Proglucagon processing profile in canine L cells expressing endogenous prohormone convertase 1/3 and prohormone convertase 2

Endocrinology

Volumn 140, Issue 10, 1999, Pages 4800-4808

  Damholt, A B ^a   Buchan, A M J ^a   Holst, J J ^a   Kofod, H ^a  

^a Beta Cell Biology   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; FURIN; GLICENTIN; GLYCOPROTEIN; HORMONE PRECURSOR; OXYNTOMODULIN; PROGLUCAGON;

ANIMAL CELL; ARTICLE; CELL CULTURE; DOG; ENZYME ACTIVITY; HORMONE SYNTHESIS; IMMUNOHISTOCHEMISTRY; NONHUMAN; PANCREAS CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; TISSUE SPECIFICITY; WESTERN BLOTTING;

EID: 0033305618     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.10.7068     Document Type: Article

References (39)

1. Enteroglucagon
2. The new enzymology of precursor processing endoproteases
3. Proprotein convertases (PC1/PC3 and PC2) in normal and neoplastic human tissues: Their use as markers of neuroendocrine differentiation
4. Immunocytochemical localization of prohormone convertases PC1/PC3 and PC2 in rat pancreatic islets
5. Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3
6. Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide
7. Role of the prohormone convertase pc2 in the processing of proglucagon to glucagon. FEBS Lett
8. Role of the prohormone convertase pc3 in the processing of proglucagon to glucagon-like peptide-1
9. Processing of mouse proglucagon by recombinant prohormone convertase 1 and immunopurified prohormone convertase 2 in vitro
10. Evidence for redundancy in propeptide/prohormone convertase activities in processing proglucagon: An antisense study
11. Role of prohormone convertases in the tissue-specific processing of proglucagon
12. Proglucagon processing in an islet cell line: Effect of PC1 overexpression and PC2 depletion
13. Morphologic and physiologic studies of canine ileal enteroglucagon-containing cells in short-term culture
14. Glucagon-like-peptide-1 secretion from canine L-cells is increased by glucose-dependent-insulinotropic-peptide but unaffected by glucose
15. 762 Facilitates the maturation of propc2 in neuroendocrine cells and is required for the expression of enzymatic-activity
16. Mechanism of the facilitation of pc2 maturation by 7b2-involvement in propc2 transport and activation but not folding
17. Production and characterization of N-terminally and C-terminally directed monoclonal antibodies against pancreatic glucagon
18. Immunocytochemical investigation of insulin-secretion by pancreatic β-cells in control and diabetic psammomys-obesus
19. Comparison of sandwich enzyme-linked immunoadsorbent assay and radio-immunoassay for determination of exogenous glucagon-like peptide-1(7-36)amide in plasma
20. Evidence that glicentin contains the entire sequence of glucagon
21. Proglucagon processing in porcine and human pancreas
22. Structure, analysis and secretion of human glucagon-like peptide-2 (GLP-2)
23. The role of prohormone convertases in insulin biosynthesis
24. Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells
25. Prohormone convertases (pc1/3 and pc2) in rat and human pancreas and islet-cell tumors-subcellular immunohistochemical analysis
26. Levels of the conversion endoproteases PC1 (PC3) and PC2 distinguish between insulin-producing pancreatic islet β cells and non-β cells
27. Distribution of the Kexin family proteases in pancreatic islets: PACE4C is specifically expressed in B cells of pancreatic islets
28. Developmental expression of the prohormone convertases pc1 and pc2 in mouse pancreaticislets
29. Cellular-distributions of the prohormone processing enzymes pc1 and pc2
30. Biosynthesis of the prohormone convertase mPC1 in AtT-20 Cells
31. The insulinotropic gut hormone glucagon-like-peptide-1
32. Defective prohormone processing and altered pancreatic-islet morphology in mice lacking active spc2
33. Incomplete processing of proinsulin to insulin accompanied by elevation of des-31,32 proinsulin intermediates in islets of mice lacking active pc2
34. Enzymatic cleavage of pro-opiomelanocortin by anterior pituitary granules. Evidence for a chymotryptic-like enzyme
35. 7B2 Is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway
36. Internal cleavage of the inhibitory 762 carboxyl-terminal peptide by pc2-a potential mechanism for its inactivation
37. Structural elements of PC2 for interaction with iits helper protein 7B2
38. Identification of the region within the neuroendocrine polypeptide 762 responsible for the inhibition of prohormone convertase pc2
39. Enzymatic characterization of immunopurified prohormone convertase 2 potent inhibition by a 762 peptide fragment