-
1
-
-
0032427906
-
How might replicative senescence contribute to human ageing?
-
Faragher RG, Kipling D. How might replicative senescence contribute to human ageing? Bioessays 1998; 20: 985-91.
-
(1998)
Bioessays
, vol.20
, pp. 985-991
-
-
Faragher, R.G.1
Kipling, D.2
-
2
-
-
0016441021
-
Current theories of biological aging
-
Hayflick L. Current theories of biological aging. Fed Proc 1975; 34: 9-13.
-
(1975)
Fed. Proc.
, vol.34
, pp. 9-13
-
-
Hayflick, L.1
-
3
-
-
0001068487
-
The relationship between in vitro cellular aging and in vivo human age
-
Schneider EL, Mitsui Y. The relationship between in vitro cellular aging and in vivo human age. Proc Natl Acad Sci USA 1976; 73: 3584-8.
-
(1976)
Proc. Natl. Acad. Sci. USA
, vol.73
, pp. 3584-3588
-
-
Schneider, E.L.1
Mitsui, Y.2
-
4
-
-
0000299214
-
Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo
-
Rohme D. Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo. Proc Natl Acad Sci USA 1981; 78: 5009-13.
-
(1981)
Proc. Natl. Acad. Sci. USA
, vol.78
, pp. 5009-5013
-
-
Rohme, D.1
-
5
-
-
0020531224
-
Genetic effects on the longevity of cultured human fibroblasts. II. DNA repair deficient syndromes
-
Thompson KV, Holliday R. Genetic effects on the longevity of cultured human fibroblasts. II. DNA repair deficient syndromes. Gerontology 1983; 29: 83-8.
-
(1983)
Gerontology
, vol.29
, pp. 83-88
-
-
Thompson, K.V.1
Holliday, R.2
-
6
-
-
0026328365
-
The endothelium of advanced arteriosclerotic plaques in humans
-
Burrig KF. The endothelium of advanced arteriosclerotic plaques in humans. Arterioscler Thromb 1991; 11: 1678-89.
-
(1991)
Arterioscler. Thromb.
, vol.11
, pp. 1678-1689
-
-
Burrig, K.F.1
-
7
-
-
0021337848
-
Human atherosclerosis. I. Cell constitution and characteristics of advanced lesions of the superficial femoral artery
-
Ross R, Wight TN, Strandness E, Thiele B. Human atherosclerosis. I. Cell constitution and characteristics of advanced lesions of the superficial femoral artery. Am J Pathol 1984; 114: 79-93.
-
(1984)
Am. J. Pathol.
, vol.114
, pp. 79-93
-
-
Ross, R.1
Wight, T.N.2
Strandness, E.3
Thiele, B.4
-
8
-
-
0027277014
-
Enhanced expression of fibronectin during in vivo cellular aging of human vascular endothelial cells and skin fibroblasts
-
Kumazaki T, Kobayashi M, Mitsui Y. Enhanced expression of fibronectin during in vivo cellular aging of human vascular endothelial cells and skin fibroblasts. Exp Cell Res 1993; 205: 396-402.
-
(1993)
Exp. Cell Res.
, vol.205
, pp. 396-402
-
-
Kumazaki, T.1
Kobayashi, M.2
Mitsui, Y.3
-
9
-
-
0032489850
-
Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic plaques
-
Bennett MR, Macdonald K, Chan SW, Boyle JJ, Weissberg PL. Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic plaques. Circ Res 1998; 82: 704-12.
-
(1998)
Circ. Res.
, vol.82
, pp. 704-712
-
-
Bennett, M.R.1
Macdonald, K.2
Chan, S.W.3
Boyle, J.J.4
Weissberg, P.L.5
-
10
-
-
0034235774
-
Accelerated replicative senescence of medial smooth muscle cells derived from abdominal aortic aneurysms compared to the adjacent inferior mesenteric artery
-
Liao S, Curci JA, Kelley BJ, Sicard GA, Thompson RW. Accelerated replicative senescence of medial smooth muscle cells derived from abdominal aortic aneurysms compared to the adjacent inferior mesenteric artery. J Surg Res 2000; 92: 85-95.
-
(2000)
J. Surg. Res.
, vol.92
, pp. 85-95
-
-
Liao, S.1
Curci, J.A.2
Kelley, B.J.3
Sicard, G.A.4
Thompson, R.W.5
-
11
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C. et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995; 92: 9363-7.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
Roskelley, C.6
-
12
-
-
0032526762
-
Cytochemical detection of a senescence-associated beta-galactosidase in endothelial and smooth muscle cells from human and rabbit blood vessels
-
van der Loo B, Fenton MJ, Erusalimsky JD. Cytochemical detection of a senescence-associated beta-galactosidase in endothelial and smooth muscle cells from human and rabbit blood vessels. Exp Cell Res 1998; 241: 309-15.
-
(1998)
Exp. Cell Res.
, vol.241
, pp. 309-315
-
-
van der Loo, B.1
Fenton, M.J.2
Erusalimsky, J.D.3
-
13
-
-
0035146421
-
Cellular senescence after single and repeated balloon catheter denudations of rabbit carotid arteries
-
Fenton M, Barker S, Kurz DJ, Erusalimsky JD. Cellular senescence after single and repeated balloon catheter denudations of rabbit carotid arteries. Arterioscler Thromb Vasc Biol 2001; 21: 220-6.
-
(2001)
Arterioscler. Thromb. Vasc. Biol.
, vol.21
, pp. 220-226
-
-
Fenton, M.1
Barker, S.2
Kurz, D.J.3
Erusalimsky, J.D.4
-
14
-
-
0037007075
-
Endothelial cell senescence in human atherosclerosis: Role of telomere in endothelial dysfunction
-
Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H, Komuro I. Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation 2002; 105: 1541-4.
-
(2002)
Circulation
, vol.105
, pp. 1541-1544
-
-
Minamino, T.1
Miyauchi, H.2
Yoshida, T.3
Ishida, Y.4
Yoshida, H.5
Komuro, I.6
-
15
-
-
3042725854
-
Ras-induced vascular smooth muscle cell senescence in human atherosclerosis
-
In press
-
Minamino T, Yoshida T, Tateno K, Miyauchi H, Zou Y, Toko H, et al. Ras-induced vascular smooth muscle cell senescence in human atherosclerosis. Circulation In press.
-
Circulation
-
-
Minamino, T.1
Yoshida, T.2
Tateno, K.3
Miyauchi, H.4
Zou, Y.5
Toko, H.6
-
16
-
-
0028957303
-
Age-related changes in vascular responses: A review
-
Marin J. Age-related changes in vascular responses: a review. Mech Ageing Dev 1995; 79: 71-114.
-
(1995)
Mech. Ageing. Dev.
, vol.79
, pp. 71-114
-
-
Marin, J.1
-
17
-
-
0033547805
-
Age-dependent impairment of angiogenesis
-
Rivard A, Fabre JE, Silver M, Chen D, Murohara T, Kearney M, et al. Age-dependent impairment of angiogenesis. Circulation 1999; 99: 111-20.
-
(1999)
Circulation
, vol.99
, pp. 111-120
-
-
Rivard, A.1
Fabre, J.E.2
Silver, M.3
Chen, D.4
Murohara, T.5
Kearney, M.6
-
18
-
-
0026650622
-
Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries
-
Schneiderman J, Sawdey MS, Keeton MR, Bordin GM, Bernstein EF, Dilley RB, et al. Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries. Proc Natl Acad Sci USA 1992; 89: 6998-7002.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 6998-7002
-
-
Schneiderman, J.1
Sawdey, M.S.2
Keeton, M.R.3
Bordin, G.M.4
Bernstein, E.F.5
Dilley, R.B.6
-
20
-
-
0033055559
-
Endothelial dysfunction: From physiology to therapy
-
Mombouli JV, Vanhoutte PM. Endothelial dysfunction: from physiology to therapy. J Mol Cell Cardiol 1999; 31: 61-74.
-
(1999)
J. Mol. Cell Cardiol.
, vol.31
, pp. 61-74
-
-
Mombouli, J.V.1
Vanhoutte, P.M.2
-
21
-
-
0027296739
-
Reduction of nitric oxide producing activity associated with in vitro aging in cultured human umbilical vein endothelial cell
-
Sato I, Morita I, Kaji K, Ikeda M, Nagao M, Murota S. Reduction of nitric oxide producing activity associated with in vitro aging in cultured human umbilical vein endothelial cell. Biochem Biophys Res Commun 1993; 195: 1070-6.
-
(1993)
Biochem. Biophys. Res. Commun.
, vol.195
, pp. 1070-1076
-
-
Sato, I.1
Morita, I.2
Kaji, K.3
Ikeda, M.4
Nagao, M.5
Murota, S.6
-
22
-
-
0035955754
-
eNOS activity is reduced in senescent human endothelial cells: Preservation by hTERT immortalization
-
Matsushita H, Chang E, Glassford AJ, Cooke JP, Chiu CP, Tsao PS. eNOS activity is reduced in senescent human endothelial cells: Preservation by hTERT immortalization. Circ Res 2001; 89: 793-8.
-
(2001)
Circ. Res.
, vol.89
, pp. 793-798
-
-
Matsushita, H.1
Chang, E.2
Glassford, A.J.3
Cooke, J.P.4
Chiu, C.P.5
Tsao, P.S.6
-
23
-
-
0035851216
-
Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: Important role of nitric oxide
-
Hoffmann J, Haendeler J, Icier A, Rossig L, Vasa M, Zeiher AM, et al. Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: important role of nitric oxide. Circ Res 2001; 89: 709-15.
-
(2001)
Circ. Res.
, vol.89
, pp. 709-715
-
-
Hoffmann, J.1
Haendeler, J.2
Icier, A.3
Rossig, L.4
Vasa, M.5
Zeiher, A.M.6
-
24
-
-
0030696009
-
Aging decreases the production of PG12 in rat aortic endothelial cells
-
Nakajima M, Hashimoto M, Wang F, Yamanaga K, Nakamura N, Uchida T, et al. Aging decreases the production of PG12 in rat aortic endothelial cells. Exp Gerontol 1997; 32: 685-93.
-
(1997)
Exp. Gerontol.
, vol.32
, pp. 685-693
-
-
Nakajima, M.1
Hashimoto, M.2
Wang, F.3
Yamanaga, K.4
Nakamura, N.5
Uchida, T.6
-
25
-
-
0029089162
-
Senescence-dependent regulation of type 1 plasminogen activator inhibitor in human vascular endothelial cells
-
Comi P, Chiaramonte R, Maier JA. Senescence-dependent regulation of type 1 plasminogen activator inhibitor in human vascular endothelial cells. Exp Cell Res 1995; 219: 304-8.
-
(1995)
Exp. Cell Res.
, vol.219
, pp. 304-308
-
-
Comi, P.1
Chiaramonte, R.2
Maier, J.A.3
-
26
-
-
0027194495
-
Senescence stimulates U937-endothelial cell interactions
-
Maier JA, Statuto M, Ragnotti G. Senescence stimulates U937-endothelial cell interactions. Exp Cell Res 1993; 208: 270-4.
-
(1993)
Exp. Cell Res.
, vol.208
, pp. 270-274
-
-
Maier, J.A.1
Statuto, M.2
Ragnotti, G.3
-
27
-
-
0034703017
-
Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity
-
Rivard A, Berthou-Soulie L, Principe N, Kearney M, Curry C, Branellec D, et al. Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity. J Biol Chem 2000; 275: 29643-7.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 29643-29647
-
-
Rivard, A.1
Berthou-Soulie, L.2
Principe, N.3
Kearney, M.4
Curry, C.5
Branellec, D.6
-
28
-
-
0033543760
-
Human endothelial cell life extension by telomerase expression
-
Yang J, Chang E, Cherry AM, Bangs CD, Oei Y, Bodnar A, et al. Human endothelial cell life extension by telomerase expression. J Biol Chem 1999; 274: 26141-8.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 26141-82614
-
-
Yang, J.1
Chang, E.2
Cherry, A.M.3
Bangs, C.D.4
Oei, Y.5
Bodnar, A.6
-
29
-
-
0026574183
-
Beta-adrenergic responsiveness in cultured aorta smooth muscle cells. Effects of subculture and aging
-
Crass MF 3rd, Borst SE, Scarpace PJ. Beta-adrenergic responsiveness in cultured aorta smooth muscle cells. Effects of subculture and aging. Biochem Pharmacol 1992; 43: 1811-5.
-
(1992)
Biochem. Pharmacol.
, vol.43
, pp. 1811-1815
-
-
Crass III, M.F.1
Borst, S.E.2
Scarpace, P.J.3
-
31
-
-
0034774859
-
Cellular senescence, cancer and aging: The telomere connection
-
Campisi J, Kim SH, Lim CS, Rubio M. Cellular senescence, cancer and aging: the telomere connection. Exp Gerontol 2001; 36: 1619-37.
-
(2001)
Exp. Gerontol.
, vol.36
, pp. 1619-1637
-
-
Campisi, J.1
Kim, S.H.2
Lim, C.S.3
Rubio, M.4
-
33
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279: 349-52.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
Holt, S.E.4
Chiu, C.P.5
Morin, G.B.6
-
34
-
-
0028856794
-
Telomere length and replicative aging in human vascular tissues
-
Chang E, Harley CB. Telomere length and replicative aging in human vascular tissues. Proc Natl Acad Sci USA 1995; 92: 11190-4.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 11190-11194
-
-
Chang, E.1
Harley, C.B.2
-
35
-
-
0035032219
-
Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation
-
Minamino T, Mitsialis SA, Kourembanas S. Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. Mol Cell Biol 2001; 21: 3336-42.
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 3336-3342
-
-
Minamino, T.1
Mitsialis, S.A.2
Kourembanas, S.3
-
36
-
-
0035929353
-
Switching and signaling at the telomere
-
Blackburn EH. Switching and signaling at the telomere. Cell 2001; 106: 661-73.
-
(2001)
Cell
, vol.106
, pp. 661-673
-
-
Blackburn, E.H.1
-
37
-
-
0035844082
-
Potl, the putative telomere end-binding protein in fission yeast and humans
-
Baumann P, Cech TR. Potl, the putative telomere end-binding protein in fission yeast and humans. Science 2001; 292: 1171-5.
-
(2001)
Science
, vol.292
, pp. 1171-1175
-
-
Baumann, P.1
Cech, T.R.2
-
39
-
-
84984775429
-
Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2
-
Broccoli D, Smogorzewska A, Chong L, de Lange T. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet 1997; 17: 231-5.
-
(1997)
Nat. Genet.
, vol.17
, pp. 231-235
-
-
Broccoli, D.1
Smogorzewska, A.2
Chong, L.3
de Lange, T.4
-
40
-
-
0036566036
-
Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres
-
Espejel S, Franco S, Rodriguez-Perales S, Bouffler SD, Cigudosa JC, Blasco MA. Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres. EMBO J 2002; 21: 2207-19.
-
(2002)
EMBO J.
, vol.21
, pp. 2207-2219
-
-
Espejel, S.1
Franco, S.2
Rodriguez-Perales, S.3
Bouffler, S.D.4
Cigudosa, J.C.5
Blasco, M.A.6
-
41
-
-
0033553536
-
Mammalian telomeres end in a large duplex loop
-
Griffith JD, Comeau L, Rosenfield S, Stansel RM, Bianchi A, Moss H, et al. Mammalian telomeres end in a large duplex loop. Cell 1999; 97: 503-14.
-
(1999)
Cell
, vol.97
, pp. 503-514
-
-
Griffith, J.D.1
Comeau, L.2
Rosenfield, S.3
Stansel, R.M.4
Bianchi, A.5
Moss, H.6
-
42
-
-
0032489012
-
TRF2 protects human telomeres from end-to-end fusions
-
van Steensel B, Smogorzewska A, de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell 1998; 92: 401-13.
-
(1998)
Cell
, vol.92
, pp. 401-413
-
-
van Steensel, B.1
Smogorzewska, A.2
de Lange, T.3
-
43
-
-
0037102234
-
Different telomere damage signaling pathways in human and mouse cells
-
Smogorzewska A, de Lange T. Different telomere damage signaling pathways in human and mouse cells. EMBO J 2002; 21: 4338-48.
-
(2002)
EMBO J.
, vol.21
, pp. 4338-4348
-
-
Smogorzewska, A.1
de Lange, T.2
-
45
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997; 88: 593-602.
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
46
-
-
0033989829
-
Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor
-
Dimri GP, Itahana K, Acosta M, Campisi J. Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor. Mol Cell Biol 2000; 20: 273-85.
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 273-285
-
-
Dimri, G.P.1
Itahana, K.2
Acosta, M.3
Campisi, J.4
-
47
-
-
0032190629
-
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
-
Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M, Lowe SW. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev 1998; 12: 3008-19.
-
(1998)
Genes. Dev.
, vol.12
, pp. 3008-30019
-
-
Lin, A.W.1
Barradas, M.2
Stone, J.C.3
van Aelst, L.4
Serrano, M.5
Lowe, S.W.6
-
48
-
-
0036242247
-
Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence
-
Wang W, Chen JX, Liao R, Deng Q, Zhou JJ, Huang S, et al. Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Mol Cell Biol 2002; 22: 3389-403.
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 3389-3403
-
-
Wang, W.1
Chen, J.X.2
Liao, R.3
Deng, Q.4
Zhou, J.J.5
Huang, S.6
-
49
-
-
0032191393
-
Tumor surveillance via the ARF-p53 pathway
-
Sherr CJ. Tumor surveillance via the ARF-p53 pathway. Genes Dev 1998; 12: 2984-91.
-
(1998)
Genes. Dev.
, vol.12
, pp. 2984-2991
-
-
Sherr, C.J.1
-
50
-
-
0032504784
-
p19ARF links the tumour suppressor p53 to Ras
-
Palmero I, Pantoja C, Serrano M. p19ARF links the tumour suppressor p53 to Ras. Nature 1998; 395: 125-6.
-
(1998)
Nature
, vol.395
, pp. 125-126
-
-
Palmero, I.1
Pantoja, C.2
Serrano, M.3
-
51
-
-
0033764030
-
Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers
-
Jacobs JJ, Keblusek P, Robanus-Maandag E, Kristel P, Lingbeek M, Nederlof PM, et al. Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers. Nat Genet 2000; 26: 291-9.
-
(2000)
Nat. Genet.
, vol.26
, pp. 291-299
-
-
Jacobs, J.J.1
Keblusek, P.2
Robanus-Maandag, E.3
Kristel, P.4
Lingbeek, M.5
Nederlof, P.M.6
-
52
-
-
0034663873
-
PML is induced by oncogenic ras and promotes premature senescence
-
Ferbeyre G, de Stanchina E, Querido E, Baptiste N, Prives C, Lowe SW. PML is induced by oncogenic ras and promotes premature senescence. Genes Dev 2000; 14: 2015-27.
-
(2000)
Genes. Dev.
, vol.14
, pp. 2015-2027
-
-
Ferbeyre, G.1
de Stanchina, E.2
Querido, E.3
Baptiste, N.4
Prives, C.5
Lowe, S.W.6
-
53
-
-
0034644274
-
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
-
Pearson M, Carbone R, Sebastiani C, Cioce M, Fagioli M, Saito S, et al. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 2000; 406: 207-10.
-
(2000)
Nature
, vol.406
, pp. 207-210
-
-
Pearson, M.1
Carbone, R.2
Sebastiani, C.3
Cioce, M.4
Fagioli, M.5
Saito, S.6
-
54
-
-
0033553516
-
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
-
Chin L, Artandi SE, Shen Q, Tam A, Lee SL, Gottlieb GJ, et al. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 1999; 97: 527-38.
-
(1999)
Cell
, vol.97
, pp. 527-538
-
-
Chin, L.1
Artandi, S.E.2
Shen, Q.3
Tam, A.4
Lee, S.L.5
Gottlieb, G.J.6
-
55
-
-
0033602033
-
Two posttranscriptional pathways that regulate p21(Cip1/Waf1/Sdi1) are identified by HPV16-E6 interaction and correlate with life span and cellular senescence
-
Burkhart BA, Alcorta DA, Chiao C, Isaacs JS, Barrett JC. Two posttranscriptional pathways that regulate p21(Cip1/Waf1/Sdi1) are identified by HPV16-E6 interaction and correlate with life span and cellular senescence. Exp Cell Res 1999; 247: 168-75.
-
(1999)
Exp. Cell Res.
, vol.247
, pp. 168-175
-
-
Burkhart, B.A.1
Alcorta, D.A.2
Chiao, C.3
Isaacs, J.S.4
Barrett, J.C.5
-
56
-
-
0035931859
-
Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
-
Ohtani N, Zebedee Z, Huot TJ, Stinson JA, Sugimoto M, Ohashi Y, et al. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. Nature 2001; 409: 1067-70.
-
(2001)
Nature
, vol.409
, pp. 1067-1070
-
-
Ohtani, N.1
Zebedee, Z.2
Huot, T.J.3
Stinson, J.A.4
Sugimoto, M.5
Ohashi, Y.6
-
57
-
-
0032510327
-
Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts
-
McConnell BB, Starborg M, Brookes S, Peters G. Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts. Curr Biol 1998; 8: 351-4.
-
(1998)
Curr. Biol.
, vol.8
, pp. 351-354
-
-
McConnell, B.B.1
Starborg, M.2
Brookes, S.3
Peters, G.4
-
58
-
-
0034626735
-
Oxidants, oxidative stress and the biology of ageing
-
Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature 2000; 408: 239-47.
-
(2000)
Nature
, vol.408
, pp. 239-247
-
-
Finkel, T.1
Holbrook, N.J.2
-
59
-
-
0034678050
-
Homocysteine accelerates endothelial cell senescence
-
Xu D, Neville R, Finkel T. Homocysteine accelerates endothelial cell senescence. FEBS Lett 2000; 470: 20-4.
-
(2000)
FEBS Lett.
, vol.470
, pp. 20-24
-
-
Xu, D.1
Neville, R.2
Finkel, T.3
-
60
-
-
0035937503
-
Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism
-
Breitschopf K, Zeiher AM, Dimmeler S. Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism. FEBS Lett 2001; 493: 21-5.
-
(2001)
FEBS Lett.
, vol.493
, pp. 21-25
-
-
Breitschopf, K.1
Zeiher, A.M.2
Dimmeler, S.3
-
61
-
-
0032493742
-
Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress
-
Furumoto K, Inoue E, Nagao N, Hiyama E, Miwa N. Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. Life Sci 1998; 63: 935-48.
-
(1998)
Life Sci.
, vol.63
, pp. 935-948
-
-
Furumoto, K.1
Inoue, E.2
Nagao, N.3
Hiyama, E.4
Miwa, N.5
-
62
-
-
0034730782
-
Nitric oxide activates telomerase and delays endothelial cell senescence
-
Vasa M, Breitschopf K, Zeiher AM, Dimmeler S. Nitric oxide activates telomerase and delays endothelial cell senescence. Circ Res 2000; 87: 540-2.
-
(2000)
Circ. Res.
, vol.87
, pp. 54054-54062
-
-
Vasa, M.1
Breitschopf, K.2
Zeiher, A.M.3
Dimmeler, S.4
-
63
-
-
0035965319
-
Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3
-
Xie S, Wang Q, Wu H, Cogswell J, Lu L, Jhanwar-Uniyal M. et al. Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3. J Biol Chem 2001; 276: 36194-9.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 36194-36199
-
-
Xie, S.1
Wang, Q.2
Wu, H.3
Cogswell, J.4
Lu, L.5
Jhanwar-Uniyal, M.6
-
64
-
-
0033583242
-
Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species
-
Lee AC, Fenster BE, Ito H, Takeda K, Bae NS, Hirai T, et al. Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J Biol Chem 1999; 274: 7936-40.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 7936-7940
-
-
Lee, A.C.1
Fenster, B.E.2
Ito, H.3
Takeda, K.4
Bae, N.S.5
Hirai, T.6
-
65
-
-
0036566326
-
Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence
-
Macip S, Igarashi M, Fang L, Chen A, Pan ZQ, Lee SW, et al. Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence. EMBO J 2002; 21: 2180-8.
-
(2002)
EMBO J.
, vol.21
, pp. 2180-2188
-
-
Macip, S.1
Igarashi, M.2
Fang, L.3
Chen, A.4
Pan, Z.Q.5
Lee, S.W.6
-
66
-
-
0033605145
-
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
-
Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 1999; 283: 1321-5.
-
(1999)
Science
, vol.283
, pp. 1321-1325
-
-
Karlseder, J.1
Broccoli, D.2
Dai, Y.3
Hardy, S.4
de Lange, T.5
-
67
-
-
0030931491
-
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
-
Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA, et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997; 91: 25-34.
-
(1997)
Cell
, vol.91
, pp. 25-34
-
-
Blasco, M.A.1
Lee, H.W.2
Hande, M.P.3
Samper, E.4
Lansdorp, P.M.5
DePinho, R.A.6
-
68
-
-
0032499210
-
Essential role of mouse telomerase in highly proliferative organs
-
Lee HW, Blasco MA, Gottlieb GJ, Horner JW 2nd, Greider CW, DePinho RA. Essential role of mouse telomerase in highly proliferative organs. Nature 1998; 392: 569-74.
-
(1998)
Nature
, vol.392
, pp. 569-574
-
-
Lee, H.W.1
Blasco, M.A.2
Gottlieb, G.J.3
Horner II, J.W.4
Greider, C.W.5
DePinho, R.A.6
-
69
-
-
0033525558
-
Longevity, stress response, and cancer in aging telomerase-deficient mice
-
Rudolph KL, Chang S, Lee HW, Blasco M, Gottlieb GJ, Greider C, et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 1999; 96: 701-12.
-
(1999)
Cell
, vol.96
, pp. 701-712
-
-
Rudolph, K.L.1
Chang, S.2
Lee, H.W.3
Blasco, M.4
Gottlieb, G.J.5
Greider, C.6
-
70
-
-
0037081078
-
Decreased B16F10 melanoma growth and impaired vascularization in telomerase-deficient mice with critically short telomeres
-
Franco S, Segura I, Riese HH, Blasco MA. Decreased B16F10 melanoma growth and impaired vascularization in telomerase-deficient mice with critically short telomeres. Cancer Res 2002; 62: 552-9.
-
(2002)
Cancer Res.
, vol.62
, pp. 552-559
-
-
Franco, S.1
Segura, I.2
Riese, H.H.3
Blasco, M.A.4
-
71
-
-
0035198143
-
Age dependent aneuploidy and telomere length of the human vascular endothelium
-
Aviv H, Khan MY, Skurnick J, Okuda K, Kimura M, Gardner J, et al. Age dependent aneuploidy and telomere length of the human vascular endothelium. Atherosclerosis 2001; 159: 281-7.
-
(2001)
Atherosclerosis
, vol.159
, pp. 281-287
-
-
Aviv, H.1
Khan, M.Y.2
Skurnick, J.3
Okuda, K.4
Kimura, M.5
Gardner, J.6
-
72
-
-
0035256310
-
Telomere length as an indicator of biological aging: The gender effect and relation with pulse pressure and pulse wave velocity
-
Benetos A, Okuda K, Lajemi M, Kimura M, Thomas F, Skurnick J, et al. Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension 2001; 37: 381-5.
-
(2001)
Hypertension
, vol.37
, pp. 381-385
-
-
Benetos, A.1
Okuda, K.2
Lajemi, M.3
Kimura, M.4
Thomas, F.5
Skurnick, J.6
-
73
-
-
0035845259
-
Telomere shortening in atherosclerosis
-
Samani NJ, Boultby R, Butler R, Thompson JR, Goodall AH. Telomere shortening in atherosclerosis. Lancet 2001; 358: 472-3.
-
(2001)
Lancet
, vol.358
, pp. 472-473
-
-
Samani, N.J.1
Boultby, R.2
Butler, R.3
Thompson, J.R.4
Goodall, A.H.5
-
74
-
-
0033816392
-
Telomere attrition of the human abdominal aorta: Relationships with age and atherosclerosis
-
Okuda K, Khan MY, Skurnick J, Kimura M, Aviv H, Aviv A. Telomere attrition of the human abdominal aorta: relationships with age and atherosclerosis. Atherosclerosis 2000; 152: 391-8.
-
(2000)
Atherosclerosis
, vol.152
, pp. 391-398
-
-
Okuda, K.1
Khan, M.Y.2
Skurnick, J.3
Kimura, M.4
Aviv, H.5
Aviv, A.6
-
75
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266: 2011-5.
-
(1994)
Science
, vol.266
, pp. 2011-2015
-
-
Kim, N.W.1
Piatyszek, M.A.2
Prowse, K.R.3
Harley, C.B.4
West, M.D.5
Ho, P.L.6
-
76
-
-
0035800881
-
Mechanisms of telomerase induction during vascular smooth muscle cell proliferation
-
Minamino T, Kourembanas S. Mechanisms of telomerase induction during vascular smooth muscle cell proliferation. Circ Res 2001; 89: 237-43.
-
(2001)
Circ. Res.
, vol.89
, pp. 237-243
-
-
Minamino, T.1
Kourembanas, S.2
-
77
-
-
0030942921
-
Telomerase activity in normal human endothelial cells
-
Hsiao R, Sharma HW, Ramakrishnan S, Keith E, Narayanan R. Telomerase activity in normal human endothelial cells. Anticancer Res 1997; 17: 827-32.
-
(1997)
Anticancer Res.
, vol.17
, pp. 827-832
-
-
Hsiao, R.1
Sharma, H.W.2
Ramakrishnan, S.3
Keith, E.4
Narayanan, R.5
-
78
-
-
0035108952
-
Telomerized human microvasculature is functional in vivo
-
Yang J, Nagavarapu U, Relloma K, Sjaastad MD, Moss WC, Passaniti A, et al. Telomerized human microvasculature is functional in vivo. Nat Biotechnol 2001; 19: 219-24.
-
(2001)
Nat. Biotechnol.
, vol.19
, pp. 219-224
-
-
Yang, J.1
Nagavarapu, U.2
Relloma, K.3
Sjaastad, M.D.4
Moss, W.C.5
Passaniti, A.6
-
79
-
-
0031019745
-
Isolation of putative progenitor endothelial cells for angiogenesis
-
Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997; 275: 964-7.
-
(1997)
Science
, vol.275
, pp. 964-967
-
-
Asahara, T.1
Murohara, T.2
Sullivan, A.3
Silver, M.4
van der Zee, R.5
Li, T.6
-
80
-
-
0032945433
-
Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization
-
Takahashi T, Kalka C, Masuda H, Chen D, Silver M, Kearney M, et al. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med 1999; 5: 434-8.
-
(1999)
Nat. Med.
, vol.5
, pp. 434-438
-
-
Takahashi, T.1
Kalka, C.2
Masuda, H.3
Chen, D.4
Silver, M.5
Kearney, M.6
-
81
-
-
17644433975
-
Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease
-
Vasa M, Fichtlscherer S, Icier A, Adler K, Urbich C, Martin H. et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 2001; 89: E1-7.
-
(2001)
Circ. Res.
, vol.89
-
-
Vasa, M.1
Fichtlscherer, S.2
Icier, A.3
Adler, K.4
Urbich, C.5
Martin, H.6
-
82
-
-
0037183542
-
Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells
-
Murasawa S, Llevadot J, Silver M, Isner JM, Losordo DW, Asahara T. Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells. Circulation 2002; 106: 1133-9.
-
(2002)
Circulation
, vol.106
, pp. 1133-1139
-
-
Murasawa, S.1
Llevadot, J.2
Silver, M.3
Isner, J.M.4
Losordo, D.W.5
Asahara, T.6
-
83
-
-
0034648768
-
Atherosclerosis
-
Lusis AJ. Atherosclerosis. Nature 2000; 407: 233-41.
-
(2000)
Nature
, vol.407
, pp. 233-241
-
-
Lusis, A.J.1
-
85
-
-
0036814405
-
Serum levels of the senescence biomarker clusterin/apolipoprotein J increase significantly in diabetes type II and during development of coronary heart disease or at myocardial infarction
-
Trougakos IP, Poulakou M, Stathatos M, Chalikia A, Melidonis A, Gonos ES. Serum levels of the senescence biomarker clusterin/apolipoprotein J increase significantly in diabetes type II and during development of coronary heart disease or at myocardial infarction. Exp Gerontol 2002; 37: 1175-87.
-
(2002)
Exp. Gerontol.
, vol.37
, pp. 1175-1187
-
-
Trougakos, I.P.1
Poulakou, M.2
Stathatos, M.3
Chalikia, A.4
Melidonis, A.5
Gonos, E.S.6
-
86
-
-
0031469636
-
Topographical association between the cyclin-dependent kinases inhibitor P21, p53 accumulation, and cellular proliferation in human atherosclerotic tissue
-
Ihling C, Menzel G, Wellens E, Monting JS, Schaefer HE, Zeiher AM. Topographical association between the cyclin-dependent kinases inhibitor P21, p53 accumulation, and cellular proliferation in human atherosclerotic tissue. Arterioscler Thromb Vasc Biol 1997; 17: 2218-24.
-
(1997)
Arterioscler Thromb. Vasc. Biol.
, vol.17
, pp. 2218-2224
-
-
Ihling, C.1
Menzel, G.2
Wellens, E.3
Monting, J.S.4
Schaefer, H.E.5
Zeiher, A.M.6
-
87
-
-
0032978142
-
The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo
-
Guevara NV, Kim HS, Antonova EI, Chan L. The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo. Nat Med 1999; 5: 335-9.
-
(1999)
Nat. Med.
, vol.5
, pp. 335-339
-
-
Guevara, N.V.1
Kim, H.S.2
Antonova, E.I.3
Chan, L.4
-
88
-
-
0035957575
-
Macrophage p53 deficiency leads to enhanced atherosclerosis in APOE*3-Leiden transgenic mice
-
van Vlijmen BJ, Gerritsen G, Franken AL, Boesten LS, Kockx MM, Gijbels MJ, et al. Macrophage p53 deficiency leads to enhanced atherosclerosis in APOE*3-Leiden transgenic mice. Circ Res 2001; 88: 780-6.
-
(2001)
Circ. Res.
, vol.88
, pp. 780-786
-
-
van Vlijmen, B.J.1
Gerritsen, G.2
Franken, A.L.3
Boesten, L.S.4
Kockx, M.M.5
Gijbels, M.J.6
-
89
-
-
0037197723
-
Induction of atherosclerotic plaque rupture in apolipoprotein E-/- mice after adenovirus-mediated transfer of p53
-
von der Thusen JH, van Vlijmen BJ, Hoeben RC, Kockx MM, Havekes LM, van Berkel TJ, et al. Induction of atherosclerotic plaque rupture in apolipoprotein E-/- mice after adenovirus-mediated transfer of p53. Circulation 2002; 105: 2064-70.
-
(2002)
Circulation
, vol.105
, pp. 2064-2070
-
-
von der Thusen, J.H.1
van Vlijmen, B.J.2
Hoeben, R.C.3
Kockx, M.M.4
Havekes, L.M.5
van Berkel, T.J.6
-
91
-
-
0032765047
-
Studies of the molecular mechanisms in the regulation of telomerase activity
-
Liu JP. Studies of the molecular mechanisms in the regulation of telomerase activity. FASEB J 1999; 13: 2091-104.
-
(1999)
FASEB J.
, vol.13
, pp. 2091-2104
-
-
Liu, J.P.1
-
92
-
-
0036167650
-
A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence
-
Peeper DS, Shvarts A, Brummelkamp T, Douma S, Koh EY, Daley GQ, et al. A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence. Nat Cell Biol 2002; 4: 148-53.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 148-153
-
-
Peeper, D.S.1
Shvarts, A.2
Brummelkamp, T.3
Douma, S.4
Koh, E.Y.5
Daley, G.Q.6
-
93
-
-
0029051426
-
Oxidative DNA damage and senescence of human diploid fibroblast cells
-
Chen Q, Fischer A, Reagan JD, Yan LJ, Ames BN. Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc Natl Acad Sci USA 1995; 92: 4337-41.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 4337-4341
-
-
Chen, Q.1
Fischer, A.2
Reagan, J.D.3
Yan, L.J.4
Ames, B.N.5
-
94
-
-
0028345161
-
Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells
-
Chen Q, Ames BN. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc Natl Acad Sci USA 1994; 91: 4130-4.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 4130-4134
-
-
Chen, Q.1
Ames, B.N.2
-
95
-
-
0025981236
-
Effect of selenium and vitamin E on the development of experimental atherosclerosis in rabbits
-
Wojcicki J, Rozewicka L, Barcew-Wiszniewska B, Samochowiec L, Juzwiak S, Kadlubowska D, et al. Effect of selenium and vitamin E on the development of experimental atherosclerosis in rabbits. Atherosclerosis 1991; 87: 9-16.
-
(1991)
Atherosclerosis
, vol.87
, pp. 9-16
-
-
Wojcicki, J.1
Rozewicka, L.2
Barcew-Wiszniewska, B.3
Samochowiec, L.4
Juzwiak, S.5
Kadlubowska, D.6
-
96
-
-
0037197722
-
Is the oxidative modification hypothesis relevant to human atherosclerosis? Do the antioxidant trials conducted to date refute the hypothesis?
-
Steinberg D, Witztum JL. Is the oxidative modification hypothesis relevant to human atherosclerosis? Do the antioxidant trials conducted to date refute the hypothesis? Circulation 2002; 105: 2107-11.
-
(2002)
Circulation
, vol.105
, pp. 2107-2111
-
-
Steinberg, D.1
Witztum, J.L.2
-
97
-
-
0037840165
-
Use of antioxidant vitamins for the prevention of cardiovascular disease: Meta-analysis of randomised trials
-
Vivekananthan DP, Penn MS, Sapp SK, Hsu A, Topol EJ. Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet 2003; 361: 2017-23.
-
(2003)
Lancet
, vol.361
, pp. 2017-2023
-
-
Vivekananthan, D.P.1
Penn, M.S.2
Sapp, S.K.3
Hsu, A.4
Topol, E.J.5
|