Superoxide and nitric oxide in senescence and aging

Frontiers in Bioscience

Volumn 14, Issue 10, 2009, Pages 3899-3912

  Afanas'ev, Igor ^a  

^a Vitamin Research Institute   (Russian Federation)

Author keywords

Age; Nitric oxide; Review; Superoxide

Indexed keywords

ANIMALIA;

ANTIOXIDANT; FREE RADICAL; NITRIC OXIDE; PROSTAGLANDIN SYNTHASE; SUPEROXIDE;

AGING; CATALYSIS; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW;

AGING; ANTIOXIDANTS; CATALYSIS; FREE RADICALS; HUMANS; NITRIC OXIDE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SUPEROXIDES;

EID: 63849285200     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2735/3499     Document Type: Article

References (132)

1. D. Harman, D: Aging: a theory based on free radical and radiation chemistry. J. Gerontology 11, 298-300(1956)
2. McCann, S. M., C. Mastronardi, A. de Laurentiis, & V. Rettori: The nitric oxide theory of aging revisited. Ann. N. Y. Acad. Sci. 1057, 64-84(2005) (Pubitemid 43211628)
3. Terman, A. & U. T. Brunk: Oxidative stress, accumulation of biological 'garbage', and aging. Antioxid. Redox. Signal. 8, 197-204(2006) (Pubitemid 43324546)
4. Navarro, A. & A. Boveris: The mitochondrial energy transduction system and the aging process. Am. J. Physiol. Cell. Physiol. 292, C670-C686 (2007)
5. Taddei, S., A. Virdis, L. Ghiadoni, D. Versari, & A. Salvetti: Endothelium, aging, and hypertension. Curr Hypertens Rep. 8, 84-89(2006)
6. Sanz, A., R. Pamplona, & Barja: Is the mitochondrial free radical theory of aging intact? Antioxid. Redox. Signal. 8,:582-99(2006) (Pubitemid 43741327)
7. Jones, D. P.: Extracellular redox state: refining the definition of oxidative stress in aging. Rejuvenation Res. 9, 169-181(2006) (Pubitemid 43856805)
8. Harman, D: Free radical theory of aging: an update: increasing the functional life span. Ann. N. Y. Acad. Sci. 1067, 10-21(2006) (Pubitemid 43806304)
9. Rattan, S. I.: Theories of biological aging: genes, proteins, and free radicals. Free Radic. Res. 40, 1230-1238(2006) (Pubitemid 44698271)
10. De Grey, A. D.: Free radicals in aging: causal complexity and its biomedical implications. Free Radic. Res. 40, 1244-1249(2006)
11. Kregel, K. C. & H. J. Zhang: An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292, R18-R36 (2007) (Pubitemid 46091599)
12. Harman, D: The biologic clock: the mitochondria? J. Am. Geriatr. Soc. 20, 145-147(1972)
13. Sawada, M. & J. C. Carlson: Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat. Mech. Ageing Dev. 41, 125-137(1987) (Pubitemid 18015544)
14. Sawada, M., U. Sester, & J. C. Carlson: Superoxide radical formation and associated biochemical alterations in the plasma membrane of brain, heart, and liver during the lifetime of the rat. J. Cell Biochem. 48, 296-304(1992)
15. Izgut-Uysal, V. N., A. Agac, I. Karadogan, & N. Derin: Peritoneal macrophages function modulation by L-carnitine in aging rats. Aging Clin. Exp. Res. 16, 337-341(2004) (Pubitemid 39618503)
16. Schreiber, S. J., D. Megow, A. Raupach, I. V. Victorov, & U. Dirnagl: Age-related changes of oxygen free radical production in the rat brain slice after hypoxia: on-line measurement using enhanced chemiluminescence. Brain Res. 703, 227-230(1995)
17. Chung, H. Y., S. H. Song, H. J. Kim, Y. Ikeno, & B. P. Yu: Modulation of renal xanthine oxidoreductase in aging: gene expression and reactive oxygen species generation. J. Nutr. Health Aging 3, 19-23(1999) (Pubitemid 129728791)
18. Hamilton, C. A., M. J. Brosnan, M. McIntyre, D. Graham, & A. F. Dominiczak: Superoxide excess in hypertension and aging: a common cause of endothelial dysfunction. Hypertension 37, 529-534(2001) (Pubitemid 32199023)
19. S. K. Moon, L. J. Thompson, N. Madamanchi, S, Ballinger, J. Papaconstantinou, C, Horaist, Ruuge, M. S. & C. Patterson: Aging, oxidative responses, and proliferative capacity in cultured mouse aortic smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 280, H2779-H2788 (2001)
20. Chen, H., D. Cangello, S. Benson, J. Folmer, H. Zhu, M. A. Trush & B. R. Zirkin: Age-related increase in mitochondrial superoxide generation in the testosteroneproducing cells of Brown Norway rat testes: relationship to reduced steroidogenic function? Exp. Gerontol. 36, 1361-1373(2001) (Pubitemid 32707873)
21. Ali, S. S., C. Hiong, J. Lucero, M. M. Behrens, L. L. Dugan & K. L. Quick: Gender differences in free radical homeostasis during aging: shorter-lived female C57BL6 mice have increased oxidative stress. Aging Cell. 5, 565-574(2006) (Pubitemid 44782625)
22. Oudot, A., C. Martin, D. Busseuil, C. Vergely, L. Demaison, & L. Rochette: NADPH oxidases are in part responsible for increased cardiovascular superoxide production. Free Radic. Biol. Med. 40, 2214-2222(2006) (Pubitemid 43922397)
23. Newaz, M. A., Z. Yousefipour, & A. Oyekan: Oxidative Stress-Associated Vascular Aging Is Xanthine Oxidase-Dependent but not NAD (P) H Oxidase-Dependent. J. Cardiovasc. Pharmacol. 48, 88-94(2006) (Pubitemid 44562947)
24. Chaves, M. M., A. L. P. Rodrigues, A. Pereira dos Reis, N. C. Gerzstein, & J. A. Nogueiro-Machado: Correlation between NADPH oxidase and protein kinase C in the ROS production by human granulocytes related to age. Gerontology 48, 354-359(2002) (Pubitemid 36152985)
25. de la Fuente, M., A. Hernanz, N. Guayerbas, P. Alvares, & C. Alvarado: Changes with age in peritoneal macrophage functions. Implication of leukocytes in the oxidative stress of senescence. Cell Mol. Biol. (Noisy-legrand) (2004)
26. Kozlov, A. V., L. Szalay, F. Umar, K. Kropik, K. Staniek, H. Niedermuller, S. Bahrami, & H. Nohl. Skeletal muscles, heart, and lung are the main sources of oxygen radicals in old rats. Biochim Biophys Acta 1740:382-389(2005) (Pubitemid 40804751)
27. Didion, S. P., D. A. Kinzenbaw, L. I. Schrader, & F. M. Fagaci: Heterozygous CuZn superoxide dismutase deficiency produces a vascular phenotype with aging. Hypertension 48, 1072-1079(2006) (Pubitemid 44772710)
28. Antier, D., H. V. Carswell, M. J. Brosnan, C. A. Hamilton, I. M. Macrae, S. Groves, E. Jardine, J. L. Reid, & A. E. Dominiczak: Increased levels of superoxide in brains from old female rats. Free Radic. Res. 38:177-183(2004) (Pubitemid 38181174)
29. Weir, C. P. & B. Robaire: Spermatozoa have decreased antioxidant enzymatic capacity and increased reactive oxygen species production during aging in the Brown Norway rat. J. Androl. 28:229-240(2007) (Pubitemid 46423904)
30. Kellogg, E. W. & I. Fridovich: Superoxide dismutase in the rat and mouse as a function of age and longevity. J. Gerontology 31, 405-408(1976)
31. Ono, T & S. Okado: Unique increase of superoxide dismutase level in brains of long living mammals. Exp. Gerontol.; 19, 349-354(1984) (Pubitemid 15186367)
32. Orr, W. C. & R. S. Sohal: Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 263, 1128-1130(1994) (Pubitemid 24105957)
33. Reiss, U. & D. Gershon: Comparison of cytoplasmic superoxide dismutase in liver, heart and brain of aging rats and mice. Biochem. Biophys. Res. Commun. 73, 255-262(1976)
34. Semsei, I., G. Rao, & A. Richardson: Changes in the expression of superoxide dismutase and catalase as a function of age and dietary restriction. Biochem. Biophys. Res. Commun. 164, 620-625(1989) (Pubitemid 19280314)
35. Anisimov, V. N., A. V. Arutiunian, T. I. Oparina, S. O. Burmistrov, V. M. Prokopenko & V. Kh. Khvinson: (Agerelated changes in the activity of free-radical processes in rat tissues and blood serum) (Article in Russian) Ross. Fiziol. Zh. Im. I. M. Sechenova 85, 502-507(1999)
36. Park, J. W., C. H. Choi, M. S. Kim, & M. H. Chung: Oxidative status in senescence-accelerated mice. J. Gerontol. A Biol. Sci. Med. Sci. 51, B337-B345 (1996)
37. Colombrita, C., V. Calabrese, A. M. Stella, F. Mattei, D. L. Alkon & G. Scapagnini: Regional rat brain distribution of heme oxygenase-1 and manganese superoxide dismutase mRNA: relevance of redox homeostasis in the aging processes. Exp. Biol. Med. (Maywood) 228, 517-524(2003) (Pubitemid 37203670)
38. Sun, D., A. Huang, E. H. Yan, Z. Wu, C. Yan, P. M. Kaminski, T. D. Oury, M. S. Wolin & G. Kaley: Reduced release of nitric oxide to shear stress in mesenteric arteries of aged rats. Am. J. Physiol. Heart Circ. Physiol. 286, H2249-H2256 (2004) (Pubitemid 38685240)
39. van der Loo, B., M. Bachschmid, J. N. Skepper, R. Laabugger, S. Schildknecht, R. Hahn, E. Mussig, D. Gygi & T. F. Luscher: Age-associated cellular relocation of Sod 1 as a self-defense is a futile mechanism to prevent vascular aging. Biochem. Biophys. Res. Commun. 344, 972-980(2006)
40. Pansarasa, O., L. Bertorelli, J. Vecchiet, G. Felzani & F. Marzatico: Age-dependent changes of antioxidant activities and markers of free radical damage in human skeletal muscle. Free Radic. Biol. Med. 27, 617-622(1999) (Pubitemid 29408649)
41. Inal, M. E., G. Kanbak & E. Sunal: Antioxidant enzyme activities and malondialdehyde levels related to aging. Clin. Chim. Acta 305, 75-80(2001) (Pubitemid 32201964)
42. Di Massimo, C., P. Scarpelli, N. D. Lorenzo, G. Caimi, F. D. Orio & M. G. Ciancarelli: Impaired plasma nitric oxide availability and extracellular superoxide dismutase activity in healthy humans with advancing age. Life Sci. 2005, 78, 1163-1167(2005)
43. Di Massimo, C., R. Lo Presti, C Corbacelli, A. Pompei, P. Scarpelli, D. De Amicis, G. Caimi & M. G. Tozzi Ciancarelli: Impairment of plasma nitric oxide availability in senescent healthy individuals: Apparent involvement of extracellular superoxide dismutase activity. Clin. Hemorheol. Microcirc. 35, 231-237(2006) (Pubitemid 44126506)
44. Congy, F., D. Bonnefont-Rousselot, S. Dever, J. Delattre & J. Emerit: (Study of oxidative stress in the elderly) (Article in French) Presse Med. 24, 1115-1118(1995)
45. Scarpa, M., A. Rigo, P. Viglino, R. Stevanato, F. Bracco & I. Battistin: Age dependence of the level of the enzymes involved in the protection against active oxygen species in the rat brain. Proc. Soc. Exp. Med. 185, 129-133(1987) (Pubitemid 17088900)
46. Judge, S., Y. M. Jang, A. Smith, T. Hagen & C. Leeuwenburgh: Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging. FASEB J. 19, 419-421(2005) (Pubitemid 40316536)
47. Barreiro, E., C. Coronell, B. Lavina, A. Ramirez-Sarmiento, M. Orozco-Levi & J. Gea: Aging, sex differences, and oxidative stress in human respiratory and limb muscles. Free Radic. Biol. Med. 41, 797-809(2006) (Pubitemid 44177663)
48. Mariani, E., V. Cornacchiola, M. C. Polidori, F. Mangialasche, M. Malavolta, R. Cecchetti, P. Bastiani, M. Baglioni, F. Mocchegiani & P. Mecocci: Antioxidant enzyme activities in healthy old subjects: influence of age, gender and zinc status: Results from the Zincage Project. Biogerontology 7:391-398, 2006.
49. Bolanos, J. P., S. Peuchen, S. J. Heales, J. M. Land & J. B. Clark: Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes. J. Neurochem. 63,:910-916(1994) (Pubitemid 24266603)
50. Cleeter, M. W., J. M. Cooper, V. M. Darley-Usmar, S. Moncada & A. H. Schapira: Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett. 345, 50-54(1994)
51. Brown, G. C. & C. E. Cooper: Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett. 356,:295-298(1994) (Pubitemid 24376992)
52. Schweizer, M. & C. Richter: Nitric oxide potently and reversibly deenergizes mitochondria at low oxygen tension. Biochem. Biophys. Res. Commun. 204, 169-175(1994) (Pubitemid 24335277)
53. Mollace, V., P. Rodino, R. Massoud, D. Rotiroti & G. Nistico: Age-dependent changes of NO synthase activity in the rat brain. Biochem. Biophys. Res. Commun. 215, 822-827(1995)
54. Amrani, M., A. T. Goodman, C. C. Gray, & M. H. Yacoub: Ageing is associated with reduced basal and stimulated release of nitric oxide by the coronary endothelium. Acta Physiol. Scand. 157, 79-84(1996) (Pubitemid 26152190)
55. Gerhard, M., M. A. Roddy, S. J. Creager, & M. A. Creager: Aging progressively impairs endotheliumdependent vasodilation in forearm resistance vessels of humans. Hypertension 27, 849-853(1996) (Pubitemid 26113830)
56. Tschudi, M. G., M. Barton, N. A. Bersinger, P. Moreau, F. Cosentino, G. Noll, T. Malinski & T. F. Luscher: Effect of age on kinetics of nitric oxide release in rat aorta and pulmonary artery. J. Clin. Invest. 98, 899-905(1996) (Pubitemid 26293306)
57. van der Loo, B., R. Labugger, J. N. Skepper, M. Bachschmid, J. Kilo, J. M. Powell, M. Palacios-Callender, J. D. Erusalimsky, T. Quaschning, T. Malinski, D. Gygi, V. Ullrich & T. F. Luscher: Enhanced Peroxynitrite Formation Is Associated with Vascular Aging. J. Exp. Med. 192, 1731-1744(2000)
58. Chou, T-C., M-H. Yen, C-Y. Li, & Y-A. Ding: Alterations of nitric oxide synthase expression with aging and hypertension in rats. Hypertension 31, 643-648(1998) (Pubitemid 28086950)
59. Smith, A. R. & T. M. Hagen: Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid. Biochem. Soc. Trans. 31, 1447-1449(2003) (Pubitemid 38030998)
60. Ferrer, M., M. Sanchez, N. Minoves, M. Salaices, & G. Balfagon: Aging increases neuronal nitric oxide release and superoxide anion generation in mesenteric arteries from spontaneously hypertensive rats. J. Vasc. Res. 40, 509-519(2003) (Pubitemid 38186461)
61. Csiszar, A., Z. Ungvari, J. G. Edwards, P. Kaminski, M. S. Wolin, A. Koller, & G. Kaley: Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function. Circ. Res. 90, 1159-1166(2002) (Pubitemid 34786900)
62. Blackwell, K. A., J. P. Sorenson, D. M. Richardson, L. A. Smith, O. Suda, K. Nath & Z. S. Katusic: Mechanisms of aging-induced impairment of endothelium-dependent relaxation: role of tetrahydrobiopterin. Am. J. Physiol. Heart Circ. Physiol. 287(6), H2448-H2453(2004) (Pubitemid 39557113)
63. Woodman, C. R., E. M. Price & M. H. Laughlin: Selected Contribution: Aging impairs nitric oxide and prostacyclin mediation of endothelium-dependent dilation in soleus feed arteries. J. Appl. Physiol. 95, 2164-2170(2003) (Pubitemid 37310405)
64. Adler, A., E. Messina, B. Sherman, Z. Wang, H. Huang, A. Linke & T. H. Hintze: NAD (P) H oxidasegenerated superoxide anion accounts for reduced control of myocardial O2 consumption by NO in old Fischer 344 rats. Am. J. Physiol. Heart Circ. Physiol. 285, H1015-H1022 (2003) (Pubitemid 37048155)
65. Adler, A., H. Huang, M. S. Wolin & P. M. Kaminski: Oxidant stress leads to impaired regulation of renal cortical oxygen consumption by nitric oxide in the aging kidney. J. Am. Soc. Nephrol. 15, 52-60(2004) (Pubitemid 38020697)
66. Roberts II, L. J. & J. F. Reckelhoff: Measurement of F (2)-isoprostanes unveils profound oxidative stress in aged rats. Biochem. Biophys. Res. Commun. 287:254-256(2001) (Pubitemid 32912491)
67. Mukai, Y., H. Shimokawa, M. Higashi, K. Morikawa, T. Matoba, Y. Hiroki, H. M. A. Talukder & A. Takeshita: Inhibition of renin-angiotensin system ameliorates endothelial dysfunction associated with aging in rats. Arterioscler. Thromb. Vasc. Biol. 22, 1445-1450(2002)
68. Kim, J. W., Y. Zou, S. Yoon, J. H. Lee, Y. K. Kim, B. P. Yu & H. Y. Chung: Vascular aging: molecular modulation of the prostanoid cascade by calorie restriction J. Gerontol. A, Biol. Sci. Med. Sci. 59, B876-B885 (2004)
69. Yamamoto, Y., K. Wakabayashi & M. Nagano: Comparison of plasma levels of lipid hydroperoxides and antioxidants in hyperlipidemic Nagase analbuminemic rats, Sprague-Dawley rats, and humans. Biochem. Biophys. Res. Commun. 189:518-523(1992) (Pubitemid 23030071)
70. Migliaccio, E., M. Giorgio, S. Mele, G. Pelicci, P. Reboldi, P. P. Pandolfi, L. Lanfrancone & P. G. Pelicci: The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature, 402(6759), 309-313(1999) (Pubitemid 129516269)
71. Francia, P., C. della Gatti, M. Bachschmid, I. Martin-Padura, C. Savoia, E. Migliaccio, P. G. Pelicci, M. Schiavoni, T. F. Luscher, M. Volpe & F. Cosentino: Deletion of p66shc gene protects against age-related endothelial dysfunction. Circulation 110, 2889-2895(2004) (Pubitemid 39473614)
72. Ikeyama, S., X.-T. Wang, J. Li, A. Podlutsky, J. L. Martindale, G. Kokkonen, R. van Huizen, M. Gorospe & N. J. Holbrook: Expression of the pro-apoptotic gene gadd153/chop is elevated in liver with aging and sensitizes cells to oxidant injury. J. Biol. Chem. 278, 16726-16731(2003) (Pubitemid 36799538)
73. Xiao, N. M., Y. M. Zhang, Q. Zheng & J. Gu: Klotho is a serum factor related to human aging. Chin. Med. J. (Engl) 117, 542-747(2004)
74. Saito, K., N. Ishizaka, H. Mitani, M. Ohno & R. Nagai: Iron chelation and a free radical scavenger suppress angiotensin II-induced downregulation of klotho, an antiaging gene, in rat. FEBS Lett. 551, 58-62(2003) (Pubitemid 37281328)
75. Nagai, T., K. Yamada, H. C. Kim, Y. S. Kim, Y. Noda, A. Imura, Y. Nabeshima, & T. Nabeshima: Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress. FASEB J. 17, 50-52(2003)
76. Mitobe, M., T. Yoshida, H. Sugiura, S. Shirota, K. Tsuchiya & H. Nihei: Oxidative stress decreases klotho expression in a mouse kidney cell line. Nephron Exp. Nephrol. 101, e67-e74 (2005) (Pubitemid 41208903)
77. Kurosu, H., M. Yamamoto, J. D. Clark, J. V. Pastor, A. Nandi, P. Gurnami, O. P. McGuinness, H. Chikuda, M. Yamaguchi, H. Kawaguchi, I. Shimomura, Y. Takayama, J. Herz, C. R. Kahn, K. P. Rosenblatt & M. Kuro-O: Suppression of aging in mice by the hormone Klotho. Science 309(5742), 1829-1833(2005) (Pubitemid 41325087)
78. Yamamoto, M., J. D. Clark, J. V. Pastor, P. Gurnani, A. Nandi H. Kurosu, M. Miyoshi, Y. Ogawa, D. H. Castrillon, K. P. Rosenblatt & M. Kuro-O: Regulation of oxidative stress by the anti-aging hormone Klotho. J. Biol. Chem. 280:38029-38034(2005) (Pubitemid 41642417)
79. Ikushima, M., H. Rakugi, K. Ishikawa, Y. Maekawa, K. Yamamoto, J. Ohta, Y. Chihara, I. Kida & T. Ogihara: Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells. Biochem. Biophys. Res. Commun. 339, 827-832(2006) (Pubitemid 41772888)
80. Ikeyama, S., G Kokkonen, S Shack, X-T Wang & NJ Holbrook: Loss in oxidative stress tolerance with aging linked to reduced extracellular signal-regulated kinase and Akt kinase activities. FASEB J. 10.1096/fj.01- 0409fje, (2001)
81. Jin, Q., B. S. Jhun, S. H. Lee, J. Lee, J. H. Cho, H. H. Baik & I. Kang: Differential regulation of phosphatidyl 3-kinase/Akt, mitogen-activated protein kinase, and AMP-activated protein kinase pathways during menadioneinduced oxidative stress in kidney of young and old rats. Biochem. Biophys. Res. Commun. 315, 555-561(2004) (Pubitemid 38229379)
82. Rice, K. M., D. L. Preston, E. M. Walker & E. R. Blough: Aging influences multiple indices of oxidative stress in the aortic media of the Fischer 344/NNia x Brown Norway/BiNia rat. Free Radic Res. 40, 185-97(2006) (Pubitemid 43050881)
83. C. Tortorella, C., I. Stella, G. Piazzolla, O. Simone, V. Caappiello & S. Antonaci: Role of defective ERK phosphorylation in the impaired GM-CSF-induced oxidative response of neutrophils in elderly humans. Mech. Ageing Dev. 125, 539-546(2004) (Pubitemid 39149997)
84. Miyauchi, H., T. Minamino, K. Tateno, T. Kunieda, H. Toko & I. Komura: Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO 23, 212-220(2004) (Pubitemid 38165761)
85. Al-Regaiey, K. A., M. M. Masternak, M. Bonkowski, L. Sun & A. Bartke: Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction. Endocrinology 146, 851-860(2005) (Pubitemid 40129843)
86. Li, M., J. F. Chiu, B. T. Mossman & N. K. Fukagawa: Down regulation of MnSOD through phosphorylation of FOXO3a by AKT in explanted VSMC from old rats. J. Biol. Chem. 281:40429-40439(2006)
87. Kennedy, M. A., S. G. Rakoczy & H. M. Brown-Borg: Long-living Ames dwarf mouse hepatocytes readily undergo apoptosis. Exp. Gerontol. 38, 997-1008(2003) (Pubitemid 37040801)
88. Tirosh, O., B. Schwartz, I. Zusman, G. Kossoy, S. Yahav & R. Miskin: Long-living alpha MUPA transgenic mice exhibit increased mitochondrion-mediated apoptotic capacity. Ann. NY Acad. Sci. USA 1019, 439-442(2004) (Pubitemid 38951353)
89. Kokoszka, J. E., P. Coskun, L. A. Esposito & D. C. Wallace: Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis. Proc. Natl. Acad. Sci. USA 98, 2278-2283(2001) (Pubitemid 32209473)
90. Phaneuf, S. & C. Leeuwenburgh: Cytochrome c release from mitochondria in the aging heart: a possible mechanism for apoptosis with age. Am. J. Physiol. Regul. Integr. Comp. Physiol. 282, R423-R430 (2002) (Pubitemid 34664592)
91. Liu, P., B. Xu, T. A. Cavalieri & C. E. Hock: Agerelated difference in myocardial function and inflammation in a rat model of myocardial ischemia-reperfusion. Cardiovasc. Res. 56, 443-453(2002) (Pubitemid 35351566)
92. Hoffmann, J., J. Haendeler, A. Aicher, L. Rossig, M. Vasa, A. M. Zeiher & S. Dimmeler: Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli. Important role of nitric oxide. Circ. Res. 89, 709-715, (2001) (Pubitemid 34627071)
93. Alexeyev, M. F., S. P. Ledoux, & G. L. Wilson: Mitochondrial DNA and aging. Clin. Sci. (London) 107, 355-364(2004) (Pubitemid 39389302)
94. Loeb, L. A., D. C. Wallace & G. M. Martin: The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations. Proc. Natl. Acad. Sci. USA 102, 18769-18770(2005) (Pubitemid 43049521)
95. Miro, O., J. Casademont, E. Casals, M. Merea, A. Urbano-Marquez, P. Rustin & F. Cardellach: Aging is associated with increased lipid peroxidation in human hearts, but not with mitochondrial respiratory chain enzyme defects. Cardiovasc. Res. 18, 624-631(2000) (Pubitemid 30646085)
96. Afanas'ev, I. B.: Interplay between superoxide and nitric oxide in aging and diseases. Biogerontology 5, 267-270(2004)
97. Afanas'ev, I. B.: Free radical mechanisms of aging processes under physiological conditions. Biogerontology 6, 283-290(2005) (Pubitemid 43118467)
98. Trochu, J-N., J-B. Bouhour, G. Kaley & T. H. Hintze: Role of endothelium-derived nitric oxide in the regulation of cardiac oxygen metabolism. Implication in health and disease. Circ. Res. 87, 1108-1117(2000)
99. Afanas'ev, I. B.: Superoxide and nitric oxide in pathological conditions associated with iron overload. The effects of antioxidants and chelators. Curr. Med. Chem. 12, 2731-2739(2005) (Pubitemid 41601570)
100. Afanas'ev, I. B.: Interplay between superoxide and nitric oxide in thalassemia and Fanconi's anemia. Hemoglobin 30, 113-118(2006)
101. Krauss, C., C-Y. Zhang, L. Scorrano, L. T. Dalgaard, J. St-Pierre, S. T. Grey ST & B. B. Lowell: Superoxidemediated activation: of uncoupling protein 2 causes pancreatic b cell dysfunction. J. Clin. Invest. 112, 1831-1842(2003) (Pubitemid 38063706)
102. Echtay, K. S., E. Winkler, K. Frischmuth & M. Klingenberg: Uncoupling proteins 2 and 3 are highly active H+ transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone) Proc. Nat. Acad. Sci USA 98, 1416-1421(2001) (Pubitemid 32165513)
103. Li, P. F., R. Dietz & R. von Harsdorf: Differential effect of hydrogen peroxide and superoxide anion on apoptosis and proliferation of vascular smooth muscle cells. Circulation 96, 3602-3609(1997) (Pubitemid 27513439)
104. Moreno-Manzano, V., Y. Ishikawa, J. Lucio-Cazana & M. Kitamura: Selective involvement of superoxide anion, but not downstream compounds hydrogen peroxide and peroxynitrite, in tumor necrosis factor-alpha-induced apoptosis of rat mesangial cells. J. Biol. Chem. 275, 12684-12691(2000) (Pubitemid 30241419)
105. Madesh, M. & G. Hajnoczky: VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. J. Cell. Biol. 156, 1003-1016(2001)
106. Afanas'ev, I. B.: Mechanism of superoxide-mediated damage. Relevance to mitochondrial aging, Ann. N. Y. Acad. Sci. 1019, 343-345(2004) (Pubitemid 38951331)
107. Afanas'ev, I. B.: On mechanism of superoxide signaling under physiological and pathophysiological conditions: Med. Hypotheses 64, 127-129(2005) (Pubitemid 39469252)
108. Afanas'ev, I. B.: Competition between superoxide and hydrogen peroxide signaling in heterolytic enzymatic processes. Med Hypotheses 66, 1125-1128(2006)
109. Ames, B. H., M. K. Shigenaga & T. M. Hagen: Oxidant, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. USA 90:7915-7922(1993) (Pubitemid 23260825)
110. Merry, B. J.: Oxidative stress and mitochondrial function with aging - the effects of calorie restriction. Aging Cell. 3, 7-12(2004) (Pubitemid 40246655)
111. Hall, D. M., I. D. Oberley, P. M. Moseley, G. R. Buettner, L. W. Oberley, R. Weindruch & K. C. Kregel: Caloric restriction improves thermotolerance and reduces hyperthermia-induced cellular damage in old rats. FASEB J. 14, 78-86(2000) (Pubitemid 30051525)
112. Lass, A., B. H. Sohal, R. Weindruch, M. J. Forster & R. S. Sohal: Caloric restriction revents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria. Free Radic. Biol. Med. 25, 1089-1097(1998) (Pubitemid 28558336)
113. Sreekumar, R., J. Unnikrishan, A. Fu, J. Nygren, K. R. Short, J. Schimke, R. Barazzoni & K. S. Nair: Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle. Am. J. Physiol. Endocrinol. Metab. 283, E38-E43 (2002) (Pubitemid 34686665)
114. Zou, Y., K. J. Jung, J. W. Kim, B. P. Yu, & H. Y. Chung: Alteration of soluble adhesion molecules during aging and their modulation by calorie restriction. FASEB J. 18, 320-322(2004)
115. Nisoli, E., C. Tonello, A. Cardile, V. Cozzi, R. Bracale, L. Tedesco, S. Falcone, A. Valerio, O. Cantoni, E. Clementi, S. Moncada, & M. O. Carruba: Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 310(5746), 314-317(2005) (Pubitemid 41457197)
116. Poulin, J. E., C. Cover, M. R. Gustafson & M. B. Kay: Vitamin E prevents oxidative modification of brain and lymphocyte band 3 proteins during aging. Proc. Natl. Acad. Sci. USA 93, 5600-5603(1996) (Pubitemid 26159497)
117. Reckelhoff, J. F., V. Kanji, L. C. Racusen, A. M. Schmidt, S. D. Yan, J. Marrow, L. J. Roberts II & A. K. Salahudeen: Vitamin E ameliorates enhanced renal lipid peroxidation and accumulation of F2-isoprostanes in aging kidneys. Am. J. Physiol. 274: R767-R774 (1998)
118. Navarro, A., C. Gomez, M. J. Sanchez-Pino, H. Gonzalez, M. J. Bandez, A. D. Boveris & A. Boveris: Vitamin E at high doses improves survival, neurological performance, and brain mitochondrial function in aging male mice. Am J Physiol Regul Integr Comp Physiol. 289, R1392-R1399 (2005) (Pubitemid 41507405)
119. Sumien, N., M. J. Forster & R. S. Sohal: Supplementation with vitamin E fails to attenuate oxidative damage in aged mice. Exp. Gerontol. 38, 699-704(2003) (Pubitemid 36694173)
120. Selman, C., J. S. McLaren, C. Meyer, J. S. Duncan, P. Redman, A. R. Collins, G. G. Duthie & J. R. Speakman: Life-long vitamin C supplementation in combination with cold exposure does not affect oxidative damage or lifespan in mice, but decreases expression of antioxidant protection genes. Mech. Ageing Dev. 127:897-904(2006) (Pubitemid 44751894)
121. Suh, J. H., R. Moreau, S. H. Heath & T. M. Hagen: Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex. Redox Rep. 10, 52-60(2005) (Pubitemid 41556830)
122. Ishii, N., N. Senoo-Matsuda, K. Miyake, K. Yasuda, T. Ishii, P. S. Hartman & S. Furukawa: Coenzyme Q10 can prolong C. elegans lifespan by lowering oxidative stress. Mech. Ageing Dev. 125, 41-46(2004) (Pubitemid 38045325)
123. Yang, X., T. A. Doser, C. X. Fang, J. M. Nunn, R. Janardhanan, M. Zhu, N. Sreejayan, M. T. Quinn & J. Ren: Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: role of oxidative stress. FASEB J. 20, 1024-1026(2006)
124. Knoll, J.: The striatal dopamine dependency of life span in male rats. Longevity study with (-) deprenyl. Mech. Ageing Dev. 46, 237-62(1988) (Pubitemid 19028951)
125. Kitani, K., K. Miyasaka, S. Kanai, M. C. Carrillo & G. O. Ivy: Upregulation of antioxidant enzyme activities by deprenyl. Implications for life span extension. Ann. NY Acad. Sci. 786, 391-409(1996)
126. Archer, J. R. & D. E. Harrison: L-deprenyl treatment in aged mice slightly increases life spans, and greatly reduces fecundity by aged males. J. Gerontol. A, Biol. Sci. Med. Sci. 51, B448-B453 (1996) (Pubitemid 26394072)
127. Kitani, K., C. Minami, K. Isobe, K. Maehara, S. Kanai, G. P. Ivy & M. C. Carrillo: Why (-) deprenyl prolongs survivals of experimental animals: increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of various humoral factors may lead to systemic anti-aging effects. Mech. Ageing Dev. 123, 1087-1100(2002) (Pubitemid 34603092)
128. Schriner, S. E., N. J. Linford, G. M. Martin, P. Treuting, C. E. Ogburn, M. Emond, P. E. Coskun, W. Ladiges, N. Wolf, H. Van Remmen, D. C. Wallace & P. S. Rabinovitch: Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 308(5730), 1909-1911(2005) (Pubitemid 40941874)
129. Melov, S., J. Ravenscroft, S. Malik, M. S. Gill, D. W. Walker, P. E. Clayton, D. C. Wallace, B. Malfroy, S. R Doctrow & G. J. Lithgow: Extension of life-span with superoxide dismutase/catalase mimetics. Science 289 (5484) 1567-1569 (2000)
130. Zhang, H. J., S. R. Doctrow, L. Xu, L. W. Oberley, B. Beecher, J. Morrison, T. D. Oberley & K. C. Kregel: Redox modulation of the liver with chronic antioxidant enzyme mimetic treatment prevents age-related oxidative damage associated with environmental stress. FASEB J. 18, 1547-1549(2004) (Pubitemid 39561628)
131. Quick, K. L., S. S. Ali, R. Arch, C. Xiong, D Wozniak, & LL Dugan: A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice. Neurobiol. Aging. 29, 117-128(2008) (Pubitemid 350102712)
132. Aiken, K. J., J. S. Bickford, M. L. Kilberg & H. S. Nick: Metabolic regulation of manganese superoxide dismutase expression via essential amino acid deprivation. J. Biol. Chem. 283:10252-10263(2008)