Efficacy of new 5-nitroimidazoles against metronidazole-susceptible and- resistant Giardia, Trichomonas, and Entamoeba spp.

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 1, 1999, Pages 73-76

  Upcroft, Jacqueline A ^a,c   Campbell, Raymond W ^a   Benakli, Kamel ^b   Upcroft, Peter ^a   Vanelle, Patrice ^b  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b AIX MARSEILLE UNIVERSITY   (France)

^c ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

5 NITROIMIDAZOLE DERIVATIVE; METRONIDAZOLE;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG SCREENING; DRUG STRUCTURE; ENTAMOEBA HISTOLYTICA; GIARDIA DUODENALIS; NONHUMAN; PRIORITY JOURNAL; TRICHOMONAS VAGINALIS; TROPHOZOITE;

EID: 0032939686     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.1.73     Document Type: Article

References (33)

1. Boreham, P. F. L., R. E. Phillips, and R. W. Shepherd. 1988. Altered uptake of metronidazole in vitro by stocks of Giardia intestinalis with different drug sensitivities. Trans. R. Soc. Trop. Med. Hyg. 82:104-106.
2. Boreham, P. F. L., N. C. Smith, and R. W. Shepherd. 1988. Drug resistance and the treatment of giardiasis, p. 3-7. In P. M. Wallis and B. R. Hammond (ed.), Advances in Giardia research. University of Calgary Press, Calgary, Alberta, Canada.
3. Bowman, W. R. 1988. Photoinduced nucleophilic substitution at sp3 carbon, p. 421-486. In M. A. Fox and M. Chanon (ed.), Photoinduced electron transfer, Part C. Elsevier, Amsterdam, The Netherlands.
4. Brown, D. M., J. A. Upcroft, and P. Upcroft. An alternative keto acid oxidoreductase in Trichomonas vaginalis. Mol. Biochem. Parasitol., in press.
5. Capon, A. G., J. A. Upcroft, P. F. L. Boreham, L. E. Cottis, and P. G. Bundesen. 1989. Similarities of Giardia antigens derived from human and animal sources. Int. J. Parasitol. 19:91-98.
6. Cosar, C., and L. Julou. 1959. Activité de l' (hydroxy-2-éthyl)-1-méthyl-2-nitro-5 imidazole (8,823 R.P.) vis-à-vis des infections expérimentales Trichomonas vaginalis. Ann. Inst. Pasteur 96:238-241.
7. Garcia-Leverde, A., and L. de Bonila. 1975. Clinical trials with metronidazole in human balantidiasis. Am. J. Trop. Med. Hyg. 24:781-783.
8. Jentzer, O., P. Vanelle, M. P. Crozet, J. Maldonado, and M. Barreau. 1991. Nouveaux 5-nitroimidazoles à noyau lactame hautement actifs: préparation et propriétés antibactériennes. Eur. J. Med. Chem. 26:687-697.
9. Johnson, P. J. 1993. Metronidazole and drug resistance. Parasitol. Today 9: 183-186.
10. Jokipii, L., and A. M. Jokipii. 1980. In vitro susceptibility of Giardia lamblia trophozoites to metronidazole and tinidazole. J. Infect. Dis. 141:317-325.
11. Kim, J. K., and J. F. Bunnett. 1970. Evidence for a radical mechanism of aromatic "nucleophilic" substitution. J. Am. Chem. Soc. 92:7463-7464.
12. Knight, R. 1980. The chemotherapy of amoebiasis. J. Antimicrob. Chemother. 6:577-593.
13. Kornblum, N., R. E. Michel, and R. C. Kerber. 1966. Radical anions as intermediates in substitution reactions. J. Am. Chem. Soc. 88:5660-5662.
14. Kornblum, N., R. E. Michel, and R. C. Kerber. 1966. Chain reactions in substitution processes which proceed via radical-anion intermediates. J. Am. Soc. Chem. 88:5662-5663.
15. Lossick, J. G. 1990. Therapy of urogenital trichomoniasis, p. 324-431. In B. M. Honigberg (ed.), Trichomonads parasitic in humans. Springer-Verlag, New York, N. Y.
16. Maeda, K., T. Osata, and H. Umezawa. 1953. A new antibiotic, azomycin. J. Antibiot. 6(Suppl. A):182.
17. Majewska, A. C., W. Kasprzak, J. F. De Jonckheere, and E. Kaczmarek. 1991. Heterogeneity in the sensitivity of stocks and clones of Giardia to metronidazole and ornidazole. Trans. R. Soc. Trop. Med. Hyg. 85:67-69.
18. Phillips, R. E., P. F. L. Boreham, and R. W. Shepherd. 1984. Cryopreservation of viable Giardia intestinalis trophozoites. Trans. R. Soc. Trop. Med. Hyg. 78:604-606.
19. Powell, S. J., L. Macleod, A. J. Wilmot, and R. Elsdoo-Dew. 1966. Metronidazole in amoebic dysentery and amoebic liver abscess. Lancet ii:1329-1331.
20. Russell, G. A., and W. C. Danen. 1966. Coupling reactions of the 2-nitro-2-propyl anion. J. Am. Chem. Soc. 88:5563-5665.
21. Samarawickrema, N. A., J. A. Upcroft, D. M. Brown, N. Thammapalerd, and P. Upcroft. 1997. Superoxide dismutase and pyruvate:ferredoxin oxidoreductase involvement in mechanisms of metronidazole resistance in Entamoeba histotytica. J. Antimicrob. Chemother. 40:833-840.
22. Scheider, J. 1961. Traitment de la giardiase (lambliase) par le métronidazole. Bull. Soc. Pathol. Exot. 54:84-93.
23. Townson, S. M., P. F. L. Boreham, P. Upcroft, and J. A. Upcroft. 1994. Resistance to the nitroheterocyclic drugs. Acta Trop. 56:173-194.
24. Townson, S. M., H. Laqua, P. Upcroft, P. F. L. Boreham, and J. A. Upcroft. 1992. Induction of metronidazole and furazolidone resistance in Giardia. Trans. R. Soc. Trop. Med. Hyg. 86:521-522.
25. Townson, S. M., J. A. Upcroft, and P. Upcroft. 1996. Characterisation and purification of pyruvate:ferredoxin oxidoreductase from Giardia duodenalis. Mol. Biochem. Parasitol. 79:183-193.
26. Upcroft, J. A., A. Healey, R. W. Mitchell, and P. Upcroft. 1994. A new rDNA repeat unit in human Giardia. J. Eukaryot. Microbiol. 41:639-642.
27. Upcroft, J. A., and P. Upcroft. 1993. Drug resistance and Giardia. Parasitol. Today 9:187-190.
28. RN1 methodology. Heterocycles 48:181-185.
29. RN1 reactions in 5-nitroimidazole series. Heterocycles 43:731-735.
30. Vanelle, P., K. Benakli, M. De MØo, J. Maldonado, M. P. Crozet, M. Laget, H. Guiraud, and G. Dumenil. 1997. Genotoxicomodulation in 5-nitroimidazole series, abstr. C16. Presented at the 33rd International Meeting on Medicinal Chemistry, Reims, France, 16 to 18 September 1997.
31. RN1 de nouveaux 5-nitroimidazoles antiparasitaires et antibactériens. Eur. J. Med. Chem. 26:167-178.
32. Vanelle, P., J. Maldonado, M. Gasquet, F. Delmas, P. Timon-David, O. Jentzer, and M. P. Crozet. 1991. Studies on antiparasitic agents: effect of the lactam nucleus substitution in the 2-position on the in-vitro activity of new 5-nitroimidazoles. J. Pharm. Pharmacol. 43:735-736.
33. Voolmann, T., and P. F. L. Boreham. 1993. Metronidazole resistant Trichomonas vaginalis in Brisbane. Med. J Aust. 159:490.