메뉴 건너뛰기




Volumn 19, Issue 9, 2013, Pages 1727-1738

Platelets in Alzheimer's disease-associated cellular senescence and inflammation

Author keywords

Aging; Alzheimer's disease; Amyloid; Inflammation; Platelets; Senescence; Therapeutic targets

Indexed keywords

ACETYLSALICYLIC ACID; AMYLOID BETA PROTEIN; CD28 ANTIGEN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DONEPEZIL; EBSELEN; GAMMA INTERFERON; HEPARIN; HIGH MOBILITY GROUP B1 PROTEIN; IBUPROFEN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; PARACETAMOL; RANTES; THROMBOCYTE FACTOR 4; TUMOR NECROSIS FACTOR ALPHA; VIMENTIN;

EID: 84876721533     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161213805219694     Document Type: Article
Times cited : (17)

References (168)
  • 1
    • 78649350746 scopus 로고    scopus 로고
    • The aging stress response
    • Haigis MC, Yankner BA. The aging stress response. Mol Cell 2010; 40: 333-44.
    • (2010) Mol Cell , vol.40 , pp. 333-344
    • Haigis, M.C.1    Yankner, B.A.2
  • 2
    • 70349807619 scopus 로고    scopus 로고
    • Immune activation in brain aging and neurodegeneration: Too much or too little?
    • Lucin KM, Wyss-Coray T. Immune activation in brain aging and neurodegeneration: too much or too little? Neuron 2009; 64: 110-22.
    • (2009) Neuron , vol.64 , pp. 110-122
    • Lucin, K.M.1    Wyss-Coray, T.2
  • 3
    • 33747888336 scopus 로고    scopus 로고
    • Differential aging of the brain: Patterns, cognitive correlates and modifiers
    • Raz N, Rodrigue KM. Differential aging of the brain: patterns, cognitive correlates and modifiers. Neurosci Biobehav Rev 2006; 30: 730-48.
    • (2006) Neurosci Biobehav Rev , vol.30 , pp. 730-748
    • Raz, N.1    Rodrigue, K.M.2
  • 4
    • 33846672434 scopus 로고    scopus 로고
    • Ageing and the brain
    • Esiri MM. Ageing and the brain. J Pathol 2007; 211: 181-7.
    • (2007) J Pathol , vol.211 , pp. 181-187
    • Esiri, M.M.1
  • 6
    • 0025283380 scopus 로고
    • Morphological adaptive response of the synaptic junctional zones in the human dentate gyrus during aging and Alzheimer's disease
    • Bertoni-Freddari C, Fattoretti P, Casoli T, Meier-Ruge W, Ulrich J. Morphological adaptive response of the synaptic junctional zones in the human dentate gyrus during aging and Alzheimer's disease. Brain Res 1990; 517: 69-75.
    • (1990) Brain Res , vol.517 , pp. 69-75
    • Bertoni-Freddari, C.1    Fattoretti, P.2    Casoli, T.3    Meier-Ruge, W.4    Ulrich, J.5
  • 9
    • 77956362155 scopus 로고    scopus 로고
    • Protein homeostasis and aging in neurodegeneration
    • Douglas PM, Dillin A. Protein homeostasis and aging in neurodegeneration. J Cell Biol 2010; 190: 719-29.
    • (2010) J Cell Biol , vol.190 , pp. 719-729
    • Douglas, P.M.1    Dillin, A.2
  • 10
    • 34249051111 scopus 로고    scopus 로고
    • Calcium homeostasis and modulation of synaptic plasticity in the aged brain
    • Foster TC. Calcium homeostasis and modulation of synaptic plasticity in the aged brain. Aging Cell 2007; 6: 319-25.
    • (2007) Aging Cell , vol.6 , pp. 319-325
    • Foster, T.C.1
  • 12
    • 45449093259 scopus 로고    scopus 로고
    • Neuronal pigmented autophagic vacuoles: Lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease
    • Sulzer D, Mosharov E, Talloczy Z, Zucca FA, Simon JD, Zecca L. Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease. J Neurochem 2008; 106: 24-36.
    • (2008) J Neurochem , vol.106 , pp. 24-36
    • Sulzer, D.1    Mosharov, E.2    Talloczy, Z.3    Zucca, F.A.4    Simon, J.D.5    Zecca, L.6
  • 13
    • 38949175007 scopus 로고    scopus 로고
    • A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging
    • Miller JA, Oldham MC, Geschwind DH. A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging. J Neurosi 2008; 28: 1410-20.
    • (2008) J Neurosi , vol.28 , pp. 1410-1420
    • Miller, J.A.1    Oldham, M.C.2    Geschwind, D.H.3
  • 14
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961; 25: 585-621.
    • (1961) Exp Cell Res , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 15
    • 0027163464 scopus 로고
    • Replicative senescence of human fibroblast-like cells in culture
    • Cristofalo VJ, Pignolo RJ. Replicative senescence of human fibroblast-like cells in culture. Physiol Rev 1993; 73: 617-38.
    • (1993) Physiol Rev , vol.73 , pp. 617-638
    • Cristofalo, V.J.1    Pignolo, R.J.2
  • 16
    • 0000299214 scopus 로고
    • Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo
    • Röhme D. Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo. Proc Natl Acad Sci USA 1981; 78: 5009-13.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 5009-5013
    • Röhme, D.1
  • 17
    • 0028298519 scopus 로고
    • Assignment of two human epidermal squamous cell carcinomas cell lines to more than one complementation group for the immortal phenotype
    • Berry IJ, Burns JE, Parkinson EK. Assignment of two human epidermal squamous cell carcinomas cell lines to more than one complementation group for the immortal phenotype. Mol Carcinog 1994; 9: 134-42.
    • (1994) Mol Carcinog , vol.9 , pp. 134-142
    • Berry, I.J.1    Burns, J.E.2    Parkinson, E.K.3
  • 19
    • 74949127989 scopus 로고    scopus 로고
    • Protocols to detect senescence associated beta-galactosidase (SAbetagal) activity, a biomarker of senescent cells in culture and in vivo
    • Debacq-Chainiaux F, Erusalimsky JD, Campisi J, Toussaint O. Protocols to detect senescence associated beta-galactosidase (SAbetagal) activity, a biomarker of senescent cells in culture and in vivo. Nat Protoc 2009; 4: 1798-806.
    • (2009) Nat Protoc , vol.4 , pp. 1798-1806
    • Debacq-Chainiaux, F.1    Erusalimsky, J.D.2    Campisi, J.3    Toussaint, O.4
  • 20
    • 63849285200 scopus 로고    scopus 로고
    • Superoxide and nitric oxide in senescence and aging
    • Afanas'ev I. Superoxide and nitric oxide in senescence and aging. Front Biosci 2009; 14:3899-912.
    • (2009) Front Biosci , vol.14 , pp. 3899-3912
    • Afanas'ev, I.1
  • 21
    • 84900969225 scopus 로고    scopus 로고
    • Ink4a/Arf expression is a biomarker of aging
    • Krishnamurthy J, Torrice C, Ramsey MR, et al. Ink4a/Arf expression is a biomarker of aging. J Clin Invest 2004; 114: 1299-307.
    • (2004) J Clin Invest , vol.114 , pp. 1299-1307
    • Krishnamurthy, J.1    Torrice, C.2    Ramsey, M.R.3
  • 22
    • 34648816970 scopus 로고    scopus 로고
    • Cellular senescence and chromatin structure
    • Funayama R, Ishikawa F. Cellular senescence and chromatin structure. Chromosoma 2007; 116: 431-40.
    • (2007) Chromosoma , vol.116 , pp. 431-440
    • Funayama, R.1    Ishikawa, F.2
  • 23
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: When bad things happen to good cells
    • Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol. 2007; 8: 729-40.
    • (2007) Nat Rev Mol Cell Biol. , vol.8 , pp. 729-740
    • Campisi, J.1    d'Adda di Fagagna, F.2
  • 24
    • 5444229646 scopus 로고    scopus 로고
    • Gene expression and regulation in H2O2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase
    • de Magalhães JP, Chainiaux F, de Longueville F, et al. Gene expression and regulation in H2O2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase. Exp Gerontol 2004; 39: 1379-89.
    • (2004) Exp Gerontol , vol.39 , pp. 1379-1389
    • de Magalhães, J.P.1    Chainiaux, F.2    de Longueville, F.3
  • 25
    • 77949881221 scopus 로고    scopus 로고
    • The senescenceassociated secretory phenotype: The dark side of tumor suppression
    • Coppé JP, Desprez PY, Krtolica A, Campisi J. The senescenceassociated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol 2010; 5: 99-118.
    • (2010) Annu Rev Pathol , vol.5 , pp. 99-118
    • Coppé, J.P.1    Desprez, P.Y.2    Krtolica, A.3    Campisi, J.4
  • 27
    • 77952105389 scopus 로고    scopus 로고
    • Inflammatory networks during cellular senescence: Causes and consequences
    • Freund A, Orjalo AV, Desprez PY, Campisi J. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med 2010; 16: 238-46.
    • (2010) Trends Mol Med , vol.16 , pp. 238-246
    • Freund, A.1    Orjalo, A.V.2    Desprez, P.Y.3    Campisi, J.4
  • 28
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990; 345: 458-60.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 29
    • 35148879733 scopus 로고    scopus 로고
    • Ageing or cancer: A review on the role of caretakers and gatekeepers
    • van Heemst D, den Reijer PM, Westendorp RG. Ageing or cancer: a review on the role of caretakers and gatekeepers. Eur J Cancer 2007; 43: 2144-52.
    • (2007) Eur J Cancer , vol.43 , pp. 2144-2152
    • van Heemst, D.1    den Reijer, P.M.2    Westendorp, R.G.3
  • 30
    • 33748080443 scopus 로고    scopus 로고
    • Regulation of cellular senescence by Rb2/p130
    • Helmbold H, Deppert W, Bohn W. Regulation of cellular senescence by Rb2/p130. Oncogene 2006; 25: 5257-62.
    • (2006) Oncogene , vol.25 , pp. 5257-5262
    • Helmbold, H.1    Deppert, W.2    Bohn, W.3
  • 31
    • 0033552588 scopus 로고    scopus 로고
    • Alternative pathways for the extension of cellular life span: Inactivation of p53/pRb and expression of telomerase
    • Vaziri H, Benchimol S. Alternative pathways for the extension of cellular life span: inactivation of p53/pRb and expression of telomerase. Oncogene 1999; 18: 7676-80.
    • (1999) Oncogene , vol.18 , pp. 7676-7680
    • Vaziri, H.1    Benchimol, S.2
  • 32
    • 0037007075 scopus 로고    scopus 로고
    • Endothelial cell senescence in human atherosclerosis: Role of telomere in endothelial dysfunction
    • Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H, Komuro I. Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation 2002; 105: 1541-4.
    • (2002) Circulation , vol.105 , pp. 1541-1544
    • Minamino, T.1    Miyauchi, H.2    Yoshida, T.3    Ishida, Y.4    Yoshida, H.5    Komuro, I.6
  • 33
    • 0037382970 scopus 로고    scopus 로고
    • Cellular senescence in the pathogenesis of benign prostatic hyperplasia
    • Castro P, Giri D, Lamb D, Ittmann M. Cellular senescence in the pathogenesis of benign prostatic hyperplasia. Prostate 2003; 55: 30-8.
    • (2003) Prostate , vol.55 , pp. 30-38
    • Castro, P.1    Giri, D.2    Lamb, D.3    Ittmann, M.4
  • 34
    • 33749171885 scopus 로고    scopus 로고
    • Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
    • Molofsky AV, Slutsky SG, Joseph NM, et al. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 2006; 443: 448-52.
    • (2006) Nature , vol.443 , pp. 448-452
    • Molofsky, A.V.1    Slutsky, S.G.2    Joseph, N.M.3
  • 35
    • 33749187810 scopus 로고    scopus 로고
    • p16INK4a induces an age-dependent decline in islet regenerative potential
    • Krishnamurthy J, Ramsey MR, Ligon KL, et al. p16INK4a induces an age-dependent decline in islet regenerative potential. Nature 2006; 443: 453-7.
    • (2006) Nature , vol.443 , pp. 453-457
    • Krishnamurthy, J.1    Ramsey, M.R.2    Ligon, K.L.3
  • 36
    • 80855138775 scopus 로고    scopus 로고
    • Clearance of p16Ink4apositive senescent cells delays ageing-associated disorders
    • Baker DJ, Wijshake T, Tchkonia T, et al. Clearance of p16Ink4apositive senescent cells delays ageing-associated disorders. Nature 2011; 479: 232-6.
    • (2011) Nature , vol.479 , pp. 232-236
    • Baker, D.J.1    Wijshake, T.2    Tchkonia, T.3
  • 37
    • 42949129074 scopus 로고    scopus 로고
    • Many roads lead to oncogene-induced senescence
    • Courtois-Cox S, Jones SL, Cichowski K. Many roads lead to oncogene-induced senescence. Oncogene 2008; 27: 2801-9.
    • (2008) Oncogene , vol.27 , pp. 2801-2809
    • Courtois-Cox, S.1    Jones, S.L.2    Cichowski, K.3
  • 39
    • 33846887598 scopus 로고    scopus 로고
    • Microglial control of neuronal death and synaptic properties
    • Bessis A, Béchade C, Bernard D, Roumier A. Microglial control of neuronal death and synaptic properties. Glia 2007; 55: 233-8.
    • (2007) Glia , vol.55 , pp. 233-238
    • Bessis, A.1    Béchade, C.2    Bernard, D.3    Roumier, A.4
  • 40
    • 63149088164 scopus 로고    scopus 로고
    • Trophic macrophages in development and disease
    • Pollard JW. Trophic macrophages in development and disease. Nat Rev Immunol 2009; 9: 259-70.
    • (2009) Nat Rev Immunol , vol.9 , pp. 259-270
    • Pollard, J.W.1
  • 41
    • 0031815256 scopus 로고    scopus 로고
    • Cytokine mRNA profiles in contused spinal cord and axotomized facial nucleus suggest a beneficial role for inflammation and gliosis
    • Streit WJ, Semple-Rowland SL, Hurley SD, Miller RC, Popovich PG, Stokes BT. Cytokine mRNA profiles in contused spinal cord and axotomized facial nucleus suggest a beneficial role for inflammation and gliosis. Exp Neurol 1998; 152: 74-87.
    • (1998) Exp Neurol , vol.152 , pp. 74-87
    • Streit, W.J.1    Semple-Rowland, S.L.2    Hurley, S.D.3    Miller, R.C.4    Popovich, P.G.5    Stokes, B.T.6
  • 42
    • 0025162755 scopus 로고
    • Brain microglia constitutively express beta-2 integrins
    • Akiyama H, McGeer PL. Brain microglia constitutively express beta-2 integrins. J Neuroimmunol 1990; 30: 81-93.
    • (1990) J Neuroimmunol , vol.30 , pp. 81-93
    • Akiyama, H.1    McGeer, P.L.2
  • 43
    • 0033822556 scopus 로고    scopus 로고
    • Thrombin-induced activation of cultured rodent microglia
    • Moller T, Hanisch UK, Ransom BR. Thrombin-induced activation of cultured rodent microglia. J Neurochem 2000; 75: 1539-47.
    • (2000) J Neurochem , vol.75 , pp. 1539-1547
    • Moller, T.1    Hanisch, U.K.2    Ransom, B.R.3
  • 45
    • 0347285467 scopus 로고    scopus 로고
    • Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes
    • Flanary BE, Streit WJ. Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes. Glia 2004; 45: 75-88.
    • (2004) Glia , vol.45 , pp. 75-88
    • Flanary, B.E.1    Streit, W.J.2
  • 46
    • 2342452013 scopus 로고    scopus 로고
    • Telomeres shorten with age in rat cerebellum and cortex in vivo
    • Flanary BE, Streit WJ. Telomeres shorten with age in rat cerebellum and cortex in vivo. J Anti-Aging Med 2003; 6: 299-308.
    • (2003) J Anti-Aging Med , vol.6 , pp. 299-308
    • Flanary, B.E.1    Streit, W.J.2
  • 48
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • Abbott NJ, Rönnbäck L, Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 2006; 7: 41-53.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 41-53
    • Abbott, N.J.1    Rönnbäck, L.2    Hansson, E.3
  • 49
    • 33847099936 scopus 로고    scopus 로고
    • Astrocytes are active players in cerebral innate immunity
    • Farina C, Aloisi F, Meinl E. Astrocytes are active players in cerebral innate immunity. Trends Immunol 2007; 28: 138-45.
    • (2007) Trends Immunol , vol.28 , pp. 138-145
    • Farina, C.1    Aloisi, F.2    Meinl, E.3
  • 50
    • 0023479327 scopus 로고
    • A morphological study of the neostriatum of aged mice with particular reference to neuroglia
    • Sturrock RR. A morphological study of the neostriatum of aged mice with particular reference to neuroglia. J Hirnforsch 1987; 28: 505-15.
    • (1987) J Hirnforsch , vol.28 , pp. 505-515
    • Sturrock, R.R.1
  • 51
    • 0019799551 scopus 로고
    • Hippocampal aging in rats: A morphometric study of multiple variables in semithin sections
    • Landfield PW, Braun LD, Pitler TA, Lindsey JD, Lynch G. Hippocampal aging in rats: a morphometric study of multiple variables in semithin sections. Neurobiol Aging 1981; 2: 265-75.
    • (1981) Neurobiol Aging , vol.2 , pp. 265-275
    • Landfield, P.W.1    Braun, L.D.2    Pitler, T.A.3    Lindsey, J.D.4    Lynch, G.5
  • 53
    • 0042360512 scopus 로고    scopus 로고
    • Analysis of glial fibrillary protein in the human entorhinal cortex during aging and in Alzheimer's disease
    • Porchet R, Probst A, Bouras C, Draberova E, Draber P, Riederer BM. Analysis of glial fibrillary protein in the human entorhinal cortex during aging and in Alzheimer's disease. Proteomics 2003; 3: 1476-85.
    • (2003) Proteomics , vol.3 , pp. 1476-1485
    • Porchet, R.1    Probst, A.2    Bouras, C.3    Draberova, E.4    Draber, P.5    Riederer, B.M.6
  • 54
  • 55
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: Molecular mechanisms and biological functions of autophagy
    • Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 2004; 6: 463-77.
    • (2004) Dev Cell , vol.6 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 56
    • 0035063178 scopus 로고    scopus 로고
    • Garbage catastrophe theory of aging: Imperfect removal of oxidative damage?
    • Terman A. Garbage catastrophe theory of aging: imperfect removal of oxidative damage? Redox Rep 2001; 6: 15-26.
    • (2001) Redox Rep , vol.6 , pp. 15-26
    • Terman, A.1
  • 57
    • 0033636620 scopus 로고    scopus 로고
    • Neuronal CDK7 in hippocampus is related to aging and Alzheimer disease
    • Zhu X, Rottkamp CA, Raina AK, et al. Neuronal CDK7 in hippocampus is related to aging and Alzheimer disease. Neurobiol Aging 2000; 21: 807-13.
    • (2000) Neurobiol Aging , vol.21 , pp. 807-813
    • Zhu, X.1    Rottkamp, C.A.2    Raina, A.K.3
  • 58
    • 0027406459 scopus 로고
    • Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia
    • Lois C, Alvarez-Buylla A. Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia. Proc Natl Acad Sci USA 1993; 90: 2074-77.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2074-2077
    • Lois, C.1    Alvarez-Buylla, A.2
  • 59
    • 0029855989 scopus 로고    scopus 로고
    • Network of tangential pathways for neuronal migration in adult mammalian brain
    • Doetsch F, Alvarez-Buylla A. Network of tangential pathways for neuronal migration in adult mammalian brain. Proc Natl Acad Sci USA 1996; 93:14895-900.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14895-14900
    • Doetsch, F.1    Alvarez-Buylla, A.2
  • 61
    • 0036470561 scopus 로고    scopus 로고
    • Why new neurons? Possible functions for adult hippocampal neurogenesis
    • Kempermann G. Why new neurons? Possible functions for adult hippocampal neurogenesis. J Neurosci 2002; 22: 635-8.
    • (2002) J Neurosci , vol.22 , pp. 635-638
    • Kempermann, G.1
  • 62
    • 0036317901 scopus 로고    scopus 로고
    • Traumatic brain injury induced cell proliferation in the adult mammalian central nervous system
    • Chirumamilla S, Sun D, Bullock MR, Colello RJ. Traumatic brain injury induced cell proliferation in the adult mammalian central nervous system. J Neurotrauma 2002; 19: 693-703.
    • (2002) J Neurotrauma , vol.19 , pp. 693-703
    • Chirumamilla, S.1    Sun, D.2    Bullock, M.R.3    Colello, R.J.4
  • 63
    • 33847372963 scopus 로고    scopus 로고
    • Anatomical integration of newly generated granule neurons following TBI in adult rats and its association to cognitive recovery
    • Sun D, McGinn MJ, Zhou Z, Harvey HB, Bullock MR, Colello RJ. Anatomical integration of newly generated granule neurons following TBI in adult rats and its association to cognitive recovery. Exp Neurol 2007; 204: 264-72.
    • (2007) Exp Neurol , vol.204 , pp. 264-272
    • Sun, D.1    McGinn, M.J.2    Zhou, Z.3    Harvey, H.B.4    Bullock, M.R.5    Colello, R.J.6
  • 64
    • 84859438357 scopus 로고    scopus 로고
    • Age-related proteomic changes in the subventricular zone and their association with neural stem/progenitor cell proliferation
    • McGinn MJ, Colello RJ, Sun D. Age-related proteomic changes in the subventricular zone and their association with neural stem/progenitor cell proliferation. J Neurosci Res 2012; 90: 1159-68.
    • (2012) J Neurosci Res , vol.90 , pp. 1159-1168
    • McGinn, M.J.1    Colello, R.J.2    Sun, D.3
  • 65
    • 0031950413 scopus 로고    scopus 로고
    • Regulation of neurogenesis by growth factors and neurotransmitters
    • Cameron HA, Hazel TG, McKay RD. Regulation of neurogenesis by growth factors and neurotransmitters. J Neurobiol 1998; 36: 287-306.
    • (1998) J Neurobiol , vol.36 , pp. 287-306
    • Cameron, H.A.1    Hazel, T.G.2    McKay, R.D.3
  • 66
    • 84876717344 scopus 로고    scopus 로고
    • USA: Oxford University Press
    • Borenstein, In: Neuroepidemiology. From Principles to Practice. USA: Oxford University Press 2004.
    • (2004) From Principles to Practice
  • 67
    • 77957130057 scopus 로고    scopus 로고
    • Behavioural symptoms in patients with Alzheimer's disease and their association with cognitive impairment
    • COOPERA Study Group
    • Fernández M, Gobartt AL, Balañá M, COOPERA Study Group. Behavioural symptoms in patients with Alzheimer's disease and their association with cognitive impairment. BMC Neurol 2010; 10: 87.
    • (2010) BMC Neurol , vol.10 , pp. 87
    • Fernández, M.1    Gobartt, A.L.2    Balañá, M.3
  • 69
    • 75649135280 scopus 로고    scopus 로고
    • Neuropathology of Alzheimer's disease
    • Perl DP. Neuropathology of Alzheimer's disease. Mt Sinai J Med 2010; 77: 32-42.
    • (2010) Mt Sinai J Med , vol.77 , pp. 32-42
    • Perl, D.P.1
  • 71
    • 77955270739 scopus 로고    scopus 로고
    • Beta-Amyloid precursor protein metabolism: Focus on the functions and degradation of its intracellular domain
    • Buoso E, Lanni C, Schettini G, Govoni S, Racchi M. Beta-Amyloid precursor protein metabolism: focus on the functions and degradation of its intracellular domain. Pharmacol Res 2010; 62: 308-17.
    • (2010) Pharmacol Res , vol.62 , pp. 308-317
    • Buoso, E.1    Lanni, C.2    Schettini, G.3    Govoni, S.4    Racchi, M.5
  • 72
    • 84655162704 scopus 로고    scopus 로고
    • Soluble Aβ oligomer production and toxicity
    • Larson ME, Lesné SE. Soluble Aβ oligomer production and toxicity. J Neurochem 2012; 120 (Suppl 1): 125-39.
    • (2012) J Neurochem , vol.120 , Issue.SUPPL. 1 , pp. 125-139
    • Larson, M.E.1    Lesné, S.E.2
  • 73
    • 77957785420 scopus 로고    scopus 로고
    • Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio
    • Kuperstein I, Broersen K, Benilova I, et al. Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio. EMBO J 2010; 29: 3408-20.
    • (2010) EMBO J , vol.29 , pp. 3408-3420
    • Kuperstein, I.1    Broersen, K.2    Benilova, I.3
  • 74
    • 0033005152 scopus 로고    scopus 로고
    • Neurotransmitters, peptides, and neural cell adhesion molecules in the cortices of normal elderly humans and Alzheimer patients: A comparison
    • Yew DT, Li WP, Webb SE, Lai HW, Zhang L. Neurotransmitters, peptides, and neural cell adhesion molecules in the cortices of normal elderly humans and Alzheimer patients: a comparison. Exp Gerontol 1999; 34: 117-33.
    • (1999) Exp Gerontol , vol.34 , pp. 117-133
    • Yew, D.T.1    Li, W.P.2    Webb, S.E.3    Lai, H.W.4    Zhang, L.5
  • 75
    • 39149122810 scopus 로고    scopus 로고
    • Amyloid Beta, Mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer's disease
    • Reddy PH, Beal MF. Amyloid Beta, Mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. Trends Mol Med 2008; 14: 45-53.
    • (2008) Trends Mol Med , vol.14 , pp. 45-53
    • Reddy, P.H.1    Beal, M.F.2
  • 76
    • 40849145511 scopus 로고    scopus 로고
    • The association of mitochondrial aldehyde dehydrogenase gene (ALDH2) polymorphism with susceptibility to late-onset Alzheimer's disease in Chinese
    • Wang B, Wang J, Zhou S, et al. The association of mitochondrial aldehyde dehydrogenase gene (ALDH2) polymorphism with susceptibility to late-onset Alzheimer's disease in Chinese. J Neurol Sci 2008; 268: 172-5.
    • (2008) J Neurol Sci , vol.268 , pp. 172-175
    • Wang, B.1    Wang, J.2    Zhou, S.3
  • 77
    • 0027390458 scopus 로고
    • Quantitative synaptic alterations in the human neocortex during normal aging
    • Masliah E, Mallory M, Hansen L, DeTeresa R, Terry RD. Quantitative synaptic alterations in the human neocortex during normal aging. Neurology 1993; 43: 192-7.
    • (1993) Neurology , vol.43 , pp. 192-197
    • Masliah, E.1    Mallory, M.2    Hansen, L.3    DeTeresa, R.4    Terry, R.D.5
  • 78
    • 77958544789 scopus 로고    scopus 로고
    • Alzheimer's Disease Neuroimaging Initiative. Selective disruption of the cerebral neocortex in Alzheimer's disease
    • Desikan RS, Sabuncu MR, Schmansky NJ, et al. Alzheimer's Disease Neuroimaging Initiative. Selective disruption of the cerebral neocortex in Alzheimer's disease. PLoS One 2010; 5: e12853.
    • (2010) PLoS One , vol.5
    • Desikan, R.S.1    Sabuncu, M.R.2    Schmansky, N.J.3
  • 79
    • 84863504256 scopus 로고    scopus 로고
    • Apolipoprotein e and apolipoprotein e receptors: Normal biology and roles in Alzheimer disease
    • Holtzman DM, Herz J, Bu G. Apolipoprotein e and apolipoprotein e receptors: normal biology and roles in Alzheimer disease. Cold Spring Harb Perspect Med 2012; 2: a006312.
    • (2012) Cold Spring Harb Perspect Med , vol.2
    • Holtzman, D.M.1    Herz, J.2    Bu, G.3
  • 80
    • 84863337843 scopus 로고    scopus 로고
    • Alzheimer mechanisms and therapeutic strategies
    • Huang Y, Mucke L. Alzheimer mechanisms and therapeutic strategies. Cell 2012; 148: 1204-22.
    • (2012) Cell , vol.148 , pp. 1204-1222
    • Huang, Y.1    Mucke, L.2
  • 81
    • 0037645793 scopus 로고    scopus 로고
    • PET studies in dementia
    • Herholz K. PET studies in dementia. Ann Nucl Med 2003; 17: 79-89.
    • (2003) Ann Nucl Med , vol.17 , pp. 79-89
    • Herholz, K.1
  • 83
    • 84856008210 scopus 로고    scopus 로고
    • Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: A consensus paper from the Alzheimer's Biomarkers Standardization Initiative
    • Vanderstichele H, Bibl M, Engelborghs S, et al. Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: a consensus paper from the Alzheimer's Biomarkers Standardization Initiative. Alzheimers Dement 2012; 8: 65-73.
    • (2012) Alzheimers Dement , vol.8 , pp. 65-73
    • Vanderstichele, H.1    Bibl, M.2    Engelborghs, S.3
  • 86
    • 80053496865 scopus 로고    scopus 로고
    • Use of memantine for the treatment of dementia
    • Lo D, Grossberg GT. Use of memantine for the treatment of dementia. Expert Rev Neurother 2011; 11: 1359-70.
    • (2011) Expert Rev Neurother , vol.11 , pp. 1359-1370
    • Lo, D.1    Grossberg, G.T.2
  • 87
    • 0029811105 scopus 로고    scopus 로고
    • Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia
    • Giulian D, Haverkamp LJ, Yu JH Karshin W, et al. Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia. J Neurosci 1996; 16: 6021-37.
    • (1996) J Neurosci , vol.16 , pp. 6021-6037
    • Giulian, D.1    Haverkamp, L.J.2    Yu, J.H.3    Karshin, W.4
  • 88
    • 0030961544 scopus 로고    scopus 로고
    • Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia
    • McDonald DR, Brunden KR, Landreth GE. Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia. J Neurosci 1997; 17: 2284-94.
    • (1997) J Neurosci , vol.17 , pp. 2284-2294
    • McDonald, D.R.1    Brunden, K.R.2    Landreth, G.E.3
  • 89
    • 0034612175 scopus 로고    scopus 로고
    • Inflammation and Alzheimer's disease
    • Akiyama H, Barger S, Barnum S, et al. Inflammation and Alzheimer's disease. Neurobiol Aging 2000; 21: 383-421.
    • (2000) Neurobiol Aging , vol.21 , pp. 383-421
    • Akiyama, H.1    Barger, S.2    Barnum, S.3
  • 90
    • 0033951505 scopus 로고    scopus 로고
    • Alzheimer's disease and inflammation: A review of cellular and therapeutic mechanisms
    • Halliday G, Robinson SR, Shepherd C, Kril J. Alzheimer's disease and inflammation: a review of cellular and therapeutic mechanisms. Clin Exp Pharmacol Physiol 2000; 27: 1-8.
    • (2000) Clin Exp Pharmacol Physiol , vol.27 , pp. 1-8
    • Halliday, G.1    Robinson, S.R.2    Shepherd, C.3    Kril, J.4
  • 91
    • 84891713034 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
    • Coppe JP, Patil CK, Rodier F, et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 2008; 6: 2853-68.
    • (2008) PLoS Biol , vol.6 , pp. 2853-2868
    • Coppe, J.P.1    Patil, C.K.2    Rodier, F.3
  • 92
    • 55349095456 scopus 로고    scopus 로고
    • Cellular senescence: Molecular mechanisms, in vivo significance, and redox considerations
    • Muller M. Cellular senescence: molecular mechanisms, in vivo significance, and redox considerations. Antioxid Redox Signal 2009; 11: 59-98.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 59-98
    • Muller, M.1
  • 93
    • 33750703909 scopus 로고    scopus 로고
    • Oxygen free radicals in cell senescence: Are they signal transducers?
    • Passos JF, Von Zglinicki T: Oxygen free radicals in cell senescence: are they signal transducers? Free Radic Res 2006; 40: 1277-83.
    • (2006) Free Radic Res , vol.40 , pp. 1277-1283
    • Passos, J.F.1    von Zglinicki, T.2
  • 95
    • 34548799705 scopus 로고    scopus 로고
    • Methods to detect biomarkers of cellular senescence: The senescence-associated betagalactosidase assay
    • Itahana K, Campisi J, Dimri GP. Methods to detect biomarkers of cellular senescence: the senescence-associated betagalactosidase assay. Methods Mol Biol 2007; 371: 21-31.
    • (2007) Methods Mol Biol , vol.371 , pp. 21-31
    • Itahana, K.1    Campisi, J.2    Dimri, G.P.3
  • 96
    • 0027250825 scopus 로고
    • Beta-amyloid peptides induce degeneration of cultured rat microglia
    • Korotzer AR, Pike CJ, Cotman CW. Beta-amyloid peptides induce degeneration of cultured rat microglia. Brain Res 1993; 624: 121-5.
    • (1993) Brain Res , vol.624 , pp. 121-125
    • Korotzer, A.R.1    Pike, C.J.2    Cotman, C.W.3
  • 97
    • 3042845492 scopus 로고    scopus 로고
    • Microglia and Alzheimer's disease pathogenesis
    • Streit WJ. Microglia and Alzheimer's disease pathogenesis. J Neurosci Res 2004; 77:1-8.
    • (2004) J Neurosci Res , vol.77 , pp. 1-8
    • Streit, W.J.1
  • 98
    • 33747877627 scopus 로고    scopus 로고
    • Microglial senescence: Does the brain's immune system have an expiration date?
    • Streit WJ. Microglial senescence: does the brain's immune system have an expiration date? Trends Neurosci 2006; 29: 506-10.
    • (2006) Trends Neurosci , vol.29 , pp. 506-510
    • Streit, W.J.1
  • 99
    • 69949118284 scopus 로고    scopus 로고
    • Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease
    • Streit WJ, Braak H, Xue QS, Bechmann I. Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease. Acta Neuropathol 2009; 118: 75-85.
    • (2009) Acta Neuropathol , vol.118 , pp. 75-85
    • Streit, W.J.1    Braak, H.2    Xue, Q.S.3    Bechmann, I.4
  • 100
    • 0037427384 scopus 로고    scopus 로고
    • Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains
    • Nagele RG, D'Andrea MR, Lee H, Venkataraman V, Wang HY. Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains. Brain Res 2003; 971: 197-209.
    • (2003) Brain Res , vol.971 , pp. 197-209
    • Nagele, R.G.1    D'Andrea, M.R.2    Lee, H.3    Venkataraman, V.4    Wang, H.Y.5
  • 102
    • 66949146836 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease
    • Sokolova A, Hill MD, Rahimi F, Warden LA, Halliday GM, Shepherd CE. Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease. Brain Pathol 2008; 19: 392-8.
    • (2008) Brain Pathol , vol.19 , pp. 392-398
    • Sokolova, A.1    Hill, M.D.2    Rahimi, F.3    Warden, L.A.4    Halliday, G.M.5    Shepherd, C.E.6
  • 103
    • 60649083945 scopus 로고    scopus 로고
    • Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease
    • Lee HG, Casadesus G, Zhu X, et al. Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease. Neurochem Int 2009; 54: 84-8.
    • (2009) Neurochem Int , vol.54 , pp. 84-88
    • Lee, H.G.1    Casadesus, G.2    Zhu, X.3
  • 104
    • 19944386244 scopus 로고    scopus 로고
    • The expression of cell cycle proteins in neurons and its relevance for Alzheimer's disease
    • Ueberham U, Arendt T. The expression of cell cycle proteins in neurons and its relevance for Alzheimer's disease. Curr Drug Targets CNS Neurol Disord 2005; 4: 293-306.
    • (2005) Curr Drug Targets CNS Neurol Disord , vol.4 , pp. 293-306
    • Ueberham, U.1    Arendt, T.2
  • 106
    • 14844303381 scopus 로고    scopus 로고
    • Extensive involvement of autophagy in Alzheimer disease: An immuno-electron microscopy study
    • Nixon RA, Wegiel J, Kumar A, et al. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J Neuropathol Exp Neurol 2005; 64: 113-22.
    • (2005) J Neuropathol Exp Neurol , vol.64 , pp. 113-122
    • Nixon, R.A.1    Wegiel, J.2    Kumar, A.3
  • 107
    • 26444587508 scopus 로고    scopus 로고
    • Macroautophagy: A novel beta-amyloid peptide-generating pathway activated in Alzheimer's disease
    • Yu WH, Cuervo AM, Kumar A, et al. Macroautophagy: a novel beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol 2005; 171: 87-98.
    • (2005) J Cell Biol , vol.171 , pp. 87-98
    • Yu, W.H.1    Cuervo, A.M.2    Kumar, A.3
  • 108
    • 45749114895 scopus 로고    scopus 로고
    • The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice
    • Pickford F, Masliah E, Britschgi M. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest 2008; 118: 2190-9.
    • (2008) J Clin Invest , vol.118 , pp. 2190-2199
    • Pickford, F.1    Masliah, E.2    Britschgi, M.3
  • 109
    • 0035097383 scopus 로고    scopus 로고
    • Central betaamyloid peptide-induced peripheral interleukin-6 responses in mice
    • Song DK, Im YB, Jung JS, Cho J, Suh HW, Kim YH. Central betaamyloid peptide-induced peripheral interleukin-6 responses in mice. J Neurochem 2001; 76: 1326-35.
    • (2001) J Neurochem , vol.76 , pp. 1326-1335
    • Song, D.K.1    Im, Y.B.2    Jung, J.S.3    Cho, J.4    Suh, H.W.5    Kim, Y.H.6
  • 110
    • 0043125779 scopus 로고    scopus 로고
    • Immunosenescence, autoimmunity, and rheumatoid arthritis
    • Weyand CM, Fulbright JW, Goronzy JJ. Immunosenescence, autoimmunity, and rheumatoid arthritis. Exp Gerontol 2003; 38: 833-41.
    • (2003) Exp Gerontol , vol.38 , pp. 833-841
    • Weyand, C.M.1    Fulbright, J.W.2    Goronzy, J.J.3
  • 111
    • 2342527293 scopus 로고    scopus 로고
    • Aging, autoimmunity and arthritis: Tcell senescence and contraction of T-cell repertoire diversity-catalysts of autoimmunity and chronic inflammation
    • Goronzy JJ, Weyand CM. Aging, autoimmunity and arthritis: Tcell senescence and contraction of T-cell repertoire diversity-catalysts of autoimmunity and chronic inflammation. Arthritis Res Ther 2003; 5: 225-34.
    • (2003) Arthritis Res Ther , vol.5 , pp. 225-234
    • Goronzy, J.J.1    Weyand, C.M.2
  • 112
    • 0036476017 scopus 로고    scopus 로고
    • KIR expression shapes cytotoxic repertoires: A developmental program of survival
    • Young NT, Uhrberg M. KIR expression shapes cytotoxic repertoires: a developmental program of survival. Trends Immunol 2002; 23: 71-5.
    • (2002) Trends Immunol , vol.23 , pp. 71-75
    • Young, N.T.1    Uhrberg, M.2
  • 113
    • 0037022209 scopus 로고    scopus 로고
    • T-cell-mediated lysis of endothelial cells in acute coronary syndromes
    • Nakajima T, Schulte S, Warrington KJ, et al. T-cell-mediated lysis of endothelial cells in acute coronary syndromes. Circulation 2002; 105: 570-5.
    • (2002) Circulation , vol.105 , pp. 570-575
    • Nakajima, T.1    Schulte, S.2    Warrington, K.J.3
  • 114
    • 34249308473 scopus 로고    scopus 로고
    • Lymphocyte subset patterns and cytokine production in Alzheimer's disease patients
    • Speciale L, Calabrese E, Saresella M, et al. Lymphocyte subset patterns and cytokine production in Alzheimer's disease patients. Neurobiol Aging 2007; 28: 1163-9.
    • (2007) Neurobiol Aging , vol.28 , pp. 1163-1169
    • Speciale, L.1    Calabrese, E.2    Saresella, M.3
  • 115
    • 67650921447 scopus 로고    scopus 로고
    • Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer's disease
    • Larbi A, Pawelec G, Witkowski JM, et al. Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer's disease. J Alzheimers Dis 2009; 17: 91-103.
    • (2009) J Alzheimers Dis , vol.17 , pp. 91-103
    • Larbi, A.1    Pawelec, G.2    Witkowski, J.M.3
  • 116
    • 68249133572 scopus 로고    scopus 로고
    • Alterations in lymphocyte subset patterns and co-stimulatory molecules in patients with Alzheimer disease
    • Xue SR, Xu DH, Yang XX, Dong WL. Alterations in lymphocyte subset patterns and co-stimulatory molecules in patients with Alzheimer disease. Chin Med J (Engl) 2009; 122: 1469-72.
    • (2009) Chin Med J (Engl) , vol.122 , pp. 1469-1472
    • Xue, S.R.1    Xu, D.H.2    Yang, X.X.3    Dong, W.L.4
  • 117
    • 79251538661 scopus 로고    scopus 로고
    • Senescent CD14+CD16+ monocytes exhibit proinflammatory and proatherosclerotic activity
    • Merino A, Buendia P, Martin-Malo A, Aljama P, Ramirez R, Carracedo J. Senescent CD14+CD16+ monocytes exhibit proinflammatory and proatherosclerotic activity. J Immunol 2011;186: 1809-15.
    • (2011) J Immunol , vol.186 , pp. 1809-1815
    • Merino, A.1    Buendia, P.2    Martin-Malo, A.3    Aljama, P.4    Ramirez, R.5    Carracedo, J.6
  • 118
    • 0037213048 scopus 로고    scopus 로고
    • Telomere shortening in T cells correlates with Alzheimer's disease status
    • Panossian LA, Porter VR, Valenzuela HF, et al. Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiol Aging 2003; 24: 77-84.
    • (2003) Neurobiol Aging , vol.24 , pp. 77-84
    • Panossian, L.A.1    Porter, V.R.2    Valenzuela, H.F.3
  • 119
    • 46049085018 scopus 로고    scopus 로고
    • Shorter telomeres may mark early risk of dementia: Preliminary analysis of 62 participants from the nurses' health study
    • Grodstein F, van Oijen M, Irizarry MC, et al. Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the nurses' health study. PLoS One 2008; 3: e1590.
    • (2008) PLoS One , vol.3
    • Grodstein, F.1    van Oijen, M.2    Irizarry, M.C.3
  • 120
    • 84856211181 scopus 로고    scopus 로고
    • Telomere length is agedependent and reduced in monocytes of Alzheimer patients
    • Hochstrasser T, Marksteiner J, Humpel C. Telomere length is agedependent and reduced in monocytes of Alzheimer patients. Exp Gerontol 2012; 47: 160-3.
    • (2012) Exp Gerontol , vol.47 , pp. 160-163
    • Hochstrasser, T.1    Marksteiner, J.2    Humpel, C.3
  • 121
    • 0028207948 scopus 로고
    • Stress response of senescent T lymphocytes: Reduced hsp70 is independent of the proliferative block
    • Effros RB, Zhu X, Walford RL. Stress response of senescent T lymphocytes: reduced hsp70 is independent of the proliferative block. J Gerontol 1994; 49: 65-70.
    • (1994) J Gerontol , vol.49 , pp. 65-70
    • Effros, R.B.1    Zhu, X.2    Walford, R.L.3
  • 122
    • 0031472503 scopus 로고    scopus 로고
    • Loss of CD28 expression on T lymphocytes: A marker of replicative senescence
    • Effros RB. Loss of CD28 expression on T lymphocytes: a marker of replicative senescence. Dev Compar Immunol 1997; 21: 471-8.
    • (1997) Dev Compar Immunol , vol.21 , pp. 471-478
    • Effros, R.B.1
  • 123
    • 0028806679 scopus 로고
    • Long-term culture of monoclonal human T lymphocytes: Models for immunosenescence?
    • Adibzadeh M, Pohla H, Rehbein A, Pawelec G. Long-term culture of monoclonal human T lymphocytes: models for immunosenescence? Mech Ageing Dev 1995; 83: 171-83.
    • (1995) Mech Ageing Dev , vol.83 , pp. 171-183
    • Adibzadeh, M.1    Pohla, H.2    Rehbein, A.3    Pawelec, G.4
  • 124
    • 0032621790 scopus 로고    scopus 로고
    • TNF-alpha plus IFN-gamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs
    • Blasko I, Marx F, Steiner E, Hartmann T, Grubeck-Loebenstein B. TNF-alpha plus IFN-gamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs. FASEB J 1999; 13: 63-8.
    • (1999) FASEB J , vol.13 , pp. 63-68
    • Blasko, I.1    Marx, F.2    Steiner, E.3    Hartmann, T.4    Grubeck-Loebenstein, B.5
  • 125
    • 0028180541 scopus 로고
    • Beta-amyloid formation by myocytes of leptomeningeal vessels
    • Wisniewski HM, Wegiel J. Beta-amyloid formation by myocytes of leptomeningeal vessels. Acta Neuropathol 1994; 87: 233-41.
    • (1994) Acta Neuropathol , vol.87 , pp. 233-241
    • Wisniewski, H.M.1    Wegiel, J.2
  • 126
    • 0026646604 scopus 로고
    • Amyloid betapeptide is produced by cultured cells during normal metabolism
    • Haass C, Schlossmacher MG, Hung AY, et al. Amyloid betapeptide is produced by cultured cells during normal metabolism. Nature 1992; 359: 322-5.
    • (1992) Nature , vol.359 , pp. 322-325
    • Haass, C.1    Schlossmacher, M.G.2    Hung, A.Y.3
  • 127
    • 0031679480 scopus 로고    scopus 로고
    • Cerebral amyloid angiopathy: Amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease
    • Weller RO, Massey A, Newman TA, Hutchings M, Kuo YM, Roher AE. Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. Am J Pathol 1998; 153: 725-33.
    • (1998) Am J Pathol , vol.153 , pp. 725-733
    • Weller, R.O.1    Massey, A.2    Newman, T.A.3    Hutchings, M.4    Kuo, Y.M.5    Roher, A.E.6
  • 128
    • 80053453111 scopus 로고    scopus 로고
    • Chemical characterization of pro-inflammatory amyloid-beta peptides in human atherosclerotic lesions and platelets
    • Kokjohn TA, Van Vickle GD, Maarouf CL, et al. Chemical characterization of pro-inflammatory amyloid-beta peptides in human atherosclerotic lesions and platelets. Biochim Biophys Acta 2011; 1812: 1508-14.
    • (2011) Biochim Biophys Acta , vol.1812 , pp. 1508-1514
    • Kokjohn, T.A.1    van Vickle, G.D.2    Maarouf, C.L.3
  • 129
    • 0028491538 scopus 로고
    • Microvascular pathology and vascular basement membrane components in Alzheimer's disease
    • Perlmutter LS. Microvascular pathology and vascular basement membrane components in Alzheimer's disease. Mol Neurobiol 1994; 9: 33-40.
    • (1994) Mol Neurobiol , vol.9 , pp. 33-40
    • Perlmutter, L.S.1
  • 130
    • 0025942961 scopus 로고
    • Intracellular membranes are more fluid in platelets of Alzheimer's disease patients
    • Piletz JE, Sarasua M, Whitehouse P, Chotani M. Intracellular membranes are more fluid in platelets of Alzheimer's disease patients. Neurobiol Aging 1991; 12: 401-6.
    • (1991) Neurobiol Aging , vol.12 , pp. 401-406
    • Piletz, J.E.1    Sarasua, M.2    Whitehouse, P.3    Chotani, M.4
  • 131
    • 0028201012 scopus 로고
    • Reduced platelet cytochrome c oxidase activity in Alzheimer's disease
    • Parker WD, Mahr NJ, Filley CM, et al. Reduced platelet cytochrome c oxidase activity in Alzheimer's disease. Neurology 1994; 44: 1086-90.
    • (1994) Neurology , vol.44 , pp. 1086-1090
    • Parker, W.D.1    Mahr, N.J.2    Filley, C.M.3
  • 133
    • 0034811885 scopus 로고    scopus 로고
    • Platelet amyloid precursor protein forms in AD: A peripheral diagnostic tool and a pharmacological target
    • Padovani A, Borroni B, Colciaghi F, et al. Platelet amyloid precursor protein forms in AD: a peripheral diagnostic tool and a pharmacological target. Mech Ageing Dev 2001; 122: 1997-2004.
    • (2001) Mech Ageing Dev , vol.122 , pp. 1997-2004
    • Padovani, A.1    Borroni, B.2    Colciaghi, F.3
  • 134
    • 29144531229 scopus 로고    scopus 로고
    • Platelet amyloid precursor protein processing: A biomarker for Alzheimer's disease
    • Tang K, Hynan LS, Baskin F, Rosenberg RN. Platelet amyloid precursor protein processing: a biomarker for Alzheimer's disease. J Neurol Sci 2006; 240: 53-58.
    • (2006) J Neurol Sci , vol.240 , pp. 53-58
    • Tang, K.1    Hynan, L.S.2    Baskin, F.3    Rosenberg, R.N.4
  • 135
    • 0031959497 scopus 로고    scopus 로고
    • Secretion of Alzheimer's disease Ab amyloid peptide by activated human platelets
    • Li QX, Whyte S, Tanner JE, Evin G, Beyreuther K, Masters CL. Secretion of Alzheimer's disease Ab amyloid peptide by activated human platelets. Lab Invest 1998; 78: 461-9.
    • (1998) Lab Invest , vol.78 , pp. 461-469
    • Li, Q.X.1    Whyte, S.2    Tanner, J.E.3    Evin, G.4    Beyreuther, K.5    Masters, C.L.6
  • 136
    • 39149131025 scopus 로고    scopus 로고
    • Platelet as a physiological model to investigate apoptotic mechanisms in Alzheimer betaamyloid peptide production
    • Casoli T, Di Stefano G, Giorgetti B, et al. Platelet as a physiological model to investigate apoptotic mechanisms in Alzheimer betaamyloid peptide production. Mech Ageing Dev 2008; 129: 154-62.
    • (2008) Mech Ageing Dev , vol.129 , pp. 154-162
    • Casoli, T.1    Di Stefano, G.2    Giorgetti, B.3
  • 139
    • 0030760170 scopus 로고    scopus 로고
    • Platelets and inflammation
    • Klinger MH. Platelets and inflammation. Anat Embryol (Berl) 1997; 196: 1-11.
    • (1997) Anat Embryol (Berl) , vol.196 , pp. 1-11
    • Klinger, M.H.1
  • 140
    • 41449104291 scopus 로고    scopus 로고
    • Differences of peripheral inflammatory markers between mild cognitive impairment and Alzheimer's disease
    • Bermejo P, Martín-Aragón S, Benedí J, et al. Differences of peripheral inflammatory markers between mild cognitive impairment and Alzheimer's disease. Immunol Lett 2008; 117: 198-202.
    • (2008) Immunol Lett , vol.117 , pp. 198-202
    • Bermejo, P.1    Martín-Aragón, S.2    Benedí, J.3
  • 141
    • 0033639245 scopus 로고    scopus 로고
    • Beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1
    • Giri R, Shen Y, Stins M, et al. Beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1. Am J Physiol Cell Physiol 2000; 279: C1772-C81.
    • (2000) Am J Physiol Cell Physiol , vol.279 , pp. 1772-1781
    • Giri, R.1    Shen, Y.2    Stins, M.3
  • 142
    • 0032487625 scopus 로고    scopus 로고
    • Alzheimer's beta-amyloid peptides induce inflammatory cascade in human vascular cells: The roles of cytokines and CD40
    • Suo Z, Tan J, Placzek A, Crawford F, Fang C, Mullan M. Alzheimer's beta-amyloid peptides induce inflammatory cascade in human vascular cells: the roles of cytokines and CD40. Brain Res 1998; 807: 107-10.
    • (1998) Brain Res , vol.807 , pp. 107-110
    • Suo, Z.1    Tan, J.2    Placzek, A.3    Crawford, F.4    Fang, C.5    Mullan, M.6
  • 143
    • 34247532374 scopus 로고    scopus 로고
    • Platelet senescence and death
    • Hartley PS. Platelet senescence and death. Clin Lab 2007; 53: 157-66.
    • (2007) Clin Lab , vol.53 , pp. 157-166
    • Hartley, P.S.1
  • 144
    • 0036252998 scopus 로고    scopus 로고
    • Platelet aging in vivo is associated with activation of apoptotic pathways: Studies in a model of suppressed thrombopoiesis in dogs
    • Pereira J, Soto M, Palomo I, et al. Platelet aging in vivo is associated with activation of apoptotic pathways: studies in a model of suppressed thrombopoiesis in dogs. Thromb Haemost 2002; 87: 905-9.
    • (2002) Thromb Haemost , vol.87 , pp. 905-909
    • Pereira, J.1    Soto, M.2    Palomo, I.3
  • 145
    • 5144229514 scopus 로고    scopus 로고
    • Procoagulant surface exposure and apoptosis in rabbit platelets: Association with shortened survival and steady-state senescence
    • Rand ML, Wang H, Bang KW, Poon KS, Packham MA, Freedman J. Procoagulant surface exposure and apoptosis in rabbit platelets: association with shortened survival and steady-state senescence. J Thromb Haemost 2004; 2: 651-9.
    • (2004) J Thromb Haemost , vol.2 , pp. 651-659
    • Rand, M.L.1    Wang, H.2    Bang, K.W.3    Poon, K.S.4    Packham, M.A.5    Freedman, J.6
  • 146
    • 33748925716 scopus 로고    scopus 로고
    • Interventions for heart disease and their effects on Alzheimer's disease
    • Wolozin B, Bednar MM. Interventions for heart disease and their effects on Alzheimer's disease. Neurol Res 2006; 28: 630-6.
    • (2006) Neurol Res , vol.28 , pp. 630-636
    • Wolozin, B.1    Bednar, M.M.2
  • 147
    • 0026389694 scopus 로고
    • Platelet protease nexin-2/amyloid beta-protein precursor. Possible pathologic and physiologic functions
    • Van Nostrand WE, Schmaier AH, Farrow JS, Cunningham DD. Platelet protease nexin-2/amyloid beta-protein precursor. Possible pathologic and physiologic functions. Ann N Y Acad Sci 1991; 640: 140-4.
    • (1991) Ann N Y Acad Sci , vol.640 , pp. 140-144
    • van Nostrand, W.E.1    Schmaier, A.H.2    Farrow, J.S.3    Cunningham, D.D.4
  • 149
    • 0035690770 scopus 로고    scopus 로고
    • Inflammatory factors are elevated in brain microvessels in Alzheimer's disease
    • Grammas P, Ovase R. Inflammatory factors are elevated in brain microvessels in Alzheimer's disease. Neurobiol Aging 2001; 22: 837-42.
    • (2001) Neurobiol Aging , vol.22 , pp. 837-842
    • Grammas, P.1    Ovase, R.2
  • 150
    • 0036447712 scopus 로고    scopus 로고
    • Proinflammatory and vasoactive effects of Abeta in the cerebrovasculature
    • Townsend KP, Obregon D, Quadros A, et al. Proinflammatory and vasoactive effects of Abeta in the cerebrovasculature. Ann N Y Acad Sci 2002; 977: 65-76.
    • (2002) Ann N Y Acad Sci , vol.977 , pp. 65-76
    • Townsend, K.P.1    Obregon, D.2    Quadros, A.3
  • 151
    • 0344737582 scopus 로고    scopus 로고
    • Vascular pathology in Alzheimer disease: Correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline
    • Thal DR, Ghebremedhin E, Orantes M, Wiestler OD. Vascular pathology in Alzheimer disease: correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline. J Neuropathol Exp Neurol 2003; 62: 1287-301.
    • (2003) J Neuropathol Exp Neurol , vol.62 , pp. 1287-1301
    • Thal, D.R.1    Ghebremedhin, E.2    Orantes, M.3    Wiestler, O.D.4
  • 152
    • 77953504104 scopus 로고    scopus 로고
    • Proteinopathy-induced neuronal senescence: A hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases
    • Golde TE, Miller VM. Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases. Alzheimers Res Ther 2009; 1: 5.
    • (2009) Alzheimers Res Ther , vol.1 , pp. 5
    • Golde, T.E.1    Miller, V.M.2
  • 153
    • 24344476294 scopus 로고    scopus 로고
    • The cell cycle in Alzheimer disease: A unique target for neuropharmacology
    • Webber KM, Raina AK, Marlatt MW, et al. The cell cycle in Alzheimer disease: a unique target for neuropharmacology. Mech Ageing Dev 2005; 126: 1019-25.
    • (2005) Mech Ageing Dev , vol.126 , pp. 1019-1025
    • Webber, K.M.1    Raina, A.K.2    Marlatt, M.W.3
  • 154
    • 33645288896 scopus 로고    scopus 로고
    • The cell cycle and hormonal fluxes in Alzheimer disease: A novel therapeutic target
    • Webber KM, Casadesus G, Zhu X, et al. The cell cycle and hormonal fluxes in Alzheimer disease: a novel therapeutic target. Curr Pharm Des 2006; 12: 691-7.
    • (2006) Curr Pharm Des , vol.12 , pp. 691-697
    • Webber, K.M.1    Casadesus, G.2    Zhu, X.3
  • 155
    • 4644265056 scopus 로고    scopus 로고
    • Targeting cyclooxygenase-2 with sodium butyrate and NSAIDs on colorectal adenoma/carcinoma cells
    • Zhang ZH, Ouyang Q, Gan HT. Targeting cyclooxygenase-2 with sodium butyrate and NSAIDs on colorectal adenoma/carcinoma cells. World J Gastroenterol 2004; 10: 2954-57.
    • (2004) World J Gastroenterol , vol.10 , pp. 2954-2957
    • Zhang, Z.H.1    Ouyang, Q.2    Gan, H.T.3
  • 156
    • 4444251441 scopus 로고    scopus 로고
    • Mefenamic acid-induced apoptosis in human liver cancer cell-lines through caspase-3 pathway
    • Woo DH, Han IS, Jung G. Mefenamic acid-induced apoptosis in human liver cancer cell-lines through caspase-3 pathway. Life Sci 2004; 75: 2439-49.
    • (2004) Life Sci , vol.75 , pp. 2439-2449
    • Woo, D.H.1    Han, I.S.2    Jung, G.3
  • 157
    • 4544293476 scopus 로고    scopus 로고
    • Nitrosulindac (NCX 1102): A new nitric oxide-donating non-steroidal anti-inflammatory drug (NO-NSAID), inhibits proliferation and induces apoptosis in human prostatic epithelial cell lines
    • Huguenin S, Fleury-Feith J, Kheuang L, et al. Nitrosulindac (NCX 1102): a new nitric oxide-donating non-steroidal anti-inflammatory drug (NO-NSAID), inhibits proliferation and induces apoptosis in human prostatic epithelial cell lines. Prostate 2004; 61: 132-141.
    • (2004) Prostate , vol.61 , pp. 132-141
    • Huguenin, S.1    Fleury-Feith, J.2    Kheuang, L.3
  • 158
    • 9644301088 scopus 로고    scopus 로고
    • Novel neuronal targets for the acetylcholinesterase inhibitor donepezil
    • Sortino MA, Frasca G, Chisari M, et al. Novel neuronal targets for the acetylcholinesterase inhibitor donepezil. Neuropharmacology 2004; 47: 1198-204.
    • (2004) Neuropharmacology , vol.47 , pp. 1198-1204
    • Sortino, M.A.1    Frasca, G.2    Chisari, M.3
  • 159
    • 4544240977 scopus 로고    scopus 로고
    • Beyond estrogen: Targeting gonadotropin hormones in the treatment of Alzheimer's disease
    • Casadesus G, Zhu X, Atwood CS, et al. Beyond estrogen: targeting gonadotropin hormones in the treatment of Alzheimer's disease. Curr Drug Targets CNS Neurol Disord 2004; 3: 281-5.
    • (2004) Curr Drug Targets CNS Neurol Disord , vol.3 , pp. 281-285
    • Casadesus, G.1    Zhu, X.2    Atwood, C.S.3
  • 160
    • 3042698408 scopus 로고    scopus 로고
    • The role of vascular cell senescence in atherosclerosis: Antisenescence as a novel therapeutic strategy for vascular aging
    • Minamino T, Miyauchi H, Yoshida T, Tateno K, Komuro I. The role of vascular cell senescence in atherosclerosis: antisenescence as a novel therapeutic strategy for vascular aging. Curr Vasc Pharmacol 2004; 2: 141-8.
    • (2004) Curr Vasc Pharmacol , vol.2 , pp. 141-148
    • Minamino, T.1    Miyauchi, H.2    Yoshida, T.3    Tateno, K.4    Komuro, I.5
  • 161
    • 0032765047 scopus 로고    scopus 로고
    • Studies of the molecular mechanisms in the regulation of telomerase activity
    • Liu JP. Studies of the molecular mechanisms in the regulation of telomerase activity. FASEB J 1999; 13: 2091-104.
    • (1999) FASEB J , vol.13 , pp. 2091-2104
    • Liu, J.P.1
  • 162
    • 0025981236 scopus 로고
    • Effect of selenium and vitamin E on the development of experimental atherosclerosis in rabbits
    • Wojcicki J, Rozewicka L, Barcew-Wiszniewska B, et al. Effect of selenium and vitamin E on the development of experimental atherosclerosis in rabbits. Atherosclerosis 1991; 87: 9-16.
    • (1991) Atherosclerosis , vol.87 , pp. 9-16
    • Wojcicki, J.1    Rozewicka, L.2    Barcew-Wiszniewska, B.3
  • 163
    • 1242275127 scopus 로고    scopus 로고
    • Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen
    • Brodsky SV, Gealekman O, Chen J, et al. Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen. Circ Res 2004; 94: 377-84.
    • (2004) Circ Res , vol.94 , pp. 377-384
    • Brodsky, S.V.1    Gealekman, O.2    Chen, J.3
  • 166
    • 34249848228 scopus 로고    scopus 로고
    • Heparin oligosaccharides as potential therapeutic agents in senile dementia
    • Ma Q, Cornelli U, Hanin I, et al. Heparin oligosaccharides as potential therapeutic agents in senile dementia. Curr Pharm Des 2007; 13: 1607-16.
    • (2007) Curr Pharm Des , vol.13 , pp. 1607-1616
    • Ma, Q.1    Cornelli, U.2    Hanin, I.3
  • 167
    • 0036719236 scopus 로고    scopus 로고
    • New mechanisms for vascular control of inflammation mediated by natural anticoagulant proteins
    • Esmon CT. New mechanisms for vascular control of inflammation mediated by natural anticoagulant proteins. J Exp Med 2002; 196: 561-4.
    • (2002) J Exp Med , vol.196 , pp. 561-564
    • Esmon, C.T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.