Synthesis and in vivo studies of the stereoisomers of N-[11C]methyl-homoepibatidine

Nuclear Medicine and Biology

Volumn 28, Issue 6, 2001, Pages 645-655

  Patt, Jörg T ^a   Spang, Jörg E ^a   Buck, Alfred ^a   Cristina, Heidi ^a   Arras, Magarete ^a   Schubiger, P August ^a   Westera, Gerrit ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Carbon 11; Epibatidine; Homoepibatidine; Neuronal nicotinic acetylcholine receptors; Positron emission tomography

Indexed keywords

CYTISINE; N METHYLHOMOEPIBATIDINE C 11; NICOTINIC RECEPTOR; RECEPTOR SUBTYPE; TRACER; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG SYNTHESIS; DRUG UPTAKE; ENANTIOMER; FEMALE; IMAGING; IN VIVO STUDY; ISOMER; ISOTOPE LABELING; METABOLITE; MOUSE; NONHUMAN; RAT; STEREOISOMERISM; SWINE; TOXICITY;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; FEMALE; LETHAL DOSE 50; MALE; MICE; MICE, INBRED ICR; NICOTINIC AGONISTS; PYRIDINES; RATS; SPECIES SPECIFICITY; STEREOISOMERISM; SWINE; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0034881912     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(01)00225-6     Document Type: Article

References (51)

1. Normalization by nicotine of deficient auditory sensory gating in relatives of schizophrenics
2. (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): A novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization
3. Synthesis of (±)-epibatidine and its analogues
4. Neuronal nAChRs stereoselective to non-natural epibatidine derivatives
5. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418
6. Beneficial effects of nicotine administered prior to a delayed matching-to-sample task in young and aged monkeys
7. Multiple nicotinic acetylcholine receptor genes are expressed in goldfish retina and tectum
8. Nicotine dependence-mechanisms and therapeutic strategies
9. (S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): A novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors
10. Dopaminergic regulation of cortical acetylcholine release: Effects of dopamine receptor agonists
11. Effects of ABT-418, a novel cholinergic channel ligand, on place learning in septal-lesioned rats
12. Effects of nicotine on spatial memory deficits in rats with septal lesions
13. Mapping nicotinic acethylcholine receptors with PET
14. Mapping nicotinic acetylcholine receptors with PET
15. Synthesis of a fluorine-18 labeled derivative of epibatidine for in vivo nicotinic acetylcholine receptor PET imaging
16. Synthesis of 2-[F-18]fluoro-3-[2(S)-2-azetindinylmethoxy]pyridine, a highly potent radioligand for in vivo imaging central nicotinic acetylcholine receptors
17. Temporally correlated expression of nAChR genes during development of the mammalian retina
18. Synthesis of a radiotracer for studying nicotinic acetylcholine receptors: (+/) Exo 2 (2 [F 18]fluoro 5 pyridyl) 7 azabicyclo[2,2.1]heptane
19. Fluorine-18-FPH for PET imaging of nicotinic acetylcholine receptors
20. Synthesis and evaluation of N-[C-11]methylated analogues of epibatidine as tracers for positron emission tomographic studies of nicotinic acetylcholine receptors
21. 2-[F-18]fluoro-A-85380, an in vivo tracer for the nicotinic acetylcholine receptors
22. Synthesis of 3-[(1-[C-11]methyl-2(S)-pyrrolidinyl)methoxy]pyridine and 3-[(1-[C-11]methyl-2(R)-pyrrolidinyl)methoxy]pyridine: Radioligands for in vivo studies of neuronal nicotinic acetylcholine receptors
23. Pharmacological evaluation of [C-11]A-84543: An enantioselective ligand for in vivo studies of neuronal nicotinic acetylcholine receptors
24. Three subtypes of alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors are expressed in chick retina
25. Synthesis of [11C]iodomethane by iodination of [11C]methane
26. Nicotinic cholinergic receptors: Potential targets for inflammatory pain relief
27. Nicotinic systems and cognitive function
28. [Br-76]-BrPH: A radiobrominated analog of epibatidine for studies of nicotinic acetylcholine receptors using PET
29. Striatal increase of neurotrophic factors as a mechanism of nicotine protection in experimental parkinsonism
30. Nicotine potentiation of haloperidol in reducing tic frequency in Tourette's disorder
31. JAVA environment for medical image data analysis: Initial application for brain PET quantitation
32. [I-125/123]IPH: A radioiodinated analog of epibatidine for in vivo studies of nicotinic acetylcholine receptors
33. Decreased uptake and binding of [11C]nicotine in brain of Alzheimer patients as visualized by positron emission tomography
34. PET Studies of the uptake of (S)- and (R)-[11C]nicotine in the human brain: Difficulties in visualizing specific receptor binding in vivo
35. Attempts to visualize nicotinic receptors in the brain of monkey and man by positron emission tomography
36. Synthesis and in vivo studies of [11C]N-methylepibatidine. Comparison of the stereoisomers
37. Synthesis and in vivo studies of [C11]N-methylepibatidine: Comparison of the stereoisomers
38. N-[11C]methylhomoepibatidine: Radiolabelling and biodistribution studies in mice
39. [11C]-N-Methyl- and [18F]Fluoroethylepibatidine: Ligands for the neuronal nicotinic receptor
40. Mecamylamine combined with nicotine skin patch facilitates smoking cessation beyond nicotine patch treatment alone
41. Development of 11C-nicotinic receptor ligands to characterize nicotinic acetylcholine receptors in the central nervous system
42. Transdermal nicotine patch and potentiation of haloperidol in Tourette's syndrome
43. Epibatidine: Pharmacological properties of a novel nicotinic acetylcholine receptor agonist and analgesic agent
44. Antidepressant effects of nicotine in an animal model of depression
45. An attempt to visualize baboon brain nicotinic receptors with N-[11C]ABT-418 and N-[11C]methyl-cytisine
46. Characterization of the nicotinic ligand 2-[18F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine in vivo
47. Imaging central nicotinic acetylcholine receptors in baboons with 18Ffluoro-A85380
48. Imaging nicotinic acetylcholine receptors with fluorine-18-FPH, an epibatidine analog
49. Synthesis and analgesic activity of epibatidine analogs
50. Total synthesis of (.+-.)-epibatidine
51. Developmental regulation of nicotinic ACh receptor subunit mRNAs in the rat central and peripheral nervous systems