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Volumn 37, Issue 5, 2013, Pages 625-633

The regulation of food intake by the gut-brain axis: Implications for obesity

Author keywords

anti obesity agents; appetite; food intake; gut hormones

Indexed keywords

AMFEBUTAMONE PLUS NALTREXONE; AMYLIN; ANTIOBESITY AGENT; CHOLECYSTOKININ; DEXFENFLURAMINE; FENFLURAMINE; GHRELIN; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; LORCASERIN; OXYNTOMODULIN; PANCREAS POLYPEPTIDE; PEPTIDE YY; PHENTERMINE PLUS TOPIRAMATE; RIMONABANT; SIBUTRAMINE; TETRAHYDROLIPSTATIN;

EID: 84877577992     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2012.93     Document Type: Review
Times cited : (152)

References (138)
  • 1
    • 0000833791 scopus 로고
    • Mechanism of the development of obesity in animals with hypothalamic lesions
    • Brobeck JR. Mechanism of the development of obesity in animals with hypothalamic lesions. Physiol Rev 1946; 26: 541-559.
    • (1946) Physiol Rev , vol.26 , pp. 541-559
    • Brobeck, J.R.1
  • 2
    • 81455134369 scopus 로고    scopus 로고
    • Set points, settling points and some alternative models: Theoretical options to understand how genes and environments combine to regulate body adiposity
    • Speakman JR, Levitsky DA, Allison DB, Bray MS, de Castro JM, Clegg DJ et al. Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity. Dis Model Mech 2011; 4: 733-745.
    • (2011) Dis Model Mech , vol.4 , pp. 733-745
    • Speakman, J.R.1    Levitsky, D.A.2    Allison, D.B.3    Bray, M.S.4    De Castro, J.M.5    Clegg, D.J.6
  • 4
    • 34347215242 scopus 로고    scopus 로고
    • Homeostatic and non-homeostatic pathways involved in the control of food intake and energy balance
    • Berthoud HR. Homeostatic and non-homeostatic pathways involved in the control of food intake and energy balance. Obesity (Silver Spring) 2006; 14(Suppl 5): 197S-200S.
    • (2006) Obesity (Silver Spring) , vol.14 , Issue.SUPPL. 5
    • Berthoud, H.R.1
  • 5
    • 0035027629 scopus 로고    scopus 로고
    • KO's and organisation of peptidergic feeding behavior mechanisms
    • Beck B. KO's and organisation of peptidergic feeding behavior mechanisms. Neurosci Biobehav Rev 2001; 25: 143-158.
    • (2001) Neurosci Biobehav Rev , vol.25 , pp. 143-158
    • Beck, B.1
  • 6
    • 33748130431 scopus 로고    scopus 로고
    • Central nervous system regulation of food intake
    • Schwartz MW. Central nervous system regulation of food intake. Obesity (Silver Spring) 2006; 14(Suppl 1): 1S-8S.
    • (2006) Obesity (Silver Spring) , vol.14 , Issue.SUPPL. 1
    • Schwartz, M.W.1
  • 7
    • 79952777193 scopus 로고    scopus 로고
    • The pharmacological treatment and management of obesity
    • Hussain SS, Bloom SR. The pharmacological treatment and management of obesity. Postgrad Med 2011; 123: 34-44.
    • (2011) Postgrad Med , vol.123 , pp. 34-44
    • Hussain, S.S.1    Bloom, S.R.2
  • 8
    • 68949120737 scopus 로고    scopus 로고
    • Control of energy homeostasis by insulin and leptin: Targeting the arcuate nucleus and beyond
    • Konner AC, Klockener T, Bruning JC. Control of energy homeostasis by insulin and leptin: targeting the arcuate nucleus and beyond. Physiol Behav 2009; 97: 632-638.
    • (2009) Physiol Behav , vol.97 , pp. 632-638
    • Konner, A.C.1    Klockener, T.2    Bruning, J.C.3
  • 9
    • 0017276160 scopus 로고
    • Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood
    • Broadwell RD, Brightman MW. Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood. J Comp Neurol 1976; 166: 257-283.
    • (1976) J Comp Neurol , vol.166 , pp. 257-283
    • Broadwell, R.D.1    Brightman, M.W.2
  • 11
    • 0033038418 scopus 로고    scopus 로고
    • Interacting appetite-regulating pathways in the hypothalamic regulation of body weight
    • Kalra SP, Dube MG, Pu S, Xu B, Horvath TL, Kalra PS. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev 1999; 20: 68-100.
    • (1999) Endocr Rev , vol.20 , pp. 68-100
    • Kalra, S.P.1    Dube, M.G.2    Pu, S.3    Xu, B.4    Horvath, T.L.5    Kalra, P.S.6
  • 12
    • 1642349297 scopus 로고    scopus 로고
    • Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice
    • Bouret SG, Draper SJ, Simerly RB. Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice. J Neurosci 2004; 24: 2797-2805.
    • (2004) J Neurosci , vol.24 , pp. 2797-2805
    • Bouret, S.G.1    Draper, S.J.2    Simerly, R.B.3
  • 14
    • 20244380014 scopus 로고    scopus 로고
    • Orexins and orexin receptors: A family of hypothalamic neuropeptides and G proteincoupled receptors that regulate feeding behavior
    • Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G proteincoupled receptors that regulate feeding behavior. Cell 1998; 92: 573-585.
    • (1998) Cell , vol.92 , pp. 573-585
    • Sakurai, T.1    Amemiya, A.2    Ishii, M.3    Matsuzaki, I.4    Chemelli, R.M.5    Tanaka, H.6
  • 15
    • 13344279395 scopus 로고    scopus 로고
    • A role for melanin-concentrating hormone in the central regulation of feeding behaviour
    • Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ et al. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 1996; 380: 243-247.
    • (1996) Nature , vol.380 , pp. 243-247
    • Qu, D.1    Ludwig, D.S.2    Gammeltoft, S.3    Piper, M.4    Pelleymounter, M.A.5    Cullen, M.J.6
  • 16
    • 0031023301 scopus 로고    scopus 로고
    • Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight
    • Rossi M, Choi SJ, O'Shea D, Miyoshi T, Ghatei MA, Bloom SR. Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology 1997; 138: 351-355.
    • (1997) Endocrinology , vol.138 , pp. 351-355
    • Rossi, M.1    Choi, S.J.2    O'shea, D.3    Miyoshi, T.4    Ghatei, M.A.5    Bloom, S.R.6
  • 17
    • 0038392755 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
    • Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones KR et al. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 2003; 6: 736-742.
    • (2003) Nat Neurosci , vol.6 , pp. 736-742
    • Xu, B.1    Goulding, E.H.2    Zang, K.3    Cepoi, D.4    Cone, R.D.5    Jones, K.R.6
  • 18
    • 30644473109 scopus 로고    scopus 로고
    • Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
    • Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V et al. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 2006; 49: 191-203.
    • (2006) Neuron , vol.49 , pp. 191-203
    • Dhillon, H.1    Zigman, J.M.2    Ye, C.3    Lee, C.E.4    McGovern, R.A.5    Tang, V.6
  • 20
    • 77956772446 scopus 로고    scopus 로고
    • Sensing the fuels: Glucose and lipid signaling in the CNS controlling energy homeostasis
    • Jordan SD, Konner AC, Bruning JC. Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis. Cell Mol Life Sci 2010; 67: 3255-3273.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 3255-3273
    • Jordan, S.D.1    Konner, A.C.2    Bruning, J.C.3
  • 21
    • 79959428713 scopus 로고    scopus 로고
    • Metabolic sensing and the brain: Who, what, where, and how?
    • Levin BE, Magnan C, Dunn-Meynell A, Le Foll C. Metabolic sensing and the brain: who, what, where, and how? Endocrinology 2011; 152: 2552-2557.
    • (2011) Endocrinology , vol.152 , pp. 2552-2557
    • Levin, B.E.1    Magnan, C.2    Dunn-Meynell, A.3    Le Foll, C.4
  • 22
    • 0036162117 scopus 로고    scopus 로고
    • The neuroanatomical axis for control of energy balance
    • Grill HJ, Kaplan JM. The neuroanatomical axis for control of energy balance. Front Neuroendocrinol 2002; 23: 2-40.
    • (2002) Front Neuroendocrinol , vol.23 , pp. 2-40
    • Grill, H.J.1    Kaplan, J.M.2
  • 23
    • 77649223913 scopus 로고    scopus 로고
    • Hypothalamic-brainstem circuits controlling eating
    • Blevins JE, Baskin DG. Hypothalamic-brainstem circuits controlling eating. Forum Nutr 2010; 63: 133-140.
    • (2010) Forum Nutr , vol.63 , pp. 133-140
    • Blevins, J.E.1    Baskin, D.G.2
  • 25
    • 33744789644 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor (BDNF) and food intake regulation: A minireview
    • Lebrun B, Bariohay B, Moyse E, Jean A. Brain-derived neurotrophic factor (BDNF) and food intake regulation: a minireview. Auton Neurosci 2006; 126-127: 30-38.
    • (2006) Auton Neurosci , vol.126-127 , pp. 30-38
    • Lebrun, B.1    Bariohay, B.2    Moyse, E.3    Jean, A.4
  • 27
    • 0033780625 scopus 로고    scopus 로고
    • The role of gastrointestinal vagal afferents in the control of food intake: Current prospects
    • Schwartz GJ. The role of gastrointestinal vagal afferents in the control of food intake: current prospects. Nutrition 2000; 16: 866-873.
    • (2000) Nutrition , vol.16 , pp. 866-873
    • Schwartz, G.J.1
  • 28
    • 40449138261 scopus 로고    scopus 로고
    • The area postrema: A brain monitor and integrator of systemic autonomic state
    • Price CJ, Hoyda TD, Ferguson AV. The area postrema: a brain monitor and integrator of systemic autonomic state. Neuroscientist 2008; 14: 182-194.
    • (2008) Neuroscientist , vol.14 , pp. 182-194
    • Price, C.J.1    Hoyda, T.D.2    Ferguson, A.V.3
  • 30
    • 0021266185 scopus 로고
    • Descending pathways from hypothalamus to dorsal motor vagus and ambiguus nuclei in the rat
    • ter Horst GJ, Luiten PG, Kuipers F. Descending pathways from hypothalamus to dorsal motor vagus and ambiguus nuclei in the rat. J Auton Nerv Syst 1984; 11: 59-75.
    • (1984) J Auton Nerv Syst , vol.11 , pp. 59-75
    • Ter Horst, G.J.1    Luiten, P.G.2    Kuipers, F.3
  • 31
    • 0025093156 scopus 로고
    • The role of the hypothalamus and dorsal vagal complex in gastrointestinal function and pathophysiology
    • Grijalva CV, Novin D. The role of the hypothalamus and dorsal vagal complex in gastrointestinal function and pathophysiology. Ann NY Acad Sci 1990; 597: 207-222.
    • (1990) Ann NY Acad Sci , vol.597 , pp. 207-222
    • Grijalva, C.V.1    Novin, D.2
  • 32
    • 36448969695 scopus 로고    scopus 로고
    • Imaging obesity: FMRI, food reward, and feeding
    • Grill HJ, Skibicka KP, Hayes MR. Imaging obesity: fMRI, food reward, and feeding. Cell Metab 2007; 6: 423-425.
    • (2007) Cell Metab , vol.6 , pp. 423-425
    • Grill, H.J.1    Skibicka, K.P.2    Hayes, M.R.3
  • 33
    • 80455122696 scopus 로고    scopus 로고
    • The gut hormones PYY(3-36) and GLP-1(7-36 amide) reduce food intake and modulate brain activity in appetite centers in humans
    • De Silva A, Salem V, Long CJ, Makwana A, Newbould RD, Rabiner EA et al. The gut hormones PYY(3-36) and GLP-1(7-36 amide) reduce food intake and modulate brain activity in appetite centers in humans. Cell Metab 2011; 14: 700-706.
    • (2011) Cell Metab , vol.14 , pp. 700-706
    • De Silva, A.1    Salem, V.2    Long, C.J.3    Makwana, A.4    Newbould, R.D.5    Rabiner, E.A.6
  • 34
    • 80053390365 scopus 로고    scopus 로고
    • Circulating glucose levels modulate neural control of desire for high-calorie foods in humans
    • Page KA, Seo D, Belfort-DeAguiar R, Lacadie C, Dzuira J, Naik S et al. Circulating glucose levels modulate neural control of desire for high-calorie foods in humans. J Clin Invest 2011; 121: 4161-4169.
    • (2011) J Clin Invest , vol.121 , pp. 4161-4169
    • Page, K.A.1    Seo, D.2    Belfort-Deaguiar, R.3    Lacadie, C.4    Dzuira, J.5    Naik, S.6
  • 35
    • 84856450553 scopus 로고    scopus 로고
    • Altered hypothalamic function in diet-induced obesity
    • Velloso LA, Schwartz MW. Altered hypothalamic function in diet-induced obesity. Int J Obes (Lond) 2011; 35: 1455-1465.
    • (2011) Int J Obes (Lond) , vol.35 , pp. 1455-1465
    • Velloso, L.A.1    Schwartz, M.W.2
  • 36
    • 0034040348 scopus 로고    scopus 로고
    • Leptin is influenced both by predisposition to obesity and diet composition
    • Raben A, Astrup A. Leptin is influenced both by predisposition to obesity and diet composition. Int J Obes Relat Metab Disord 2000; 24: 450-459.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 450-459
    • Raben, A.1    Astrup, A.2
  • 37
    • 33845875966 scopus 로고    scopus 로고
    • Gut hormones and the regulation of energy homeostasis
    • Murphy KG, Bloom SR. Gut hormones and the regulation of energy homeostasis. Nature 2006; 444: 854-859.
    • (2006) Nature , vol.444 , pp. 854-859
    • Murphy, K.G.1    Bloom, S.R.2
  • 38
    • 33845343275 scopus 로고    scopus 로고
    • Brain mechanisms underlying flavour and appetite
    • Rolls ET. Brain mechanisms underlying flavour and appetite. Philos Trans R Soc Lond B Biol Sci 2006; 361: 1123-1136.
    • (2006) Philos Trans R Soc Lond B Biol Sci , vol.361 , pp. 1123-1136
    • Rolls, E.T.1
  • 39
    • 77649212149 scopus 로고    scopus 로고
    • Brainstem integrative function in the central nervous system control of food intake
    • Schwartz GJ. Brainstem integrative function in the central nervous system control of food intake. Forum Nutr 2010; 63: 141-151.
    • (2010) Forum Nutr , vol.63 , pp. 141-151
    • Schwartz, G.J.1
  • 41
    • 0019381381 scopus 로고
    • C-terminal octapeptide of cholecystokinin decreases food intake in man
    • Kissileff HR, Pi-Sunyer FX, Thornton J, Smith GP. C-terminal octapeptide of cholecystokinin decreases food intake in man. Am J Clin Nutr 1981; 34: 154-160.
    • (1981) Am J Clin Nutr , vol.34 , pp. 154-160
    • Kissileff, H.R.1    Pi-Sunyer, F.X.2    Thornton, J.3    Smith, G.P.4
  • 42
    • 0017290537 scopus 로고
    • Immunohistochemical identification of the cholecystokinin cell in the intestinal mucosa
    • Buffa R, Solcia E, Go VL. Immunohistochemical identification of the cholecystokinin cell in the intestinal mucosa. Gastroenterology 1976; 70: 528-532.
    • (1976) Gastroenterology , vol.70 , pp. 528-532
    • Buffa, R.1    Solcia, E.2    Go, V.L.3
  • 44
    • 31044453754 scopus 로고    scopus 로고
    • On the tissue-specific processing of procholecystokinin in the brain and gut-A short review
    • Rehfeld JF, Bungaard JR, Friis-Hansen L, Goetze JP. On the tissue-specific processing of procholecystokinin in the brain and gut-a short review. J Physiol Pharmacol 2003; 54(Suppl 4): 73-79.
    • (2003) J Physiol Pharmacol , vol.54 , Issue.SUPPL. 4 , pp. 73-79
    • Rehfeld, J.F.1    Bungaard, J.R.2    Friis-Hansen, L.3    Goetze, J.P.4
  • 45
    • 0026522625 scopus 로고
    • Blockade of type A, not type B, CCK receptors attenuates satiety actions of exogenous and endogenous CCK
    • Moran TH, Ameglio PJ, Schwartz GJ, McHugh PR. Blockade of type A, not type B, CCK receptors attenuates satiety actions of exogenous and endogenous CCK. Am J Physiol 1992; 262(1 Pt 2): R46-R50.
    • (1992) Am J Physiol , vol.262 , Issue.1 PART 2
    • Moran, T.H.1    Ameglio, P.J.2    Schwartz, G.J.3    McHugh, P.R.4
  • 46
    • 0032861493 scopus 로고    scopus 로고
    • C-fos protein expression in the nucleus of the solitary tract correlates with cholecystokinin dose injected and food intake in rats
    • Zittel TT, Glatzle J, Kreis ME, Starlinger M, Eichner M, Raybould HE et al. C-fos protein expression in the nucleus of the solitary tract correlates with cholecystokinin dose injected and food intake in rats. Brain Res 1999; 846: 1-11.
    • (1999) Brain Res , vol.846 , pp. 1-11
    • Zittel, T.T.1    Glatzle, J.2    Kreis, M.E.3    Starlinger, M.4    Eichner, M.5    Raybould, H.E.6
  • 47
    • 0034737686 scopus 로고    scopus 로고
    • Brain regions where cholecystokinin suppresses feeding in rats
    • Blevins JE, Stanley BG, Reidelberger RD. Brain regions where cholecystokinin suppresses feeding in rats. Brain Res 2000; 860: 1-10.
    • (2000) Brain Res , vol.860 , pp. 1-10
    • Blevins, J.E.1    Stanley, B.G.2    Reidelberger, R.D.3
  • 48
    • 0031944277 scopus 로고    scopus 로고
    • Disordered food intake and obesity in rats lacking cholecystokinin A receptors
    • Moran TH, Katz LF, Plata-Salaman CR, Schwartz GJ. Disordered food intake and obesity in rats lacking cholecystokinin A receptors. Am J Physiol 1998; 274(3 Pt 2): R618-R625.
    • (1998) Am J Physiol , vol.274 , Issue.3 PART 2
    • Moran, T.H.1    Katz, L.F.2    Plata-Salaman, C.R.3    Schwartz, G.J.4
  • 49
    • 0032905886 scopus 로고    scopus 로고
    • The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight
    • Kopin AS, Mathes WF, McBride EW, Nguyen M, Al-Haider W, Schmitz F et al. The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight. J Clin Invest 1999; 103: 383-391.
    • (1999) J Clin Invest , vol.103 , pp. 383-391
    • Kopin, A.S.1    Mathes, W.F.2    McBride, E.W.3    Nguyen, M.4    Al-Haider, W.5    Schmitz, F.6
  • 50
    • 0020522487 scopus 로고
    • Rapid development of tolerance to the behavioural actions of cholecystokinin
    • Crawley JN, Beinfeld MC. Rapid development of tolerance to the behavioural actions of cholecystokinin. Nature 1983; 302: 703-706.
    • (1983) Nature , vol.302 , pp. 703-706
    • Crawley, J.N.1    Beinfeld, M.C.2
  • 51
    • 0021433344 scopus 로고
    • Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats
    • West DB, Fey D, Woods SC. Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats. Am J Physiol 1984; 246(5 Pt 2): R776-R787.
    • (1984) Am J Physiol , vol.246 , Issue.5 PART 2
    • West, D.B.1    Fey, D.2    Woods, S.C.3
  • 52
    • 0023104654 scopus 로고
    • Infusion of cholecystokinin between meals into free-feeding rats fails to prolong the intermeal interval
    • West DB, Greenwood MR, Sullivan AC, Prescod L, Marzullo LR, Triscari J. Infusion of cholecystokinin between meals into free-feeding rats fails to prolong the intermeal interval. Physiol Behav 1987; 39: 111-115.
    • (1987) Physiol Behav , vol.39 , pp. 111-115
    • West, D.B.1    Greenwood, M.R.2    Sullivan, A.C.3    Prescod, L.4    Marzullo, L.R.5    Triscari, J.6
  • 53
    • 15544385058 scopus 로고    scopus 로고
    • Ghrelin: Structure and function
    • Kojima M, Kangawa K. Ghrelin: structure and function. Physiol Rev 2005; 85: 495-522.
    • (2005) Physiol Rev , vol.85 , pp. 495-522
    • Kojima, M.1    Kangawa, K.2
  • 54
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-660.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 55
    • 81755161509 scopus 로고    scopus 로고
    • Ghrelin and appetite control in humans-Potential application in the treatment of obesity
    • Patterson M, Bloom SR, Gardiner JV. Ghrelin and appetite control in humans-Potential application in the treatment of obesity. Peptides 2011; 32: 2290-2294.
    • (2011) Peptides , vol.32 , pp. 2290-2294
    • Patterson, M.1    Bloom, S.R.2    Gardiner, J.V.3
  • 56
  • 58
    • 17944379112 scopus 로고    scopus 로고
    • Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans
    • Ariyasu H, Takaya K, Tagami T, Ogawa Y, Hosoda K, Akamizu T et al. Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab 2001; 86: 4753-4758.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4753-4758
    • Ariyasu, H.1    Takaya, K.2    Tagami, T.3    Ogawa, Y.4    Hosoda, K.5    Akamizu, T.6
  • 62
    • 0036144322 scopus 로고    scopus 로고
    • Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers
    • Lawrence CB, Snape AC, Baudoin FM, Luckman SM. Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers. Endocrinology 2002; 143: 155-162.
    • (2002) Endocrinology , vol.143 , pp. 155-162
    • Lawrence, C.B.1    Snape, A.C.2    Baudoin, F.M.3    Luckman, S.M.4
  • 70
    • 47549111187 scopus 로고    scopus 로고
    • Changes in gut hormones after bariatric surgery
    • Vincent RP, le Roux CW. Changes in gut hormones after bariatric surgery. Clin Endocrinol (Oxf) 2008; 69: 173-179.
    • (2008) Clin Endocrinol (Oxf) , vol.69 , pp. 173-179
    • Vincent, R.P.1    Le Roux, C.W.2
  • 71
    • 79952385410 scopus 로고    scopus 로고
    • Diet and gastrointestinal bypass-induced weight loss: The roles of ghrelin and peptide YY
    • Chandarana K, Gelegen C, Karra E, Choudhury AI, Drew ME, Fauveau V et al. Diet and gastrointestinal bypass-induced weight loss: the roles of ghrelin and peptide YY. Diabetes 2011; 60: 810-818.
    • (2011) Diabetes , vol.60 , pp. 810-818
    • Chandarana, K.1    Gelegen, C.2    Karra, E.3    Choudhury, A.I.4    Drew, M.E.5    Fauveau, V.6
  • 74
    • 34047216695 scopus 로고    scopus 로고
    • Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects
    • Sloth B, Holst JJ, Flint A, Gregersen NT, Astrup A. Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects. Am J Physiol Endocrinol Metab 2007; 292: E1062-E1068.
    • (2007) Am J Physiol Endocrinol Metab , vol.292
    • Sloth, B.1    Holst, J.J.2    Flint, A.3    Gregersen, N.T.4    Astrup, A.5
  • 76
    • 0031919929 scopus 로고    scopus 로고
    • International union of pharmacology recommendations for the nomenclature of neuropeptide y, peptide yy, and pancreatic polypeptide receptors
    • Michel MC, Beck-Sickinger A, Cox H, Doods HN, Herzog H, Larhammar D et al. XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol Rev 1998; 50: 143-150.
    • (1998) Pharmacol Rev , vol.50 , pp. 143-150
    • Michel, M.C.1    Beck-Sickinger, A.2    Cox, H.3    Doods, H.N.4    Herzog, H.5    Larhammar, D.6
  • 77
    • 24344498659 scopus 로고    scopus 로고
    • A role for pancreatic polypeptide in the regulation of gastric emptying and short-term metabolic control
    • Schmidt PT, Naslund E, Gryback P, Jacobsson H, Holst JJ, Hilsted L et al. A role for pancreatic polypeptide in the regulation of gastric emptying and short-term metabolic control. J Clin Endocrinol Metab 2005; 90: 5241-5246.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5241-5246
    • Schmidt, P.T.1    Naslund, E.2    Gryback, P.3    Jacobsson, H.4    Holst, J.J.5    Hilsted, L.6
  • 78
    • 0033383202 scopus 로고    scopus 로고
    • Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice
    • Asakawa A, Inui A, Ueno N, Fujimiya M, Fujino MA, Kasuga M. Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice. Peptides 1999; 20: 1445-1448.
    • (1999) Peptides , vol.20 , pp. 1445-1448
    • Asakawa, A.1    Inui, A.2    Ueno, N.3    Fujimiya, M.4    Fujino, M.A.5    Kasuga, M.6
  • 80
    • 79952653954 scopus 로고    scopus 로고
    • Peptide YY 3-36 and pancreatic polypeptide differentially regulate hypothalamic neuronal activity in mice in vivo as measured by manganese-enhanced magnetic resonance imaging
    • Hankir MK, Parkinson JR, Minnion JS, Addison ML, Bloom SR, Bell JD. Peptide YY 3-36 and pancreatic polypeptide differentially regulate hypothalamic neuronal activity in mice in vivo as measured by manganese-enhanced magnetic resonance imaging. J Neuroendocrinol 2011; 23: 371-380.
    • (2011) J Neuroendocrinol , vol.23 , pp. 371-380
    • Hankir, M.K.1    Parkinson, J.R.2    Minnion, J.S.3    Addison, M.L.4    Bloom, S.R.5    Bell, J.D.6
  • 81
    • 0030012124 scopus 로고    scopus 로고
    • Role of prohormone convertases in the tissue-specific processing of proglucagon
    • Dhanvantari S, Seidah NG, Brubaker PL. Role of prohormone convertases in the tissue-specific processing of proglucagon. Mol Endocrinol 1996; 10: 342-355.
    • (1996) Mol Endocrinol , vol.10 , pp. 342-355
    • Dhanvantari, S.1    Seidah, N.G.2    Brubaker, P.L.3
  • 82
    • 0028838030 scopus 로고
    • Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients
    • Herrmann C, Goke R, Richter G, Fehmann HC, Arnold R, Goke B. Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients. Digestion 1995; 56: 117-126.
    • (1995) Digestion , vol.56 , pp. 117-126
    • Herrmann, C.1    Goke, R.2    Richter, G.3    Fehmann, H.C.4    Arnold, R.5    Goke, B.6
  • 83
    • 0032982267 scopus 로고    scopus 로고
    • Role of the vagus nerve in mediating proximal nutrientinduced glucagon-like peptide-1 secretion
    • Rocca AS, Brubaker PL. Role of the vagus nerve in mediating proximal nutrientinduced glucagon-like peptide-1 secretion. Endocrinology 1999; 140: 1687-1694.
    • (1999) Endocrinology , vol.140 , pp. 1687-1694
    • Rocca, A.S.1    Brubaker, P.L.2
  • 84
    • 42449126696 scopus 로고    scopus 로고
    • A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release
    • Chu ZL, Carroll C, Alfonso J, Gutierrez V, He H, Lucman A et al. A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release. Endocrinology 2008; 149: 2038-2047.
    • (2008) Endocrinology , vol.149 , pp. 2038-2047
    • Chu, Z.L.1    Carroll, C.2    Alfonso, J.3    Gutierrez, V.4    He, H.5    Lucman, A.6
  • 85
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7-36: A physiological incretin in man
    • Kreymann B, Williams G, Ghatei MA, Bloom SR. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 1987; 2: 1300-1304.
    • (1987) Lancet , vol.2 , pp. 1300-1304
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3    Bloom, S.R.4
  • 86
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker DJ. The biology of incretin hormones. Cell Metab 2006; 3: 153-165.
    • (2006) Cell Metab , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 87
    • 57749169279 scopus 로고    scopus 로고
    • Differential patterns of neuronal activation in the brainstem and hypothalamus following peripheral injection of GLP-1, oxyntomodulin and lithium chloride in mice detected by manganese-enhanced magnetic resonance imaging (MEMRI)
    • Parkinson JR, Chaudhri OB, Kuo YT, Field BC, Herlihy AH, Dhillo WS et al. Differential patterns of neuronal activation in the brainstem and hypothalamus following peripheral injection of GLP-1, oxyntomodulin and lithium chloride in mice detected by manganese-enhanced magnetic resonance imaging (MEMRI). Neuroimage 2009; 44: 1022-1031.
    • (2009) Neuroimage , vol.44 , pp. 1022-1031
    • Parkinson, J.R.1    Chaudhri, O.B.2    Kuo, Y.T.3    Field, B.C.4    Herlihy, A.H.5    Dhillo, W.S.6
  • 90
    • 84862207266 scopus 로고    scopus 로고
    • Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide
    • e-pub ahead of print 16 August 2011; doi10.1038/ijo.2011.158
    • Astrup A, Carraro R, Finer N, Harper A, Kunesova M, Lean ME et al. Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide. Int J Obes (Lond) 2011; e-pub ahead of print 16 August 2011; doi:10.1038/ijo.2011.158.
    • (2011) Int J Obes (Lond)
    • Astrup, A.1    Carraro, R.2    Finer, N.3    Harper, A.4    Kunesova, M.5    Lean, M.E.6
  • 91
    • 84859003663 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 receptor agonists on weight loss: Systematic review and meta-analyses of randomised controlled trials
    • Vilsboll T, Christensen M, Junker AE, Knop FK, Gluud LL. Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials. BMJ 2012; 344: d7771.
    • (2012) BMJ , vol.344
    • Vilsboll, T.1    Christensen, M.2    Junker, A.E.3    Knop, F.K.4    Gluud, L.L.5
  • 92
    • 77951151612 scopus 로고    scopus 로고
    • Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4
    • Arakawa M, Mita T, Azuma K, Ebato C, Goto H, Nomiyama T et al. Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4. Diabetes 2010; 59: 1030-1037.
    • (2010) Diabetes , vol.59 , pp. 1030-1037
    • Arakawa, M.1    Mita, T.2    Azuma, K.3    Ebato, C.4    Goto, H.5    Nomiyama, T.6
  • 93
    • 0023950336 scopus 로고
    • Distribution of glucagonlike peptide i (GLP-I), glucagon, and glicentin in the rat brain: An immunocytochemical study
    • Jin SL, Han VK, Simmons JG, Towle AC, Lauder JM, Lund PK. Distribution of glucagonlike peptide I (GLP-I), glucagon, and glicentin in the rat brain: an immunocytochemical study. J Comp Neurol 1988; 271: 519-532.
    • (1988) J Comp Neurol , vol.271 , pp. 519-532
    • Jin, S.L.1    Han, V.K.2    Simmons, J.G.3    Towle, A.C.4    Lauder, J.M.5    Lund, P.K.6
  • 95
    • 4143116741 scopus 로고    scopus 로고
    • Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure
    • Baggio LL, Huang Q, Brown TJ, Drucker DJ. Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure. Gastroenterology 2004; 127: 546-558.
    • (2004) Gastroenterology , vol.127 , pp. 546-558
    • Baggio, L.L.1    Huang, Q.2    Brown, T.J.3    Drucker, D.J.4
  • 97
    • 33749339257 scopus 로고    scopus 로고
    • Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: A randomised controlled trial
    • Wynne K, Park AJ, Small CJ, Meeran K, Ghatei MA, Frost GS et al. Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomised controlled trial. Int J Obes (Lond) 2006; 30: 1729-1736.
    • (2006) Int J Obes (Lond) , vol.30 , pp. 1729-1736
    • Wynne, K.1    Park, A.J.2    Small, C.J.3    Meeran, K.4    Ghatei, M.A.5    Frost, G.S.6
  • 98
    • 33749478768 scopus 로고    scopus 로고
    • Differential hypothalamic neuronal activation following peripheral injection of GLP-1 and oxyntomodulin in mice detected by manganese-enhanced magnetic resonance imaging
    • Chaudhri OB, Parkinson JR, Kuo YT, Druce MR, Herlihy AH, Bell JD et al. Differential hypothalamic neuronal activation following peripheral injection of GLP-1 and oxyntomodulin in mice detected by manganese-enhanced magnetic resonance imaging. Biochem Biophys Res Commun 2006; 350: 298-306.
    • (2006) Biochem Biophys Res Commun , vol.350 , pp. 298-306
    • Chaudhri, O.B.1    Parkinson, J.R.2    Kuo, Y.T.3    Druce, M.R.4    Herlihy, A.H.5    Bell, J.D.6
  • 100
    • 0027971885 scopus 로고
    • Relative quantitative analysis of glucagon receptor mRNA in rat tissues
    • Svoboda M, Tastenoy M, Vertongen P, Robberecht P. Relative quantitative analysis of glucagon receptor mRNA in rat tissues. Mol Cell Endocrinol 1994; 105: 131-137.
    • (1994) Mol Cell Endocrinol , vol.105 , pp. 131-137
    • Svoboda, M.1    Tastenoy, M.2    Vertongen, P.3    Robberecht, P.4
  • 103
    • 0018144618 scopus 로고
    • Insulin and glucagon as determinants of body weight set point and microregulation in rats
    • de Castro JM, Paullin SK, DeLugas GM. Insulin and glucagon as determinants of body weight set point and microregulation in rats. J Comp Physiol Psychol 1978; 92: 571-579.
    • (1978) J Comp Physiol Psychol , vol.92 , pp. 571-579
    • De Castro, J.M.1    Paullin, S.K.2    Delugas, G.M.3
  • 104
    • 37049184904 scopus 로고
    • Stimulation of feeding in rats by intraperitoneal injection of antibodies to glucagon
    • Langhans W, Zeiger U, Scharrer E, Geary N. Stimulation of feeding in rats by intraperitoneal injection of antibodies to glucagon. Science 1982; 218: 894-896.
    • (1982) Science , vol.218 , pp. 894-896
    • Langhans, W.1    Zeiger, U.2    Scharrer, E.3    Geary, N.4
  • 106
    • 70349644658 scopus 로고    scopus 로고
    • Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice
    • Pocai A, Carrington PE, Adams JR, Wright M, Eiermann G, Zhu L et al. Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice. Diabetes 2009; 58: 2258-2266.
    • (2009) Diabetes , vol.58 , pp. 2258-2266
    • Pocai, A.1    Carrington, P.E.2    Adams, J.R.3    Wright, M.4    Eiermann, G.5    Zhu, L.6
  • 108
    • 84872493849 scopus 로고    scopus 로고
    • Pharmacological characterisation of rat amylin receptors: Implications for the identification of amylin receptor subtypes
    • Oct 20
    • Bailey RJ, Walker CS, Ferner AH, Loomes KM, Prijic G, Halim A et al. Pharmacological characterisation of rat amylin receptors: implications for the identification of amylin receptor subtypes. Br J Pharmacol 2011; Oct: 20.
    • (2011) Br J Pharmacol
    • Bailey, R.J.1    Walker, C.S.2    Ferner, A.H.3    Loomes, K.M.4    Prijic, G.5    Halim, A.6
  • 109
    • 3042802319 scopus 로고    scopus 로고
    • Effect of pramlintide on weight in overweight and obese insulin-treated type 2 diabetes patients
    • Hollander P, Maggs DG, Ruggles JA, Fineman M, Shen L, Kolterman OG et al. Effect of pramlintide on weight in overweight and obese insulin-treated type 2 diabetes patients. Obes Res 2004; 12: 661-668.
    • (2004) Obes Res , vol.12 , pp. 661-668
    • Hollander, P.1    Maggs, D.G.2    Ruggles, J.A.3    Fineman, M.4    Shen, L.5    Kolterman, O.G.6
  • 111
    • 26844475055 scopus 로고    scopus 로고
    • Anorexigenic hormones leptin, insulin, and alphamelanocyte-stimulating hormone directly induce neurotensin (NT) gene expression in novel NT-expressing cell models
    • Cui H, Cai F, Belsham DD. Anorexigenic hormones leptin, insulin, and alphamelanocyte-stimulating hormone directly induce neurotensin (NT) gene expression in novel NT-expressing cell models. J Neurosci 2005; 25: 9497-9506.
    • (2005) J Neurosci , vol.25 , pp. 9497-9506
    • Cui, H.1    Cai, F.2    Belsham, D.D.3
  • 112
    • 50049131792 scopus 로고    scopus 로고
    • Impaired anorectic effect of leptin in neurotensin receptor 1-deficient mice
    • Kim ER, Leckstrom A, Mizuno TM. Impaired anorectic effect of leptin in neurotensin receptor 1-deficient mice. Behav Brain Res 2008; 194: 66-71.
    • (2008) Behav Brain Res , vol.194 , pp. 66-71
    • Kim, E.R.1    Leckstrom, A.2    Mizuno, T.M.3
  • 114
    • 27744600963 scopus 로고    scopus 로고
    • Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake
    • Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 2005; 310: 996-999.
    • (2005) Science , vol.310 , pp. 996-999
    • Zhang, J.V.1    Ren, P.G.2    Avsian-Kretchmer, O.3    Luo, C.W.4    Rauch, R.5    Klein, C.6
  • 116
    • 0033305618 scopus 로고    scopus 로고
    • Proglucagon processing profile in canine L cells expressing endogenous prohormone convertase 1/3 and prohormone convertase 2
    • Damholt AB, Buchan AM, Holst JJ, Kofod H. Proglucagon processing profile in canine L cells expressing endogenous prohormone convertase 1/3 and prohormone convertase 2. Endocrinology 1999; 140: 4800-4808.
    • (1999) Endocrinology , vol.140 , pp. 4800-4808
    • Damholt, A.B.1    Buchan, A.M.2    Holst, J.J.3    Kofod, H.4
  • 117
    • 0033914183 scopus 로고    scopus 로고
    • The proglucagonderived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake
    • Tang-Christensen M, Larsen PJ, Thulesen J, Romer J, Vrang N. The proglucagonderived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake. Nat Med 2000; 6: 802-807.
    • (2000) Nat Med , vol.6 , pp. 802-807
    • Tang-Christensen, M.1    Larsen, P.J.2    Thulesen, J.3    Romer, J.4    Vrang, N.5
  • 118
    • 0031735064 scopus 로고    scopus 로고
    • GLP-2 augments the adaptive response to massive intestinal resection in rat
    • Scott RB, Kirk D, MacNaughton WK, Meddings JB. GLP-2 augments the adaptive response to massive intestinal resection in rat. Am J Physiol 1998; 275(5 Pt 1): G911-G921.
    • (1998) Am J Physiol , vol.275 , Issue.5 PART 1
    • Scott, R.B.1    Kirk, D.2    Macnaughton, W.K.3    Meddings, J.B.4
  • 119
    • 0242266558 scopus 로고    scopus 로고
    • Peripheral administration of GLP-2 to humans has no effect on gastric emptying or satiety
    • Schmidt PT, Naslund E, Gryback P, Jacobsson H, Hartmann B, Holst JJ et al. Peripheral administration of GLP-2 to humans has no effect on gastric emptying or satiety. Regul Pept 2003; 116: 21-25.
    • (2003) Regul Pept , vol.116 , pp. 21-25
    • Schmidt, P.T.1    Naslund, E.2    Gryback, P.3    Jacobsson, H.4    Hartmann, B.5    Holst, J.J.6
  • 120
    • 34247860921 scopus 로고    scopus 로고
    • Lifestyle modification for the management of obesity
    • Wadden TA, Butryn ML, Wilson C. Lifestyle modification for the management of obesity. Gastroenterology 2007; 132: 2226-2238.
    • (2007) Gastroenterology , vol.132 , pp. 2226-2238
    • Wadden, T.A.1    Butryn, M.L.2    Wilson, C.3
  • 121
    • 47249156732 scopus 로고    scopus 로고
    • Dietary adherence and weight loss success among overweight women: Results from the A to Z weight loss study
    • Alhassan S, Kim S, Bersamin A, King AC, Gardner CD. Dietary adherence and weight loss success among overweight women: results from the A TO Z weight loss study. Int J Obes (Lond) 2008; 32: 985-991.
    • (2008) Int J Obes (Lond) , vol.32 , pp. 985-991
    • Alhassan, S.1    Kim, S.2    Bersamin, A.3    King, A.C.4    Gardner, C.D.5
  • 122
    • 77951666149 scopus 로고    scopus 로고
    • Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
    • Johnson PM, Kenny PJ. Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nat Neurosci 2010; 13: 635-641.
    • (2010) Nat Neurosci , vol.13 , pp. 635-641
    • Johnson, P.M.1    Kenny, P.J.2
  • 123
    • 37249083878 scopus 로고    scopus 로고
    • Long term pharmacotherapy for obesity and overweight: Updated meta-analysis
    • Rucker D, Padwal R, Li SK, Curioni C, Lau DC. Long term pharmacotherapy for obesity and overweight: updated meta-analysis. BMJ 2007; 335: 1194-1199.
    • (2007) BMJ , vol.335 , pp. 1194-1199
    • Rucker, D.1    Padwal, R.2    Li, S.K.3    Curioni, C.4    Lau, D.C.5
  • 124
    • 33845968044 scopus 로고    scopus 로고
    • Effect of orlistat on weight regain and cardiovascular risk factors following a very-lowenergy diet in abdominally obese patients: A 3-year randomized, placebocontrolled study
    • Richelsen B, Tonstad S, Rossner S, Toubro S, Niskanen L, Madsbad S et al. Effect of orlistat on weight regain and cardiovascular risk factors following a very-lowenergy diet in abdominally obese patients: a 3-year randomized, placebocontrolled study. Diabetes Care 2007; 30: 27-32.
    • (2007) Diabetes Care , vol.30 , pp. 27-32
    • Richelsen, B.1    Tonstad, S.2    Rossner, S.3    Toubro, S.4    Niskanen, L.5    Madsbad, S.6
  • 125
    • 34748899434 scopus 로고    scopus 로고
    • Long-term persistence with orlistat and sibutramine in a population-based cohort
    • Padwal R, Kezouh A, Levine M, Etminan M. Long-term persistence with orlistat and sibutramine in a population-based cohort. Int J Obes (Lond) 2007; 31: 1567-1570.
    • (2007) Int J Obes (Lond) , vol.31 , pp. 1567-1570
    • Padwal, R.1    Kezouh, A.2    Levine, M.3    Etminan, M.4
  • 126
    • 0016816599 scopus 로고
    • Fenfluramine: A review of its pharmacological properties and therapeutic efficacy in obesity
    • Pinder RM, Brogden RN, Sawyer PR, Speight TM, Avery GS. Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity. Drugs 1975; 10: 241-323.
    • (1975) Drugs , vol.10 , pp. 241-323
    • Pinder, R.M.1    Brogden, R.N.2    Sawyer, P.R.3    Speight, T.M.4    Avery, G.S.5
  • 128
    • 17144382751 scopus 로고    scopus 로고
    • Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study
    • Van Gaal LF, Rissanen AM, Scheen AJ, Ziegler O, Rossner S. Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet 2005; 365: 1389-1397.
    • (2005) Lancet , vol.365 , pp. 1389-1397
    • Van Gaal, L.F.1    Rissanen, A.M.2    Scheen, A.J.3    Ziegler, O.4    Rossner, S.5
  • 129
    • 36048995288 scopus 로고    scopus 로고
    • Efficacy and safety of the weight-loss drug rimonabant: A meta-analysis of randomised trials
    • Christensen R, Kristensen PK, Bartels EM, Bliddal H, Astrup A. Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials. Lancet 2007; 370: 1706-1713.
    • (2007) Lancet , vol.370 , pp. 1706-1713
    • Christensen, R.1    Kristensen, P.K.2    Bartels, E.M.3    Bliddal, H.4    Astrup, A.5
  • 130
    • 36849095595 scopus 로고    scopus 로고
    • Cardiovascular responses to weight management and sibutramine in high-risk subjects: An analysis from the SCOUT trial
    • Torp-Pedersen C, Caterson I, Coutinho W, Finer N, Van Gaal L, Maggioni A et al. Cardiovascular responses to weight management and sibutramine in high-risk subjects: an analysis from the SCOUT trial. Eur Heart J 2007; 28: 2915-2923.
    • (2007) Eur Heart J , vol.28 , pp. 2915-2923
    • Torp-Pedersen, C.1    Caterson, I.2    Coutinho, W.3    Finer, N.4    Van Gaal, L.5    Maggioni, A.6
  • 132
    • 27344441682 scopus 로고    scopus 로고
    • Neurogenesis in the hypothalamus of adult mice: Potential role in energy balance
    • Kokoeva MV, Yin H, Flier JS. Neurogenesis in the hypothalamus of adult mice: potential role in energy balance. Science 2005; 310: 679-683.
    • (2005) Science , vol.310 , pp. 679-683
    • Kokoeva, M.V.1    Yin, H.2    Flier, J.S.3
  • 133
    • 0035836760 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity
    • Lambert PD, Anderson KD, Sleeman MW, Wong V, Tan J, Hijarunguru A et al. Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. Proc Natl Acad Sci USA 2001; 98: 4652-4657.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4652-4657
    • Lambert, P.D.1    Anderson, K.D.2    Sleeman, M.W.3    Wong, V.4    Tan, J.5    Hijarunguru, A.6
  • 134
    • 0037687348 scopus 로고    scopus 로고
    • Recombinant variant of ciliary neurotrophic factor for weight loss in obese adults: A randomized, dose-ranging study
    • Ettinger MP, Littlejohn TW, Schwartz SL, Weiss SR, McIlwain HH, Heymsfield SB et al. Recombinant variant of ciliary neurotrophic factor for weight loss in obese adults: a randomized, dose-ranging study. JAMA 2003; 289: 1826-1832.
    • (2003) JAMA , vol.289 , pp. 1826-1832
    • Ettinger, M.P.1    Littlejohn, T.W.2    Schwartz, S.L.3    Weiss, S.R.4    McIlwain, H.H.5    Heymsfield, S.B.6
  • 135
    • 58149485810 scopus 로고    scopus 로고
    • Bariatric surgery and reduction in morbidity and mortality: Experiences from the SOS study
    • Sjostrom L. Bariatric surgery and reduction in morbidity and mortality: experiences from the SOS study. Int J Obes (Lond) 2008; 32(Suppl 7): S93-S97.
    • (2008) Int J Obes (Lond) , vol.32 , Issue.SUPPL. 7
    • Sjostrom, L.1
  • 138
    • 77954252801 scopus 로고    scopus 로고
    • PYY3-36 and oxyntomodulin can be additive in their effect on food intake in overweight and obese humans
    • Field BC, Wren AM, Peters V, Baynes KC, Martin NM, Patterson M et al. PYY3-36 and oxyntomodulin can be additive in their effect on food intake in overweight and obese humans. Diabetes 2010; 59: 1635-1639.
    • (2010) Diabetes , vol.59 , pp. 1635-1639
    • Field, B.C.1    Wren, A.M.2    Peters, V.3    Baynes, K.C.4    Martin, N.M.5    Patterson, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.