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Volumn 72, Issue 13, 2012, Pages 3414-3423

CD44s regulates the TGF-β-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

HERMES ANTIGEN; MESSENGER RNA; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UVOMORULIN; VIMENTIN;

EID: 84863603551     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-0299     Document Type: Article
Times cited : (192)

References (48)
  • 1
    • 80053088189 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • El-Serag HB. Hepatocellular carcinoma. N Engl J Med 2011;365:1118-27.
    • (2011) N Engl J Med , vol.365 , pp. 1118-1127
    • El-Serag, H.B.1
  • 2
    • 0035876047 scopus 로고    scopus 로고
    • Clinicopathologic features of long-term survivors and disease-free survivors after resection of hepatocellular carcinoma: A study of a prospective cohort
    • Poon RT, Ng IO, Fan ST, Lai EC, Lo CM, Liu CL, et al. Clinicopathologic features of long-term survivors and disease-free survivors after resection of hepatocellular carcinoma: a study of a prospective cohort. J Clin Oncol 2001;19:3037-44. (Pubitemid 32565441)
    • (2001) Journal of Clinical Oncology , vol.19 , Issue.12 , pp. 3037-3044
    • Poon, R.T.-P.1    Ng, I.O.-L.2    Fan, S.-T.3    Lai, E.C.-S.4    Lo, C.-M.5    Liu, C.-L.6    Wong, J.7
  • 3
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 2009;9:265-73.
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 4
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009;139:871-90.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 5
    • 72949120827 scopus 로고    scopus 로고
    • Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma
    • Yang MH, Chen CL, Chau GY, Chiou SH, Su CW, Chou TY, et al. Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma. Hepatology 2009;50:1464-74.
    • (2009) Hepatology , vol.50 , pp. 1464-1474
    • Yang, M.H.1    Chen, C.L.2    Chau, G.Y.3    Chiou, S.H.4    Su, C.W.5    Chou, T.Y.6
  • 7
    • 77951176116 scopus 로고    scopus 로고
    • CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients
    • Chen L, Chan TH, Yuan YF, Hu L, Huang J, Ma S, et al. CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients. J Clin Invest 2010;120:1178-91.
    • (2010) J Clin Invest , vol.120 , pp. 1178-1191
    • Chen, L.1    Chan, T.H.2    Yuan, Y.F.3    Hu, L.4    Huang, J.5    Ma, S.6
  • 10
    • 79953042645 scopus 로고    scopus 로고
    • CD44: Can a cancer-initiating cell profit from an abundantly expressed molecule?
    • Zoller M. CD44: can a cancer-initiating cell profit from an abundantly expressed molecule? Nat Rev Cancer 2011;11:254-67.
    • (2011) Nat Rev Cancer , vol.11 , pp. 254-267
    • Zoller, M.1
  • 11
    • 79952370202 scopus 로고    scopus 로고
    • The cancer stem cell: Premises, promises and challenges
    • Clevers H. The cancer stem cell: premises, promises and challenges. Nat Med 2011;17:313-9.
    • (2011) Nat Med , vol.17 , pp. 313-319
    • Clevers, H.1
  • 17
    • 79958265710 scopus 로고    scopus 로고
    • Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
    • Scheel C, Eaton EN, Li SH, Chaffer CL, Reinhardt F, Kah KJ, et al. Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell 2011;145:926-40.
    • (2011) Cell , vol.145 , pp. 926-940
    • Scheel, C.1    Eaton, E.N.2    Li, S.H.3    Chaffer, C.L.4    Reinhardt, F.5    Kah, K.J.6
  • 18
    • 79952528125 scopus 로고    scopus 로고
    • CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth
    • Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H, et al. CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. Cancer Cell 2011;19:387-400.
    • (2011) Cancer Cell , vol.19 , pp. 387-400
    • Ishimoto, T.1    Nagano, O.2    Yae, T.3    Tamada, M.4    Motohara, T.5    Oshima, H.6
  • 19
    • 63449126920 scopus 로고    scopus 로고
    • MicroRNA-21 regulates the proliferation and invasion in esophageal squamous cell carcinoma
    • Hiyoshi Y, Kamohara H, Karashima R, Sato N, Imamura Y, Nagai Y, et al. MicroRNA-21 regulates the proliferation and invasion in esophageal squamous cell carcinoma. Clin Cancer Res 2009;15:1915-22.
    • (2009) Clin Cancer Res , vol.15 , pp. 1915-1922
    • Hiyoshi, Y.1    Kamohara, H.2    Karashima, R.3    Sato, N.4    Imamura, Y.5    Nagai, Y.6
  • 20
    • 79955820751 scopus 로고    scopus 로고
    • Hepatic stellate cells accelerate the malignant behavior of cholangiocarcinoma cells
    • Okabe H, Beppu T, Hayashi H, Ishiko T, Masuda T, Otao R, et al. Hepatic stellate cells accelerate the malignant behavior of cholangiocarcinoma cells. Ann Surg Oncol 2011;18:1175-84.
    • (2011) Ann Surg Oncol , vol.18 , pp. 1175-1184
    • Okabe, H.1    Beppu, T.2    Hayashi, H.3    Ishiko, T.4    Masuda, T.5    Otao, R.6
  • 21
    • 0035710746 scopus 로고    scopus 로고
    • -DeltaDeltaCT method
    • DOI 10.1006/meth.2001.1262
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402-8. (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 23
    • 34249322375 scopus 로고    scopus 로고
    • Staging of hepatocellular carcinoma: Assessment of the Japanese TNM and AJCC/UICC TNM systems in a cohort of 13,772 patients in Japan
    • DOI 10.1097/01.sla.0000254368.65878.da, PII 0000065820070600000012
    • Minagawa M, Ikai I, Matsuyama Y,Yamaoka Y, Makuuchi M. Staging of hepatocellular carcinoma: assessment of the Japanese TNM and AJCC/UICC TNM systems in a cohort of 13,772 patients in Japan. Ann Surg 2007;245:909-22. (Pubitemid 46809293)
    • (2007) Annals of Surgery , vol.245 , Issue.6 , pp. 909-922
    • Minagawa, M.1    Ikai, I.2    Matsuyama, Y.3    Yamaoka, Y.4    Makuuchi, M.5
  • 26
    • 0033962047 scopus 로고    scopus 로고
    • Protein expression of CD44 (standard and variant isoforms) in hepatocellular carcinoma: Relationships with tumor grade, clinicopathologic parameters, p53 expression, and patient survival
    • Endo K, Terada T. Protein expression of CD44 (standard and variant isoforms) in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, p53 expression, and patient survival. J Hepatol 2000;32:78-84. (Pubitemid 30039450)
    • (2000) Journal of Hepatology , vol.32 , Issue.1 , pp. 78-84
    • Endo, K.1    Terada, T.2
  • 27
    • 77949593175 scopus 로고    scopus 로고
    • CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis
    • Ishimoto T, Oshima H, Oshima M, Kai K, Torii R, Masuko T, et al. CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis. Cancer Sci 2010;101:673-8.
    • (2010) Cancer Sci , vol.101 , pp. 673-678
    • Ishimoto, T.1    Oshima, H.2    Oshima, M.3    Kai, K.4    Torii, R.5    Masuko, T.6
  • 28
    • 54249132606 scopus 로고    scopus 로고
    • The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma
    • Chiba T, Miyagi S, Saraya A, Aoki R, Seki A, Morita Y, et al. The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma. Cancer Res 2008;68:7742-9.
    • (2008) Cancer Res , vol.68 , pp. 7742-7749
    • Chiba, T.1    Miyagi, S.2    Saraya, A.3    Aoki, R.4    Seki, A.5    Morita, Y.6
  • 29
    • 60449087921 scopus 로고    scopus 로고
    • EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    • Yamashita T, Ji J, Budhu A, Forgues M, Yang W, Wang HY, et al. EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology 2009;136:1012-24.
    • (2009) Gastroenterology , vol.136 , pp. 1012-1024
    • Yamashita, T.1    Ji, J.2    Budhu, A.3    Forgues, M.4    Yang, W.5    Wang, H.Y.6
  • 30
    • 34249980343 scopus 로고    scopus 로고
    • Identification and Characterization of Tumorigenic Liver Cancer Stem/Progenitor Cells
    • DOI 10.1053/j.gastro.2007.04.025, PII S001650850700786X
    • Ma S, Chan KW, Hu L, Lee TK, Wo JY, Ng IO, et al. Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology 2007;132:2542-56. (Pubitemid 46890873)
    • (2007) Gastroenterology , vol.132 , Issue.7 , pp. 2542-2556
    • Ma, S.1    Chan, K.2    Hu, L.3    Lee, T.K.4    Wo, J.Y.5    Ng, I.O.6    Zheng, B.7    Guan, X.8
  • 32
    • 77952896646 scopus 로고    scopus 로고
    • TGFbeta signalling: A complex web in cancer progression
    • Ikushima H, Miyazono K. TGFbeta signalling: a complex web in cancer progression. Nat Rev Cancer 2010;10:415-24.
    • (2010) Nat Rev Cancer , vol.10 , pp. 415-424
    • Ikushima, H.1    Miyazono, K.2
  • 33
    • 43949140575 scopus 로고    scopus 로고
    • Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells
    • DOI 10.1002/hep.22201
    • Fransvea E, Angelotti U, Antonaci S, Giannelli G. Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells. Hepatology 2008;47:1557-66. (Pubitemid 351702739)
    • (2008) Hepatology , vol.47 , Issue.5 , pp. 1557-1566
    • Fransvea, E.1    Angelotti, U.2    Antonaci, S.3    Giannelli, G.4
  • 34
    • 0028959114 scopus 로고
    • Transforming growth factor-beta 1 (TGF-beta 1) and TGF-beta 1 receptors in normal, cirrhotic, and neoplastic human livers
    • Bedossa P, Peltier E, Terris B, Franco D, Poynard T. Transforming growth factor-beta 1 (TGF-beta 1) and TGF-beta 1 receptors in normal, cirrhotic, and neoplastic human livers. Hepatology 1995;21:760-6.
    • (1995) Hepatology , vol.21 , pp. 760-766
    • Bedossa, P.1    Peltier, E.2    Terris, B.3    Franco, D.4    Poynard, T.5
  • 38
    • 0031557680 scopus 로고    scopus 로고
    • Regulation of endothelial CD44 expression and endothelium-tumour cell interactions by hepatocyte growth factor/scatter factor
    • DOI 10.1006/bbrc.1997.6388
    • Hiscox S, Jiang WG. Regulation of endothelial CD44 expression and endothelium-tumour cell interactions by hepatocyte growth factor/scatter factor. Biochem Biophys Res Commun 1997;233:1-5. (Pubitemid 27215897)
    • (1997) Biochemical and Biophysical Research Communications , vol.233 , Issue.1 , pp. 1-5
    • Hiscox, S.1    Jiang, W.G.2
  • 39
    • 0035674835 scopus 로고    scopus 로고
    • Heparan sulfate enhances invasion by human colon carcinoma cell lines through expression of CD44 variant exon 3
    • Kuniyasu H, Oue N, Tsutsumi M, Tahara E, Yasui W. Heparan sulfate enhances invasion by human colon carcinoma cell lines through expression of CD44 variant exon 3. Clin Cancer Res 2001;7:4067-72. (Pubitemid 34044629)
    • (2001) Clinical Cancer Research , vol.7 , Issue.12 , pp. 4067-4072
    • Kuniyasu, H.1    Oue, N.2    Tsutsumi, M.3    Tahara, E.4    Yasui, W.5
  • 40
    • 0030743447 scopus 로고    scopus 로고
    • The expression of the CD44 variant exon 6 is associated with lymph node metastasis in non-small cell lung cancer
    • Miyoshi T, Kondo K, Hino N, Uyama T, Monden Y. The expression of the CD44 variant exon 6 is associated with lymph node metastasis in non-small cell lung cancer. Clin Cancer Res 1997;3:1289-97. (Pubitemid 27362389)
    • (1997) Clinical Cancer Research , vol.3 , Issue.8 , pp. 1289-1297
    • Miyoshi, T.1    Kondo, K.2    Hino, N.3    Uyama, T.4    Monden, Y.5
  • 41
    • 79952227361 scopus 로고    scopus 로고
    • CD44 splice isoformswitching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression
    • Brown RL, Reinke LM, Damerow MS, Perez D, Chodosh LA, Yang J, et al. CD44 splice isoformswitching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. J Clin Invest 2011;121:1064-74.
    • (2011) J Clin Invest , vol.121 , pp. 1064-1074
    • Brown, R.L.1    Reinke, L.M.2    Damerow, M.S.3    Perez, D.4    Chodosh, L.A.5    Yang, J.6
  • 42
    • 41149157649 scopus 로고    scopus 로고
    • TGFbeta Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4
    • DOI 10.1016/j.cell.2008.01.046, PII S0092867408002110
    • Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR, et al. TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 2008;133:66-77. (Pubitemid 351442989)
    • (2008) Cell , vol.133 , Issue.1 , pp. 66-77
    • Padua, D.1    Zhang, X.H.-F.2    Wang, Q.3    Nadal, C.4    Gerald, W.L.5    Gomis, R.R.6    Massague, J.7
  • 44
    • 81255205399 scopus 로고    scopus 로고
    • Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis
    • Labelle M, Begum S, Hynes RO. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 2011;20:576-90.
    • (2011) Cancer Cell , vol.20 , pp. 576-590
    • Labelle, M.1    Begum, S.2    Hynes, R.O.3
  • 45
    • 78649986150 scopus 로고    scopus 로고
    • TGF-beta receptor inhibitors target the CD44(high)/Id1(high) glioma-initiating cell population in human glioblastoma
    • Anido J, Saez-Borderias A, Gonzalez-Junca A, Rodon L, Folch G, Carmona MA, et al. TGF-beta receptor inhibitors target the CD44(high)/Id1(high) glioma-initiating cell population in human glioblastoma. Cancer Cell 2010;18:655-68.
    • (2010) Cancer Cell , vol.18 , pp. 655-668
    • Anido, J.1    Saez-Borderias, A.2    Gonzalez-Junca, A.3    Rodon, L.4    Folch, G.5    Carmona, M.A.6
  • 46
    • 48749122568 scopus 로고    scopus 로고
    • Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression
    • Hoot KE, Lighthall J, Han G, Lu SL, Li A, Ju W, et al. Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression. J Clin Invest 2008;118:2722-32.
    • (2008) J Clin Invest , vol.118 , pp. 2722-2732
    • Hoot, K.E.1    Lighthall, J.2    Han, G.3    Lu, S.L.4    Li, A.5    Ju, W.6
  • 47
    • 68249092353 scopus 로고    scopus 로고
    • A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition
    • Vincent T, Neve EP, Johnson JR, Kukalev A, Rojo F, Albanell J, et al. A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition. Nat Cell Biol 2009;11:943-50.
    • (2009) Nat Cell Biol , vol.11 , pp. 943-950
    • Vincent, T.1    Neve, E.P.2    Johnson, J.R.3    Kukalev, A.4    Rojo, F.5    Albanell, J.6
  • 48
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • Chaffer CL, Weinberg RA. A perspective on cancer cell metastasis. Science 2011;331:1559-64.
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.