메뉴 건너뛰기




Volumn 32, Issue , 2008, Pages S32-S38

UCP1: Its involvement and utility in obesity

Author keywords

Brown adipocytes; Thermogenesis; Transcription synergy; UCP1 transgenic mice; White adipose tissue

Indexed keywords

FAT; INSULIN; UNCOUPLING PROTEIN 1;

EID: 58149529580     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2008.236     Document Type: Review
Times cited : (164)

References (40)
  • 2
    • 0018646453 scopus 로고
    • A role for brown adipose tissue in dietinduced thermogenesis
    • Rothwell NJ, Stock MJ. A role for brown adipose tissue in dietinduced thermogenesis. Nature 1979; 281: 31–35.
    • (1979) Nature , vol.281 , pp. 31-35
    • Rothwell, N.J.1    Stock, M.J.2
  • 3
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: Function and physiological significance
    • Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 2004; 84: 277–359.
    • (2004) Physiol Rev , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 4
    • 0017364207 scopus 로고
    • Thermogenic defect in preobese ob/ob mice
    • Trayhurn P, Thurlby PL, James WPT. Thermogenic defect in preobese ob/ob mice. Nature 1977; 266: 60–62.
    • (1977) Nature , vol.266 , pp. 60-62
    • Trayhurn, P.1    Thurlby, P.L.2    James, W.P.T.3
  • 5
    • 0017823678 scopus 로고
    • A mitochondrial defect in brown adipose tissue of the obese (Ob/ob) mouse: Reduced binding of purine nucleotides and a failure to respond to cold by an increase in binding
    • Himms-Hagen J, Desautels M. A mitochondrial defect in brown adipose tissue of the obese (ob/ob) mouse: reduced binding of purine nucleotides and a failure to respond to cold by an increase in binding. Biochem Biophys Res Commun 1978; 83: 628–634.
    • (1978) Biochem Biophys Res Commun , vol.83 , pp. 628-634
    • Himms-Hagen, J.1    Desautels, M.2
  • 7
    • 0242365491 scopus 로고    scopus 로고
    • Dietary fat interacts with QTLs controlling induction of Pgc-1 alpha and Ucp1 during conversion of white to brown fat
    • Coulter AA, Bearden CM, Liu X, Koza RA, Kozak LP. Dietary fat interacts with QTLs controlling induction of Pgc-1 alpha and Ucp1 during conversion of white to brown fat. Physiol Genomics 2003; 14: 139–147.
    • (2003) Physiol Genomics , vol.14 , pp. 139-147
    • Coulter, A.A.1    Bearden, C.M.2    Liu, X.3    Koza, R.A.4    Kozak, L.P.5
  • 8
    • 33845977987 scopus 로고    scopus 로고
    • Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat
    • Xue B, Rim JS, Hogan JC, Coulter AA, Koza RA, Kozak LP. Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat. J Lipid Res 2007; 48: 41–51.
    • (2007) J Lipid Res , vol.48 , pp. 41-51
    • Xue, B.1    Rim, J.S.2    Hogan, J.C.3    Coulter, A.A.4    Koza, R.A.5    Kozak, L.P.6
  • 9
    • 33845969892 scopus 로고    scopus 로고
    • UCP1-independent thermogenesis in white adipose tissue of cold-acclimated Ucp1-mice
    • Ukropec J, Anunciado RP, Ravussin Y, Hulver MW, Kozak LP. UCP1-independent thermogenesis in white adipose tissue of cold-acclimated Ucp1-mice. J Biol Chem 2006; 281: 31894-31908.
    • (2006) J Biol Chem , vol.281 , pp. 31894-31908
    • Ukropec, J.1    Anunciado, R.P.2    Ravussin, Y.3    Hulver, M.W.4    Kozak, L.P.5
  • 10
    • 0035853702 scopus 로고    scopus 로고
    • Effects of genetic background on thermoregulation and fatty acidinduced uncoupling of mitochondria in UCP1-deficient mice
    • Hofmann WE, Liu X, Bearden CM, Harper M-E, Kozak LP. Effects of genetic background on thermoregulation and fatty acidinduced uncoupling of mitochondria in UCP1-deficient mice. J Biol Chem 2001; 276: 12460–12465.
    • (2001) J Biol Chem , vol.276 , pp. 12460-12465
    • Hofmann, W.E.1    Liu, X.2    Bearden, C.M.3    Harper, M.-E.4    Kozak, L.P.5
  • 11
    • 33645841079 scopus 로고    scopus 로고
    • Leptin is required for uncoupling protein-1-independent thermogenesis during cold stress
    • Ukropec J, Anunciado RV, Ravussin Y, Kozak LP. Leptin is required for uncoupling protein-1-independent thermogenesis during cold stress. Endocrinology 2006; 147: 2468–2480.
    • (2006) Endocrinology , vol.147 , pp. 2468-2480
    • Ukropec, J.1    Anunciado, R.V.2    Ravussin, Y.3    Kozak, L.P.4
  • 12
    • 0030971049 scopus 로고    scopus 로고
    • Obesity. Some heat but not enough light
    • Hirsch J. Obesity. Some heat but not enough light. Nature 1997; 387: 27–28.
    • (1997) Nature , vol.387 , pp. 27-28
    • Hirsch, J.1
  • 14
    • 0037031846 scopus 로고    scopus 로고
    • Normal thyroid thermogenesis but reduced viability and adiposity in mice lacking the mitochondrial glycerol phosphate dehydrogenase
    • Brown LJ, Koza RA, Everett C, Reitman ML, Marshall L, Fahien LA et al. Normal thyroid thermogenesis but reduced viability and adiposity in mice lacking the mitochondrial glycerol phosphate dehydrogenase. J Biol Chem 2002; 277: 32892–32898.
    • (2002) J Biol Chem , vol.277 , pp. 32892-32898
    • Brown, L.J.1    Koza, R.A.2    Everett, C.3    Reitman, M.L.4    Marshall, L.5    Fahien, L.A.6
  • 15
    • 0001742515 scopus 로고
    • Dehydroepiandosterone induces enzymes that permit thermogenesis and decrease metabolic efficiency
    • Lardy H, Stratman F, Elsevier: New York
    • Lardy H, Su CY, Kneer N, Wielgus S. Dehydroepiandosterone induces enzymes that permit thermogenesis and decrease metabolic efficiency. In: Lardy H, Stratman F (eds). Hormones, thermogenesis, and obesity. Elsevier: New York, 1989, pp 415–426.
    • (1989) Hormones, Thermogenesis, and Obesity , pp. 415-426
    • Lardy, H.1    Su, C.Y.2    Kneer, N.3    Wielgus, S.4
  • 16
    • 0028865142 scopus 로고
    • Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
    • Kopecky J, Clarke G, Enerback S, Spiegelman B, Kozak LP. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest 1995; 96: 2914–2923.
    • (1995) J Clin Invest , vol.96 , pp. 2914-2923
    • Kopecky, J.1    Clarke, G.2    Enerback, S.3    Spiegelman, B.4    Kozak, L.P.5
  • 17
    • 0029894407 scopus 로고    scopus 로고
    • Reduction of dietary obesity in aP2-Ucp transgenic mice: Physiology and adipose tissue distribution
    • Kopecky J, Hodny Z, Rossmeisl M, Syrovy I, Kozak LP. Reduction of dietary obesity in aP2-Ucp transgenic mice: physiology and adipose tissue distribution. Am J Physiol 1996; 270: E768–E775.
    • (1996) Am J Physiol , vol.270 , pp. E768-E775
    • Kopecky, J.1    Hodny, Z.2    Rossmeisl, M.3    Syrovy, I.4    Kozak, L.P.5
  • 18
    • 0006877856 scopus 로고    scopus 로고
    • Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
    • Clapham JC, Arch JR, Chapman H, Haynes A, Lister C, Moore GB et al. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Nature 2000; 406: 415–418.
    • (2000) Nature , vol.406 , pp. 415-418
    • Clapham, J.C.1    Arch, J.R.2    Chapman, H.3    Haynes, A.4    Lister, C.5    Moore, G.B.6
  • 19
    • 0031016659 scopus 로고    scopus 로고
    • Transgenic mice overexpressing the beta 1-adrenergic receptor in adipose tissue are resistant to obesity
    • Soloveva V, Graves RA, Rasenick MM, Spiegelman BM, Ross SR. Transgenic mice overexpressing the beta 1-adrenergic receptor in adipose tissue are resistant to obesity. Mol Endocrinol 1997; 11: 27–38.
    • (1997) Mol Endocrinol , vol.11 , pp. 27-38
    • Soloveva, V.1    Graves, R.A.2    Rasenick, M.M.3    Spiegelman, B.M.4    Ross, S.R.5
  • 20
    • 0029737861 scopus 로고    scopus 로고
    • Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A
    • Cummings DE, Brandon EP, Planas JV, Motamed K, Idzerda RL, McKnight GS. Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A. Nature 1996; 382: 622–626.
    • (1996) Nature , vol.382 , pp. 622-626
    • Cummings, D.E.1    Brandon, E.P.2    Planas, J.V.3    Motamed, K.4    Idzerda, R.L.5    McKnight, G.S.6
  • 21
    • 17944377509 scopus 로고    scopus 로고
    • FOXC2 is a winged helix gene that counteracts obesity, hypertriglceridemia, and diet-induced insulin resistance
    • Cederberg A, Gronning LM, Ahren B, Tasken P, Carlsson P, Enerback S. FOXC2 is a winged helix gene that counteracts obesity, hypertriglceridemia, and diet-induced insulin resistance. Cell 2001; 106: 563–573.
    • (2001) Cell , vol.106 , pp. 563-573
    • Cederberg, A.1    Gronning, L.M.2    Ahren, B.3    Tasken, P.4    Carlsson, P.5    Enerback, S.6
  • 23
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPARg2, a lipid-activated transcription factor
    • Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPARg2, a lipid-activated transcription factor. Cell 1994; 79: 1147–1156.
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 24
    • 0029941669 scopus 로고    scopus 로고
    • Differentiationdependent expression of the brown adipocyte uncoupling protein gene: Regulation by peroxisome proliferator-activated receptor gamma
    • Sears IB, MacGinnitie MA, Kovacs LG, Graves RA. Differentiationdependent expression of the brown adipocyte uncoupling protein gene: regulation by peroxisome proliferator-activated receptor gamma. Mol Cell Biol 1996; 16: 3410–3419.
    • (1996) Mol Cell Biol , vol.16 , pp. 3410-3419
    • Sears, I.B.1    Macginnitie, M.A.2    Kovacs, L.G.3    Graves, R.A.4
  • 25
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998; 92: 829–839.
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 26
    • 0028153698 scopus 로고
    • An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene
    • Kozak UC, Kopecky J, Teisinger J, Enerback S, Boyer B, Kozak LP. An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene. Mol Cell Biol 1994; 14: 59–67.
    • (1994) Mol Cell Biol , vol.14 , pp. 59-67
    • Kozak, U.C.1    Kopecky, J.2    Teisinger, J.3    Enerback, S.4    Boyer, B.5    Kozak, L.P.6
  • 27
    • 1642293248 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene
    • Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X et al. P38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Mol Cell Biol 2004; 24: 3057–3067.
    • (2004) Mol Cell Biol , vol.24 , pp. 3057-3067
    • Cao, W.1    Daniel, K.W.2    Robidoux, J.3    Puigserver, P.4    Medvedev, A.V.5    Bai, X.6
  • 28
    • 0026525053 scopus 로고
    • Analysis of a tissuespecific enhancer: ARF6 regulates adipogenic gene expression
    • Graves RA, Tontonoz P, Spiegelman BM. Analysis of a tissuespecific enhancer: ARF6 regulates adipogenic gene expression. Mol Cell Biol 1992; 12: 1202–1208.
    • (1992) Mol Cell Biol , vol.12 , pp. 1202-1208
    • Graves, R.A.1    Tontonoz, P.2    Spiegelman, B.M.3
  • 29
    • 0033213637 scopus 로고    scopus 로고
    • PPAR gamma is required for placental, cardiac, and adipose tissue development
    • Barak Y, Nelson MC, Ong ES, Jones YZ, Ruiz-Lozano P, Chien KR et al. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell 1999; 4: 585–595.
    • (1999) Mol Cell , vol.4 , pp. 585-595
    • Barak, Y.1    Nelson, M.C.2    Ong, E.S.3    Jones, Y.Z.4    Ruiz-Lozano, P.5    Chien, K.R.6
  • 31
    • 0031435337 scopus 로고    scopus 로고
    • Defective adipocyte differentiation in mice lacking the C/EBPb and C/EPBd gene
    • Tanaka T, Yoshida N, Kishimoto T, Akira S. Defective adipocyte differentiation in mice lacking the C/EBPb and C/EPBd gene. EMBO J 1997; 16: 7432–7443.
    • (1997) EMBO J , vol.16 , pp. 7432-7443
    • Tanaka, T.1    Yoshida, N.2    Kishimoto, T.3    Akira, S.4
  • 32
    • 0027938708 scopus 로고
    • In vitro interactions between nuclear proteins and uncoupling protein gene promoter reveal several putative transactivating factors including Ets1, retinoid X receptor, thyroid hormone receptor, and a CACCC box-binding protein
    • Cassard-Doulcier AM, Larose M, Matamala JC, Champigny O, Bouillaud F, Ricquier D. In vitro interactions between nuclear proteins and uncoupling protein gene promoter reveal several putative transactivating factors including Ets1, retinoid X receptor, thyroid hormone receptor, and a CACCC box-binding protein. J Biol Chem 1994; 269: 24335–24342.
    • (1994) J Biol Chem , vol.269 , pp. 24335-24342
    • Cassard-Doulcier, A.M.1    Larose, M.2    Matamala, J.C.3    Champigny, O.4    Bouillaud, F.5    Ricquier, D.6
  • 33
    • 0034943375 scopus 로고    scopus 로고
    • The multiple contributions of thyroid hormone to heat production
    • Silva JE. The multiple contributions of thyroid hormone to heat production. J Clin Invest 2001; 108: 35–37.
    • (2001) J Clin Invest , vol.108 , pp. 35-37
    • Silva, J.E.1
  • 34
    • 12144287013 scopus 로고    scopus 로고
    • Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation
    • Hansen JB, Jorgensen C, Petersen RK, Hallenborg P, De Matteis R, Boye HA et al. Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation. Proc Natl Acad Sci USA 2004; 101: 4112–4117.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4112-4117
    • Hansen, J.B.1    Jorgensen, C.2    Petersen, R.K.3    Hallenborg, P.4    De Matteis, R.5    Boye, H.A.6
  • 36
    • 0032528169 scopus 로고    scopus 로고
    • Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity
    • Guerra C, Koza RA, Yamashita H, Walsh K, Kozak LP. Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J Clin Invest 1998; 102: 412–420.
    • (1998) J Clin Invest , vol.102 , pp. 412-420
    • Guerra, C.1    Koza, R.A.2    Yamashita, H.3    Walsh, K.4    Kozak, L.P.5
  • 37
    • 0034602264 scopus 로고    scopus 로고
    • Synergistic gene interactions control the induction of the mitochondrial uncoupling protein (Ucp1) gene in white fat tissue
    • Koza RA, Hohmann SM, Guerra C, Rossmeisl M, Kozak LP. Synergistic gene interactions control the induction of the mitochondrial uncoupling protein (Ucp1) gene in white fat tissue. J Biol Chem 2000; 275: 34486–34492.
    • (2000) J Biol Chem , vol.275 , pp. 34486-34492
    • Koza, R.A.1    Hohmann, S.M.2    Guerra, C.3    Rossmeisl, M.4    Kozak, L.P.5
  • 38
    • 24344476219 scopus 로고    scopus 로고
    • Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots
    • Xue B, Coulter A, Rim JS, Koza RA, Kozak LP. Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots. Mol Cell Biol 2005; 25: 8311–8322.
    • (2005) Mol Cell Biol , vol.25 , pp. 8311-8322
    • Xue, B.1    Coulter, A.2    Rim, J.S.3    Koza, R.A.4    Kozak, L.P.5
  • 39
    • 33845977987 scopus 로고    scopus 로고
    • Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat
    • Xue B, Rim JS, Hogan JC, Coulter AA, Koza RA, Kozak LP. Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat. J Lipid Res 2007; 48/1: 41–51.
    • (2007) J Lipid Res , vol.48 , Issue.1 , pp. 41-51
    • Xue, B.1    Rim, J.S.2    Hogan, J.C.3    Coulter, A.A.4    Koza, R.A.5    Kozak, L.P.6
  • 40
    • 34248372084 scopus 로고    scopus 로고
    • Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages
    • Timmons JA, Wennmalm K, Larsson O, Walden TB, Lassmann T, Petrovic N et al. Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc Natl Acad Sci USA 2007; 104: 4401–4406.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 4401-4406
    • Timmons, J.A.1    Wennmalm, K.2    Larsson, O.3    Walden, T.B.4    Lassmann, T.5    Petrovic, N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.