메뉴 건너뛰기




Volumn 10, Issue 3, 2013, Pages 270-278

Therapeutic effects of quetiapine on memory deficit and brain β-amyloid plaque pathology in a transgenic mouse model of Alzheimer's disease

Author keywords

amyloid; Alzheimer's disease; APP PS1 double transgenic mouse model; Memory; Plaque; Quetiapine

Indexed keywords

AMYLOID BETA PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; PRESENILIN 1; QUETIAPINE;

EID: 84876846625     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/1567205011310030006     Document Type: Article
Times cited : (14)

References (83)
  • 1
    • 0032902647 scopus 로고    scopus 로고
    • The amyloid precursor protein of Alzheimer's disease and the Abeta peptide
    • Storey E, Cappai R. The amyloid precursor protein of Alzheimer's disease and the Abeta peptide. Neuropathol Appl Neurobiol 25(2): 81-97 (1999).
    • (1999) Neuropathol Appl Neurobiol , vol.25 , Issue.2 , pp. 81-97
    • Storey, E.1    Cappai, R.2
  • 2
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure
    • Selkoe DJ. Alzheimer's disease is a synaptic failure. Science: 298(5594): 789-791 (2002).
    • (2002) Science , vol.298 , Issue.5594 , pp. 789-791
    • Selkoe, D.J.1
  • 3
    • 0037378001 scopus 로고    scopus 로고
    • Amyloid, presenilins, and Alzheimer's disease
    • Van Gassen G, Annaert W. Amyloid, presenilins, and Alzheimer's disease. Neuroscientist 9(2): 117-126 (2003).
    • (2003) Neuroscientist , vol.9 , Issue.2 , pp. 117-126
    • van Gassen, G.1    Annaert, W.2
  • 4
    • 0036736218 scopus 로고    scopus 로고
    • Amyloid precursor protein, presenilins, and alpha-synuclein: Molecular pathogenesis and pharmacological applications in Alzheimer's disease
    • Suh YH, Checler F. Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease. Pharmacol Rev 54(3): 469-525 (2002).
    • (2002) Pharmacol Rev , vol.54 , Issue.3 , pp. 469-525
    • Suh, Y.H.1    Checler, F.2
  • 5
    • 1542349913 scopus 로고    scopus 로고
    • Beta-secretase activity increases with aging in human, monkey, and mouse brain
    • Fukumoto H, Rosene DL, Moss MB, Raju S, Hyman BT, Irizarry MC. Beta-secretase activity increases with aging in human, monkey, and mouse brain. Am J Pathol 164(2): 719-725 (2004).
    • (2004) Am J Pathol , vol.164 , Issue.2 , pp. 719-725
    • Fukumoto, H.1    Rosene, D.L.2    Moss, M.B.3    Raju, S.4    Hyman, B.T.5    Irizarry, M.C.6
  • 6
    • 20044377403 scopus 로고    scopus 로고
    • Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice
    • Lazarov O, Robinson J, Tang YP, Hairston IS, Korade-Mirnics Z, Lee VM, et al. Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell 120(5): 701-713 (2005).
    • (2005) Cell , vol.120 , Issue.5 , pp. 701-713
    • Lazarov, O.1    Robinson, J.2    Tang, Y.P.3    Hairston, I.S.4    Korade-Mirnics, Z.5    Lee, V.M.6
  • 7
    • 0031052381 scopus 로고    scopus 로고
    • Amyloid, the presenilins and Alzheimer's disease
    • Hardy J. Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci 20(4): 154-159 (1997).
    • (1997) Trends Neurosci , vol.20 , Issue.4 , pp. 154-159
    • Hardy, J.1
  • 8
    • 0028985574 scopus 로고
    • Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
    • Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature: 373(6514): 523-527 (1995).
    • (1995) Nature , vol.373 , Issue.6514 , pp. 523-527
    • Games, D.1    Adams, D.2    Alessandrini, R.3    Barbour, R.4    Berthelette, P.5    Blackwell, C.6
  • 9
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
    • Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274(5284): 99-102 (1996).
    • (1996) Science , vol.274 , Issue.5284 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3    Eckman, C.4    Harigaya, Y.5    Younkin, S.6
  • 11
    • 0031914718 scopus 로고    scopus 로고
    • Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
    • Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 4(1): 97-100 (1998).
    • (1998) Nat Med , vol.4 , Issue.1 , pp. 97-100
    • Holcomb, L.1    Gordon, M.N.2    McGowan, E.3    Yu, X.4    Benkovic, S.5    Jantzen, P.6
  • 12
    • 67349203223 scopus 로고    scopus 로고
    • Beneficial effects of quetiapine in a transgenic mouse model of Alzheimer's disease
    • He J, Luo H, Yan B, Yu Y, Wang H, Wei Z, et al. Beneficial effects of quetiapine in a transgenic mouse model of Alzheimer's disease. Neurobiol Aging 30(8): 1205-1216 (2009).
    • (2009) Neurobiol Aging , vol.30 , Issue.8 , pp. 1205-1216
    • He, J.1    Luo, H.2    Yan, B.3    Yu, Y.4    Wang, H.5    Wei, Z.6
  • 13
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297(5580): 353-356 (2002).
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 14
    • 13944276825 scopus 로고    scopus 로고
    • Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective
    • Tanzi RE, Bertram L. Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell 120(4): 545-555 (2005).
    • (2005) Cell , vol.120 , Issue.4 , pp. 545-555
    • Tanzi, R.E.1    Bertram, L.2
  • 16
    • 33846633336 scopus 로고    scopus 로고
    • Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
    • Lacor PN, Buniel MC, Furlow PW, Clemente AS, Velasco PT, Wood M, et al. Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci 27(4): 796-807 (2007).
    • (2007) J Neurosci , vol.27 , Issue.4 , pp. 796-807
    • Lacor, P.N.1    Buniel, M.C.2    Furlow, P.W.3    Clemente, A.S.4    Velasco, P.T.5    Wood, M.6
  • 17
    • 0035036143 scopus 로고    scopus 로고
    • Neuropsychological change in patients with schizophrenia after treatment with quetiapine or haloperidol
    • Purdon SE, Malla A, Labelle A, and Lit W. Neuropsychological change in patients with schizophrenia after treatment with quetiapine or haloperidol. J Psychiatry Neurosci 26(2): 137-149 (2001).
    • (2001) J Psychiatry Neurosci , vol.26 , Issue.2 , pp. 137-149
    • Purdon, S.E.1    Malla, A.2    Labelle, A.3    Lit, W.4
  • 18
    • 0346250792 scopus 로고    scopus 로고
    • Treatment of non-schizophrenic disorders: Focus on atypical antipsychotics
    • Jeste DV, Dolder CR. Treatment of non-schizophrenic disorders: focus on atypical antipsychotics. J Psychiatr Res 38(1): 73-103 (2004).
    • (2004) J Psychiatr Res , vol.38 , Issue.1 , pp. 73-103
    • Jeste, D.V.1    Dolder, C.R.2
  • 20
    • 33846946448 scopus 로고    scopus 로고
    • Pharmacological treatment of the psychosis of Alzheimer's disease: What is the best approach?
    • Madhusoodanan S, Shah P, Brenner R, and Gupta S. Pharmacological treatment of the psychosis of Alzheimer's disease: what is the best approach? CNS Drugs 21(2): 101-115 (2007).
    • (2007) CNS Drugs , vol.21 , Issue.2 , pp. 101-115
    • Madhusoodanan, S.1    Shah, P.2    Brenner, R.3    Gupta, S.4
  • 21
    • 33745868380 scopus 로고    scopus 로고
    • The effects of chronic administration of quetiapine on the methamphetamine-induced recognition memory impairment and dopaminergic terminal deficit in rats
    • He J, Yang Y, Yu Y, Li X, Li XM. The effects of chronic administration of quetiapine on the methamphetamine-induced recognition memory impairment and dopaminergic terminal deficit in rats. Behav. Brain Res 172(1): 39-45 (2006).
    • (2006) Behav Brain Res , vol.172 , Issue.1 , pp. 39-45
    • He, J.1    Yang, Y.2    Yu, Y.3    Li, X.4    Li, X.M.5
  • 22
    • 17044435056 scopus 로고    scopus 로고
    • Chronic administration of quetiapine alleviates the anxiety-like behavioural changes induced by a neurotoxic regimen of dl-amphetamine in rats
    • He J, Xu H, Yang Y, Zhang X, Li XM. Chronic administration of quetiapine alleviates the anxiety-like behavioural changes induced by a neurotoxic regimen of dl-amphetamine in rats. Behav. Brain Res 160(1): 178-187 (2005).
    • (2005) Behav. Brain Res , vol.160 , Issue.1 , pp. 178-187
    • He, J.1    Xu, H.2    Yang, Y.3    Zhang, X.4    Li, X.M.5
  • 23
    • 32044451085 scopus 로고    scopus 로고
    • The effects of chronic administration of quetiapine on the phencyclidine-induced reference memory impairment and decrease of Bcl-XL/Bax ratio in the posterior cingulate cortex in rats
    • He J, Xu H, Yang Y, Rajakumar D, Li X, Li XM. The effects of chronic administration of quetiapine on the phencyclidine-induced reference memory impairment and decrease of Bcl-XL/Bax ratio in the posterior cingulate cortex in rats. Behav Brain Res 168(2): 236-242 (2006).
    • (2006) Behav Brain Res , vol.168 , Issue.2 , pp. 236-242
    • He, J.1    Xu, H.2    Yang, Y.3    Rajakumar, D.4    Li, X.5    Li, X.M.6
  • 24
    • 3242761438 scopus 로고    scopus 로고
    • In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain
    • Li X, Zhu W, Roh MS, Friedman AB, Rosborough K, Jope RS. In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain. Neuropsychopharmacology 29(8): 1426-1431 (2004).
    • (2004) Neuropsychopharmacology , vol.29 , Issue.8 , pp. 1426-1431
    • Li, X.1    Zhu, W.2    Roh, M.S.3    Friedman, A.B.4    Rosborough, K.5    Jope, R.S.6
  • 25
    • 34447115083 scopus 로고    scopus 로고
    • Haloperidol and clozapine differentially regulate signals upstream of glycogen synthase kinase 3 in the rat frontal cortex
    • Roh MS, Seo MS, Kim Y, Kim SH, Jeon WJ, Ahn YM, et al. Haloperidol and clozapine differentially regulate signals upstream of glycogen synthase kinase 3 in the rat frontal cortex. Exp Mol Med 39(3): 353-360 (2007).
    • (2007) Exp Mol Med , vol.39 , Issue.3 , pp. 353-360
    • Roh, M.S.1    Seo, M.S.2    Kim, Y.3    Kim, S.H.4    Jeon, W.J.5    Ahn, Y.M.6
  • 26
    • 14644389398 scopus 로고    scopus 로고
    • Antipsychotics alter the protein expression levels of beta-catenin and GSK-3 in the rat medial prefrontal cortex and striatum
    • Alimohamad H, Rajakumar N, Seah YH, Rushlow W. Antipsychotics alter the protein expression levels of beta-catenin and GSK-3 in the rat medial prefrontal cortex and striatum. Biol. Psychiatry 57(5): 533-542 (2005).
    • (2005) Biol. Psychiatry , vol.57 , Issue.5 , pp. 533-542
    • Alimohamad, H.1    Rajakumar, N.2    Seah, Y.H.3    Rushlow, W.4
  • 27
    • 34447626493 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3: A key regulator of cellular fate
    • Forde JE, Dale TC. Glycogen synthase kinase 3: a key regulator of cellular fate. Cell Mol. Life Sci 64(15): 1930-1944 (2007).
    • (2007) Cell Mol Life Sci , vol.64 , Issue.15 , pp. 1930-1944
    • Forde, J.E.1    Dale, T.C.2
  • 28
    • 58149314221 scopus 로고    scopus 로고
    • Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models
    • Qing H, He G, Ly PT, Fox CJ, Staufenbiel M, Cai F, et al. Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models. J Exp Med 205(12): 2781-2789 (2008).
    • (2008) J Exp Med , vol.205 , Issue.12 , pp. 2781-2789
    • Qing, H.1    He, G.2    Ly, P.T.3    Fox, C.J.4    Staufenbiel, M.5    Cai, F.6
  • 29
    • 33846129434 scopus 로고    scopus 로고
    • Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration
    • Leroy K, Yilmaz Z, and Brion JP. Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration. Neuropathol. Appl. Neurobiol 33(1): 43-55 (2007).
    • (2007) Neuropathol. Appl Neurobiol , vol.33 , Issue.1 , pp. 43-55
    • Leroy, K.1    Yilmaz, Z.2    Brion, J.P.3
  • 30
    • 16044366039 scopus 로고    scopus 로고
    • Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
    • Duff K, Eckman C, Zehr C, Yu X, Prada CM, Perez-tur J, et al. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature 383(6602): 710-713 (1996).
    • (1996) Nature , vol.383 , Issue.6602 , pp. 710-713
    • Duff, K.1    Eckman, C.2    Zehr, C.3    Yu, X.4    Prada, C.M.5    Perez-tur, J.6
  • 31
    • 45549101680 scopus 로고    scopus 로고
    • Quetiapine facilitates oligodendrocyte development and prevents mice from myelin breakdown and behavioral changes
    • Xiao L, Xu H, Zhang Y, Wei Z, He J, Jiang W, et al. Quetiapine facilitates oligodendrocyte development and prevents mice from myelin breakdown and behavioral changes. Mol Psychiatry 13(7): 697-708 (2008).
    • (2008) Mol Psychiatry , vol.13 , Issue.7 , pp. 697-708
    • Xiao, L.1    Xu, H.2    Zhang, Y.3    Wei, Z.4    He, J.5    Jiang, W.6
  • 32
    • 0030088028 scopus 로고    scopus 로고
    • The role of nitric oxide in dizocilpine-induced impairment of spontaneous alternation behavior in mice
    • Yamada K, Noda Y, Hasegawa T, Komori Y, Nikai T, Sugihara H, et al. The role of nitric oxide in dizocilpine-induced impairment of spontaneous alternation behavior in mice. J Pharmacol Exp Ther 276(2): 460-466 (1996).
    • (1996) J Pharmacol Exp Ther , vol.276 , Issue.2 , pp. 460-466
    • Yamada, K.1    Noda, Y.2    Hasegawa, T.3    Komori, Y.4    Nikai, T.5    Sugihara, H.6
  • 33
    • 0021173996 scopus 로고
    • Developments of a water-maze procedure for studying spatial learning in the rat
    • Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci. Methods 11(1): 47-60 (1984).
    • (1984) J Neurosci Methods , vol.11 , Issue.1 , pp. 47-60
    • Morris, R.1
  • 34
    • 80055104131 scopus 로고    scopus 로고
    • A technique for serial collection of cerebrospinal fluid from the cisterna magna in mouse
    • Liu L, Duff K. A technique for serial collection of cerebrospinal fluid from the cisterna magna in mouse. J Vis Exp (21) (2008).
    • (2008) J Vis Exp , Issue.21
    • Liu, L.1    Duff, K.2
  • 35
    • 9644252796 scopus 로고    scopus 로고
    • Longitudinal observation on CSF Abeta42 levels in young to middle-aged amyloid precursor protein/presenilin-1 doubly transgenic mice
    • Liu L, Herukka SK, Minkeviciene R, van Groen T, Tanila H. Longitudinal observation on CSF Abeta42 levels in young to middle-aged amyloid precursor protein/presenilin-1 doubly transgenic mice. Neurobiol Dis 17(3): 516-523 (2004).
    • (2004) Neurobiol Dis , vol.17 , Issue.3 , pp. 516-523
    • Liu, L.1    Herukka, S.K.2    Minkeviciene, R.3    van Groen, T.4    Tanila, H.5
  • 36
    • 0030009752 scopus 로고    scopus 로고
    • Cerebral metastases of an allogenic renal cell carcinoma in a heart recipient without renal cell carcinoma
    • Meyding-Lamade U, Krieger D, Schnabel P, Sartor K, Sack FU, Gass P, et al. Cerebral metastases of an allogenic renal cell carcinoma in a heart recipient without renal cell carcinoma. J Neurol 243(5): 425-427 (1996).
    • (1996) J Neurol , vol.243 , Issue.5 , pp. 425-427
    • Meyding-Lamade, U.1    Krieger, D.2    Schnabel, P.3    Sartor, K.4    Sack, F.U.5    Gass, P.6
  • 38
    • 71849113134 scopus 로고    scopus 로고
    • Increased hippocampal neurogenesis in the progressive stage of Alzheimer's disease phenotype in an APP/PS1 double transgenic mouse model
    • Yu Y, He J, Zhang Y, Luo H, Zhu S, Yang Y, et al. Increased hippocampal neurogenesis in the progressive stage of Alzheimer's disease phenotype in an APP/PS1 double transgenic mouse model. Hippocampus 19(12): 1247-1253 (2009).
    • (2009) Hippocampus , vol.19 , Issue.12 , pp. 1247-1253
    • Yu, Y.1    He, J.2    Zhang, Y.3    Luo, H.4    Zhu, S.5    Yang, Y.6
  • 40
    • 2642552331 scopus 로고    scopus 로고
    • Lithium, a common drug for bipolar disorder treatment, regulates amyloidbeta precursor protein processing
    • Su Y, Ryder J, Li B, Wu X, Fox N, Solenberg P, et al. Lithium, a common drug for bipolar disorder treatment, regulates amyloidbeta precursor protein processing. Biochemistry 43(22): 6899-6908 (2004).
    • (2004) Biochemistry , vol.43 , Issue.22 , pp. 6899-6908
    • Su, Y.1    Ryder, J.2    Li, B.3    Wu, X.4    Fox, N.5    Solenberg, P.6
  • 41
    • 0442276554 scopus 로고    scopus 로고
    • The glamour and gloom of glycogen synthase kinase-3
    • Jope RS, Johnson GV. The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci 29(2): 95-102 (2004).
    • (2004) Trends Biochem Sci , vol.29 , Issue.2 , pp. 95-102
    • Jope, R.S.1    Johnson, G.V.2
  • 42
    • 34247865533 scopus 로고    scopus 로고
    • A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation
    • Lochhead PA, Kinstrie R, Sibbet G, Rawjee T, Morrice N, Cleghon V. A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation. Mol Cell 24(4): 627-633 (2006).
    • (2006) Mol Cell , vol.24 , Issue.4 , pp. 627-633
    • Lochhead, P.A.1    Kinstrie, R.2    Sibbet, G.3    Rawjee, T.4    Morrice, N.5    Cleghon, V.6
  • 43
    • 0035830686 scopus 로고    scopus 로고
    • Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes
    • Arendash GW, King DL, Gordon MN, Morgan D, Hatcher JM, Hope CE, et al. Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes. Brain Res 891(1-2): 42-53 (2001).
    • (2001) Brain Res , vol.891 , Issue.1-2 , pp. 42-53
    • Arendash, G.W.1    King, D.L.2    Gordon, M.N.3    Morgan, D.4    Hatcher, J.M.5    Hope, C.E.6
  • 44
    • 0035067311 scopus 로고    scopus 로고
    • Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease
    • Matsuoka Y, Picciano M, Malester B, LaFrancois J, Zehr C, Daeschner JM, et al. Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease. Am. J Pathol 158(4): 1345-1354 (2001).
    • (2001) Am J Pathol , vol.158 , Issue.4 , pp. 1345-1354
    • Matsuoka, Y.1    Picciano, M.2    Malester, B.3    LaFrancois, J.4    Zehr, C.5    Daeschner, J.M.6
  • 45
  • 46
    • 0036235633 scopus 로고    scopus 로고
    • Hippocampal A beta 42 levels correlate with spatial memory deficit in APP and PS1 double transgenic mice
    • Puolivali J, Wang J, Heikkinen T, Heikkilä M, Tapiola T, van Groen T, et al. Hippocampal A beta 42 levels correlate with spatial memory deficit in APP and PS1 double transgenic mice. Neurobiol Dis 9(3): 339-347 (2002).
    • (2002) Neurobiol Dis , vol.9 , Issue.3 , pp. 339-347
    • Puolivali, J.1    Wang, J.2    Heikkinen, T.3    Heikkilä, M.4    Tapiola, T.5    van Groen, T.6
  • 47
    • 12144288683 scopus 로고    scopus 로고
    • Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease
    • Schmitz C, Rutten BP, Pielen A, Schäfer S, Wirths O, Tremp G, et al. Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease. Am. J Pathol 164(4): 1495-1502 (2004).
    • (2004) Am J Pathol , vol.164 , Issue.4 , pp. 1495-1502
    • Schmitz, C.1    Rutten, B.P.2    Pielen, A.3    Schäfer, S.4    Wirths, O.5    Tremp, G.6
  • 48
    • 77955056492 scopus 로고    scopus 로고
    • The etiology of agerelated dementia is more complicated than we think
    • McDonald RJ, Craig LA, and Hong NS. The etiology of agerelated dementia is more complicated than we think. Behav. Brain Res 214(1): 3-11 (2010).
    • (2010) Behav Brain Res , vol.214 , Issue.1 , pp. 3-11
    • McDonald, R.J.1    Craig, L.A.2    Hong, N.S.3
  • 49
    • 42949155299 scopus 로고    scopus 로고
    • Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: Prevention by systemic passive immunization
    • Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, et al. Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization. J Neurosci 28(16): 4231-4237 (2008).
    • (2008) J Neurosci , vol.28 , Issue.16 , pp. 4231-4237
    • Klyubin, I.1    Betts, V.2    Welzel, A.T.3    Blennow, K.4    Zetterberg, H.5    Wallin, A.6
  • 50
    • 49149124343 scopus 로고    scopus 로고
    • Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    • Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, et al. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 14(8): 837-842 (2008).
    • (2008) Nat Med , vol.14 , Issue.8 , pp. 837-842
    • Shankar, G.M.1    Li, S.2    Mehta, T.H.3    Garcia-Munoz, A.4    Shepardson, N.E.5    Smith, I.6
  • 51
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, et al. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30(4): 572-580 (1991).
    • (1991) Ann Neurol , vol.30 , Issue.4 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    DeTeresa, R.5    Hill, R.6
  • 52
    • 0027495192 scopus 로고
    • The synaptic organization of the neocortex in Alzheimer's disease
    • Masliah E, Miller A, Terry RD. The synaptic organization of the neocortex in Alzheimer's disease. Med Hypotheses 41(4): 334-340 (1993).
    • (1993) Med Hypotheses , vol.41 , Issue.4 , pp. 334-340
    • Masliah, E.1    Miller, A.2    Terry, R.D.3
  • 53
    • 0034659732 scopus 로고    scopus 로고
    • Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: Maintenance of core components independent of actin filaments and microtubules
    • Allison DW, Chervin AS, Gelfand VI, Craig AM. Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: maintenance of core components independent of actin filaments and microtubules. J Neurosci 20(12): 4545-4554 (2000).
    • (2000) J Neurosci , vol.20 , Issue.12 , pp. 4545-4554
    • Allison, D.W.1    Chervin, A.S.2    Gelfand, V.I.3    Craig, A.M.4
  • 54
    • 14644401845 scopus 로고    scopus 로고
    • Drebrin A is a postsynaptic protein that localizes in vivo to the submembranous surface of dendritic sites forming excitatory synapses
    • Aoki C, Sekino Y, Hanamura K, Fujisawa S, Mahadomrongkul V, Ren Y, et al. Drebrin A is a postsynaptic protein that localizes in vivo to the submembranous surface of dendritic sites forming excitatory synapses. J Comp. Neurol 483(4): 383-402 (2005).
    • (2005) J Comp Neurol , vol.483 , Issue.4 , pp. 383-402
    • Aoki, C.1    Sekino, Y.2    Hanamura, K.3    Fujisawa, S.4    Mahadomrongkul, V.5    Ren, Y.6
  • 55
    • 0037166050 scopus 로고    scopus 로고
    • Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome
    • Shim KS, Lubec G. Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome. Neurosci Lett 324(3): 209-212 (2002).
    • (2002) Neurosci Lett , vol.324 , Issue.3 , pp. 209-212
    • Shim, K.S.1    Lubec, G.2
  • 56
    • 4444223956 scopus 로고    scopus 로고
    • Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model
    • Calon F, Lim GP, Yang F, Morihara T, Teter B, Ubeda O, et al. Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron 43(5): 633-645 (2004).
    • (2004) Neuron , vol.43 , Issue.5 , pp. 633-645
    • Calon, F.1    Lim, G.P.2    Yang, F.3    Morihara, T.4    Teter, B.5    Ubeda, O.6
  • 57
    • 21244480573 scopus 로고    scopus 로고
    • Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L transgenic mice
    • Rutten BP, Van der Kolk NM, Schafer S, van Zandvoort MA, Bayer TA, Steinbusch HW, et al. Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L transgenic mice. Am J Pathol 167(1): 161-173 (2005).
    • (2005) Am J Pathol , vol.167 , Issue.1 , pp. 161-173
    • Rutten, B.P.1    van der Kolk, N.M.2    Schafer, S.3    van Zandvoort, M.A.4    Bayer, T.A.5    Steinbusch, H.W.6
  • 58
    • 33645830313 scopus 로고    scopus 로고
    • Vicious cycles within the neuropathophysiologic mechanisms of Alzheimer's disease
    • Standridge JB. Vicious cycles within the neuropathophysiologic mechanisms of Alzheimer's disease. Curr. Alzheimer Res 3(2): 95-108 (2006).
    • (2006) Curr Alzheimer Res , vol.3 , Issue.2 , pp. 95-108
    • Standridge, J.B.1
  • 59
    • 0042838303 scopus 로고    scopus 로고
    • Alzheimer's disease-affected brain: Presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
    • Gong Y, Chang L, Viola KL, Lacor PN, Lambert MP, Finch CE, et al. Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc Natl Acad Sci USA 100(18): 10417-10422 (2003).
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.18 , pp. 10417-10422
    • Gong, Y.1    Chang, L.2    Viola, K.L.3    Lacor, P.N.4    Lambert, M.P.5    Finch, C.E.6
  • 60
    • 14044279957 scopus 로고    scopus 로고
    • Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease
    • Georganopoulou DG, Chang L, Nam JM, Thaxton CS, Mufson EJ, Klein WL, et al. Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease. Proc Natl Acad Sci USA 102(7): 2273-2276 (2005).
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.7 , pp. 2273-2276
    • Georganopoulou, D.G.1    Chang, L.2    Nam, J.M.3    Thaxton, C.S.4    Mufson, E.J.5    Klein, W.L.6
  • 61
    • 77957272505 scopus 로고    scopus 로고
    • Neurotrophins enhance CaMKII activity and rescue amyloid-beta-induced deficits in hippocampal synaptic plasticity
    • Zeng Y, Zhao D, Xie CW. Neurotrophins enhance CaMKII activity and rescue amyloid-beta-induced deficits in hippocampal synaptic plasticity. J Alzheimers Dis 21(3): 823-831 (2010).
    • (2010) J Alzheimers Dis , vol.21 , Issue.3 , pp. 823-831
    • Zeng, Y.1    Zhao, D.2    Xie, C.W.3
  • 62
    • 0037087022 scopus 로고    scopus 로고
    • Quetiapine attenuates the immobilization stress-induced decrease of brain-derived neurotrophic factor expression in rat hippocampus
    • Xu H, Qing H, Lu W, Keegan D, Richardson JS, Chlan-Fourney J, et al. Quetiapine attenuates the immobilization stress-induced decrease of brain-derived neurotrophic factor expression in rat hippocampus. Neurosci Lett 321(1-2): 65-68 (2002).
    • (2002) Neurosci Lett , vol.321 , Issue.1-2 , pp. 65-68
    • Xu, H.1    Qing, H.2    Lu, W.3    Keegan, D.4    Richardson, J.S.5    Chlan-Fourney, J.6
  • 63
    • 4644252709 scopus 로고    scopus 로고
    • Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801
    • Fumagalli F, Molteni R, Bedogni F, Gennarelli M, Perez J, Racagni G, et al. Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801. Neuroreport 15(13): 2109-2112 (2004).
    • (2004) Neuroreport , vol.15 , Issue.13 , pp. 2109-2112
    • Fumagalli, F.1    Molteni, R.2    Bedogni, F.3    Gennarelli, M.4    Perez, J.5    Racagni, G.6
  • 64
    • 2342451962 scopus 로고    scopus 로고
    • Antipsychotic drugs clozapine and olanzapine upregulate bcl-2 mRNA and protein in rat frontal cortex and hippocampus
    • Bai O, Zhang H, Li XM. Antipsychotic drugs clozapine and olanzapine upregulate bcl-2 mRNA and protein in rat frontal cortex and hippocampus. Brain Res 1010(1-2): 81-86 (2004).
    • (2004) Brain Res , vol.1010 , Issue.1-2 , pp. 81-86
    • Bai, O.1    Zhang, H.2    Li, X.M.3
  • 65
    • 0032575688 scopus 로고    scopus 로고
    • The Bcl-2 protein family: Arbiters of cell survival
    • Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 281(5381): 1322-1326 (1998).
    • (1998) Science , vol.281 , Issue.5381 , pp. 1322-1326
    • Adams, J.M.1    Cory, S.2
  • 67
    • 24744433317 scopus 로고    scopus 로고
    • Olanzapine and quetiapine protect PC12 cells from beta-amyloid peptide(25-35)-induced oxidative stress and the ensuing apoptosis
    • Wang H, Xu H, Dyck LE, Li XM. Olanzapine and quetiapine protect PC12 cells from beta-amyloid peptide(25-35)-induced oxidative stress and the ensuing apoptosis. J Neurosci Res 81(4): 572-580 (2005).
    • (2005) J Neurosci Res , vol.81 , Issue.4 , pp. 572-580
    • Wang, H.1    Xu, H.2    Dyck, L.E.3    Li, X.M.4
  • 69
    • 77949381494 scopus 로고    scopus 로고
    • GSK-3 beta inhibits presynaptic vesicle exocytosis by phosphorylating P/Q-type calcium channel and interrupting SNARE complex formation
    • Zhu LQ, Liu D, Hu J, Cheng J, Wang SH, Wang Q, et al. GSK-3 beta inhibits presynaptic vesicle exocytosis by phosphorylating P/Q-type calcium channel and interrupting SNARE complex formation. J Neurosci 30(10): 3624-3633 (2010).
    • (2010) J Neurosci , vol.30 , Issue.10 , pp. 3624-3633
    • Zhu, L.Q.1    Liu, D.2    Hu, J.3    Cheng, J.4    Wang, S.H.5    Wang, Q.6
  • 70
    • 36048937547 scopus 로고    scopus 로고
    • Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments
    • Zhu LQ, Wang SH, Liu D, Yin YY, Tian Q, Wang XC, et al. Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments. J Neurosci 27(45): 12211-12220 (2007).
    • (2007) J Neurosci , vol.27 , Issue.45 , pp. 12211-12220
    • Zhu, L.Q.1    Wang, S.H.2    Liu, D.3    Yin, Y.Y.4    Tian, Q.5    Wang, X.C.6
  • 71
    • 54249140068 scopus 로고    scopus 로고
    • GSK-3 inhibitors: A ray of hope for the treatment of Alzheimer's disease?
    • Martinez A, Perez DI. GSK-3 inhibitors: a ray of hope for the treatment of Alzheimer's disease? J Alzheimers Dis 15(2): 181-191 (2008).
    • (2008) J Alzheimers Dis , vol.15 , Issue.2 , pp. 181-191
    • Martinez, A.1    Perez, D.I.2
  • 72
    • 0030035749 scopus 로고    scopus 로고
    • In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta
    • Aplin AE, Gibb GM, Jacobsen JS, Gallo JM, Anderton BH. In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta. J Neurochem 67(2): 699-707 (1996).
    • (1996) J Neurochem , vol.67 , Issue.2 , pp. 699-707
    • Aplin, A.E.1    Gibb, G.M.2    Jacobsen, J.S.3    Gallo, J.M.4    Anderton, B.H.5
  • 73
    • 0035477020 scopus 로고    scopus 로고
    • GSK3 takes centre stage more than 20 years after its discovery
    • Frame S, Cohen P. GSK3 takes centre stage more than 20 years after its discovery. Biochem. J: 359(Pt 1): 1-16 (2001).
    • (2001) Biochem J , vol.359 , Issue.PART 1 , pp. 1-16
    • Frame, S.1    Cohen, P.2
  • 74
  • 75
    • 33751539763 scopus 로고    scopus 로고
    • Cognitive effects of atypical antipsychotics in patients with Alzheimer's disease and comorbid psychiatric or behavioral problems: A retrospective study
    • Caballero J, Hitchcock M, Scharre D, Beversdorf D, Nahata MC. Cognitive effects of atypical antipsychotics in patients with Alzheimer's disease and comorbid psychiatric or behavioral problems: a retrospective study. Clin Ther 28(10): 1695-1700 (2006).
    • (2006) Clin Ther , vol.28 , Issue.10 , pp. 1695-1700
    • Caballero, J.1    Hitchcock, M.2    Scharre, D.3    Beversdorf, D.4    Nahata, M.C.5
  • 76
    • 0036283590 scopus 로고    scopus 로고
    • Cognitive and behavioral effects of quetiapine in Alzheimer disease patients
    • Scharre DW, Chang SI. Cognitive and behavioral effects of quetiapine in Alzheimer disease patients. Alzheimer Dis Assoc Disord 16(2): 128-130 (2002).
    • (2002) Alzheimer Dis Assoc Disord , vol.16 , Issue.2 , pp. 128-130
    • Scharre, D.W.1    Chang, S.I.2
  • 78
    • 80052431861 scopus 로고    scopus 로고
    • Cognitive effects of atypical antipsychotic medications in patients with Alzheimer's disease: Outcomes from CATIE-AD
    • Vigen CL, Mack WJ, Keefe RS, Sano M, Sultzer DL, Stroup TS, et al. Cognitive effects of atypical antipsychotic medications in patients with Alzheimer's disease: outcomes from CATIE-AD. Am J Psychiatry 168(8): 831-839 (2011).
    • (2011) Am J Psychiatry , vol.168 , Issue.8 , pp. 831-839
    • Vigen, C.L.1    Mack, W.J.2    Keefe, R.S.3    Sano, M.4    Sultzer, D.L.5    Stroup, T.S.6
  • 80
    • 84861755926 scopus 로고    scopus 로고
    • Sensorimotor gating and memory deficits in an APP/PS1 double transgenic mouse model of Alzheimer's disease
    • Wang H, He J, Zhang R, Zhu S, Wang J, Kong L, et al. Sensorimotor gating and memory deficits in an APP/PS1 double transgenic mouse model of Alzheimer's disease. Behav Brain Res 233(1): 237-243 (2012).
    • (2012) Behav Brain Res , vol.233 , Issue.1 , pp. 237-243
    • Wang, H.1    He, J.2    Zhang, R.3    Zhu, S.4    Wang, J.5    Kong, L.6
  • 81
    • 0032982714 scopus 로고    scopus 로고
    • Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia
    • Kapur S, Zipursky RB, Remington G. Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia. Am J Psychiatry 156(2): 286-293 (1999).
    • (1999) Am J Psychiatry , vol.156 , Issue.2 , pp. 286-293
    • Kapur, S.1    Zipursky, R.B.2    Remington, G.3
  • 82
    • 0032973806 scopus 로고    scopus 로고
    • Rapid release of antipsychotic drugs from dopamine D2 receptors: An explanation for low receptor occupancy and early clinical relapse upon withdrawal of clozapine or quetiapine
    • Seeman P, Tallerico T. Rapid release of antipsychotic drugs from dopamine D2 receptors: an explanation for low receptor occupancy and early clinical relapse upon withdrawal of clozapine or quetiapine. Am J Psychiatry 156(6): 876-884(1999).
    • (1999) Am J Psychiatry , vol.156 , Issue.6 , pp. 876-884
    • Seeman, P.1    Tallerico, T.2
  • 83
    • 67049101057 scopus 로고    scopus 로고
    • Neuroprotective effect of atypical antipsychotics in cognitive and non-cognitive behavioral impairment in animal models
    • He J, Kong J, Tan QR, Li XM. Neuroprotective effect of atypical antipsychotics in cognitive and non-cognitive behavioral impairment in animal models. Cell Adh Migr 3(1): 129-137 (2009).
    • (2009) Cell Adh Migr , vol.3 , Issue.1 , pp. 129-137
    • He, J.1    Kong, J.2    Tan, Q.R.3    Li, X.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.