Combinatorial optimization of isatin-β-thiosemicarbazones as anti-poxvirus agents

Journal of Medicinal Chemistry

Volumn 48, Issue 8, 2005, Pages 3045-3050

  Pirrung, Michael C ^a,c   Pansare, Sunil V ^a,d   Das Sarma, Koushik ^a   Keith, Kathy A ^b   Kern, Earl R ^b  

^a DUKE UNIVERSITY   (United States)

^b UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; ISATIN 3 THIOSEMICARBAZONE; ISATIN DERIVATIVE; N AMINOMETHYLISATIN BETA THIOSEMICARBAZONE; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; COMBINATORIAL CHEMISTRY; CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; MONKEYPOX; MONKEYPOX VIRUS; POXVIRUS; POXVIRUS INFECTION; SMALLPOX; TRANSCRIPTION TERMINATION; VACCINIA VIRUS; VIRUS INFECTION; VIRUS INHIBITION;

ANTIVIRAL AGENTS; CELL LINE; COMBINATORIAL CHEMISTRY TECHNIQUES; COWPOX VIRUS; HUMANS; ISATIN; ORTHOPOXVIRUS; PLAQUE ASSAY; STRUCTURE-ACTIVITY RELATIONSHIP; THIOSEMICARBAZONES; VACCINIA VIRUS;

EID: 17444427138     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049147h     Document Type: Article

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37. a. Pirrung, M. C.; Chen, J. Preparation and Screening Against Acetylcholinesterase of a Non-Peptide 'Indexed' Combinatorial Library. J. Am. Chem. Soc. 1995, 117, 1240-45. Pirrung, M. C.; Chau, J. H.-L.; Chen, J. Discovery of a Novel Tetrahydroacridine Acetylcholinesterase Inhibitor through an Indexed Combinatorial Library. Chem. Biol. 1995, 3, 621-26. Pirrung, M. C.; Chau, J. H.-L.; Chen, J. Indexed Combinatorial Libraries: Non-Oligomeric Chemical Diversity for the Discovery of Novel Enzyme Inhibitors. In Combinatorial Chemistry: A High-Tech Search for New Drug Candidates; Wilson, S. R., Murphy, R., Eds.; John Wiley & Sons: New York, 1996. An, H.; Haly, B. D.; Cook, P.D. Discovery of Novel Pyridinopolyamines With Potent Antimicrobial Activity. Deconvolution of Mixtures Synthesized By Solution-Phase Combinatorial Chemistry. J. Med. Chem. 1998, 41, 706-16. Andrus, M. B.; Turner, T. M.; Sauna, Z. E.; Ambudkar, S. V. The Synthesis and Evaluation of a Solution-Phase Indexed Combinatorial Library of Nonnatural Polyenes for Multidrug Resistance Reversal. J. Org. Chem. 1999, 64, 2978-79. Andrus, M. B.; Turner, T. M.; Sauna, Z. E.; Ambudkar, S.V. The Synthesis and Evaluation of a Solution Phase Indexed Combinatorial Library of Non-Natural Polyenes For Reversal of P-Glycoprotein Mediated Multidrug Resistance. J. Org. Chem. 2000, 65, 4973-83. Boger, D. L.; Dechantsreiter, M. A.; Ishii, T.; Fink, B. E.; Hedrick, M. P. Assessment of Solution-Phase Positional Scanning Libraries Based on Distamycin A for the Discovery of New DNA Binding Agents. Bioorg. Med. Chem. 2000, 8, 2049-57. Boger, D. L.; Lee, J. K.; Goldberg, J.; Jin, Q. Two Comparisons of the Performance of Positional Scanning and Deletion Synthesis for the Identification of Active Constituents In Mixture Combinatorial Libraries. J. Org. Chem. 2000, 65, 1467-74. Teixido J.; Michelotti, E. L.; Tice, C. M. Ruminations Regarding the Design of Small Mixtures for Biological Testing. J. Comb. Chem. 2000, 2, 658-74. Ambroise, Y.; Yaspan, B.; Ginsberg, M. H.; Boger, D. L. Inhibitors of Cell Migration That Inhibit Intracellular Paxillin/alpha4 Binding: A Well-Documented Use of Positional Scanning Libraries. Chem. Biol. 2002, 9, 1219-26. Ding, B.; Taotofa, U.; Orsak, T.; Chadwell, M.; Savage, P. B. Synthesis and Characterization of Peptide-Cationic Steroid Antibiotic Conjugates. Org. Lett. 2004, 6, 3433-6.
38. a. Pirrung, M. C.; Chen, J. Preparation and Screening Against Acetylcholinesterase of a Non-Peptide 'Indexed' Combinatorial Library. J. Am. Chem. Soc. 1995, 117, 1240-45. Pirrung, M. C.; Chau, J. H.-L.; Chen, J. Discovery of a Novel Tetrahydroacridine Acetylcholinesterase Inhibitor through an Indexed Combinatorial Library. Chem. Biol. 1995, 3, 621-26. Pirrung, M. C.; Chau, J. H.-L.; Chen, J. Indexed Combinatorial Libraries: Non-Oligomeric Chemical Diversity for the Discovery of Novel Enzyme Inhibitors. In Combinatorial Chemistry: A High-Tech Search for New Drug Candidates; Wilson, S. R., Murphy, R., Eds.; John Wiley & Sons: New York, 1996. An, H.; Haly, B. D.; Cook, P.D. Discovery of Novel Pyridinopolyamines With Potent Antimicrobial Activity. Deconvolution of Mixtures Synthesized By Solution-Phase Combinatorial Chemistry. J. Med. Chem. 1998, 41, 706-16. Andrus, M. B.; Turner, T. M.; Sauna, Z. E.; Ambudkar, S. V. The Synthesis and Evaluation of a Solution-Phase Indexed Combinatorial Library of Nonnatural Polyenes for Multidrug Resistance Reversal. J. Org. Chem. 1999, 64, 2978-79. Andrus, M. B.; Turner, T. M.; Sauna, Z. E.; Ambudkar, S.V. The Synthesis and Evaluation of a Solution Phase Indexed Combinatorial Library of Non-Natural Polyenes For Reversal of P-Glycoprotein Mediated Multidrug Resistance. J. Org. Chem. 2000, 65, 4973-83. Boger, D. L.; Dechantsreiter, M. A.; Ishii, T.; Fink, B. E.; Hedrick, M. P. Assessment of Solution-Phase Positional Scanning Libraries Based on Distamycin A for the Discovery of New DNA Binding Agents. Bioorg. Med. Chem. 2000, 8, 2049-57. Boger, D. L.; Lee, J. K.; Goldberg, J.; Jin, Q. Two Comparisons of the Performance of Positional Scanning and Deletion Synthesis for the Identification of Active Constituents In Mixture Combinatorial Libraries. J. Org. Chem. 2000, 65, 1467-74. Teixido J.; Michelotti, E. L.; Tice, C. M. Ruminations Regarding the Design of Small Mixtures for Biological Testing. J. Comb. Chem. 2000, 2, 658-74. Ambroise, Y.; Yaspan, B.; Ginsberg, M. H.; Boger, D. L. Inhibitors of Cell Migration That Inhibit Intracellular Paxillin/alpha4 Binding: A Well-Documented Use of Positional Scanning Libraries. Chem. Biol. 2002, 9, 1219-26. Ding, B.; Taotofa, U.; Orsak, T.; Chadwell, M.; Savage, P. B. Synthesis and Characterization of Peptide-Cationic Steroid Antibiotic Conjugates. Org. Lett. 2004, 6, 3433-6.
39. a. Pirrung, M. C.; Chen, J. Preparation and Screening Against Acetylcholinesterase of a Non-Peptide 'Indexed' Combinatorial Library. J. Am. Chem. Soc. 1995, 117, 1240-45. Pirrung, M. C.; Chau, J. H.-L.; Chen, J. Discovery of a Novel Tetrahydroacridine Acetylcholinesterase Inhibitor through an Indexed Combinatorial Library. Chem. Biol. 1995, 3, 621-26. Pirrung, M. C.; Chau, J. H.-L.; Chen, J. Indexed Combinatorial Libraries: Non-Oligomeric Chemical Diversity for the Discovery of Novel Enzyme Inhibitors. In Combinatorial Chemistry: A High-Tech Search for New Drug Candidates; Wilson, S. R., Murphy, R., Eds.; John Wiley & Sons: New York, 1996. An, H.; Haly, B. D.; Cook, P.D. Discovery of Novel Pyridinopolyamines With Potent Antimicrobial Activity. Deconvolution of Mixtures Synthesized By Solution-Phase Combinatorial Chemistry. J. Med. Chem. 1998, 41, 706-16. Andrus, M. B.; Turner, T. M.; Sauna, Z. E.; Ambudkar, S. V. The Synthesis and Evaluation of a Solution-Phase Indexed Combinatorial Library of Nonnatural Polyenes for Multidrug Resistance Reversal. J. Org. Chem. 1999, 64, 2978-79. Andrus, M. B.; Turner, T. M.; Sauna, Z. E.; Ambudkar, S.V. The Synthesis and Evaluation of a Solution Phase Indexed Combinatorial Library of Non-Natural Polyenes For Reversal of P-Glycoprotein Mediated Multidrug Resistance. J. Org. Chem. 2000, 65, 4973-83. Boger, D. L.; Dechantsreiter, M. A.; Ishii, T.; Fink, B. E.; Hedrick, M. P. Assessment of Solution-Phase Positional Scanning Libraries Based on Distamycin A for the Discovery of New DNA Binding Agents. Bioorg. Med. Chem. 2000, 8, 2049-57. Boger, D. L.; Lee, J. K.; Goldberg, J.; Jin, Q. Two Comparisons of the Performance of Positional Scanning and Deletion Synthesis for the Identification of Active Constituents In Mixture Combinatorial Libraries. J. Org. Chem. 2000, 65, 1467-74. Teixido J.; Michelotti, E. L.; Tice, C. M. Ruminations Regarding the Design of Small Mixtures for Biological Testing. J. Comb. Chem. 2000, 2, 658-74. Ambroise, Y.; Yaspan, B.; Ginsberg, M. H.; Boger, D. L. Inhibitors of Cell Migration That Inhibit Intracellular Paxillin/alpha4 Binding: A Well-Documented Use of Positional Scanning Libraries. Chem. Biol. 2002, 9, 1219-26. Ding, B.; Taotofa, U.; Orsak, T.; Chadwell, M.; Savage, P. B. Synthesis and Characterization of Peptide-Cationic Steroid Antibiotic Conjugates. Org. Lett. 2004, 6, 3433-6.
40. a. Pirrung, M. C.; Chen, J. Preparation and Screening Against Acetylcholinesterase of a Non-Peptide 'Indexed' Combinatorial Library. J. Am. Chem. Soc. 1995, 117, 1240-45. Pirrung, M. C.; Chau, J. H.-L.; Chen, J. Discovery of a Novel Tetrahydroacridine Acetylcholinesterase Inhibitor through an Indexed Combinatorial Library. Chem. Biol. 1995, 3, 621-26. Pirrung, M. C.; Chau, J. H.-L.; Chen, J. Indexed Combinatorial Libraries: Non-Oligomeric Chemical Diversity for the Discovery of Novel Enzyme Inhibitors. In Combinatorial Chemistry: A High-Tech Search for New Drug Candidates; Wilson, S. R., Murphy, R., Eds.; John Wiley & Sons: New York, 1996. An, H.; Haly, B. D.; Cook, P.D. Discovery of Novel Pyridinopolyamines With Potent Antimicrobial Activity. Deconvolution of Mixtures Synthesized By Solution-Phase Combinatorial Chemistry. J. Med. Chem. 1998, 41, 706-16. Andrus, M. B.; Turner, T. M.; Sauna, Z. E.; Ambudkar, S. V. The Synthesis and Evaluation of a Solution-Phase Indexed Combinatorial Library of Nonnatural Polyenes for Multidrug Resistance Reversal. J. Org. Chem. 1999, 64, 2978-79. Andrus, M. B.; Turner, T. M.; Sauna, Z. E.; Ambudkar, S.V. The Synthesis and Evaluation of a Solution Phase Indexed Combinatorial Library of Non-Natural Polyenes For Reversal of P-Glycoprotein Mediated Multidrug Resistance. J. Org. Chem. 2000, 65, 4973-83. Boger, D. L.; Dechantsreiter, M. A.; Ishii, T.; Fink, B. E.; Hedrick, M. P. Assessment of Solution-Phase Positional Scanning Libraries Based on Distamycin A for the Discovery of New DNA Binding Agents. Bioorg. Med. Chem. 2000, 8, 2049-57. Boger, D. L.; Lee, J. K.; Goldberg, J.; Jin, Q. Two Comparisons of the Performance of Positional Scanning and Deletion Synthesis for the Identification of Active Constituents In Mixture Combinatorial Libraries. J. Org. Chem. 2000, 65, 1467-74. Teixido J.; Michelotti, E. L.; Tice, C. M. Ruminations Regarding the Design of Small Mixtures for Biological Testing. J. Comb. Chem. 2000, 2, 658-74. Ambroise, Y.; Yaspan, B.; Ginsberg, M. H.; Boger, D. L. Inhibitors of Cell Migration That Inhibit Intracellular Paxillin/alpha4 Binding: A Well-Documented Use of Positional Scanning Libraries. Chem. Biol. 2002, 9, 1219-26. Ding, B.; Taotofa, U.; Orsak, T.; Chadwell, M.; Savage, P. B. Synthesis and Characterization of Peptide-Cationic Steroid Antibiotic Conjugates. Org. Lett. 2004, 6, 3433-6.
41. a. Pirrung, M. C.; Chen, J. Preparation and Screening Against Acetylcholinesterase of a Non-Peptide 'Indexed' Combinatorial Library. J. Am. Chem. Soc. 1995, 117, 1240-45. Pirrung, M. C.; Chau, J. H.-L.; Chen, J. Discovery of a Novel Tetrahydroacridine Acetylcholinesterase Inhibitor through an Indexed Combinatorial Library. Chem. Biol. 1995, 3, 621-26. Pirrung, M. C.; Chau, J. H.-L.; Chen, J. Indexed Combinatorial Libraries: Non-Oligomeric Chemical Diversity for the Discovery of Novel Enzyme Inhibitors. In Combinatorial Chemistry: A High-Tech Search for New Drug Candidates; Wilson, S. R., Murphy, R., Eds.; John Wiley & Sons: New York, 1996. An, H.; Haly, B. D.; Cook, P.D. Discovery of Novel Pyridinopolyamines With Potent Antimicrobial Activity. Deconvolution of Mixtures Synthesized By Solution-Phase Combinatorial Chemistry. J. Med. Chem. 1998, 41, 706-16. Andrus, M. B.; Turner, T. M.; Sauna, Z. E.; Ambudkar, S. V. The Synthesis and Evaluation of a Solution-Phase Indexed Combinatorial Library of Nonnatural Polyenes for Multidrug Resistance Reversal. J. Org. Chem. 1999, 64, 2978-79. Andrus, M. B.; Turner, T. M.; Sauna, Z. E.; Ambudkar, S.V. The Synthesis and Evaluation of a Solution Phase Indexed Combinatorial Library of Non-Natural Polyenes For Reversal of P-Glycoprotein Mediated Multidrug Resistance. J. Org. Chem. 2000, 65, 4973-83. Boger, D. L.; Dechantsreiter, M. A.; Ishii, T.; Fink, B. E.; Hedrick, M. P. Assessment of Solution-Phase Positional Scanning Libraries Based on Distamycin A for the Discovery of New DNA Binding Agents. Bioorg. Med. Chem. 2000, 8, 2049-57. Boger, D. L.; Lee, J. K.; Goldberg, J.; Jin, Q. Two Comparisons of the Performance of Positional Scanning and Deletion Synthesis for the Identification of Active Constituents In Mixture Combinatorial Libraries. J. Org. Chem. 2000, 65, 1467-74. Teixido J.; Michelotti, E. L.; Tice, C. M. Ruminations Regarding the Design of Small Mixtures for Biological Testing. J. Comb. Chem. 2000, 2, 658-74. Ambroise, Y.; Yaspan, B.; Ginsberg, M. H.; Boger, D. L. Inhibitors of Cell Migration That Inhibit Intracellular Paxillin/alpha4 Binding: A Well-Documented Use of Positional Scanning Libraries. Chem. Biol. 2002, 9, 1219-26. Ding, B.; Taotofa, U.; Orsak, T.; Chadwell, M.; Savage, P. B. Synthesis and Characterization of Peptide-Cationic Steroid Antibiotic Conjugates. Org. Lett. 2004, 6, 3433-6.
42. a. Pirrung, M. C.; Chen, J. Preparation and Screening Against Acetylcholinesterase of a Non-Peptide 'Indexed' Combinatorial Library. J. Am. Chem. Soc. 1995, 117, 1240-45. Pirrung, M. C.; Chau, J. H.-L.; Chen, J. Discovery of a Novel Tetrahydroacridine Acetylcholinesterase Inhibitor through an Indexed Combinatorial Library. Chem. Biol. 1995, 3, 621-26. Pirrung, M. C.; Chau, J. H.-L.; Chen, J. Indexed Combinatorial Libraries: Non-Oligomeric Chemical Diversity for the Discovery of Novel Enzyme Inhibitors. In Combinatorial Chemistry: A High-Tech Search for New Drug Candidates; Wilson, S. R., Murphy, R., Eds.; John Wiley & Sons: New York, 1996. An, H.; Haly, B. D.; Cook, P.D. Discovery of Novel Pyridinopolyamines With Potent Antimicrobial Activity. Deconvolution of Mixtures Synthesized By Solution-Phase Combinatorial Chemistry. J. Med. Chem. 1998, 41, 706-16. Andrus, M. B.; Turner, T. M.; Sauna, Z. E.; Ambudkar, S. V. The Synthesis and Evaluation of a Solution-Phase Indexed Combinatorial Library of Nonnatural Polyenes for Multidrug Resistance Reversal. J. Org. Chem. 1999, 64, 2978-79. Andrus, M. B.; Turner, T. M.; Sauna, Z. E.; Ambudkar, S.V. The Synthesis and Evaluation of a Solution Phase Indexed Combinatorial Library of Non-Natural Polyenes For Reversal of P-Glycoprotein Mediated Multidrug Resistance. J. Org. Chem. 2000, 65, 4973-83. Boger, D. L.; Dechantsreiter, M. A.; Ishii, T.; Fink, B. E.; Hedrick, M. P. Assessment of Solution-Phase Positional Scanning Libraries Based on Distamycin A for the Discovery of New DNA Binding Agents. Bioorg. Med. Chem. 2000, 8, 2049-57. Boger, D. L.; Lee, J. K.; Goldberg, J.; Jin, Q. Two Comparisons of the Performance of Positional Scanning and Deletion Synthesis for the Identification of Active Constituents In Mixture Combinatorial Libraries. J. Org. Chem. 2000, 65, 1467-74. Teixido J.; Michelotti, E. L.; Tice, C. M. Ruminations Regarding the Design of Small Mixtures for Biological Testing. J. Comb. Chem. 2000, 2, 658-74. Ambroise, Y.; Yaspan, B.; Ginsberg, M. H.; Boger, D. L. Inhibitors of Cell Migration That Inhibit Intracellular Paxillin/alpha4 Binding: A Well-Documented Use of Positional Scanning Libraries. Chem. Biol. 2002, 9, 1219-26. Ding, B.; Taotofa, U.; Orsak, T.; Chadwell, M.; Savage, P. B. Synthesis and Characterization of Peptide-Cationic Steroid Antibiotic Conjugates. Org. Lett. 2004, 6, 3433-6.
43. a. Pirrung, M. C.; Chen, J. Preparation and Screening Against Acetylcholinesterase of a Non-Peptide 'Indexed' Combinatorial Library. J. Am. Chem. Soc. 1995, 117, 1240-45. Pirrung, M. C.; Chau, J. H.-L.; Chen, J. Discovery of a Novel Tetrahydroacridine Acetylcholinesterase Inhibitor through an Indexed Combinatorial Library. Chem. Biol. 1995, 3, 621-26. Pirrung, M. C.; Chau, J. H.-L.; Chen, J. Indexed Combinatorial Libraries: Non-Oligomeric Chemical Diversity for the Discovery of Novel Enzyme Inhibitors. In Combinatorial Chemistry: A High-Tech Search for New Drug Candidates; Wilson, S. R., Murphy, R., Eds.; John Wiley & Sons: New York, 1996. An, H.; Haly, B. D.; Cook, P.D. Discovery of Novel Pyridinopolyamines With Potent Antimicrobial Activity. Deconvolution of Mixtures Synthesized By Solution-Phase Combinatorial Chemistry. J. Med. Chem. 1998, 41, 706-16. Andrus, M. B.; Turner, T. M.; Sauna, Z. E.; Ambudkar, S. V. The Synthesis and Evaluation of a Solution-Phase Indexed Combinatorial Library of Nonnatural Polyenes for Multidrug Resistance Reversal. J. Org. Chem. 1999, 64, 2978-79. Andrus, M. B.; Turner, T. M.; Sauna, Z. E.; Ambudkar, S.V. The Synthesis and Evaluation of a Solution Phase Indexed Combinatorial Library of Non-Natural Polyenes For Reversal of P-Glycoprotein Mediated Multidrug Resistance. J. Org. Chem. 2000, 65, 4973-83. Boger, D. L.; Dechantsreiter, M. A.; Ishii, T.; Fink, B. E.; Hedrick, M. P. Assessment of Solution-Phase Positional Scanning Libraries Based on Distamycin A for the Discovery of New DNA Binding Agents. Bioorg. Med. Chem. 2000, 8, 2049-57. Boger, D. L.; Lee, J. K.; Goldberg, J.; Jin, Q. Two Comparisons of the Performance of Positional Scanning and Deletion Synthesis for the Identification of Active Constituents In Mixture Combinatorial Libraries. J. Org. Chem. 2000, 65, 1467-74. Teixido J.; Michelotti, E. L.; Tice, C. M. Ruminations Regarding the Design of Small Mixtures for Biological Testing. J. Comb. Chem. 2000, 2, 658-74. Ambroise, Y.; Yaspan, B.; Ginsberg, M. H.; Boger, D. L. Inhibitors of Cell Migration That Inhibit Intracellular Paxillin/alpha4 Binding: A Well-Documented Use of Positional Scanning Libraries. Chem. Biol. 2002, 9, 1219-26. Ding, B.; Taotofa, U.; Orsak, T.; Chadwell, M.; Savage, P. B. Synthesis and Characterization of Peptide-Cationic Steroid Antibiotic Conjugates. Org. Lett. 2004, 6, 3433-6.
44. a. Pirrung, M. C.; Chen, J. Preparation and Screening Against Acetylcholinesterase of a Non-Peptide 'Indexed' Combinatorial Library. J. Am. Chem. Soc. 1995, 117, 1240-45. Pirrung, M. C.; Chau, J. H.-L.; Chen, J. Discovery of a Novel Tetrahydroacridine Acetylcholinesterase Inhibitor through an Indexed Combinatorial Library. Chem. Biol. 1995, 3, 621-26. Pirrung, M. C.; Chau, J. H.-L.; Chen, J. Indexed Combinatorial Libraries: Non-Oligomeric Chemical Diversity for the Discovery of Novel Enzyme Inhibitors. In Combinatorial Chemistry: A High-Tech Search for New Drug Candidates; Wilson, S. R., Murphy, R., Eds.; John Wiley & Sons: New York, 1996. An, H.; Haly, B. D.; Cook, P.D. Discovery of Novel Pyridinopolyamines With Potent Antimicrobial Activity. Deconvolution of Mixtures Synthesized By Solution-Phase Combinatorial Chemistry. J. Med. Chem. 1998, 41, 706-16. Andrus, M. B.; Turner, T. M.; Sauna, Z. E.; Ambudkar, S. V. The Synthesis and Evaluation of a Solution-Phase Indexed Combinatorial Library of Nonnatural Polyenes for Multidrug Resistance Reversal. J. Org. Chem. 1999, 64, 2978-79. Andrus, M. B.; Turner, T. M.; Sauna, Z. E.; Ambudkar, S.V. The Synthesis and Evaluation of a Solution Phase Indexed Combinatorial Library of Non-Natural Polyenes For Reversal of P-Glycoprotein Mediated Multidrug Resistance. J. Org. Chem. 2000, 65, 4973-83. Boger, D. L.; Dechantsreiter, M. A.; Ishii, T.; Fink, B. E.; Hedrick, M. P. Assessment of Solution-Phase Positional Scanning Libraries Based on Distamycin A for the Discovery of New DNA Binding Agents. Bioorg. Med. Chem. 2000, 8, 2049-57. Boger, D. L.; Lee, J. K.; Goldberg, J.; Jin, Q. Two Comparisons of the Performance of Positional Scanning and Deletion Synthesis for the Identification of Active Constituents In Mixture Combinatorial Libraries. J. Org. Chem. 2000, 65, 1467-74. Teixido J.; Michelotti, E. L.; Tice, C. M. Ruminations Regarding the Design of Small Mixtures for Biological Testing. J. Comb. Chem. 2000, 2, 658-74. Ambroise, Y.; Yaspan, B.; Ginsberg, M. H.; Boger, D. L. Inhibitors of Cell Migration That Inhibit Intracellular Paxillin/alpha4 Binding: A Well-Documented Use of Positional Scanning Libraries. Chem. Biol. 2002, 9, 1219-26. Ding, B.; Taotofa, U.; Orsak, T.; Chadwell, M.; Savage, P. B. Synthesis and Characterization of Peptide-Cationic Steroid Antibiotic Conjugates. Org. Lett. 2004, 6, 3433-6.
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