Synthesis of 1H-1,2,3-triazole linked β-lactam-isatin bi-functional hybrids and preliminary analysis of in vitro activity against the protozoal parasite Trichomonas vaginalis

European Journal of Medicinal Chemistry

Volumn 63, Issue , 2013, Pages 897-906

  Raj, Raghu ^a   Singh, Pardeep ^a   Haberkern, Nathan T ^b   Faucher, Ryan M ^b   Patel, Neal ^b   Land, Kirkwood M ^b   Kumar, Vipan ^a  

^a GURU NANAK DEV UNIVERSITY   (India)

^b UNIVERSITY OF THE PACIFIC   (United States)

Author keywords

Lactam isatin conjugates; 1H 1,2,3 Triazole; Click chemistry; Cytotoxicity; Trichomonas vaginalis

Indexed keywords

1 [ 1 ( 1 BENZYL 2 OXO 4 STYRYLAZETIDIN 3 YL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 1 [ 1 ( 1 BENZYL 2 OXO 4 STYRYLAZETIDIN 3 YL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 5 CHLORO 1H INDOLE 2,3 DIONE; 1 [ 1 ( 1 BENZYL 2 OXO 4 STYRYLAZETIDIN 3 YL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 5 FLUORO 1H INDOLE 2,3 DIONE; 1 [ 1 ( 1 CYCLOHEXYL 2 OXO 4 STYRYLAZETIDIN 3 YL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 1 [ 1 ( 1 CYCLOHEXYL 2 OXO 4 STYRYLAZETIDIN 3 YL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 5 FLUORO 1H INDOLE 2,3 DIONE; 1 [ 1 ( 1 CYCLOHEXYL 2 OXO 4 STYRYLAZETIDIN 3 YL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 5 METHYL 1H INDOLE 2,3 DIONE; 1 [ 1 ( 2 OXO 2 PHENYL 4 STYRYLAZETIDIN 3 YL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 1 [ 1 ( 2 OXO 4 STYRYL 1,4 TOLYLAZETIDIN 3 YL) 1H [1,2,3]TRIAZOL 4YLMETHYL] 1H INDOLE 2,3 DIONE; 1 [ 1 [ 1 ( 4 CHLOROPHENYL) 2 OXO 4 STYRYLAZETIDIN 3 YL] 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 1 [ 1 [ 1 ( 4 FLUOROPHENYL) 2 OXO 4 STYRYLAZETIDIN 3 YL] 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 1,2,3 TRIAZOLE DERIVATIVE; 5 BROMO 1 [ 1 ( 1 CYCLOHEXYL 2 OXO 4 STYRYLAZETIDIN 3 YL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 5 BROMO 1 [ 1 ( 2 OXO 1 PHENYL 4 STYRYLAZETIDIN 3 YL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 5 BROMO 1 [ 1 [ 1 ( 4 FLUOROPHENYL) 2 OXO 4 STYRYLAZETIDIN 3 YL] 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 5 CHLORO 1 [ 1 ( 1 CYCLOHEXYL 2 OXO 4 STYRYLAZETIDIN 3 YL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 5 CHLORO 1 [ 1 ( 2 OXO 1 PHENYL 4 STYRYLAZETIDIN 3 YL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 5 CHLORO 1 [ 1 ( 2 OXO 4 STYRYL 1,4 TOLYLAZETIDIN 3 YL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 5 CHLORO 1 [ 1 [ 1 ( 4 CHLOROPHENYL) 2 OXO 4 STYRYLAZETIDIN 3 YL] 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 5 CHLORO 1 [ 1 [ 1 ( 4 FLUOROPHENYL) 2 OXO 4 STYRYLAZETIDIN 3 YL] 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 5 FLUORO 1 [ 1 ( 2 OXO 1 PHENYL 4 STYRYLAZETIDIN 3 YL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 5 FLUORO 1 [ 1 ( 2 OXO 4 STYRYL 1,4 TOLYLAZETIDIN 3 YL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 5 FLUORO 1 [ 1 [ 1 ( 4 FLUOROPHENYL) 2 OXO 4 STYRYLAZETIDIN 3 YL] 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 5 METHYL 1 [ 1 ( 2 OXO 1 PHENYL 4 STYRYLAZETIDIN 3 YL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; ANTITRICHOMONAL AGENT; BETA LACTAM DERIVATIVE; COPPER; ISATIN; METRONIDAZOLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CATALYST; CELL CULTURE; CLICK CHEMISTRY; CONTROLLED STUDY; CYTOTOXICITY; DRUG CONJUGATION; DRUG SYNTHESIS; GROWTH INHIBITION; IC 50; IN VITRO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRICHOMONAS VAGINALIS;

ANIMALS; ANTIPROTOZOAL AGENTS; BETA-LACTAMS; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; INHIBITORY CONCENTRATION 50; ISATIN; MODELS, CHEMICAL; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; TRICHOMONAS VAGINALIS;

EID: 84877034891     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.03.019     Document Type: Article

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