Management of HCC

Journal of Hepatology

Volumn 56, Issue SUPPL. 1, 2012, Pages

  De Lope, Carlos Rodríguez ^a   Tremosini, Silvia ^a   Forner, Alejandro ^a,b   Reig, María ^a,b   Bruix, Jordi ^a,b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Diagnosis; Hepatocellular carcinoma; Prognosis; Treatment

Indexed keywords

ADENOSINE KINASE; ADIPONECTIN; APOLIPOPROTEIN B; CERAMIDE; CYTOKINE; FATTY ACID; GLYCEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN RECEPTOR SUBSTRATE; INSULIN SENSITIZING AGENT; INTERLEUKIN 18; INTERLEUKIN 6; LIPOPROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3 KINASE; PIOGLITAZONE; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN P70; PROTEIN TYROSINE PHOSPHATASE; S6 KINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

ADIPOSE TISSUE; AGING; ALCOHOL ABUSE; ANTIVIRAL THERAPY; ARTICLE; AUTOPHOSPHORYLATION; BLOODSTREAM INFECTION; BODY MASS; CARDIOVASCULAR DISEASE; CELL MEMBRANE; CHOLESTEROL BLOOD LEVEL; CHRONIC LIVER DISEASE; DISEASE SEVERITY; ENDOPLASMIC RETICULUM; FATTY LIVER; FOLLOW UP; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GOLD STANDARD; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERTRIGLYCERIDEMIA; HYPOBETALIPOPROTEINEMIA; IN VITRO STUDY; INSULIN RESISTANCE; KIDNEY TRANSPLANTATION; LIFE CYCLE; LIPID BLOOD LEVEL; LIPID METABOLISM; LIPOGENESIS; LIPOLYSIS; LIVER CELL; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FIBROSIS; LIVER TRANSPLANTATION; METABOLIC SYNDROME X; MORBIDITY; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; OBESITY; ORAL GLUCOSE TOLERANCE TEST; OUTCOME ASSESSMENT; PANDEMIC; PATHOPHYSIOLOGY; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; STEATOSIS; UPREGULATION; VIRUS CELL INTERACTION;

CARCINOMA, HEPATOCELLULAR; CATHETER ABLATION; CHEMOEMBOLIZATION, THERAPEUTIC; EARLY DETECTION OF CANCER; HEPATECTOMY; HUMANS; LIVER NEOPLASMS; LIVER TRANSPLANTATION; MOLECULAR TARGETED THERAPY;

EID: 84856472292     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(12)60009-9     Document Type: Article

References (181)

1. J Ferlay, HR Shin, F Bray, D Forman, C Mathers, DM Parkin Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 Int J Cancer 127 2010 2893 2917
2. FX Bosch, J Ribes, M Diaz, R Cleries Primary liver cancer: worldwide incidence and trends Gastroenterology 127 2004 S5 S16
3. DY But, CL Lai, MF Yuen Natural history of hepatitis-related hepatocellular carcinoma World J Gastroenterol 14 2008 1652 1656 (Pubitemid 351493370)
4. G Fattovich, L Brollo, G Giustina, F Noventa, P Pontisso, A Alberti et al. Natural history and prognostic factors for chronic hepatitis type B Gut 32 1991 294 298
5. HI Yang, SN Lu, YF Liaw, SL You, CA Sun, LY Wang et al. Hepatitis B e antigen and the risk of hepatocellular carcinoma N Engl J Med 347 2002 168 174
6. HI Yang, M Sherman, J Su, PJ Chen, YF Liaw, UH Iloeje et al. Nomograms for risk of hepatocellular carcinoma in patients with chronic hepatitis B virus infection J Clin Oncol 28 2010 2437 2444
7. GS Qian, RK Ross, MC Yu, JM Yuan, YT Gao, BE Henderson et al. A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China Cancer Epidemiol Biomarkers Prev 3 1994 3 10 (Pubitemid 24172514)
8. G Fattovich, G Giustina, F Degos, F Tremolada, G Diodati, P Almasio et al. Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of 384 patients Gastroenterology 112 1997 463 472 (Pubitemid 27078833)
9. F Degos, C Christidis, N Ganne-Carrie, JP Farmachidi, C Degott, C Guettier et al. Hepatitis C virus related cirrhosis: time to occurrence of hepatocellular carcinoma and death Gut 47 2000 131 136 (Pubitemid 30430422)
10. AS Lok, LB Seeff, TR Morgan, AM di Bisceglie, RK Sterling, TM Curto et al. Incidence of hepatocellular carcinoma and associated risk factors in hepatitis C-related advanced liver disease Gastroenterology 136 2009 138 148
11. J Bruix, M Sherman Management of hepatocellular carcinoma: an update Hepatology 53 2011 1020 1022
12. RS O'Shea, S Dasarathy, AJ McCullough Alcoholic liver disease Hepatology 51 2010 307 328
13. RF Velazquez, M Rodriguez, CA Navascues, A Linares, R Perez, NG Sotorrios et al. Prospective analysis of risk factors for hepatocellular carcinoma in patients with liver cirrhosis Hepatology 37 2003 520 527 (Pubitemid 36258772)
14. MM Hassan, LY Hwang, CJ Hatten, M Swaim, D Li, JL Abbruzzese et al. Risk factors for hepatocellular carcinoma: synergism of alcohol with viral hepatitis and diabetes mellitus Hepatology 36 2002 1206 1213 (Pubitemid 35253437)
15. EE Calle, C Rodriguez, K Walker-Thurmond, MJ Thun Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults N Engl J Med 348 2003 1625 1638 (Pubitemid 36459468)
16. HB El-Serag, T Tran, JE Everhart Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma Gastroenterology 126 2004 460 468 (Pubitemid 38182303)
17. A Erez, OA Shchelochkov, SE Plon, F Scaglia, B Lee Insights into the pathogenesis and treatment of cancer from inborn errors of metabolism Am J Hum Genet 88 2011 402 421
18. WE Naugler, T Sakurai, S Kim, S Maeda, K Kim, AM Elsharkawy et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production Science 317 2007 121 124 (Pubitemid 47056470)
19. JM Croswell, DF Ransohoff, BS Kramer Principles of cancer screening: lessons from history and study design issues Semin Oncol 37 2010 202 215
20. A Singal, ML Volk, A Waljee, R Salgia, P Higgins, MA Rogers et al. Meta-analysis: surveillance with ultrasound for early-stage hepatocellular carcinoma in patients with cirrhosis Aliment Pharmacol Ther 30 2009 37 47
21. DJ Brenner, EJ Hall Computed tomography-an increasing source of radiation exposure N Engl J Med 357 2007 2277 2284 (Pubitemid 350190758)
22. M Sherman Serological surveillance for hepatocellular carcinoma: time to quit J Hepatol 52 2010 614 615
23. AM Di Bisceglie, RK Sterling, RT Chung, JE Everhart, JL Dienstag, HL Bonkovsky et al. Serum alpha-fetoprotein levels in patients with advanced hepatitis C: results from the HALT-C Trial J Hepatol 43 2005 434 441 (Pubitemid 41111424)
24. IC Lee, YH Huang, CC Chan, TI Huo, CJ Chu, CR Lai et al. Correlation between clinical indication for treatment and liver histology in HBeAg-negative chronic hepatitis B: a novel role of alpha-fetoprotein Liver Int 30 2010 1161 1168
25. M Miyazawa, T Torii, Y Toshimitsu, N Kamizasa, T Suzuki, N Shinozuka et al. Alpha-fetoprotein-producing clear cell carcinoma of the extrahepatic bile ducts J Clin Gastroenterol 40 2006 555 557 (Pubitemid 44318142)
26. X Liu, Y Cheng, W Sheng, H Lu, Y Xu, Z Long et al. Clinicopathologic features and prognostic factors in alpha-fetoprotein-producing gastric cancers: analysis of 104 cases J Surg Oncol 102 2010 249 255
27. H Okuda, T Nakanishi, K Takatsu, A Saito, N Hayashi, K Watanabe et al. Measurement of serum levels of des-gamma-carboxy prothrombin in patients with hepatocellular carcinoma by a revised enzyme immunoassay kit with increased sensitivity Cancer 85 1999 812 818 (Pubitemid 29077557)
28. JA Marrero, GL Su, W Wei, D Emick, HS Conjeevaram, RJ Fontana et al. Desgamma carboxyprothrombin can differentiate hepatocellular carcinoma from nonmalignant chronic liver disease in american patients Hepatology 37 2003 1114 1121 (Pubitemid 36538688)
29. M Capurro, IR Wanless, M Sherman, G Deboer, W Shi, E Miyoshi et al. Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma Gastroenterology 125 2003 89 97 (Pubitemid 36799110)
30. JA Marrero, Z Feng, Y Wang, MH Nguyen, AS Befeler, LR Roberts et al. Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma Gastroenterology 137 2009 110 118
31. BH Zhang, BH Yang, ZY Tang Randomized controlled trial of screening for hepatocellular carcinoma J Cancer Res Clin Oncol 130 2004 417 422
32. L Bolondi, S Sofia, S Siringo, S Gaiani, A Casali, G Zironi et al. Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysis Gut 48 2001 251 259 (Pubitemid 32141852)
33. A Sangiovanni, E Del Ninno, P Fasani, C De Fazio, G Ronchi, R Romeo et al. Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance Gastroenterology 126 2004 1005 1014 (Pubitemid 38451172)
34. V Santi, F Trevisani, A Gramenzi, A Grignaschi, F Mirici-Cappa, P Del Poggio et al. Semiannual surveillance is superior to annual surveillance for the detection of early hepatocellular carcinoma and patient survival J Hepatol 53 2010 291 297
35. JC Trinchet, C Chaffaut, V Bourcier, F Degos, J Henrion, H Fontaine et al. Ultrasonographic surveillance of hepatocellular carcinoma in cirrhosis: A randomized trial comparing 3- and 6-month periodicities Hepatology 54 6 2011 1987 1997
36. M Kojiro, T Roskams Early hepatocellular carcinoma and dysplastic nodules Semin Liver Dis 25 2005 133 142 (Pubitemid 40781066)
37. Pathologic diagnosis of early hepatocellular carcinoma: a report of the international consensus group for hepatocellular neoplasia Hepatology 49 2009 658 664
38. L Di Tommaso, A Destro, JY Seok, E Balladore, L Terracciano, A Sangiovanni et al. The application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma J Hepatol 50 2009 746 754
39. A Forner, R Vilana, C Ayuso, L Bianchi, M Sole, JR Ayuso et al. Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: Prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma Hepatology 47 2008 97 104 (Pubitemid 351171046)
40. Vilana R, Forner A, Bianchi L, Garcia-Criado A, Rimola J, de Lope CR, et al. Intrahepatic peripheral cholangiocarcinoma in cirrhosis patients may display a vascular pattern similar to hepatocellular carcinoma on contrast-enhanced ultrasound. Hepatology; 51:2020-2029.
41. KA McGlynn, RE Tarone, HB El-Serag A comparison of trends in the incidence of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in the United States Cancer Epidemiol Biomarkers Prev 15 2006 1198 1203
42. SA Khan, SD Taylor-Robinson, MB Toledano, A Beck, P Elliott, HC Thomas Changing international trends in mortality rates for liver, biliary and pancreatic tumours J Hepatol 37 2002 806 813 (Pubitemid 35404220)
43. RM Wolfort, PW Papillion, RH Turnage, DL Lillien, MR Ramaswamy, GB Zibari Role of FDG-PET in the evaluation and staging of hepatocellular carcinoma with comparison of tumor size, AFP level, and histologic grade Int Surg 95 2010 67 75
44. ARM Forner, C Rodriguez de Lope, J Bruix Current Strategy for Staging and Treatment: the BCLC Update and Future Prospects Semin Liver Dis 30 2010 61 74
45. U Cillo, A Vitale, F Grigoletto, F Farinati, A Brolese, G Zanus et al. Prospective validation of the Barcelona Clinic Liver Cancer staging system J Hepatol 44 2006 723 731
46. A Grieco, M Pompili, G Caminiti, L Miele, M Covino, B Alfei et al. Prognostic factors for survival in patients with early-intermediate hepatocellular carcinoma undergoing non-surgical therapy: comparison of Okuda, CLIP, and BCLC staging systems in a single Italian centre Gut 54 2005 411 418 (Pubitemid 40299100)
47. JA Marrero, RJ Fontana, A Barrat, F Askari, HS Conjeevaram, GL Su et al. Prognosis of hepatocellular carcinoma: comparison of 7 staging systems in an American cohort Hepatology 41 2005 707 716 (Pubitemid 40462931)
48. J Bruix, M Sherman, JM Llovet, M Beaugrand, R Lencioni, AK Burroughs et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver J Hepatol 35 2001 421 430 (Pubitemid 32844200)
49. JM Llovet, MI Real, X Montana, R Planas, S Coll, J Aponte et al. Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial Lancet 359 2002 1734 1739 (Pubitemid 34607087)
50. JM Llovet, S Ricci, V Mazzaferro, P Hilgard, E Gane, JF Blanc et al. Sorafenib in advanced hepatocellular carcinoma N Engl J Med 359 2008 378 390
51. M Kojiro Pathology of Hepatocellular 2006 Wiley-Blackwell Carcinoma
52. S Arii, Y Yamaoka, S Futagawa, K Inoue, K Kobayashi, M Kojiro et al. Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan Hepatology 32 2000 1224 1229
53. D Choi, HK Lim, H Rhim, YS Kim, WJ Lee, SW Paik et al. Percutaneous radiofrequency ablation for early-stage hepatocellular carcinoma as a first-line treatment: long-term results and prognostic factors in a large singleinstitution series Eur Radiol 17 2007 684 692
54. SM Lin, CJ Lin, CC Lin, CW Hsu, YC Chen Randomised controlled trial comparing percutaneous radiofrequency thermal ablation, percutaneous ethanol injection, and percutaneous acetic acid injection to treat hepatocellular carcinoma of 3 cm or less Gut 54 2005 1151 1156
55. T Livraghi, F Meloni, M Di Stasi, E Rolle, L Solbiati, C Tinelli et al. Sustained complete response and complications rates after radiofrequency ablation of very early hepatocellular carcinoma in cirrhosis: Is resection still the treatment of choice? Hepatology 47 2008 82 89 (Pubitemid 351171044)
56. M Omata, R Tateishi, H Yoshida, S Shiina Treatment of hepatocellular carcinoma by percutaneous tumor ablation methods: Ethanol injection therapy and radiofrequency ablation Gastroenterology 127 2004 S159 S166
57. M Sala, JM Llovet, R Vilana, L Bianchi, M Sole, C Ayuso et al. Initial response to percutaneous ablation predicts survival in patients with hepatocellular carcinoma Hepatology 40 2004 1352 1360 (Pubitemid 39657009)
58. S Shiina, T Teratani, S Obi, S Sato, R Tateishi, T Fujishima et al. A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma Gastroenterology 129 2005 122 130 (Pubitemid 41002049)
59. R Tateishi, S Shiina, T Teratani, S Obi, S Sato, Y Koike et al. Percutaneous radiofrequency ablation for hepatocellular carcinoma. An analysis of 1000 cases Cancer 103 2005 1201 1209 (Pubitemid 40328091)
60. JS Lee, IS Chu, J Heo, DF Calvisi, Z Sun, T Roskams et al. Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling Hepatology 40 2004 667 676 (Pubitemid 39265589)
61. S Boyault, DS Rickman, A de Reynies, C Balabaud, S Rebouissou, E Jeannot et al. Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets Hepatology 45 2007 42 52 (Pubitemid 46144363)
62. Y Hoshida, SM Nijman, M Kobayashi, JA Chan, JP Brunet, DY Chiang et al. Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma Cancer Res 69 2009 7385 7392
63. JM Llovet, AM Di Bisceglie, J Bruix, BS Kramer, R Lencioni, AX Zhu et al. Design and endpoints of clinical trials in hepatocellular carcinoma J Natl Cancer Inst 100 2008 698 711
64. CM Lo, H Ngan, WK Tso, CL Liu, CM Lam, RT Poon et al. Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma Hepatology 35 2002 1164 1171 (Pubitemid 34454013)
65. K Malagari, E Alexopoulou, K Chatzimichail, B Hall, J Koskinas, S Ryan et al. Transcatheter chemoembolization in the treatment of HCC in patients not eligible for curative treatments: midterm results of doxorubicin-loaded DC bead Abdom Imaging 33 2008 512 519
66. M Reig, M Burrel, A Forner, M Barrufet, C Rodríguez de Lope, M Varela et al. Resultados actuales de la quimioembolización en pacientes con carcinoma hepatocelular. Impacto en práctica clinica e investigatión Gastroenterol Hepatol 34 2011 139 209
67. K Takayasu, S Arii, I Ikai, M Kudo, Y Matsuyama, M Kojiro et al. Overall survival after transarterial lipiodol infusion chemotherapy with or without embolization for unresectable hepatocellular carcinoma: propensity score analysis AJR Am J Roentgenol 194 2010 830 837
68. G Cabibbo, M Enea, M Attanasio, J Bruix, A Craxi, C Camma A meta-analysis of survival rates of untreated patients in randomized clinical trials of hepatocellular carcinoma Hepatology 51 2010 1274 1283
69. M Makuuchi, K Sano The surgical approach to HCC: our progress and results in Japan Liver Transpl 10 2004 S46 S52
70. JM Llovet, M Schwartz, V Mazzaferro Resection and liver transplantation for hepatocellular carcinoma Semin Liver Dis 25 2005 181 200 (Pubitemid 40781071)
71. O Farges, J Belghiti, R Kianmanesh, JM Regimbeau, R Santoro, V Vilgrain et al. Portal vein embolization before right hepatectomy: prospective clinical trial Ann Surg 237 2003 208 217 (Pubitemid 38173248)
72. S Arii, S Tanaka, Y Mitsunori, N Nakamura, A Kudo, N Noguchi et al. Surgical strategies for hepatocellular carcinoma with special reference to anatomical hepatic resection and intraoperative contrast-enhanced ultrasonography Oncology 78 Suppl 1 2010 125 130
73. S Eguchi, T Kanematsu, S Arii, M Okazaki, K Okita, M Omata et al. Comparison of the outcomes between an anatomical subsegmentectomy and a non-anatomical minor hepatectomy for single hepatocellular carcinomas based on a Japanese nationwide survey Surgery 143 2008 469 475 (Pubitemid 351406380)
74. T Wakai, Y Shirai, J Sakata, K Kaneko, PV Cruz, K Akazawa et al. Anatomic resection independently improves long-term survival in patients with T1-T2 hepatocellular carcinoma Ann Surg Oncol 14 2007 1356 1365 (Pubitemid 46536830)
75. H Imamura, Y Matsuyama, E Tanaka, T Ohkubo, K Hasegawa, S Miyagawa et al. Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy J Hepatol 38 2003 200 207 (Pubitemid 36169630)
76. K Hasegawa, N Kokudo, H Imamura, Y Matsuyama, T Aoki, M Minagawa et al. Prognostic impact of anatomic resection for hepatocellular carcinoma Ann Surg 242 2005 252 259 (Pubitemid 41033442)
77. M Shi, RP Guo, XJ Lin, YQ Zhang, MS Chen, CQ Zhang et al. Partial hepatectomy with wide versus narrow resection margin for solitary hepatocellular carcinoma: a prospective randomized trial Ann Surg 245 2007 36 43 (Pubitemid 46035433)
78. RT Poon, ST Fan, IO Ng, CM Lo, CL Liu, J Wong Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma Cancer 89 2000 500 507 (Pubitemid 30640096)
79. S Roayaie, IN Blume, SN Thung, M Guido, MI Fiel, S Hiotis et al. A system of classifying microvascular invasion to predict outcome after resection in patients with hepatocellular carcinoma Gastroenterology 137 2009 850 855
80. G Belli, C Fantini, A D'Agostino, L Cioffi, S Langella, N Russolillo et al. Laparoscopic versus open liver resection for hepatocellular carcinoma in patients with histologically proven cirrhosis: short- and middle-term results Surg Endosc 21 2007 2004 2011 (Pubitemid 47620293)
81. YM Zhou, WY Shao, YF Zhao, DH Xu, B Li Meta-analysis of laparoscopic versus open resection for hepatocellular carcinoma Dig Dis Sci 56 7 2011 1937 1943
82. G D'Amico, G Garcia-Tsao, L Pagliaro Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies J Hepatol 44 2006 217 231 (Pubitemid 41772537)
83. JM Llovet, J Fuster, J Bruix Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation Hepatology 30 1999 1434 1440
84. T Ishizawa, K Hasegawa, T Aoki, M Takahashi, Y Inoue, K Sano et al. Neither multiple tumors nor portal hypertension are surgical contraindications for hepatocellular carcinoma Gastroenterology 134 2008 1908 1916 (Pubitemid 351783260)
85. M Makuuchi, N Kokudo Clinical practice guidelines for hepatocellular carcinoma: the first evidence based guidelines from Japan World J Gastroenterol 12 2006 828 829 (Pubitemid 43380776)
86. BK Kim, KH Han, YN Park, MS Park, KS Kim, JS Choi et al. Prediction of microvascular invasion before curative resection of hepatocellular carcinoma J Surg Oncol 97 2008 246 252
87. K Shirabe, S Itoh, T Yoshizumi, Y Soejima, A Taketomi, S Aishima et al. The predictors of microvascular invasion in candidates for liver transplantation with hepatocellular carcinoma-with special reference to the serum levels of des-gamma-carboxy prothrombin J Surg Oncol 95 2007 235 240
88. H Chandarana, E Robinson, CH Hajdu, L Drozhinin, JS Babb, B Taouli Microvascular invasion in hepatocellular carcinoma: is it predictable with pretransplant MRI? AJR Am J Roentgenol 196 2011 1083 1089
89. M Kaibori, M Ishizaki, K Matsui, AH Kwon Predictors of microvascular invasion before hepatectomy for hepatocellular carcinoma J Surg Oncol 102 2010 462 468
90. S Eguchi, M Takatsuki, M Hidaka, A Soyama, T Tomonaga, I Muraoka et al. Predictor for histological microvascular invasion of hepatocellular carcinoma: a lesson from 229 consecutive cases of curative liver resection World J Surg 34 2010 1034 1038
91. Y Nagano, H Shimada, K Takeda, M Ueda, K Matsuo, K Tanaka et al. Predictive factors of microvascular invasion in patients with hepatocellular carcinoma larger than 5 cm World J Surg 32 2008 2218 2222
92. NF Esnaola, GY Lauwers, NQ Mirza, DM Nagorney, D Doherty, I Ikai et al. Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplantation J Gastrointest Surg 6 2002 224 232; discussion 232 (Pubitemid 40433575)
93. PV Korita, T Wakai, Y Shirai, Y Matsuda, J Sakata, X Cui et al. Overexpression of osteopontin independently correlates with vascular invasion and poor prognosis in patients with hepatocellular carcinoma Hum Pathol 39 2008 1777 1783
94. PP McHugh, J Gilbert, S Vera, A Koch, D Ranjan, R Gedaly Alpha-fetoprotein and tumour size are associated with microvascular invasion in explanted livers of patients undergoing transplantation with hepatocellular carcinoma HPB (Oxford) 12 2010 56 61
95. B Mínguez, Y Hoshida, A Villanueva, S Toffanin, L Cabellos, S Thung et al. Gene-expression signature of vascular invasion in hepatocellular carcinoma J Hepatol 55 6 2011 1325 1331
96. J Huang, L Yan, Z Cheng, H Wu, L Du, J Wang et al. A randomized trial comparing radiofrequency ablation and surgical resection for HCC conforming to the Milan criteria Ann Surg 252 2010 903 912
97. MS Chen, JQ Li, Y Zheng, RP Guo, HH Liang, YQ Zhang et al. A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma Ann Surg 243 2006 321 328 (Pubitemid 43327762)
98. I Bargellini, R Sacco, E Bozzi, M Bertini, B Ginanni, A Romano et al. Transarterial chemoembolization in very early and early-stage hepatocellular carcinoma patients excluded from curative treatment: A prospective cohort study Eur J Radiol 2011
99. YK Cho, JK Kim, WT Kim, JW Chung Hepatic resection versus radiofrequency ablation for very early stage hepatocellular carcinoma: a Markov model analysis Hepatology 51 2010 1284 1290
100. M Sala, J Fuster, JM Llovet, M Navasa, M Sole, M Varela et al. High pathological risk of recurrence after surgical resection for hepatocellular carcinoma: an indication for salvage liver transplantation Liver Transpl 10 2004 1294 1300 (Pubitemid 39406086)
101. D Fuks, S Dokmak, V Paradis, M Diouf, F Durand, J Belghiti Benefit of initial resection of hepatocellular carcinoma followed by transplantation in case of recurrence: An intention-to-treat analysis Hepatology 55 2012 132 140
102. Y Hoshida, A Villanueva, M Kobayashi, J Peix, DY Chiang, A Camargo et al. Gene expression in fixed tissues and outcome in hepatocellular carcinoma N Engl J Med 359 2008 1995 2004
103. J Subramanian, R Simon What should physicians look for in evaluating prognostic gene-expression signatures? Nat Rev Clin Oncol 7 2010 327 334
104. WP Zhou, EC Lai, AJ Li, SY Fu, JP Zhou, ZY Pan et al. A prospective, randomized, controlled trial of preoperative transarterial chemoembolization for resectable large hepatocellular carcinoma Ann Surg 249 2009 195 202
105. WY Lau, TW Leung, SK Ho, M Chan, D Machin, J Lau et al. Adjuvant intra-arterial iodine-131-labelled lipiodol for resectable hepatocellular carcinoma: a prospective randomised trial Lancet 353 1999 797 801 (Pubitemid 29110405)
106. T Takayama, T Sekine, M Makuuchi, S Yamasaki, T Kosuge, J Yamamoto et al. Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial Lancet 356 2000 802 807
107. Y Muto, H Moriwaki, M Ninomiya, S Adachi, A Saito, KT Takasaki et al. Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma Prevention Study Group N Engl J Med 334 1996 1561 1567 (Pubitemid 26177483)
108. S Breitenstein, D Dimitroulis, H Petrowsky, MA Puhan, B Mullhaupt, PA Clavien Systematic review and meta-analysis of interferon after curative treatment of hepatocellular carcinoma in patients with viral hepatitis Br J Surg 96 2009 975 981
109. Y Miyake, A Takaki, Y Iwasaki, K Yamamoto Meta-analysis: interferon-alpha prevents the recurrence after curative treatment of hepatitis C virus-related hepatocellular carcinoma J Viral Hepat 17 2010 287 292
110. YC Shen, C Hsu, LT Chen, CC Cheng, FC Hu, AL Cheng Adjuvant interferon therapy after curative therapy for hepatocellular carcinoma (HCC): a metaregression approach J Hepatol 52 2010 889 894
111. S Iwatsuki, TE Starzl, DG Sheahan, I Yokoyama, AJ Demetris, S Todo et al. Hepatic resection versus transplantation for hepatocellular carcinoma Ann Surg 214 1991 221 228 discussion 228-229.
112. H Bismuth, L Chiche, R Adam, D Castaing Surgical treatment of hepatocellular carcinoma in cirrhosis: liver resection or transplantation? Transplant Proc 25 1993 1066 1067 (Pubitemid 23078899)
113. S Iwatsuki, RD Gordon, BW Shaw Jr., TE Starzl Role of liver transplantation in cancer therapy Ann Surg 202 1985 401 407 (Pubitemid 16248052)
114. V Mazzaferro, E Regalia, R Doci, S Andreola, A Pulvirenti, F Bozzetti et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis N Engl J Med 334 1996 693 699 (Pubitemid 26079803)
115. JM Llovet, J Bruix, J Fuster, A Castells, JC Garcia-Valdecasas, L Grande et al. Liver transplantation for small hepatocellular carcinoma: the tumor-nodemetastasis classification does not have prognostic power Hepatology 27 1998 1572 1577 (Pubitemid 28264681)
116. S Jonas, WO Bechstein, T Steinmuller, M Herrmann, C Radke, T Berg et al. Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis Hepatology 33 2001 1080 1086 (Pubitemid 32378206)
117. FY Yao, L Ferrell, NM Bass, JJ Watson, P Bacchetti, A Venook et al. Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival Hepatology 33 2001 1394 1403 (Pubitemid 32496976)
118. R Adam, D Azoulay, D Castaing, R Eshkenazy, G Pascal, K Hashizume et al. Liver resection as a bridge to transplantation for hepatocellular carcinoma on cirrhosis: a reasonable strategy? Ann Surg 238 2003 508 518 discussion 518-509.
119. JW Marsh, I Dvorchik Liver organ allocation for hepatocellular carcinoma: are we sure? Liver Transpl 9 2003 693 696 (Pubitemid 36874455)
120. U Cillo, A Vitale, M Bassanello, P Boccagni, A Brolese, G Zanus et al. Liver transplantation for the treatment of moderately or well-differentiated hepatocellular carcinoma Ann Surg 239 2004 150 159 (Pubitemid 38176347)
121. T Decaens, F Roudot-Thoraval, S Hadni-Bresson, C Meyer, J Gugenheim, F Durand et al. Impact of UCSF criteria according to pre- and post-OLT tumor features: analysis of 479 patients listed for HCC with a short waiting time Liver Transpl 12 2006 1761 1769 (Pubitemid 44911801)
122. JP Duffy, A Vardanian, E Benjamin, M Watson, DG Farmer, RM Ghobrial et al. Liver transplantation criteria for hepatocellular carcinoma should be expanded: a 22-year experience with 467 patients at UCLA Ann Surg 246 2007 502 509 discussion 509-511. (Pubitemid 47312148)
123. N Onaca, GL Davis, RM Goldstein, LW Jennings, GB Klintmalm Expanded criteria for liver transplantation in patients with hepatocellular carcinoma: a report from the International Registry of Hepatic Tumors in Liver Transplantation Liver Transpl 13 2007 391 399 (Pubitemid 46444468)
124. JI Herrero, B Sangro, F Pardo, J Quiroga, M Inarrairaegui, F Rotellar et al. Liver transplantation in patients with hepatocellular carcinoma across Milan criteria Liver Transpl 14 2008 272 278 (Pubitemid 351425478)
125. C Toso, J Trotter, A Wei, DL Bigam, S Shah, J Lancaster et al. Total tumor volume predicts risk of recurrence following liver transplantation in patients with hepatocellular carcinoma Liver Transpl 14 2008 1107 1115
126. V Mazzaferro, JM Llovet, R Miceli, S Bhoori, M Schiavo, L Mariani et al. Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis Lancet Oncol 10 2009 35 43
127. S Roayaie, JS Frischer, SH Emre, TM Fishbein, PA Sheiner, M Sung et al. Long-term results with multimodal adjuvant therapy and liver transplantation for the treatment of hepatocellular carcinomas larger than 5 centimeters Ann Surg 235 2002 533 539 (Pubitemid 34258353)
128. EA Pomfret, K Washburn, C Wald, MA Nalesnik, D Douglas, M Russo et al. Report of a national conference on liver allocation in patients with hepatocellular carcinoma in the United States Liver Transpl 16 2010 262 278
129. FY Yao, NM Bass, B Nikolai, R Merriman, TJ Davern, R Kerlan et al. A follow-up analysis of the pattern and predictors of dropout from the waiting list for liver transplantation in patients with hepatocellular carcinoma: implications for the current organ allocation policy Liver Transpl 9 2003 684 692 (Pubitemid 36874454)
130. YK Maddala, L Stadheim, JC Andrews, LJ Burgart, CB Rosen, WK Kremers et al. Drop-out rates of patients with hepatocellular cancer listed for liver transplantation: outcome with chemoembolization Liver Transpl 10 2004 449 455 (Pubitemid 38380323)
131. RB Freeman, EB Edwards, AM Harper Waiting list removal rates among patients with chronic and malignant liver diseases Am J Transplant 6 2006 1416 1421 (Pubitemid 44030324)
132. K Washburn, E Edwards, A Harper, R Freeman Hepatocellular carcinoma patients are advantaged in the current liver transplant allocation system Am J Transplant 10 2010 1643 1648
133. NA Terrault, ML Shiffman, AS Lok, S Saab, L Tong, RS Brown Jr. et al. Outcomes in hepatitis C virus-infected recipients of living donor vs. deceased donor liver transplantation Liver Transpl 13 2007 122 129 (Pubitemid 46099981)
134. A Rimola, JM Llovet, M Navasa, J Bruix, MC Londono, J Fuster et al. Applicability of adult-to-adult living donor liver transplantation J Hepatol 43 2005 104 109 (Pubitemid 40805280)
135. RM Ghobrial, CE Freise, JF Trotter, L Tong, AO Ojo, JH Fair et al. Donor morbidity after living donation for liver transplantation Gastroenterology 135 2008 468 476
136. S Kaihara, T Kiuchi, M Ueda, F Oike, Y Fujimoto, K Ogawa et al. Living-donor liver transplantation for hepatocellular carcinoma Transplantation 75 2003 S37 S40
137. S Todo, H Furukawa Living donor liver transplantation for adult patients with hepatocellular carcinoma: experience in Japan Ann Surg 240 2004 451 459 discussion 459-461.
138. GE Gondolesi, S Roayaie, L Munoz, L Kim-Schluger, T Schiano, TM Fishbein et al. Adult living donor liver transplantation for patients with hepatocellular carcinoma: extending UNOS priority criteria Ann Surg 239 2004 142 149 (Pubitemid 38176346)
139. T Ito, Y Takada, M Ueda, H Haga, Y Maetani, F Oike et al. Expansion of selection criteria for patients with hepatocellular carcinoma in living donor liver transplantation Liver Transpl 13 2007 1637 1644
140. S Jonas, J Mittler, A Pascher, G Schumacher, T Theruvath, C Benckert et al. Living donor liver transplantation of the right lobe for hepatocellular carcinoma in cirrhosis in a European center Liver Transpl 13 2007 896 903 (Pubitemid 46939443)
141. RA Fisher, LM Kulik, CE Freise, AS Lok, TH Shearon, RS Brown Jr. et al. Hepatocellular carcinoma recurrence and death following living and deceased donor liver transplantation Am J Transplant 7 2007 1601 1608 (Pubitemid 46776250)
142. FP Sarasin, PE Majno, JM Llovet, J Bruix, G Mentha, A Hadengue Living donor liver transplantation for early hepatocellular carcinoma: A life-expectancy and cost-effectiveness perspective Hepatology 33 2001 1073 1079 (Pubitemid 32378205)
143. JM Llovet, X Mas, JJ Aponte, J Fuster, M Navasa, E Christensen et al. Cost effectiveness of adjuvant therapy for hepatocellular carcinoma during the waiting list for liver transplantation Gut 50 2002 123 128 (Pubitemid 34028315)
144. P Majno, E Giostra, G Mentha Management of hepatocellular carcinoma on the waiting list before liver transplantation: time for controlled trials? Liver Transpl 13 2007 S27 S35
145. PS Kamath, RH Wiesner, M Malinchoc, W Kremers, TM Therneau, CL Kosberg et al. A model to predict survival in patients with end-stage liver disease Hepatology 33 2001 464 470 (Pubitemid 32119037)
146. RB Freeman Jr., RH Wiesner, A Harper, SV McDiarmid, J Lake, E Edwards et al. The new liver allocation system: moving toward evidence-based transplantation policy Liver Transpl 8 2002 851 858 (Pubitemid 35012300)
147. R Lencioni Loco-regional treatment of hepatocellular carcinoma Hepatology 52 2010 762 773
148. RA Lencioni, HP Allgaier, D Cioni, M Olschewski, P Deibert, L Crocetti et al. Small hepatocellular carcinoma in cirrhosis: randomized comparison of radio-frequency thermal ablation versus percutaneous ethanol injection Radiology 228 2003 235 240 (Pubitemid 36736097)
149. F Brunello, A Veltri, P Carucci, E Pagano, G Ciccone, P Moretto et al. Radiofrequency ablation versus ethanol injection for early hepatocellular carcinoma: A randomized controlled trial Scand J Gastroenterol 43 2008 727 735 (Pubitemid 351868714)
150. T Livraghi, SN Goldberg, S Lazzaroni, F Meloni, L Solbiati, GS Gazelle Small hepatocellular carcinoma: treatment with radio-frequency ablation versus ethanol injection Radiology 210 1999 655 661 (Pubitemid 29124024)
151. G Germani, M Pleguezuelo, K Gurusamy, T Meyer, G Isgro, AK Burroughs Clinical outcomes of radiofrequency ablation, percutaneous alcohol and acetic acid injection for hepatocelullar carcinoma: a meta-analysis J Hepatol 52 2010 380 388
152. YK Cho, JK Kim, MY Kim, H Rhim, JK Han Systematic review of randomized trials for hepatocellular carcinoma treated with percutaneous ablation therapies Hepatology 49 2009 453 459
153. A Orlando, G Leandro, M Olivo, A Andriulli, M Cottone Radiofrequency thermal ablation vs. percutaneous ethanol injection for small hepatocellular carcinoma in cirrhosis: meta-analysis of randomized controlled trials Am J Gastroenterol 104 2009 514 524
154. G Cabibbo, A Craxi Needle track seeding following percutaneous procedures for hepatocellular carcinoma World J Hepatol 1 2009 62 66
155. R Lencioni, D Cioni, L Crocetti, C Franchini, CD Pina, J Lera et al. Early-stage hepatocellular carcinoma in patients with cirrhosis: long-term results of percutaneous image-guided radiofrequency ablation Radiology 234 2005 961 967 (Pubitemid 40250844)
156. DY Lin, YF Liaw, TY Lee, CM Lai Hepatic arterial embolization in patients with unresectable hepatocellular carcinoma-a randomized controlled trial Gastroenterology 94 1988 453 456
157. Groupe d'Etude et de Traitement du Carcinome Hepatocellulaire A comparison of lipiodol chemoembolization and conservative treatment for unresectable hepatocellular carcinoma N Engl J Med 332 1995 1256 1261
158. J Bruix, JM Llovet, A Castells, X Montana, C Bru, MC Ayuso et al. Transarterial embolization versus symptomatic treatment in patients with advanced hepatocellular carcinoma: results of a randomized, controlled trial in a single institution Hepatology 27 1998 1578 1583 (Pubitemid 28264682)
159. G Pelletier, M Ducreux, F Gay, M Luboinski, H Hagege, T Dao et al. Treatment of unresectable hepatocellular carcinoma with lipiodol chemoembolization: a multicenter randomized trial. Groupe CHC J Hepatol 29 1998 129 134 (Pubitemid 28307992)
160. JM Llovet, J Bruix Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival Hepatology 37 2003 429 442 (Pubitemid 36152543)
161. C Camma, F Schepis, A Orlando, M Albanese, L Shahied, F Trevisani et al. Transarterial chemoembolization for unresectable hepatocellular carcinoma: meta-analysis of randomized controlled trials Radiology 224 2002 47 54 (Pubitemid 34680374)
162. RS Oliveri, J Wetterslev, C Gluud Transarterial (chemo)embolisation for unresectable hepatocellular carcinoma Cochrane Database Syst Rev 3 2011 CD004787
163. L Marelli, R Stigliano, C Triantos, M Senzolo, E Cholongitas, N Davies et al. Transarterial therapy for hepatocellular carcinoma: which technique is more effective? A systematic review of cohort and randomized studies Cardiovasc Intervent Radiol 30 2007 6 25 (Pubitemid 44900485)
164. M Varela, MI Real, M Burrel, A Forner, M Sala, M Brunet et al. Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics] Hepatol 46 2007 474 481 (Pubitemid 46201723)
165. J Lammer, K Malagari, T Vogl, F Pilleul, A Denys, A Watkinson et al. Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: Results of the PRECISION V Study Cardiovasc Intervent Radiol 33 1 2010 41 52
166. JW Chung, JH Park, JK Han, BI Choi, MC Han, HS Lee et al. Hepatic tumors: predisposing factors for complications of transcatheter oily chemoembolization Radiology 198 1996 33 40
167. AO Chan, MF Yuen, CK Hui, WK Tso, CL Lai A prospective study regarding the complications of transcatheter intraarterial lipiodol chemoembolization in patients with hepatocellular carcinoma Cancer 94 2002 1747 1752 (Pubitemid 34241113)
168. A Forner, C Ayuso, M Varela, J Rimola, AJ Hessheimer, CR de Lope et al. Evaluation of tumor response after locoregional therapies in hepatocellular carcinoma: are response evaluation criteria in solid tumors reliable? Cancer 115 2009 616 623
169. R Lencioni, JM Llovet Modified RECIST (mRECIST) assessment for hepatocellular carcinoma Semin Liver Dis 30 2010 52 60
170. R Salem, RJ Lewandowski, MF Mulcahy, A Riaz, RK Ryu, S Ibrahim et al. Radioembolization for hepatocellular carcinoma using Yttrium-90 microspheres: a comprehensive report of long-term outcomes Gastroenterology 138 2010 52 64
171. R Salem, RJ Lewandowski, L Kulik, E Wang, A Riaz, RK Ryu et al. Radioembolization results in longer time-to-progression and reduced toxicity compared with chemoembolization in patients with hepatocellular carcinoma Gastroenterology 140 2011 497 507 e492
172. LM Kulik, BI Carr, MF Mulcahy, RJ Lewandowski, B Atassi, RK Ryu et al. Safety and efficacy of 90Y radiotherapy for hepatocellular carcinoma with and without portal vein thrombosis Hepatology 47 2008 71 81 (Pubitemid 351171043)
173. D Hanahan, RA Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
174. AL Cheng, YK Kang, Z Chen, CJ Tsao, S Qin, JS Kim et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial Lancet Oncol 10 2009 25 34
175. DJ Jonker, CJ O'Callaghan, CS Karapetis, JR Zalcberg, D Tu, HJ Au et al. Cetuximab for the treatment of colorectal cancer N Engl J Med 357 2007 2040 2048 (Pubitemid 350106711)
176. A Sandler, R Gray, MC Perry, J Brahmer, JH Schiller, A Dowlati et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer N Engl J Med 355 2006 2542 2550 (Pubitemid 44917502)
177. JM Llovet, J Bruix Molecular targeted therapies in hepatocellular carcinoma Hepatology 48 2008 1312 1327
178. A Villanueva, JM Llovet Targeted therapies for hepatocellular carcinoma Gastroenterology 140 2011 1410 1426
179. AM Di Bisceglie, ML Shiffman, GT Everson, KL Lindsay, JE Everhart, EC Wright et al. Prolonged therapy of advanced chronic hepatitis C with low-dose peginterferon N Engl J Med 359 2008 2429 2441
180. J Bruix, T Poynard, M Colombo, E Schiff, K Burak, EJ Heathcote et al. Maintenance therapy with peginterferon alfa-2b does not prevent hepatocellular carcinoma in cirrhotic patients with chronic hepatitis C Gastroenterology 140 7 2011 1990 1999
181. A Forner, JM Llovet, J Bruix Hepatocellular carcinoma Lancet 2012 in press.