Neurotransmitters, peptides, and neural cell adhesion molecules in the cortices of normal elderly humans and Alzheimer patients: A comparison

Experimental Gerontology

Volumn 34, Issue 1, 1999, Pages 117-133

  Yew, D T ^a   Li, W P ^b   Webb, S E ^a   Lai, H W L ^a   Zhang, L ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b First Military Medical College   (China)

Author keywords

Aging; Alzheimer disease; Cortex; Human; Neurotransmitters; Peptides

Indexed keywords

4 AMINOBUTYRIC ACID; CHOLINE ACETYLTRANSFERASE; LEUCINE ENKEPHALIN; NERVE CELL ADHESION MOLECULE; NEUROPEPTIDE; NEUROTRANSMITTER; SUBSTANCE P; TYROSINE 3 MONOOXYGENASE;

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN CORTEX; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; FRONTAL CORTEX; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MALE; NEUROTRANSMITTER RELEASE; OCCIPITAL CORTEX; PEPTIDE ANALYSIS; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; BRAIN CHEMISTRY; FEMALE; FRONTAL LOBE; HIPPOCAMPUS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; NEURAL CELL ADHESION MOLECULES; NEUROPEPTIDES; NEUROTRANSMITTER AGENTS; OCCIPITAL LOBE;

EID: 0033005152     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(98)00017-5     Document Type: Article

References (51)

1. Araujo D.M., Lapchak P.A., Meaney M.J., Collier B., Quirion R. Effect of ageing on nicotinic and muscarinic autoreceptor function in the rat brain Relationship to presynaptic cholinergic markers and binding sites . J. Neurosci. 10:1990;3069-3078.
2. Auchus A.P., Green R.C., Nemeroff C.B. Cortical and subcortical neuropeptides in Alzheimer's disease. Neurobiol. Aging. 15:1994;589-595.
3. Bjorklund A., Lindvall O. Dopamine-containing system in CNS. Bjorklund A., Hokfelt T. Handbook of Chemical Neuroanatomy, Classical Transmitters in the CNS, Part I. Vol. 2:1984;5-122 Elsevier, Amsterdam.
4. Blake M.J., Appel N.M., Joseph J.A., Stagg C.A., Arson M., De Souza E., Roth G.S. Muscarinic acetylcholine receptor subtypes, mRNA expression and ligand binding in the aged rat fore-brain. Neurobiol. Aging. 12:1991;193-199.
5. Boissiere F., Faucheux B., Agid Y., Hirsch E.C. Choline acetyltransferase mRNA expression in the striatal neurons of patients with Alzheimer disease. Neurosci. Lett. 225:1997;169-172.
6. Cote, L.J., and Kremzner, L.T., Changes in neurotransmitter systems with increasing age in the human brain. In: Transections of the American Society for Neurochemistry, 5th Annual Meeting, p. 83, New Orleans, LA, 1974.
7. Cullen K.M., Halliday G.M., Double K.L., Brooks W.S., Creasey H., Broe G.A. Cell loss in the nucleus basalis is related to regional cortical atrophy in Alzheimer disease. Neuroscience. 78:1997;641-652.
8. Dahlstrom A., Fuxe K. Evidence of the existence of monoamine containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiol. Scan. 62:1964;1-55.
9. Decker M.W. The effects of ageing on hippocampal and cortical projections of the forebrain cholinergic system. Brain Res. Rev. 12:1987;423-438.
10. De Keyser J., De Backer J.P., Vauquelinn G., Ebinger G. The effect of aging on the D1 dopamine receptors in human frontal cortex. Brain Res. 528:1990;308-310.
11. Doherty P., Fazeli M.S., Walsh F.S. The neural cell adhesion molecule and synaptic plasticity. J. Neurobiol. 26:1995;437-446.
12. Finch C.E. Catecholamine metabolism in the brain of aging male mice. Brain Res. 52:1973;261-276.
13. Freeman T.B., Spence M.S., Boss B.D., Spector D.H., Strecker R.E., Olanow C.W., Kordower J.H. Development of dopaminergic neurons in the human substantia nigra. Exp. Neurol. 113:1991;344-353.
14. Gillian A.M., Brion J.P., Breen K.C. Expression of the neural cell adhesion molecule (NCAM) in Alzheimer's disease. Neurodegeneration. 3:1994;283-291.
15. Giorgi O., Pibri M.G., Dal Toso R., Ragatzu G. Age-related changes in the turnover rates of D1-dopamine receptors in the retina and in the distinct areas of the rat brain. Brain Res. 569:1992;323-329.
16. Gozlan H., Daval G., Verge D., Spampinato U., Fattaccini C.M., Gallissot M.C., El Mestikawy S., Hamon M. Aging associated changes in serotoninergic and dopaminergic pre- and post-synaptic neurochemical markers in the rat brain. Neurobiol. Aging. 11:1990;437-449.
17. Hendry S.H., Huntsman M.M., Vinuela A., Mohler H., De Blas A.L., Jones E.G. GABA receptor subunit immunoreactivity in primate visual cortex Distribution in macaques and humans and regulation by visual input in adulthood . J. Neurosci. 14:1994;2383-2401.
18. Hornung J.P., De Tribolet N. Distribution of GABA-containing neurones in human frontal cortex A quantitative immunocytochemical study . Anat. Embryol. 189:1994;139-145.
19. Huntley G.W., Morrison J.H., Prikhozhan A., Sealfon S.C. Localisation of multiple dopamine receptor subtype mRNAs in human and monkey motor cortex and striatum. Brain Res. Mol. Brain Res. 15:1992;181-188.
20. Hyttel J. Parallel decrease in the density of dopamine D1 and D2 receptors in corpus striatum of rats from 3 to 25 months of age. Pharmacol. Toxicol. 64:1989;55-57.
21. Hyyppa M. Hypothalamic monoamines in human fetuses. Neuroendocrinology. 9:1972;257-266.
22. Jellinger K. Quantitative changes in some subcortical nuclei in ageing, Alzheimer's disease and Parkinson's disease. Neurobiol. Aging. 8:1987;556-561.
23. Jones B.E. The organization of central cholinergic systems and their functional importance in sleep-waking states. Prog. Brain Res. 98:1993;61-71.
24. Jorgensen O.S. Neural cell adhesion molecule (NCAM) as a quantitative marker in synaptic remodelling. Neurochem. Res. 20:1995;533-547.
25. Joseph, J.A., Roth, G.S., and Strong, R., The striatum, a microcosm for the examination of age related alterations in the CNS, a selected review. In: Review of Biological Research in Aging, Rothstein, M. (Editor), pp. 181-189, Alan Liss, New York, 1990.
26. Kisvarday Z.F., Gulyas A., Beroukas D., North J.B., Chubb I.W., Somogyi P. Synapses, axonal and dendritic patterns of GABA-immunoreactive neurons in human cerebral cortex. Brain. 113:1990;793-812.
27. Kornhuber, J. and Kornhuber, M.E., Presynaptic dopaminergic modulation of cortical input to the striatum. Life Sci. 39, 699-674, 1986.
28. Kowall N.W., Quigley B.J. Jr, Krause J.E., Lu F., Kosofsk B.E., Ferrante R.J. Substance P and substance P receptor histochemistry in human neurodegenerative diseases. Regul. Pept. 46:1993;174-185.
29. Lawrence, A.D. and Sahakian, B.J., Alzheimer disease, attention and cholinergic system. Alzheimer Dis. Assoc. Disorder9 (Suppl. 2), 43-49, 1995.
30. Li W.P., Chan W.Y., Lai H.W.L., Yew D.T. TUNEL positive cells in different regions of the brain in normal aging and Alzheimer patients. J. Mol. Neurosci. 8:1997;75-82.
31. Lindvall O., Bjorklund A., Divac I. Organization of catecholamine neurons projecting to the frontal cortex in the rat. Brain Res. 142:1978;1-24.
32. Mann D.M.A., Yates P.O., Hawkes J. The pathology of the human locus coeruleus. Clin. Neuropathol. 2:1983;1-7.
33. McGeer, E.G., Fibiger, H.C., McGeer P.L., and Wickson, V., Aging and brain enzymes. Exp. Gerontol.6, 391-396, 1971.
34. McGeer P.L., Itagaki S., Akijama H., McGeer E.G. Comparison of neuronal loss in Parkinson's disease and aging. Calne D.B. Parkinsonism and Aging. 1989;25-34 Raven press, New York.
35. Miklos P., Brownstein M.J. Locus coeruleus. Adv. Cell Neurobiol. 4:1983;81-104.
36. Morris, J.C., Drazer, M., Fulling, K., Grant, E.A., and Goldring, J., Clinical and pathological aspects of parkinsonism in Alzheimer's disease. A role for extranigral factors? Arch. Neurol. 46, 651-657, 1989.
37. Olson L., Nystrom B., Seiger A. Monoamine fluorescence histochemistry of human postmortem brain. Brain Res. 63:1973;231-247.
38. Ong W.Y., Garey L.J. Distribution of GABA and neuropeptides in the human cerebral cortex. A light and electronmicroscopic study. Anat. Embryol. 183:1991;397-413.
39. Oyanagi K., Takahashi H., Wakabayashi K., Ikuta F. Correlative decrease of large neurons in the neostriatum and basal nucleus of Meynert in Alzheimer's disease. Brain Res. 504:1989;354-357.
40. Palmer A.M. Neurochemical studies of Alzheimer disease. Neurodegeneration. 5:1996;381-391.
41. Procter A.W., Palmer A.M., Francis P.T., Lowe S.L., Neary D., Murphy E., Doshi R., Bowen D.M. Evidence of glutamatergic denervation and possible abnormal metabolism in Alzheimer's disease. J. Neurochem. 50:1988;790-802.
42. Ronn L.C., Bock E., Linnemann D., Jahnsen H. NCAM-antibodies modulate induction of long-term potentiation in rat hippocampal CA1. Brain Res. 677:1995;145-151.
43. Shen Z.X. Acetylcholinesterase provides deeper insights into Alzheimer's disease. Med. Hypotheses. 43:1994;21-30.
44. Slotkin T.A., Nemeroff C.B., Bissette G., Seidler F.J. Over-expression of the high affinity choline transporter in cortical regions affected by Alzheimer's disease. Evidence from rapid autopsy studies. J. Clin. Invest. 94:1994;696-702.
45. Smale G., Nichols N.R., Brady D.R., Finch C.E., Horton W.E. Jr. Evidence for apoptotic cell death in Alzheimer's disease. Exp. Neurol. 133:1995;225-230.
46. Su J.H., Anderson A.J., Cummings B.J., Cotman W. Immunohistochemical evidence for apoptosis in Alzheimer's disease. Neuroreport. 5:1994;2529-2533.
47. Swanson L.W., Hartman B.K. The central adrenergic system. An immunofluorescence study of the localization of cell bodies and their efferent connections in the rat utilizing dopamine-β-hydroxylase as a marker. J. comp. neurol. 163:1975;467-505.
48. Taquet H., Javoy-Agid F., Mauborgne A., Benoliel J.J., Agid Y., Legrand J.C., Tramu G., Cesselin F., Hamon M. Biochemical mapping of cholecystokinin-, substance P, [Met]enkephalin-, [Leu]enkephalin- and dynorphin A(1-8)-like immunoreactivities in the human cerebral cortex. Neuroscience. 27:1988;871-883.
49. Venero J.L., Machado A., Cano J. Turnover of dopamine and serotonin and their metabolites in the striatum of aged rats. J. Neurochem. 56:1991;1940-1948.
50. Vernadakis A., Mangoura D.A. Factors influencing glia growth in culture Nutrients and cell-secreted factors . Prog. in Clin. & Biol. Res. 259:1988;57-79.
51. Voorn P., Kalsbeek A., Jorritsma-Byham B., Groenewegen H.J. The pre- and postnatal development of the dopaminergic cell groups in the ventral mesencephalon and the dopaminergic innervation of the striatum of the rat. Neuroscience. 25:1988;857-887.