Synthesis, anti-HIV and antitubercular activities of lamivudine prodrugs

European Journal of Medicinal Chemistry

Volumn 40, Issue 12, 2005, Pages 1373-1376

  Sriram, Dharmarajan ^a   Yogeeswari, Perumal ^a   Gopal, Gayatri ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Anti HIV activity; Antimycobacterial activity; Lamivudine prodrug

Indexed keywords

3 [[1 [2 (HYDROXYMETHYL) 1,3 OXATHIOLAN 5 YL] 1,2 DIHYDROPYRIMIDIN 4 YL]IMINO] 1 [(1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 4 OXO 3 QUINOLINE CARBOXYLIC ACID 7 PIPERAZINYL)METHYL] 1,3 DIHYDRO 2H INDOL 2 ONE; 3 [[1 [2 (HYDROXYMETHYL) 1,3 OXATHIOLAN 5 YL] 1,2 DIHYDROPYRIMIDIN 4 YL]IMINO] 1 [(1 ETHYL 6 FLUORO 1,4 DIHYDRO 4 OXO 3 QUINOLINE CARBOXYLIC ACID 7 PIPERAZINYL)METHYL] 1,3 DIHYDRO 2H INDOL 2 ONE; 3 [[1 [2 (HYDROXYMETHYL) 1,3 OXATHIOLAN 5 YL] 1,2 DIHYDROPYRIMIDIN 4 YL]IMINO] 1,3 DIHYDRO 2H INDOL 2 ONE; 5 CHLORO 3 [[1 [2 (HYDROXYMETHYL) 1,3 OXATHIOLAN 5 YL] 1,2 DIHYDROPYRIMIDIN 4 YL]IMINO] 1 [[1 CYCLOPROPYL 6 FLUORO 8 METHOXY 1,4 DIHYDRO 4 OXO 3 QUINOLINE CARBOXYLIC ACID 7 (3 METHYL)PIPERAZINYL]METHYL] 1,3 DIHYDRO 2H INDOL 2 ONE; ANTIRETROVIRUS AGENT; LAMIVUDINE; PRODRUG; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG STABILITY; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS; LIPOPHILICITY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHYSICAL CHEMISTRY;

ANTI-HIV AGENTS; ANTITUBERCULAR AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; HIV-1; HUMANS; LAMIVUDINE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 27744493324     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.07.006     Document Type: Article

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