In vivo estimation of cerebral blood flow, oxygen consumption and glucose metabolism in the pig by [15O]water injection, [15O]oxygen inhalation and dual injections of [18F]fluorodeoxyglucose

Journal of Neuroscience Methods

Volumn 77, Issue 2, 1997, Pages 199-209

  Poulsen, P H ^a   Smith, D F ^a   Ostergaard L ^a   Danielsen, E H ^a   Gee, A ^a   Hansen, S B ^a   Astrup, J ^a   Gjedde, A ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Carbon dioxide response; Cerebral metabolic rates; Lumped constant; Oxygen extraction fraction; Oxygen glucose metabolic ratio; Positron emission tomography

Indexed keywords

FLUORODEOXYGLUCOSE F 18; OXYGEN 15;

ANIMAL EXPERIMENT; ARTERIAL CARBON DIOXIDE TENSION; ARTICLE; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; BRAIN OXYGEN CONSUMPTION; BRAIN SCINTISCANNING; GLUCOSE METABOLISM; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SWINE;

ADMINISTRATION, INHALATION; ANIMALS; CEREBELLUM; FLUORODEOXYGLUCOSE F18; GLUCOSE; INJECTIONS, INTRAVENOUS; OXYGEN CONSUMPTION; OXYGEN RADIOISOTOPES; REGIONAL BLOOD FLOW; SWINE; TOMOGRAPHY, EMISSION-COMPUTED; WATER;

EID: 0031425018     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0270(97)00127-1     Document Type: Article

References (34)

1. Andersen K, Waaben J, Husum B, Voldby B, Bødker A, Hansen AJ, Gjedde A. Nonpulsatile cardiopulmonary bypass disrupts the flow metabolism couple in the brain.. J Thorac Cardiovasc Surg 1985;90:570-9.
2. Akeson J, Nilson F, Ryding E, Messeter K. A porcine model for sequential assessments of cerebral haemodynamics and metabolism. Acta Anaesthesiol Scand 1992;36:419-26.
3. 2 reactivity in pigs anaesthetized with fentanyl, nitrous oxide and pancuronium.. Acta Anaesthesiol Scand 1993a;37:85-91.
4. Akeson J, Björkman S, Messeter K, Rosen I, Helfer M. Cerebral pharmacodynamics of anaesthetic and subanaesthetic doses of ketamine in the normoventilated pig. Acta Anaesthesiol Scand 1993b;37:211-8.
5. Åkeson J, Björkman S, Messeter K, Rosen I. Low-dose midazolam antagonizes cerebral metabolic stimulation by ketamine in the pig. Acta Anaesthesiol Scand 1993;37:525-31.
6. 15O continuous inhalation technique and positron emission tomography (PET): Experimental evidence and normal values in man. J Cereb Blood Flow Metab 1981;1 Suppl:S5-S6.
7. Bartels H, Harms H. Sauerstoffdissoziationskurven des Blutes von Säugetieren (Mensch, Kaninchen, Meerschweinchen, Hund, Katze, Schwein, Rind und Scharf). Pflügers Arch 1959;268: 334-65.
8. Foreman DL, Sanders M, Bloor CM. Total and regional cerebral blood flow during moderate and severe exercise in miniature swine. J Appl Physiol 1976;40:191-5.
9. 2 and positron emission tomography: Theory, procedure and normal values. J Comput Assist Tomogr 1980;4:727-36.
10. 11C]Methamphetamine using PET. Quantification of brain function using PET. New York: Academic Press, 1996;42-46.
11. Ginsberg MD, Lockwood AH, Busto R, Finn RD, Butler CM, Cendan IE, Goddard J. A simplified in vivo autoradiographic strategy for the determination of regional cerebral blood flow by positron emission tomography theoretical considerations and validation studies in the rat. J Cereb Blood Flow Metab 1982;2:89-98.
12. Gjedde A. High- and low-affinity transport of D-glucose from blood to brain. J Neurochem 1981;36:1463-71.
13. Gjedde A. Calculation of cerebral glucose phosphorylation from brain uptake of glucose analogs in vivo: a re-examination.. Brain Res Rev 1982;4:237-74.
14. Gjedde A. Modulation of substrate transport to the brain. Acta Neurol Scand 1983;67:3-25.
15. Huang SC, Feng DG, Phelps ME. Model dependency and estimation reliability in measurements of cerebral oxygen utilization rate with oxygen-15 and positron emission tomography. J Cereb Blood Flow Metab 1986;6:105-19.
16. 18F]Fluorodeoxyglucose. J Cereb Blood Flow Metab 1990;10:180-9.
17. Madsen FF, Jensen FT, Waeth M, Djurhuus JC. Regional cerebral blood flow in pigs estimated by microspheres. Acta Neurochir (Vienna), 1990;103:139-147.
18. 2 inhalation and dynamic positron emission tomography. J Cereb Blood Flow Metab 1987;7:403-14.
19. Mintun MA, Raichle ME, Martin WRW, Herscovitch P. Brain oxygen utilization measured with oxygen-15 radiotracers and positron emission tomography. J Nucl Med 1984;25:177-87.
20. 18F] FDG double injection and new graphical analysis. Neuro Image 1995;2: S81.
21. Ohta S, Meyer E, Thompson CJ, Gjedde A. Oxygen consumption of the living human brain measured after a single inhalation of positron emitting oxygen. J Cereb Blood Flow Metab 1992;12:179-92.
22. 15O]water clearance in humans determined by PET: 1. Theory and normal values. J Cereb Blood Flow Metab 1996;5:765-80.
23. CO2 changes. Stroke 1971;2:519-540.
24. Oren RE, Rasool NA, Rubinstein EH. Effect of ketamine on cerebral cortical blood flow and metabolism in rabbits. Stroke 1986;18:441-444.
25. Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 1983;3:1-7.
26. 2 Implementation and validation. J Nucl Med 1983;24:790-8.
27. Redies C, Diksic M, Evans AC, Gjedde A, Yamamoto YL. Double-label autoradiographic deoxyglucose method for sequential measurement of regional cerebral glucose utilization. Neurosci 1987;22:601-19.
28. CO2 and cerebral hemodynamics. Am J Physiol 1964;206:25-35.
29. 18FDG studies. NeuroImage 1995;2:S65.
30. Rovida E, Russo V, Niggeler M, Samaja M. Blood oxygen affinity in large white pig. Experientia 1983;39:1352-3.
31. Schwedler M, Miletich DJ, Albrecht RF. Cerebral blood flow and metabolism following ketamine administration. Can Anaesth Soc J 1982;29:222-6.
32. 11C]Nefopam as a potential PET tracer of serotonin reuptake sites. Initial findings in living pig brain. Quantification of brain function using PET. New York: Academic Press, 1996;38-41.
33. 14C]deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 1977;28:897-916.
34. Takeshita H, Okuda Y, Sari A. The effects of ketamine on cerebral circulation and metabolism in man. Anesthesiology 1971;36:69-75.