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Volumn 85, Issue 23, 2011, Pages 12292-12303

Hepatitis C virus-induced cancer stem cell-like signatures in cell culture and murine tumor xenografts

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; CD133 ANTIGEN; CELL MARKER; CYTOKERATIN 19; DOUBLECORTIN AND CAM KINASE LIKE 1; MATRIGEL; MYC PROTEIN; NONSTRUCTURAL PROTEIN 5B; PROTEIN; PROTEIN LGR5; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS RNA;

EID: 81255200425     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.05920-11     Document Type: Article
Times cited : (74)

References (63)
  • 1
    • 0036889329 scopus 로고    scopus 로고
    • Cell-free replication of the hepatitis C virus subgenomic replicon
    • Ali, N., K. D. Tardif, and A. Siddiqui. 2002. Cell-free replication of the hepatitis C virus subgenomic replicon. J. Virol. 76:12001-12007.
    • (2002) J. Virol. , vol.76 , pp. 12001-12007
    • Ali, N.1    Tardif, K.D.2    Siddiqui, A.3
  • 2
    • 28444449065 scopus 로고    scopus 로고
    • Liver stem cells: implications for hepatocarcinogenesis
    • Alison, M. R. 2005. Liver stem cells: implications for hepatocarcinogenesis. Stem Cell Rev. 1:253-260.
    • (2005) Stem Cell Rev , vol.1 , pp. 253-260
    • Alison, M.R.1
  • 3
    • 77949318258 scopus 로고    scopus 로고
    • Initiation factor eIF2-independent mode of c-Src mRNA translation occurs via an internal ribosome entry site
    • Allam, H., and N. Ali. 2010. Initiation factor eIF2-independent mode of c-Src mRNA translation occurs via an internal ribosome entry site. J. Biol. Chem. 285:5713-5725.
    • (2010) J. Biol. Chem. , vol.285 , pp. 5713-5725
    • Allam, H.1    Ali, N.2
  • 4
    • 41949134533 scopus 로고    scopus 로고
    • Generation of pluripotent stem cells from adult mouse liver and stomach cells
    • Aoi, T., et al. 2008. Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science 321:699-702.
    • (2008) Science , vol.321 , pp. 699-702
    • Aoi, T.1
  • 6
    • 70249126860 scopus 로고    scopus 로고
    • Hepatitis C virus-induced hepatocarcinogenesis
    • Bartosch, B., R. Thimme, H. E. Blum, and F. Zoulim. 2009. Hepatitis C virus-induced hepatocarcinogenesis. J. Hepatol. 51:810-820.
    • (2009) J. Hepatol. , vol.51 , pp. 810-820
    • Bartosch, B.1    Thimme, R.2    Blum, H.E.3    Zoulim, F.4
  • 7
    • 0036893332 scopus 로고    scopus 로고
    • Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication
    • Blight, K. J., J. A. McKeating, and C. M. Rice. 2002. Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication. J. Virol. 76:13001-13014.
    • (2002) J. Virol. , vol.76 , pp. 13001-13014
    • Blight, K.J.1    McKeating, J.A.2    Rice, C.M.3
  • 8
    • 2542608297 scopus 로고    scopus 로고
    • From proteomic analysis to clinical significance: overexpression of cytokeratin 19 correlates with hepatocellular carcinoma metastasis
    • Ding, S. J., et al. 2004. From proteomic analysis to clinical significance: overexpression of cytokeratin 19 correlates with hepatocellular carcinoma metastasis. Mol. Cell. Proteomics 3:73-81.
    • (2004) Mol. Cell. Proteomics , vol.3 , pp. 73-81
    • Ding, S.J.1
  • 10
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: from genes to environment
    • Farazi, P. A., and R. A. DePinho. 2006. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. Cancer. 6:674-687.
    • (2006) Nat. Rev. Cancer. , vol.6 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 11
    • 0037179698 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
    • Fried, M. W., et al. 2002. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N. Engl. J. Med. 347:975-982.
    • (2002) N. Engl. J. Med. , vol.347 , pp. 975-982
    • Fried, M.W.1
  • 12
    • 77649199607 scopus 로고    scopus 로고
    • Cellular lipid droplets and hepatitis C virus life cycle
    • Fukasawa, M. 2010. Cellular lipid droplets and hepatitis C virus life cycle. Biol. Pharm. Bull. 33:355-359.
    • (2010) Biol. Pharm. Bull. , vol.33 , pp. 355-359
    • Fukasawa, M.1
  • 13
    • 23944485662 scopus 로고    scopus 로고
    • Evasion of intracellular host defence by hepatitis C virus
    • Gale, M., Jr., and E. M. Foy. 2005. Evasion of intracellular host defence by hepatitis C virus. Nature 436:939-945.
    • (2005) Nature , vol.436 , pp. 939-945
    • Gale Jr., M.1    Foy, E.M.2
  • 14
    • 0034888396 scopus 로고    scopus 로고
    • Effect of alpha interferon on the hepatitis C virus replicon
    • Guo, J. T., V. V. Bichko, and C. Seeger. 2001. Effect of alpha interferon on the hepatitis C virus replicon. J. Virol. 75:8516-8523.
    • (2001) J. Virol. , vol.75 , pp. 8516-8523
    • Guo, J.T.1    Bichko, V.V.2    Seeger, C.3
  • 15
    • 77649275936 scopus 로고    scopus 로고
    • A nonviral minicircle vector for deriving human iPS cells
    • Jia, F., et al. 2010. A nonviral minicircle vector for deriving human iPS cells. Nat. Methods 7:197-199.
    • (2010) Nat. Methods , vol.7 , pp. 197-199
    • Jia, F.1
  • 16
    • 64749111225 scopus 로고    scopus 로고
    • Virus-free induction of pluripotency and subsequent excision of reprogramming factors
    • Kaji, K., et al. 2009. Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 458:771-775.
    • (2009) Nature , vol.458 , pp. 771-775
    • Kaji, K.1
  • 17
    • 70349687407 scopus 로고    scopus 로고
    • Direct reprogramming of human neural stem cells by OCT4
    • Kim, J. B., et al. 2009. Direct reprogramming of human neural stem cells by OCT4. Nature 461:649-653.
    • (2009) Nature , vol.461 , pp. 649-653
    • Kim, J.B.1
  • 18
    • 0242501574 scopus 로고    scopus 로고
    • The DCX-domain tandems of doublecortin and doublecortin-like kinase
    • Kim, M. H., et al. 2003. The DCX-domain tandems of doublecortin and doublecortin-like kinase. Nat. Struct. Biol. 10:324-333.
    • (2003) Nat. Struct. Biol. , vol.10 , pp. 324-333
    • Kim, M.H.1
  • 19
    • 50149114689 scopus 로고    scopus 로고
    • Association of hepatitis C virus replication complexes with microtubules and actin filaments is dependent on the interaction of NS3 and NS5A
    • Lai, C. K., K. S. Jeng, K. Machida, and M. M. Lai. 2008. Association of hepatitis C virus replication complexes with microtubules and actin filaments is dependent on the interaction of NS3 and NS5A. J. Virol. 82:8838-8848.
    • (2008) J. Virol. , vol.82 , pp. 8838-8848
    • Lai, C.K.1    Jeng, K.S.2    Machida, K.3    Lai, M.M.4
  • 20
    • 33947507817 scopus 로고    scopus 로고
    • Hepatitis C virus replication in transfected and serum-infected cultured human fetal hepatocytes
    • Lazaro, C. A., et al. 2007. Hepatitis C virus replication in transfected and serum-infected cultured human fetal hepatocytes. Am. J. Pathol. 170:478-489.
    • (2007) Am. J. Pathol. , vol.170 , pp. 478-489
    • Lazaro, C.A.1
  • 21
    • 32844454531 scopus 로고    scopus 로고
    • Wnt/Frizzled signaling in hepatocellular carcinoma
    • Lee, H. C., M. Kim, and J. R. Wands. 2006. Wnt/Frizzled signaling in hepatocellular carcinoma. Front. Biosci. 11:1901-1915.
    • (2006) Front. Biosci. , vol.11 , pp. 1901-1915
    • Lee, H.C.1    Kim, M.2    Wands, J.R.3
  • 22
    • 33645742425 scopus 로고    scopus 로고
    • A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells
    • Lee, J. S., et al. 2006. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat. Med. 12:410-416.
    • (2006) Nat. Med. , vol.12 , pp. 410-416
    • Lee, J.S.1
  • 23
    • 33745527481 scopus 로고    scopus 로고
    • Viral hepatitis and liver cancer: the case of hepatitis C
    • Levrero, M. 2006. Viral hepatitis and liver cancer: the case of hepatitis C. Oncogene 25:3834-3847.
    • (2006) Oncogene , vol.25 , pp. 3834-3847
    • Levrero, M.1
  • 24
    • 0034671293 scopus 로고    scopus 로고
    • DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization
    • Lin, P. T., J. G. Gleeson, J. C. Corbo, L. Flanagan, and C. A. Walsh. 2000. DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization. J. Neurosci. 20:9152-9161.
    • (2000) J. Neurosci. , vol.20 , pp. 9152-9161
    • Lin, P.T.1    Gleeson, J.G.2    Corbo, J.C.3    Flanagan, L.4    Walsh, C.A.5
  • 25
    • 23944476834 scopus 로고    scopus 로고
    • Unravelling hepatitis C virus replication from genome to function
    • Lindenbach, B. D., and C. M. Rice. 2005. Unravelling hepatitis C virus replication from genome to function. Nature 436:933-938.
    • (2005) Nature , vol.436 , pp. 933-938
    • Lindenbach, B.D.1    Rice, C.M.2
  • 26
    • 41349090105 scopus 로고    scopus 로고
    • Generation of human induced pluripotent stem cells from dermal fibroblasts
    • Lowry, W. E., et al. 2008. Generation of human induced pluripotent stem cells from dermal fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 105:2883-2888.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 2883-2888
    • Lowry, W.E.1
  • 27
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial
    • Manns, M. P., et al. 2001. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 358:958-965.
    • (2001) Lancet , vol.358 , pp. 958-965
    • Manns, M.P.1
  • 28
    • 77955852219 scopus 로고    scopus 로고
    • Epigenetic regulation of cancer stem cells in liver cancer: current concepts and clinical implications
    • Marquardt, J. U., V. M. Factor, and S. S. Thorgeirsson. 2010. Epigenetic regulation of cancer stem cells in liver cancer: current concepts and clinical implications. J. Hepatol. 53:568-577.
    • (2010) J. Hepatol. , vol.53 , pp. 568-577
    • Marquardt, J.U.1    Factor, V.M.2    Thorgeirsson, S.S.3
  • 29
    • 43049128928 scopus 로고    scopus 로고
    • Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice
    • May, R., et al. 2008. Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice. Stem Cells 26:630-637.
    • (2008) Stem Cells , vol.26 , pp. 630-637
    • May, R.1
  • 30
    • 70350239859 scopus 로고    scopus 로고
    • Doublecortin and CaM kinase-like-1 and leucine-richrepeat-containing G-protein-coupled receptor mark quiescent and cycling intestinal stem cells, respectively
    • May, R., et al. 2009. Doublecortin and CaM kinase-like-1 and leucine-richrepeat-containing G-protein-coupled receptor mark quiescent and cycling intestinal stem cells, respectively. Stem Cells 27:2571-2579.
    • (2009) Stem Cells , vol.27 , pp. 2571-2579
    • May, R.1
  • 31
    • 77955599004 scopus 로고    scopus 로고
    • Identification of a novel putative pancreatic stem/ progenitor cell marker DCAMKL-1 in normal mouse pancreas
    • May, R., et al. 2010. Identification of a novel putative pancreatic stem/ progenitor cell marker DCAMKL-1 in normal mouse pancreas. Am. J. Physiol. Gastrointest. Liver Physiol. 299:G303-G310.
    • (2010) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.299
    • May, R.1
  • 32
    • 0028871988 scopus 로고
    • Investigation of the pattern of hepatitis C virus sequence diversity in different geographical regions: implications for virus classification, The International HCV Collaborative Study Group
    • Mellor, J., E. C. Holmes, L. M. Jarvis, P. L. Yap, and P. Simmonds. 1995. Investigation of the pattern of hepatitis C virus sequence diversity in different geographical regions: implications for virus classification. The International HCV Collaborative Study Group. J. Gen. Virol. 76(Pt. 10):2493-2507.
    • (1995) J. Gen. Virol. , vol.76 , Issue.PART 10 , pp. 2493-2507
    • Mellor, J.1    Holmes, E.C.2    Jarvis, L.M.3    Yap, P.L.4    Simmonds, P.5
  • 33
    • 58949088366 scopus 로고    scopus 로고
    • Liver stem cells and hepatocellular carcinoma
    • Mishra, L., et al. 2009. Liver stem cells and hepatocellular carcinoma. Hepatology 49:318-329.
    • (2009) Hepatology , vol.49 , pp. 318-329
    • Mishra, L.1
  • 34
    • 3142764760 scopus 로고    scopus 로고
    • Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes
    • Moradpour, D., et al. 2004. Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes. J. Virol. 78:7400-7409.
    • (2004) J. Virol. , vol.78 , pp. 7400-7409
    • Moradpour, D.1
  • 36
    • 77649270350 scopus 로고    scopus 로고
    • Side-population cells in luminal-type breast cancer have tumour-initiating cell properties, and are regulated by HER2 expres- sion and signalling
    • Nakanishi, T., et al. 2010. Side-population cells in luminal-type breast cancer have tumour-initiating cell properties, and are regulated by HER2 expres- sion and signalling. Br. J. Cancer 102:815-826.
    • (2010) Br. J. Cancer , vol.102 , pp. 815-826
    • Nakanishi, T.1
  • 37
    • 31144472895 scopus 로고    scopus 로고
    • Effect of cell growth on hepatitis C virus (HCV) replication and a mechanism of cell confluence-based inhibition of HCV RNA and protein expression
    • Nelson, H. B., and H. Tang. 2006. Effect of cell growth on hepatitis C virus (HCV) replication and a mechanism of cell confluence-based inhibition of HCV RNA and protein expression. J. Virol. 80:1181-1190.
    • (2006) J. Virol. , vol.80 , pp. 1181-1190
    • Nelson, H.B.1    Tang, H.2
  • 38
    • 70349735843 scopus 로고    scopus 로고
    • Nonstructural 5A protein activates beta-catenin signa cascades: implication of hepatitis C virus-induced liver pathogenesis
    • Park, C. Y., et al. 2009. Nonstructural 5A protein activates beta-catenin signa cascades: implication of hepatitis C virus-induced liver pathogenesis. J. Hepatol. 51:853-864.
    • (2009) J. Hepatol. , vol.51 , pp. 853-864
    • Park, C.Y.1
  • 39
    • 38049187707 scopus 로고    scopus 로고
    • Reprogramming of human somatic cells to pluripotency with defined factors
    • Park, I. H., et al. 2008. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 451:141-146.
    • (2008) Nature , vol.451 , pp. 141-146
    • Park, I.H.1
  • 40
    • 0035467993 scopus 로고    scopus 로고
    • Global cancer statistics in the year 2000
    • Parkin, D. M. 2001. Global cancer statistics in the year 2000. Lancet Oncol. 2:533-543.
    • (2001) Lancet Oncol , vol.2 , pp. 533-543
    • Parkin, D.M.1
  • 41
    • 77958487999 scopus 로고    scopus 로고
    • New insights into structure and replication of the hepatitis C virus and clinical implications
    • Poenisch, M., and R. Bartenschlager. 2010. New insights into structure and replication of the hepatitis C virus and clinical implications. Semin. Liver Dis. 30:333-347.
    • (2010) Semin. Liver Dis. , vol.30 , pp. 333-347
    • Poenisch, M.1    Bartenschlager, R.2
  • 42
    • 77958513288 scopus 로고    scopus 로고
    • Hepatitis A and hepatitis C viruses: diver- gent infection outcomes marked by similarities in induction and evasion of interferon responses
    • Qu, L., and S. M. Lemon. 2010. Hepatitis A and hepatitis C viruses: diver- gent infection outcomes marked by similarities in induction and evasion of interferon responses. Semin. Liver Dis. 30:319-332.
    • (2010) Semin. Liver Dis. , vol.30 , pp. 319-332
    • Qu, L.1    Lemon, S.M.2
  • 43
    • 77957936172 scopus 로고    scopus 로고
    • Hepatitis C virus infection impairs IRF-7 and alpha interferon synthesis in immortalized human hepatocytes
    • Raychoudhuri, A., et al. 2010. Hepatitis C virus infection impairs IRF-7 and alpha interferon synthesis in immortalized human hepatocytes. J. Virol. 84:10991-10998.
    • (2010) J. Virol. , vol.84 , pp. 10991-10998
    • Raychoudhuri, A.1
  • 44
    • 67649400809 scopus 로고    scopus 로고
    • Initiation of hepatitis C virus infection requires the dynamic microtubule network: role of the viral nucleocapsid protein
    • Roohvand, F., et al. 2009. Initiation of hepatitis C virus infection requires the dynamic microtubule network: role of the viral nucleocapsid protein. J. Biol. Chem. 284:13778-13791.
    • (2009) J. Biol. Chem. , vol.284 , pp. 13778-13791
    • Roohvand, F.1
  • 45
    • 79959478969 scopus 로고    scopus 로고
    • Clinical practice. Chronic hepatitis C infection
    • Rosen, H. R. 2011. Clinical practice. Chronic hepatitis C infection. N. Engl. J. Med. 364:2429-2438.
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2429-2438
    • Rosen, H.R.1
  • 46
    • 53749088741 scopus 로고    scopus 로고
    • Identification of side population cells in human hepatocellular carcinoma cell lines with stepwise metastatic potentials
    • Shi, G. M., et al. 2008. Identification of side population cells in human hepatocellular carcinoma cell lines with stepwise metastatic potentials. J. Cancer Res. Clin. Oncol. 134:1155-1163.
    • (2008) J. Cancer Res. Clin. Oncol. , vol.134 , pp. 1155-1163
    • Shi, G.M.1
  • 47
    • 33645403647 scopus 로고    scopus 로고
    • Oval cells in hepatitis B virus-positive and hepatitis C virus-positive liver cirrhosis: histological and ultrastructural study
    • Sun, C., X. L. Jin, and J. C. Xiao. 2006. Oval cells in hepatitis B virus-positive and hepatitis C virus-positive liver cirrhosis: histological and ultrastructural study. Histopathology 48:546-555.
    • (2006) Histopathology , vol.48 , pp. 546-555
    • Sun, C.1    Jin, X.L.2    Xiao, J.C.3
  • 48
    • 67650991981 scopus 로고    scopus 로고
    • Selective blockade of DCAMKL-1 results in tumor growth arrest by a Let-7a MicroRNA-dependent mechanism
    • Sureban, S. M., et al. 2009. Selective blockade of DCAMKL-1 results in tumor growth arrest by a Let-7a MicroRNA-dependent mechanism. Gastroenterology 137:649-659.
    • (2009) Gastroenterology , vol.137 , pp. 649-659
    • Sureban, S.M.1
  • 49
    • 16244405250 scopus 로고    scopus 로고
    • Hepatitis C virus, ER stress, and oxidative stress
    • Tardif, K. D., G. Waris, and A. Siddiqui. 2005. Hepatitis C virus, ER stress, and oxidative stress. Trends Microbiol. 13:159-163.
    • (2005) Trends Microbiol , vol.13 , pp. 159-163
    • Tardif, K.D.1    Waris, G.2    Siddiqui, A.3
  • 50
    • 34248674146 scopus 로고    scopus 로고
    • WNT/beta-catenin signaling in liver health and disease
    • Thompson, M. D., and S. P. Monga. 2007. WNT/beta-catenin signaling in liver health and disease. Hepatology 45:1298-1305.
    • (2007) Hepatology , vol.45 , pp. 1298-1305
    • Thompson, M.D.1    Monga, S.P.2
  • 51
    • 33746762849 scopus 로고    scopus 로고
    • Potential role of hepatic progenitor cells expression in cases of chronic hepatitis C and their relation to response to therapy: a clinicopathologic study
    • Tsamandas, A. C., et al. 2006. Potential role of hepatic progenitor cells expression in cases of chronic hepatitis C and their relation to response to therapy: a clinicopathologic study. Liver Int. 26:817-826.
    • (2006) Liver Int , vol.26 , pp. 817-826
    • Tsamandas, A.C.1
  • 52
    • 22544470874 scopus 로고    scopus 로고
    • Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
    • Wakita, T., et al. 2005. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat. Med. 11:791-796.
    • (2005) Nat. Med. , vol.11 , pp. 791-796
    • Wakita, T.1
  • 53
    • 0037111954 scopus 로고    scopus 로고
    • Endoplasmic reticulum (ER) stress: hepatitis C virus induces an ER-nucleus signal transduction pathway and activates NF-kappaB and STAT-3
    • Waris, G., K. D. Tardif, and A. Siddiqui. 2002. Endoplasmic reticulum (ER) stress: hepatitis C virus induces an ER-nucleus signal transduction pathway and activates NF-kappaB and STAT-3. Biochem. Pharmacol. 64:1425-1430.
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 1425-1430
    • Waris, G.1    Tardif, K.D.2    Siddiqui, A.3
  • 54
    • 55249090938 scopus 로고    scopus 로고
    • A dynamic view of hepatitis C virus replication complexes
    • Wolk, B., B. Buchele, D. Moradpour, and C. M. Rice. 2008. A dynamic view of hepatitis C virus replication complexes. J. Virol. 82:10519-10531.
    • (2008) J. Virol. , vol.82 , pp. 10519-10531
    • Wolk, B.1    Buchele, B.2    Moradpour, D.3    Rice, C.M.4
  • 55
    • 77951037177 scopus 로고    scopus 로고
    • Identification of a cholangiocarcinoma-like gene expression trait in hepatocellular carcinoma
    • Woo, H. G., et al. 2010. Identification of a cholangiocarcinoma-like gene expression trait in hepatocellular carcinoma. Cancer Res. 70:3034-3041.
    • (2010) Cancer Res , vol.70 , pp. 3034-3041
    • Woo, H.G.1
  • 56
    • 0029794269 scopus 로고    scopus 로고
    • Classification of hepatocellular carcinoma according to hepatocellular and biliary differentiation markers, Clinical and biological implications
    • Wu, P. C., et al. 1996. Classification of hepatocellular carcinoma according to hepatocellular and biliary differentiation markers. Clinical and biological implications. Am. J. Pathol. 149:1167-1175.
    • (1996) Am. J. Pathol. , vol.149 , pp. 1167-1175
    • Wu, P.C.1
  • 57
    • 34247549347 scopus 로고    scopus 로고
    • Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma
    • Wurmbach, E., et al. 2007. Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma. Hepatology 45:938-947.
    • (2007) Hepatology , vol.45 , pp. 938-947
    • Wurmbach, E.1
  • 58
    • 77957734999 scopus 로고    scopus 로고
    • Epidemiology and management of hepatocellular carcinoma
    • Yang, J. D., and L. R. Roberts. 2010. Epidemiology and management of hepatocellular carcinoma. Infect. Dis. Clin. North Am. 24:899-919.
    • (2010) Infect. Dis. Clin. North Am. , vol.24 , pp. 899-919
    • Yang, J.D.1    Roberts, L.R.2
  • 60
    • 77954215506 scopus 로고    scopus 로고
    • Notch signaling: emerging molecular targets for cancer therapy
    • Yin, L., O. C. Velazquez, and Z. J. Liu. 2010. Notch signaling: emerging molecular targets for cancer therapy. Biochem. Pharmacol. 80:690-701.
    • (2010) Biochem. Pharmacol. , vol.80 , pp. 690-701
    • Yin, L.1    Velazquez, O.C.2    Liu, Z.J.3
  • 61
    • 56149087044 scopus 로고    scopus 로고
    • The stem cell niche of human livers: symmetry between development and regeneration
    • Zhang, L., N. Theise, M. Chua, and L. M. Reid. 2008. The stem cell niche of human livers: symmetry between development and regeneration. Hepatology 48:1598-1607.
    • (2008) Hepatology , vol.48 , pp. 1598-1607
    • Zhang, L.1    Theise, N.2    Chua, M.3    Reid, L.M.4
  • 62
    • 68149145797 scopus 로고    scopus 로고
    • Derivation and characterization of hepatic progenitor cells from human embryonic stem cells
    • Zhao, D., et al. 2009. Derivation and characterization of hepatic progenitor cells from human embryonic stem cells. PLoS One 4:e6468.
    • (2009) PLoS One , vol.4
    • Zhao, D.1
  • 63
    • 73949099275 scopus 로고    scopus 로고
    • Nuclear beta-catenin induces an early liver progenitor phenotype in hepatocellular carcinoma and promotes tumor recurrence
    • Zulehner, G., et al. 2010. Nuclear beta-catenin induces an early liver progenitor phenotype in hepatocellular carcinoma and promotes tumor recurrence. Am. J. Pathol. 176:472-481.
    • (2010) Am. J. Pathol. , vol.176 , pp. 472-481
    • Zulehner, G.1


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