ^a,c   Pedersen, Mads D ^b   Minuzzi, Luciano ^a   Mezzomo, Kelin ^a   Danielsen, Erik H ^a   Iversen, Peter ^a   Aagaard, Dorthe ^a   Keiding, Susanne ^a   Munk, Ole L ^a   Finsen, Bente ^b  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Autoradiography; Brain; Microglia; Peripheral benzodiazepine receptor; PET; Pig; PK11195

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; BENZODIAZEPINE RECEPTOR; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; BRAIN TISSUE; CONTROLLED STUDY; IN VITRO STUDY; LIGAND BINDING; MESENCEPHALON; MICROGLIA; MINIPIG; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RECEPTOR AFFINITY; SWINE; TISSUE DISTRIBUTION; TISSUE SECTION; WHITE MATTER;

ANIMALS; AUTORADIOGRAPHY; BINDING SITES; BRAIN; CARBON RADIOISOTOPES; FEMALE; ISOQUINOLINES; PARKINSONIAN DISORDERS; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, GABA-A; SWINE;

EID: 33646057347     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20257     Document Type: Article

References (63)

1. 3H]PK11195 binding to activated microglia. J Neurocytol 26:377-382.
2. Banati RB, Newcombe J, Gunn RN, Cagnin A, Turkheimer F, Heppner F, Price G, Myers R. 2000. The peripheral benzodiazepine binding site in the brain in multiple sclerosis: Quantitative in vivo imaging of microglia as a measure of disease activity. Brain 123:2321-2337.
3. Bianchin MM, Capella HM, Chaves DL, Steindel M, Grisard EC, Ganev GG, da Silva JP, Jr., Neto ES, Poffo MA, Walz R, Carlotti CG, Jr., Skamoto AC. 2004. Nasu-Hakola disease (polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy-PLOSL): A dementia associated with bone cystic lesions. From clinical to genetic and molecular aspects. Cell Mol Neurobiol 24:1-24.
4. Cagnin A, Brooks DJ, Kennedy AM, Gunn RN, Myers R, Turkheimer FE, Jones T, Banati RB. 2001. In vivo measurement of activated microglia in dementia. Lancet 358:461-467.
5. Chen MK, Baidoo K, Verina T, Guilarte TR. 2004. Peripheral benzodiazepine receptor imaging in CNS demyelination: Functional implications of anatomical and cellular localization. Brain 127:1379-1392.
6. Cuadros MA, Navascues J. 1998. The origin and differentiation of microglial cells during development. Prog Neurobiol 56:173-189.
7. Cumming P, Danielsen EH, Vafaee M, Falborg L, Steffensen E, Sørensen JC, Gillings N, Bender D, Marthi K, Andersen F, Munk OL, Smith D, Møller A, Gjedde A. 2001a. Normalization of markers for dopamine innervation in striatum of MPTP-lesioned miniature pigs with intrastriatal grafts. Acta Neurol Scand 103:309-315.
8. Cumming P, Kretszchmar M, Brust P, Smith DF. 2001b. Quantitative radioluminography of serotonin uptake sites in the porcine brain. Synapse 39:351-355.
9. 18F-DOPA metabolism in the immature pig brain studied by positron emission tomography. Synapse 33:247-258.
10. Danielsen EH, Cumming P, Andersen F, Bender D, Brevig T, Falborg L, Gee A, Gillings NM, Hansen SB, Hermansen F, Johansen J, Johansen TE, Dahl-Jørgenseon A, Jøregensen HA, Meyer M, Munk O, Pedersen EB, Poulsen PH, Rodell AB, Sakoh M, Simonsen CZ, Smith DF, Sørensen JC, Østergård L, Zimmer J, Gjedde A, Møller A. 2000. The DaNeX study of fetal mesencephalic dopaminergic tissue grafted to striatum in a minipig model of Parkinson's disease: Experimental design with a preliminary report of the effects of MPTP-poisoning on striatal dopaminergic markers. Cell Transplant 9:247-259.
11. Delavoie F, Li H, Hardwick M, Robert JC, Giatzakis C, Peranzi G, et al. 2003. In vivo and in vitro peripheral-type benzodiazepine receptor polymerization: Functional significance in drug ligand and cholesterol binding. Biochemistry 42:4506-4519.
12. del Río-Hortega P. 1932. Microglia. In: Penfield W, editor. Cytology and Cellular Pathology of the Nervous System. New York: Hoeber. Vol. 2, p 481-534.
13. Fedoroff S, Zhai R, Novak JP. 1997. Microglia and astroglia have a common progenitor cell. J Neurosci Res 50:477-486.
14. Ferger B, Leng A, Mura A, Hengerer B, Feldon J. 2004. Genetic ablation of tumor necrosis factor-α (TNF-α) and pharmacological inhibition of TNF-synthesis attenuates MPTP toxicity in mouse striatum. J Neurochem 89:822-833.
15. 11C](R)-PK11195 PET in idiopathic Parkinson's disease. Neurobiol Dis 21:404-412.
16. 11C](R)- PK11195 PET study. Neuroimage 24:591-595.
17. Gillings NM, Bender D, Falborg L, Marthi K, Munk OL, Cumming P. 2001. The kinetics of radiopharmaceutical metabolism in living minipigs. Nucl Med Biol 28:97-104.
18. 11C]raclopride positron emission tomography study in cats. Biol Psychiatry 55:1188-1194.
19. Gjedde A. 1981. High- and low-affinity transport of D-glucose from blood to brain. J Neurochem 36:1463-1471.
20. Gregersen R, Lambertsen K, Finsen B. 2000. Microglia and macrophages are the major source of tumor necrosis factor in permanent middle cerebral artery occlusion in mice. J Cereb Blood Flow Metab 20:53-65.
21. 11C]vinpocetine in human subjects. Acta Neurol Scand 106:325-332.
22. Gulyás B, Halldin C, Sovago J, Sandell J, Cselenyi Z, Vas A, Kiss B, Karpati E, Farde L. 2002b. Drug distribution in man: A positron emission tomography study after oral administration of the labelled neuroprotective drug vinpocetine. Eur J Nucl Med Mol Imaging 29:1031-1038.
23. 11C]vinpocetine: A prospective peripheral benzodiazepine receptor ligand for primate PET studies. J Neurol Sci 229/230:219-223.
24. Hashimoto K, Inoue O, Suzuki K, Yamasaki T, Kojima M. 1989. Synthesis and evaluation of 11C-PK 11105 for in vivo study of peripheral-type benzodiazepine receptors using positron emission tomography. Ann Nucl Med 3:63-71.
25. Itzhak Y, Baker L, Norenberg MD. 1993. Characterization of the peripheral-type benzodiazepine receptors in cultured astrocytes: Evidence for multiplicity. Glia 9:211-218.
26. 11C]-DASB for PET imaging of serotonin transporters in living porcine brain. Synapse 49:170-177.
27. Jorda EG, Jimenez A, Verdaguer E, Canudas AM, Folch J, Sureda FX, Camins A, Pallas M. 2005. Evidence in favour of a role for peripheral-type benzodiazepine receptor ligands in amplification of neuronal apoptosis. Apoptosis 10:91-104.
28. Kim WG, Mohney RP, Wilson B, Jeohn GH, Liu B, Hong JS. 2000. Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: Role of microglia. J Neurosci 20:6309-6316.
29. Kuhlmann AC, Guilarte TR. 1999. Regional and temporal expression of the peripheral benzodiazepine receptor in MPTP neurotoxicity. Toxicol Sci 48:107-116.
30. Lawson LJ, Perry VH, Dri P, Gordon S. 1990. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 39:151-170.
31. Lee DH, Kang SK, Lee RH, Ryu JM, Park HY, Choi HS, Bae YC, Suh KT, Kim YK, Jung JS. 2004. Effects of peripheral benzodiazepine receptor ligands on proliferation and differentiation of human mesenchymal stem cells. J Cell Physiol 198:91-99.
32. 3H]PK11195 in vulnerable regions of the rat brain in thiamine deficiency encephalopathy. J Cereb Blood Flow Metab 14:100-105.
33. Lu SY, Shipley MT, Norman AB, Sanberg PR. 1991. Striatal, ventral mesencephalic and cortical transplants into the intact rat striatum: A neuroanatomical study. Exp Neurol 113:109-130.
34. Lyck L, Jelsing J, Jensen PS, Lambertsen KL, Pakkenberg B, Finsen B. 2005. Immunohistochemical visualization of neurons and specific glia cells for stereological applications in the porcine neocortex. J Neurosci Methods (Epub ahead of print).
35. 11C]DAA1106 for PET: An imaging tool for glial cells in brain. Synapse 52:283-291.
36. McGeer PL, Schwab C, Parent A, Doudet D. 2003. Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine administration. Ann Neurol 54:599-604.
37. Minuzzi L, Olsen AK, Bender D, Arnfred S, Danielsen EH, Grant R, Cumming P. 2006. Quantitative autoradiography of ligands for dopamine receptors and transporters in brain of Göttingen minipig: Correlation with results in vivo. Synapse 59:211-219.
38. 18F]fluorodopa/PET and histology of fetal mesencephalic dopaminergic grafts to the striatum of MPTP-poisoned minipigs. Cell Transplant 11:733-746.
39. 15O]water clearance in humans determined by PET. I. Theory and normal values. J Cereb Blood Flow Metab 16:765-780.
40. Ouchi Y, Yoshikawa E, Sekine Y, Futatsubashi M, Kanno T, Ogusu T, Torizuka T. 2005. Microglial activation and dopamine terminal loss in early Parkinson's disease. Ann Neurol 57:168-175.
41. Papadopoulos V, Amri H, Boujrad N, Cascio C, Culty M, Garnier M, Hardwick M, Li H, Vidic B, Brown AS, Reversa JL. 1997. Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis. Steroids 62:21-28.
42. Patlak CS, Blasberg RG, Fenstermacher JD. 1983. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3:1-7.
43. Rao VLR, Dogan A, Bowen KK, Dempsey RJ. 2000. Traumatic brain injury leads to increased expression of peripheral-type benzodiazepine receptors, neuronal death, and activation of astrocytes and microglia in rat thalamus. Exp Neurol 161:102-114.
44. Rao VLR, Bowen KK, Rao AM, Dempsey RJ. 2001. Up-regulation of the peripheral-type benzodiazepine receptor expression and [(3)H]PK11195 binding in gerbil hippocampus after transient forebrain ischemia. J Neurosci Res 64:493-500.
45. Revuelta M, Venero JL, Machado A, Cano J. 1999. Serotonin hyperinnervation in the adult rat ventral mesencephalon following unilateral transaction of the medial forebrain bundle. Correlation with reactive microglia and astroglia populations. Neuroscience 91:567-577.
46. Rezaie P, Male D. 1999. Colonisation of the developing human brain and spinal cord by microglia: A review. Microsc Res Tech 45:359-382.
47. 11C]NMSP binding in living pig brain. Synapse 53:222-233.
48. Rosa-Neto P, Olsen AK, Gjedde A, Munk OL, Watanabe H, Cumming P. 2004b. MDMA-evoked changes in cerebral blood flow in living porcine brain: correlation with hyperthermia. Synapse 53:214-221.
49. Sakoh M, Østergaard L, Rohr L, Smith DF, Simonsen CZ, Sørensen JC, Poulsen JV, Gyldensted C, Sakaki S, Gjedde A. 2000. Relationship between residual cerebral blood flow and oxygen metabolism as predictive of ischemic tissue viability: Sequential multitracer positron emission tomography scanning of middle cerebral artery occlusion during the critical first 6 hours after stroke in pigs. J Neurosurg 93:647-657.
50. Schmid CD, Sautkulis LN, Danielson PE, Cooper J, Hassel KW, Hillbush BS, Sutcliffe KJ, Carson MJ. 2002. Heterogenous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia. J Neurochem 83:1309-1320.
51. 11C]PK 11195 and comparison of their behaviours as radioligands for PK binding sites in rats. Nucl Med Biol 21:573-581.
52. Stagaard M, Balslev Y, Lundberg JJ, Mollgard K. 1987. Microglia in the hypendyma of the rat subcommissural organ following brain lesion with serotonin neurotoxin. J Neurocytol 16:131-142.
53. Stephenson DT, Schober DA, Smalstig EB, Mincy RE, Gehlert DR, Clemens JA. 1995. Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat. J Neurosci 15:5263-5274.
54. Sutter AP, Maaser K, Hopfner M, Barthel B, Grabowski P, Faiss S, Carayon P, Zeitz M, Scherubl H. 2002. Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human esophageal cancer cells. Int J Cancer 102:318-327.
55. 3H]citalopram binding in the CA-3 area of rat hippocampus. Neurosci Lett 335:49-53.
56. Takahashi K, Rochford CD, Neumann H. 2005. Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J Exp Med 201:647-657.
57. Turkheimer FE, Hinz R, Cunningham VJ. 2003. On the undecidability among kinetic models: From model selection to model averaging. J Cereb Blood Flow Metab 23:490-498.
58. 11C](R)-PK11195 positron emission tomography study. Neurobiol Dis 15:601-609.
59. Versijpt J, Debruyne JC, Van Laere KJ, De Vos F, Keppens J, Strijckmans K, Achten E, Slegers G, Dierckx RA, Korf J, De Reuck JL. 2005. Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: A correlative study. Mult Scler 11:127-134.
60. Vowinckel E, Reutens D, Becher B, Verge G, Evans A, Owens T, Antel JP. 1997. PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis. J Neurosci Res 50:345-353.
61. Watanabe H, Andersen F, Simonsen CZ, Evans SM, The DaNeX Study Group, Gjedde A, Cumming P. 2001. MR-based statistical atlas of the Göttingen minipig brain. Neuroimage 14:1089-1096.
62. Wilson MA, Molliver ME. 1994. Microglial response to degeneration of serotonergic axon terminals. Glia 11:18-34.
63. Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, Vadseth C, Choi DK, Ischiropoulos H, Przedborski S. 2002. Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci 22:1763-1771.