MicroRNAs and liver disease

Translational Research

Volumn 157, Issue 4, 2011, Pages 241-252

  Kerr, Thomas A ^a   Korenblat, Kevin M ^a   Davidson, Nicholas O ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

3 hydroxy 3 methyl glutaryl CoA; A disintegrin and metalloprotease 17; ADAM17; alanine aminotransferase; ALT; antisense oligonucleotide; ASO; aspartate aminotransferase; aST; FAS; fatty acid synthase; HCC; HCV; heme oxygenase 1; hepatitis C virus; hepatocellular carcinoma; HMG CoA; HO 1; internal ribosomal entry site; IRES; LNA; locked nucleic acid; mammalian target of rapamycin; microRNA; miRNA; miRNA recognition element; MRE; mTOR; NAFLD; NASH; NCR; non alcoholic steatohepatitis; nonalcoholic fatty liver disease; noncoding region; PCR; polymerase chain reaction; reverse transcription PCR; RISC; RNA interference; RNA induced silencing complex; RNAi; RT PCR; single nucleotide polymorphism; SNP; SREBP 1c; sterol regulatory element binding protein 1 c; untranslated region; UTR

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTISENSE OLIGONUCLEOTIDE; ASPARTATE AMINOTRANSFERASE; CD133 ANTIGEN; EXPORTIN 5; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MICRORNA; RNA INDUCED SILENCING COMPLEX;

3' UNTRANSLATED REGION; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE ACID METABOLISM; BIOGENESIS; CELL MIGRATION; CELL STRAIN HEPG2; HEPATITIS B; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; INTERNAL RIBOSOME ENTRY SITE; LIVER CELL CARCINOMA; MICROARRAY ANALYSIS; NONALCOHOLIC FATTY LIVER; NONHUMAN; OUTCOME ASSESSMENT; POSTTRANSCRIPTIONAL GENE SILENCING; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVIEW; RNA CLEAVAGE; RNA DEGRADATION; RNA REPLICATION; RNA STABILITY; RNA TRANSLATION;

EID: 79952792083     PISSN: 19315244     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trsl.2011.01.008     Document Type: Review

References (83)

1. A. Fire, S. Xu, and M.K. Montgomery Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature 391 1998 806 811 (Pubitemid 28099681)
2. D.P. Bartel MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 2004 281 297
3. J. Krutzfeldt, and M. Stoffel MicroRNAs: a new class of regulatory genes affecting metabolism Cell Metab 4 2006 9 12 (Pubitemid 43942256)
4. L.F. Lu, and A. Liston MicroRNA in the immune system, microRNA as an immune system Immunology 127 2009 291 298
5. T. Kawamata, and Y. Tomari Making RISC Trends Biochem Sci 35 2010 368 376
6. L. Ding, and M. Han GW182 family proteins are crucial for microRNA-mediated gene silencing Trends Cell Biol 17 2007 411 416 (Pubitemid 47375102)
7. R.C. Lee, R.L. Feinbaum, V. Ambros, and C. The elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 Cell 75 1993 843 854 (Pubitemid 24014542)
8. S. Griffiths-Jones The microRNA registry Nucleic Acids Res 32 2004 D109 D111
9. C.G. Liu, G.A. Calin, S. Volinia, and C.M. Croce MicroRNA expression profiling using microarrays Nat Protoc 3 2008 563 578 (Pubitemid 351516752)
10. M. Thomas, J. Lieberman, and A. Lal Desperately seeking microRNA targets Nat Struct Mol Biol 17 2010 1169 1174
11. J. Krutzfeldt, N. Rajewsky, and R. Braich Silencing of microRNAs in vivo with "antagomirs." Nature 438 2005 685 689
12. C. Esau, S. Davis, and S.F. Murray miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting Cell Metab 3 2006 87 98
13. J. Chang, E. Nicolas, and D. Marks miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1 RNA Biol 1 2004 106 113
14. M. Girard, E. Jacquemin, A. Munnich, S. Lyonnet, and A. Henrion-Caude miR-122, a paradigm for the role of microRNAs in the liver J Hepatol 48 2008 648 656
15. J. Elmen, M. Lindow, and A. Silahtaroglu Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver Nucleic Acids Res 36 2008 1153 1162 (Pubitemid 351330933)
16. O. Cheung, P. Puri, and C. Eicken Nonalcoholic steatohepatitis is associated with altered hepatic microRNA expression Hepatology 48 2008 1810 1820
17. D. Gatfield, G. Le Martelot, and C.E. Vejnar Integration of microRNA miR-122 in hepatic circadian gene expression Genes Dev 23 2009 1313 1326
18. K.H. Song, T. Li, E. Owsley, and J.Y. Chiang A putative role of microRNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes J Lipid Res 51 2010 2223 2233
19. D.M. Baker, S.L. Wang, D.J. Bell, C.A. Drevon, and R.A. Davis One or more labile proteins regulate the stability of chimeric mRNAs containing the 3′-untranslated region of cholesterol-7alpha-hydroxylase mRNA J Biol Chem 275 2000 19985 19991 (Pubitemid 30441606)
20. N. Nakanishi, Y. Nakagawa, and N. Tokushige The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice Biochem Biophys Res Commun 385 2009 492 496
21. D. Iliopoulos, K. Drosatos, Y. Hiyama, I.J. Goldberg, and V.I. Zannis MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism J Lipid Res 51 2010 1513 1523
22. S.H. Najafi-Shoushtari, F. Kristo, and Y. Li MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis Science 328 2010 1566 1569
23. I. Gerin, L.A. Clerbaux, and O. Haumont Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation J Biol Chem 285 2010 33652 33661
24. T.J. Marquart, R.M. Allen, D.S. Ory, and A. Baldan miR-33 links SREBP-2 induction to repression of sterol transporters Proc Natl Acad Sci U S A 107 2010 12228 12232
25. C.L. Jopling, M. Yi, A.M. Lancaster, S.M. Lemon, and P. Sarnow Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA Science 309 2005 1577 1581 (Pubitemid 41266486)
26. C.L. Jopling, S. Schutz, and P. Sarnow Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome Cell Host Microbe 4 2008 77 85 (Pubitemid 351944051)
27. R.K. Jangra, M. Yi, and S.M. Lemon Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122 J Virol 84 2010 6615 6625
28. R.T. Marquez, S. Bandyopadhyay, and E.B. Wendlandt Correlation between microRNA expression levels and clinical parameters associated with chronic hepatitis C viral infection in humans Lab Invest 90 2010 1727 1736
29. R.E. Lanford, E.S. Hildebrandt-Eriksen, and A. Petri Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection Science 327 2010 198 201
30. D.D. Young, C.M. Connelly, C. Grohmann, and A. Deiters Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma J Am Chem Soc 132 2010 7976 7981
31. Y. Murakami, H.H. Aly, A. Tajima, I. Inoue, and K. Shimotohno Regulation of the hepatitis C virus genome replication by miR-199a J Hepatol 50 2009 453 460
32. W. Hou, Q. Tian, J. Zheng, and H.L. Bonkovsky MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins Hepatology 51 2010 1494 1504
33. J. Huang, Y. Wang, Y. Guo, and S. Sun Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1 Hepatology 52 2010 60 70
34. Y. Murakami, T. Yasuda, and K. Saigo Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues Oncogene 25 2006 2537 2545
35. H. Kutay, S. Bai, and J. Datta Downregulation of miR-122 in the rodent and human hepatocellular carcinomas J Cell Biochem 99 2006 671 678 (Pubitemid 44521987)
36. L. Gramantieri, M. Ferracin, and F. Fornari Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma Cancer Res 67 2007 6092 6099 (Pubitemid 47037488)
37. W.C. Tsai, P.W. Hsu, and T.C. Lai MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma Hepatology 49 2009 1571 1582
38. P. Pineau, S. Volinia, and K. McJunkin miR-221 overexpression contributes to liver tumorigenesis Proc Natl Acad Sci U S A 107 2010 264 269
39. Y.S. Huang, Y. Dai, and X.F. Yu Microarray analysis of microRNA expression in hepatocellular carcinoma and non-tumorous tissues without viral hepatitis J Gastroenterol Hepatol 23 2008 87 94 (Pubitemid 350265207)
40. Q.H. Ye, L.X. Qin, and M. Forgues Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning Nat Med 9 2003 416 423 (Pubitemid 36460075)
41. S. Ma, K.H. Tang, and Y.P. Chan miR-130b promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1 Cell Stem Cell 7 2010 694 707
42. W. Li, L. Xie, and X. He Diagnostic and prognostic implications of microRNAs in human hepatocellular carcinoma Int J Cancer 123 2008 1616 1622
43. J. Ji, J. Shi, and A. Budhu MicroRNA expression, survival, and response to interferon in liver cancer N Engl J Med 361 2009 1437 1447
44. K. Wang, S. Zhang, and B. Marzolf Circulating microRNAs, potential biomarkers for drug-induced liver injury Proc Natl Acad Sci U S A 106 2009 4402 4407
45. O.F. Laterza, L. Lim, and P.W. Garrett-Engele Plasma microRNAs as sensitive and specific biomarkers of tissue injury Clin Chem 55 2009 1977 1983
46. A.C. Fan, M.M. Goldrick, and J. Ho A quantitative PCR method to detect blood microRNAs associated with tumorigenesis in transgenic mice Mol Cancer 7 2008 74
47. J. Xu, C. Wu, and X. Che Circulating microRNAs, miR-21, miR-122, and miR-223, in patients with hepatocellular carcinoma or chronic hepatitis Mol Carcinog 50 2011 136 142
48. S. Sekine, R. Ogawa, and R. Ito Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis Gastroenterology 136 2009 2304 2315
49. N.J. Hand, Z.R. Master, J. Le Lay, and J.R. Friedman Hepatic function is preserved in the absence of mature microRNAs Hepatology 49 2009 618 626
50. E. Bernstein, S.Y. Kim, and M.A. Carmell Dicer is essential for mouse development Nat Genet 35 2003 215 217 (Pubitemid 37363172)
51. R. Whittaker, P.A. Loy, and E. Sisman Identification of microRNAs that control lipid droplet formation and growth in hepatocytes via high-content screening J Biomol Screen 15 2010 798 805
52. K.J. Rayner, Y. Suarez, and A. Davalos miR-33 contributes to the regulation of cholesterol homeostasis Science 328 2010 1570 1573
53. M. Estep, D. Armistead, and N. Hossain Differential expression of miRNAs in the visceral adipose tissue of patients with non-alcoholic fatty liver disease Aliment Pharmacol Ther 32 2010 487 497
54. M.G. Ghany, D.B. Strader, D.L. Thomas, and L.B. Seeff Diagnosis, management, and treatment of hepatitis C: an update Hepatology 49 2009 1335 1374
55. T. Suzuki, H. Aizaki, K. Murakami, I. Shoji, and T. Wakita Molecular biology of hepatitis C virus J Gastroenterol 42 2007 411 423 (Pubitemid 47050003)
56. T.V. Pestova, I.N. Shatsky, S.P. Fletcher, R.J. Jackson, and C.U. Hellen A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs Genes Dev 12 1998 67 83 (Pubitemid 28083659)
57. V. Lohmann, F. Korner, and J. Koch Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line Science 285 1999 110 113 (Pubitemid 29307577)
58. A.J. Hamilton, and D.C. Baulcombe A species of small antisense RNA in posttranscriptional gene silencing in plants Science 286 1999 950 952
59. G. Randall, M. Panis, and J.D. Cooper Cellular cofactors affecting hepatitis C virus infection and replication Proc Natl Acad Sci U S A 104 2007 12884 12889 (Pubitemid 47255249)
60. J.I. Henke, D. Goergen, and J. Zheng MicroRNA-122 stimulates translation of hepatitis C virus RNA EMBO J 27 2008 3300 3310
61. J. Chang, J.T. Guo, and D. Jiang Liver-specific microRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells J Virol 82 2008 8215 8223
62. E. Lehmann, W.H. El-Tantawy, and M. Ocker The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response Hepatology 51 2010 398 404
63. Y. Shan, J. Zheng, R.W. Lambrecht, and H.L. Bonkovsky Reciprocal effects of microRNA-122 on expression of heme oxygenase-1 and hepatitis C virus genes in human hepatocytes Gastroenterology 133 2007 1166 1174 (Pubitemid 47494462)
64. T. Date, T. Kato, and M. Miyamoto Genotype 2a hepatitis C virus subgenomic replicon can replicate in HepG2 and IMY-N9 cells J Biol Chem 279 2004 22371 22376 (Pubitemid 38679434)
65. T. Kato, T. Date, and M. Miyamoto Nonhepatic cell lines HeLa and 293 support efficient replication of the hepatitis C virus genotype 2a subgenomic replicon J Virol 79 2005 592 596 (Pubitemid 39648411)
66. Q. Zhu, J.T. Guo, and C. Seeger Replication of hepatitis C virus subgenomes in nonhepatic epithelial and mouse hepatoma cells J Virol 77 2003 9204 9210 (Pubitemid 37011017)
67. M. Sarasin-Filipowicz, J. Krol, I. Markiewicz, M.H. Heim, and W. Filipowicz Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy Nat Med 15 2009 31 33
68. I.M. Pedersen, G. Cheng, and S. Wieland Interferon modulation of cellular microRNAs as an antiviral mechanism Nature 449 2007 919 922 (Pubitemid 47598616)
69. L. Qiu, H. Fan, and W. Jin miR-122-induced down-regulation of HO-1 negatively affects miR-122-mediated suppression of HBV Biochem Biophys Res Commun 398 2010 771 777
70. R. Garzon, G. Marcucci, and C.M. Croce Targeting microRNAs in cancer: rationale, strategies and challenges Nat Rev Drug Discov 9 2010 775 789
71. G.A. Calin, C. Sevignani, and C.D. Dumitru Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers Proc Natl Acad Sci U S A 101 2004 2999 3004 (Pubitemid 38327724)
72. G.A. Calin, C.D. Dumitru, and M. Shimizu Frequent deletions and down-regulation of microRNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia Proc Natl Acad Sci U S A 99 2002 15524 15529 (Pubitemid 35403967)
73. A. van den Berg, B.J. Kroesen, and K. Kooistra High expression of B-cell receptor inducible gene BIC in all subtypes of Hodgkin lymphoma Genes Chromosomes Cancer 37 2003 20 28 (Pubitemid 36417918)
74. M.Z. Michael, S.M. O'Connor, N.G. van Holst Pellekaan, G.P. Young, and R.J. James Reduced accumulation of specific microRNAs in colorectal neoplasia Mol Cancer Res 1 2003 882 891 (Pubitemid 37288707)
75. T. Xu, Y. Zhu, and Q.K. Wei A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma Carcinogenesis 29 2008 2126 2131
76. A. Budhu, H.L. Jia, and M. Forgues Identification of metastasis-related microRNAs in hepatocellular carcinoma Hepatology 47 2008 897 907 (Pubitemid 351449681)
77. S. Ma, K.W. Chan, and L. Hu Identification and characterization of tumorigenic liver cancer stem/progenitor cells Gastroenterology 132 2007 2542 2556 (Pubitemid 46890873)
78. S. Ma, T.K. Lee, B.J. Zheng, K.W. Chan, and X.Y. Guan CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway Oncogene 27 2008 1749 1758 (Pubitemid 351380265)
79. S. Shimizu, T. Takehara, and H. Hikita The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma J Hepatol 52 2010 698 704
80. J. Kota, R.R. Chivukula, and K.A. O'Donnell Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model Cell 137 2009 1005 1017
81. J. Ozer, M. Ratner, M. Shaw, W. Bailey, and S. Schomaker The current state of serum biomarkers of hepatotoxicity Toxicology 245 2008 194 205
82. M. Miyamoto, M. Yanai, and S. Ookubo Detection of cell-free, liver-specific mRNAs in peripheral blood from rats with hepatotoxicity: a potential toxicological biomarker for safety evaluation Toxicol Sci 106 2008 538 545
83. B.A. Wetmore, D.J. Brees, and R. Singh Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury Hepatology 51 2010 2127 2139