Synthesis and structure-activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 1, 2006, Pages 237-246

  Moon, Myoung Ju ^a   Lee, Sang Kook ^b   Lee, Jong Won ^b   Song, Woo Keun ^a   Kim, Si Wouk ^c   Kim, Jae Il ^a   Cho, Chunghee ^a   Choi, Soo Jeong ^a   Kim, Yong Chul ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b Ewha Womans University   (South Korea)

^c Chosun University   (South Korea)

Author keywords

Anti proliferative activity; Cyclin dependent kinases; Indirubin

Indexed keywords

5 (3 METHYLBUT 2 ENAMIDO)INDIRUBIN 3' OXIME; 5 (3,3 DIMETHYLBUTANAMIDO)INDIRUBIN 3' OXIME; 5 (CYCLOPROPANECARBOXAMIDO)INDIRUBIN 3' OXIME; 5 ACETAMIDOINDIRUBIN 3' OXIME; 5 AMINOINDIRUBIN; 5 BROMO 5 NITROINDIRUBIN 3' OXIME; 5 BROMOINDIRUBIN 3' OXIME; 5 BUTYRAMIDOINDIRUBIN 3' OXIME; 5 CHLORO 7 DIMETHYLINDIRUBIN 3' OXIME; 5 CHLOROINDIRUBIN 3' OXIME; 5 FLUOROINDIRUBIN 3' OXIME; 5 IODOINDIRUBIN 3' OXIME; 5 METHYLINDIRUBIN 3' OXIME; 5 NITROINDIRUBIN 3' OXIME; 5 PENTANAMIDOINDIRUBIN 3' OXIME; 5 PROPIONAMIDOINDIRUBIN 3' OXIME; 5 TRIFLUOROMETHOXYINDIRUBIN 3' OXIME; 5 TRIMETHYLACETAMIDOINDIRUBIN 3' OXIME; 5,7 DIMETHYLINDIRUBIN 3' OXIME; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR; HALIDE; INDIRUBIN; INDIRUBIN 3' HYDRAZONE; INDIRUBIN 3' OXIME; INDIRUBIN 3' OXIME 5 SULFONIC ACID; N ACYLAMINO ACID; N1' ACETYLINDIRUBIN; NITROGEN DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE 2; ENZYME INHIBITORS; HUMANS; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 27744489247     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.08.008     Document Type: Article

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