Lessons learned and unlearned in periodontal microbiology

Periodontology 2000

Volumn 62, Issue 1, 2013, Pages 95-162

  Teles, Ricardo ^a   Teles, Flavia ^a   Frias Lopez, Jorge ^a   Paster, Bruce ^a   Haffajee, Anne ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BIOFILM; CLASSIFICATION; GROWTH, DEVELOPMENT AND AGING; HOST PATHOGEN INTERACTION; HUMAN; MICROBIOLOGY; MICROFLORA; MOLECULAR BIOLOGY; ORGANISMAL INTERACTION; PERIODONTAL DISEASE; PHYSIOLOGY; VIROLOGY;

BIOFILMS; HOST-PATHOGEN INTERACTIONS; HUMANS; MICROBIAL INTERACTIONS; MICROBIOTA; MOLECULAR BIOLOGY; PERIODONTAL DISEASES;

EID: 84876337783     PISSN: 09066713     EISSN: 16000757     Source Type: Journal    
DOI: 10.1111/prd.12010     Document Type: Article

References (413)

1. Consensus report. Periodontal diseases: pathogenesis and microbial factors. Ann Periodontol 1996: 1: 926-932.
2. Proceedings of the 1996 World Workshop in Periodontics. Lansdowne, Virginia, July 13-17, 1996. Ann Periodontol 1996: 1: 1-947.
3. Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE. Defining the normal bacterial flora of the oral cavity. J Clin Microbiol 2005: 43: 5721-5732.
4. Abiko Y, Sato T, Mayanagi G, Takahashi N. Profiling of subgingival plaque biofilm microflora from periodontally healthy subjects and from subjects with periodontitis using quantitative real-time PCR. J Periodontal Res 2010: 45: 389-395.
5. Abramson JS, Mills EL. Depression of neutrophil function induced by viruses and its role in secondary microbial infections. Rev Infect Dis 1988: 10: 326-341.
6. Ahn J, Yang L, Paster BJ, Ganly I, Morris L, Pei Z, Hayes RB. Oral microbiome profiles: 16S rRNA pyrosequencing and microarray assay comparison. PLoS One 2011: 6: e22788.
7. Al-Ahmad A, Wunder A, Auschill TM, Follo M, Braun G, Hellwig E, Arweiler NB. The in vivo dynamics of Streptococcus spp., Actinomyces naeslundii, Fusobacterium nucleatum and Veillonella spp. in dental plaque biofilm as analysed by five-colour multiplex fluorescence in situ hybridization. J Med Microbiol 2007: 56: 681-687.
8. Albandar JM, Brunelle JA, Kingman A. Destructive periodontal disease in adults 30years of age and older in the United States, 1988-1994. J Periodontol 1999: 70: 13-29.
9. Albandar JM, Khattab R, Monem F, Barbuto SM, Paster BJ. The subgingival microbiota of Papillon-Lefevre syndrome. J Periodontol 2012: 83: 902-908.
10. Albandar JM, Kingman A, Lamster IB. Crevicular fluid level of beta-glucuronidase in relation to clinical periodontal parameters and putative periodontal pathogens in early-onset periodontitis. J Clin Periodontol 1998: 25: 630-639.
11. Ali RW, Martin L, Haffajee AD, Socransky SS. Detection of identical ribotypes of Porphyromonas gingivalis in patients residing in the United States, Sudan, Romania and Norway. Oral Microbiol Immunol 1997: 12: 106-111.
12. Allison KR, Brynildsen MP, Collins JJ. Metabolite-enabled eradication of bacterial persisters by aminoglycosides. Nature 2011: 473: 216-220.
13. Amann R, Ludwig W. Ribosomal RNA-targeted nucleic acid probes for studies in microbial ecology. FEMS Microbiol Rev 2000: 24: 555-565.
14. Amann RI, Ludwig W, Schleifer KH. Phylogenetic identification and in situ detection of individual microbial cells without cultivation. Microbiol Rev 1995: 59: 143-169.
15. Aparna MS, Yadav S. Biofilms: microbes and disease. Braz J Infect Dis 2008: 12: 526-530.
16. Apatzidou DA, Riggio MP, Kinane DF. Impact of smoking on the clinical, microbiological and immunological parameters of adult patients with periodontitis. J Clin Periodontol 2005: 32: 973-983.
17. Armitage GC, Dickinson WR, Jenderseck RS, Levine SM, Chambers DW. Relationship between the percentage of subgingival spirochetes and the severity of periodontal disease. J Periodontol 1982: 53: 550-556.
18. Arno A, Waerhaug J, Lovdal A, Schei O. Incidence of gingivitis as related to sex, occupation, tobacco consumption, toothbrushing, and age. Oral Surg Oral Med Oral Pathol 1958: 11: 587-595.
19. Ashimoto A, Chen C, Bakker I, Slots J. Polymerase chain reaction detection of 8 putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesions. Oral Microbiol Immunol 1996: 11: 266-273.
20. Asikainen S, Chen C. Oral ecology and person-to-person transmission of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. Periodontol 2000 1999: 20: 65-81.
21. Asikainen S, Dogan B, Turgut Z, Paster BJ, Bodur A, Oscarsson J. Specified species in gingival crevicular fluid predict bacterial diversity. PLoS One 2010: 5: e13589.
22. Atwood KC, Schneider LK, Ryan FJ. Periodic selection in Escherichia coli. Proc Natl Acad Sci U S A 1951: 37: 146-155.
23. Axelsson P, Lindhe J. Effect of controlled oral hygiene procedures on caries and periodontal disease in adults. J Clin Periodontol 1978: 5: 133-151.
24. Axelsson P, Lindhe J. Effect of controlled oral hygiene procedures on caries and periodontal disease in adults. Results after 6years. J Clin Periodontol 1981: 8: 239-248.
25. Axelsson P, Lindhe J. Effect of oral hygiene instruction and professional toothcleaning on caries and gingivitis in schoolchildren. Community Dent Oral Epidemiol 1981: 9: 251-255.
26. Axelsson P, Lindhe J, Nystrom B. On the prevention of caries and periodontal disease. Results of a 15-year longitudinal study in adults. J Clin Periodontol 1991: 18: 182-189.
27. Axelsson P, Nystrom B, Lindhe J. The long-term effect of a plaque control program on tooth mortality, caries and periodontal disease in adults. Results after 30years of maintenance. J Clin Periodontol 2004: 31: 749-757.
28. Badersten A, Nilveus R, Egelberg J. Scores of plaque, bleeding, suppuration and probing depth to predict probing attachment loss, 5years of observation following nonsurgical periodontal therapy. J Clin Periodontol 1990: 17: 102-107.
29. Balto K, Sasaki H, Stashenko P. Interleukin-6 deficiency increases inflammatory bone destruction. Infect Immun 2001: 69: 744-750.
30. Barnard A, Mahon BP, Watkins J, Redhead K, Mills KH. Th1/Th2 cell dichotomy in acquired immunity to Bordetella pertussis: variables in the in vivo priming and in vitro cytokine detection techniques affect the classification of T-cell subsets as Th1, Th2 or Th0. Immunology 1996: 87: 372-380.
31. Barnes VM, Teles R, Trivedi HM, Devizio W, Xu T, Mitchell MW, Milburn MV, Guo L. Acceleration of purine degradation by periodontal diseases. J Dent Res 2009: 88: 851-855.
32. Barton ES, White DW, Cathelyn JS, Brett-McClellan KA, Engle M, Diamond MS, Miller VL, Virgin HW 4th. Herpesvirus latency confers symbiotic protection from bacterial infection. Nature 2007: 447: 326-329.
33. Bayles KW. The biological role of death and lysis in biofilm development. Nat Rev Microbiol 2007: 5: 721-726.
34. Beikler T, Peters U, Prior K, Ehmke B, Flemmig TF. Sequence variations in rgpA and rgpB of Porphyromonas gingivalis in periodontitis. J Periodontal Res 2005: 40: 193-198.
35. Berezow AB, Darveau RP. Microbial shift and periodontitis. Periodontol 2000 2011: 55: 36-47.
36. Bernard CS, Giraud C, Spagnolo J, Bentzmann Sd. Biofilms: the secret story of microbial communities. In: Locht C, Simonet M, editors. Bacterial Pathogenesis Molecular and Cellular Mechanisms. Norfolk: Caister Academic Press, 2012: 129-168.
37. Bjarnsholt T. Introduction to Biofilms. In: Bjarnsholt T, Moser C, Jenses PO, Hoiby N, editors. Biofilm Infections. New York: Springer, 2011: 1-10.
38. Bogren A, Teles RP, Torresyap G, Haffajee AD, Socransky SS, Wennstrom JL. Clinical and microbiologic changes associated with the combined use of a powered toothbrush and a triclosan/copolymer dentifrice: a 3-year prospective study. J Periodontol 2007: 78: 1708-1717.
39. Booth V, Downes J, Van den Berg J, Wade WG. Gram-positive anaerobic bacilli in human periodontal disease. J Periodontal Res 2004: 39: 213-220.
40. Botero JE, Vidal C, Contreras A, Parra B. Comparison of nested polymerase chain reaction (PCR), real-time PCR and viral culture for the detection of cytomegalovirus in subgingival samples. Oral Microbiol Immunol 2008: 23: 239-244.
41. Boutaga K, van Winkelhoff AJ, Vandenbroucke-Grauls CM, Savelkoul PH. The additional value of real-time PCR in the quantitative detection of periodontal pathogens. J Clin Periodontol 2006: 33: 427-433.
42. Brinig MM, Lepp PW, Ouverney CC, Armitage GC, Relman DA. Prevalence of bacteria of division TM7 in human subgingival plaque and their association with disease. Appl Environ Microbiol 2003: 69: 1687-1694.
43. Broadbent JM, Thomson WM, Boyens JV, Poulton R. Dental plaque and oral health during the first 32years of life. J Am Dent Assoc 2011: 142: 415-426.
44. Brunner J, Wittink FR, Jonker MJ, de Jong M, Breit TM, Laine ML, de Soet JJ, Crielaard W. The core genome of the anaerobic oral pathogenic bacterium Porphyromonas gingivalis. BMC Microbiol 2010: 10: 252.
45. Campos MS, Marchini L, Bernardes LA, Paulino LC, Nobrega FG. Biofilm microbial communities of denture stomatitis. Oral Microbiol Immunol 2008: 23: 419-424.
46. Carranza F. Microbiology. In: Carranza F, Shklar G, editors. History of Periodontology. Carol Stream: Quintessence Publishing Co, Inc, 2003: 80-91.
47. Cassai E, Galvan M, Trombelli L, Rotola A. HHV-6, HHV-7, HHV-8 in gingival biopsies from chronic adult periodontitis patients. A case-control study. J Clin Periodontol 2003: 30: 184-191.
48. Chalabi M, Rezaie F, Moghim S, Mogharehabed A, Rezaei M, Mehraban B. Periodontopathic bacteria and herpesviruses in chronic periodontitis. Mol Oral Microbiol 2010: 25: 236-240.
49. Chandler DP, Fredrickson JK, Brockman FJ. Effect of PCR template concentration on the composition and distribution of total community 16S rDNA clone libraries. Mol Ecol 1997: 6: 475-482.
50. Chen CK, Sunday GJ, Zambon JJ, Wilson ME. Restriction endonuclease analysis of Eikenella corrodens. J Clin Microbiol 1990: 28: 1265-1270.
51. Chen T, Yu WH, Izard J, Baranova OV, Lakshmanan A, Dewhirst FE. The human oral microbiome database: a web accessible resource for investigating oral microbe taxonomic and genomic information. Database (Oxford) 2010: baq013.
52. Chen X, Zhang M, Zhou C, Kallenbach NR, Ren D. Control of bacterial persister cells by Trp/Arg-containing antimicrobial peptides. Appl Environ Microbiol 2011: 77: 4878-4885.
53. Chiang N, Fredman G, Backhed F, Oh SF, Vickery T, Schmidt BA, Serhan CN. Infection regulates pro-resolving mediators that lower antibiotic requirements. Nature 2012: 484: 524-528.
54. Cionca N, Giannopoulou C, Ugolotti G, Mombelli A. Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis. J Periodontol 2009: 80: 364-371.
55. Cionca N, Giannopoulou C, Ugolotti G, Mombelli A. Microbiologic testing and outcomes of full-mouth scaling and root planing with or without amoxicillin/metronidazole in chronic periodontitis. J Periodontol 2010: 81: 15-23.
56. Claffey N, Egelberg J. Clinical indicators of probing attachment loss following initial periodontal treatment in advanced periodontitis patients. J Clin Periodontol 1995: 22: 690-696.
57. Cohan FM. Bacterial species and speciation. Syst Biol 2001: 50: 513-524.
58. Colombo AP, Bennet S, Cotton SL, Goodson JM, Kent R, Haffajee AD, Socransky SS, Hasturk H, Van Dyke TE, Dewhirst FE, Paster BJ. Impact of periodontal therapy on the subgingival microbiota of severe periodontitis: comparison between good responders and individuals with refractory periodontitis using the human oral microbe identification microarray. J Periodontol 2012: 83: 1279-1287.
59. Colombo AP, Boches SK, Cotton SL, Goodson JM, Kent R, Haffajee AD, Socransky SS, Hasturk H, Van Dyke TE, Dewhirst F, Paster BJ. Comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray. J Periodontol 2009: 80: 1421-1432.
60. Colombo AP, Teles RP, Torres MC, Souto R, Rosalem WJ, Mendes MC, Uzeda M. Subgingival microbiota of Brazilian subjects with untreated chronic periodontitis. J Periodontol 2002: 73: 360-369.
61. Contreras A, Nowzari H, Slots J. Herpesviruses in periodontal pocket and gingival tissue specimens. Oral Microbiol Immunol 2000: 15: 15-18.
62. Contreras A, Slots J. Herpesviruses in human periodontal disease. J Periodontal Res 2000: 35: 3-16.
63. Contreras A, Umeda M, Chen C, Bakker I, Morrison JL, Slots J. Relationship between herpesviruses and adult periodontitis and periodontopathic bacteria. J Periodontol 1999: 70: 478-484.
64. Cortelli JR, Aquino DR, Cortelli SC, Fernandes CB, de Carvalho-Filho J, Franco GC, Costa FO, Kawai T. Etiological analysis of initial colonization of periodontal pathogens in oral cavity. J Clin Microbiol 2008: 46: 1322-1329.
65. Costello EK, Lauber CL, Hamady M, Fierer N, Gordon JI, Knight R. Bacterial community variation in human body habitats across space and time. Science 2009: 326: 1694-1697.
66. Costerton JW, Lewandowski Z, DeBeer D, Caldwell D, Korber D, James G. Biofilms, the customized microniche. J Bacteriol 1994: 176: 2137-2142.
67. Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science 1999: 284: 1318-1322.
68. Cugini MA, Haffajee AD, Smith C, Kent RL Jr, Socransky SS. The effect of scaling and root planing on the clinical and microbiological parameters of periodontal diseases: 12-month results. J Clin Periodontol 2000: 27: 30-36.
69. Dahlén G, Leonhardt A. A new checkerboard panel for testing bacterial markers in periodontal disease. Oral Microbiol Immunol 2006: 21: 6-11.
70. Dalwai F, Spratt DA, Pratten J. Modeling shifts in microbial populations associated with health or disease. Appl Environ Microbiol 2006: 72: 3678-3684.
71. de Jong EC, Vieira PL, Kalinski P, Schuitemaker JH, Tanaka Y, Wierenga EA, Yazdanbakhsh M, Kapsenberg ML. Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse th cell-polarizing signals. J Immunol 2002: 168: 1704-1709.
72. de Lillo A, Ashley FP, Palmer RM, Munson MA, Kyriacou L, Weightman AJ, Wade WG. Novel subgingival bacterial phylotypes detected using multiple universal polymerase chain reaction primer sets. Oral Microbiol Immunol 2006: 21: 61-68.
73. De Souza RF, Nascimento C, Regis RR, Silva-Lovato CH, Paranhos HF. Effects of the domestic use of a disclosing solution on the denture biofilm: a preliminary study. J Oral Rehabil 2009: 36: 491-497.
74. del Pozo JL, Patel R. The challenge of treating biofilm-associated bacterial infections. Clin Pharmacol Ther 2007: 82: 204-209.
75. Dewhirst FE, Chen T, Izard J, Paster BJ, Tanner AC, Yu WH, Lakshmanan A, Wade WG. The human oral microbiome. J Bacteriol 2010: 192: 5002-5017.
76. Dewhirst FE, Tamer MA, Ericson RE, Lau CN, Levanos VA, Boches SK, Galvin JL, Paster BJ. The diversity of periodontal spirochetes by 16S rRNA analysis. Oral Microbiol Immunol 2000: 15: 196-202.
77. Diaz PI. Microbial diversity and interactions in subgingival biofilm communities. Front Oral Biol 2012: 15: 17-40.
78. Diaz PI, Dupuy AK, Abusleme L, Reese B, Obergfell C, Choquette L, Dongari-Bagtzoglou A, Peterson DE, Terzi E, Strausbaugh LD. Using high throughput sequencing to explore the biodiversity in oral bacterial communities. Mol Oral Microbiol 2012: 27: 182-201.
79. Dinarello CA. Anti-cytokine therapeutics and infections. Vaccine 2003: 21(Suppl 2): S24-S34.
80. Donachie SP, Foster JS, Brown MV. Culture clash: challenging the dogma of microbial diversity. ISME J 2007: 1: 97-99.
81. Downes J, Dewhirst FE, Tanner AC, Wade WG. Alloprevotella rava gen. nov., sp. nov., isolated from the human oral cavity, and reclassification of Prevotella tannerae (Moore, Johnson & Moore, 1994) as Alloprevotella tannerae gen. nov., comb. nov. Int J Syst Evol Microbiol 2012: doi: 10.1099/ijs.0.041376-0.
82. Downes J, Tanner AC, Dewhirst FE, Wade WG. Prevotella saccharolytica sp. nov., isolated from the human oral cavity. Int J Syst Evol Microbiol 2010: 60: 2458-2461.
83. Downes J, Vartoukian SR, Dewhirst FE, Izard J, Chen T, Yu WH, Sutcliffe IC, Wade WG. Pyramidobacter piscolens gen. nov., sp. nov., a member of the phylum 'Synergistetes' isolated from the human oral cavity. Int J Syst Evol Microbiol 2009: 59: 972-980.
84. Dumitrescu AL, Abd-El-Aleem S, Morales-Aza B, Donaldson LF. A model of periodontitis in the rat: effect of lipopolysaccharide on bone resorption, osteoclast activity, and local peptidergic innervation. J Clin Periodontol 2004: 31: 596-603.
85. Duran-Pinedo AE, Paster B, Teles R, Frias-Lopez J. Correlation network analysis applied to complex biofilm communities. PLoS One 2011: 6: e28438.
86. Dzink JL, Sheenan MT, Socransky SS. Proposal of three subspecies of Fusobacterium nucleatum Knorr 1922: Fusobacterium nucleatum subsp. nucleatum subsp. nov., comb. nov.; Fusobacterium nucleatum subsp. polymorphum subsp. nov., nom. rev., comb. nov.; and Fusobacterium nucleatum subsp. vincentii subsp. nov., nom. rev., comb. nov. Int J Syst Bacteriol 1990: 40: 74-78.
87. Dzink JL, Socransky SS, Haffajee AD. The predominant cultivable microbiota of active and inactive lesions of destructive periodontal diseases. J Clin Periodontol 1988: 15: 316-323.
88. Dzink JL, Tanner AC, Haffajee AD, Socransky SS. Gram negative species associated with active destructive periodontal lesions. J Clin Periodontol 1985: 12: 648-659.
89. Eckert KA, Kunkel TA. DNA polymerase fidelity and the polymerase chain reaction. PCR Methods Appl 1991: 1: 17-24.
90. Ehmke B, Moter A, Beikler T, Milian E, Flemmig TF. Adjunctive antimicrobial therapy of periodontitis: long-term effects on disease progression and oral colonization. J Periodontol 2005: 76: 749-759.
91. El-Sharkawy H, Aboelsaad N, Eliwa M, Darweesh M, Alshahat M, Kantarci A, Hasturk H, Van Dyke TE. Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 Fatty acids and low-dose aspirin. J Periodontol 2010: 81: 1635-1643.
92. Enersen M, Olsen I, Caugant DA. Genetic diversity of Porphyromonas gingivalis isolates recovered from single 'refractory' periodontitis sites. Appl Environ Microbiol 2008: 74: 5817-5821.
93. Enersen M, Olsen I, van Winkelhoff AJ, Caugant DA. Multilocus sequence typing of Porphyromonas gingivalis strains from different geographic origins. J Clin Microbiol 2006: 44: 35-41.
94. Farrelly V, Rainey FA, Stackebrandt E. Effect of genome size and rrn gene copy number on PCR amplification of 16S rRNA genes from a mixture of bacterial species. Appl Environ Microbiol 1995: 61: 2798-2801.
95. Faveri M, Mayer MP, Feres M, de Figueiredo LC, Dewhirst FE, Paster BJ. Microbiological diversity of generalized aggressive periodontitis by 16S rRNA clonal analysis. Oral Microbiol Immunol 2008: 23: 112-118.
96. Feres M. Antibiotics in the treatment of periodontal diseases: microbiological basis and clinical applications. Ann R Australas Coll Dent Surg 2008: 19: 37-44.
97. Filoche S, Wong L, Sissons CH. Oral biofilms: emerging concepts in microbial ecology. J Dent Res 2010: 89: 8-18.
98. Fine DH, Mandel ID. Indicators of periodontal disease activity: an evaluation. J Clin Periodontol 1986: 13: 533-546.
99. Fine DH, Markowitz K, Furgang D, Fairlie K, Ferrandiz J, Nasri C, McKiernan M, Gunsolley J. Aggregatibacter actinomycetemcomitans and its relationship to initiation of localized aggressive periodontitis: longitudinal cohort study of initially healthy adolescents. J Clin Microbiol 2007: 45: 3859-3869.
100. Frank DN, Pace NR. Gastrointestinal microbiology enters the metagenomics era. Curr Opin Gastroenterol 2008: 24: 4-10.
101. Fraser C, Alm EJ, Polz MF, Spratt BG, Hanage WP. The bacterial species challenge: making sense of genetic and ecological diversity. Science 2009: 323: 741-746.
102. Frias-Lopez J, Duran-Pinedo A. Effect of periodontal pathogens on the metatranscriptome of a healthy multispecies biofilm model. J Bacteriol 2012: 194: 2082-2095.
103. Frias-Lopez J, Shi Y, Tyson GW, Coleman ML, Schuster SC, Chisholm SW, Delong EF. Microbial community gene expression in ocean surface waters. Proc Natl Acad Sci U S A 2008: 105: 3805-3810.
104. Friedman MT, Barber PM, Mordan NJ, Newman HN. The 'plaque-free zone' in health and disease: a scanning electron microscope study. J Periodontol 1992: 63: 890-896.
105. Galitski T. Molecular networks in model systems. Annu Rev Genomics Hum Genet 2004: 5: 177-187.
106. Gao H, Yang ZK, Gentry TJ, Wu L, Schadt CW, Zhou J. Microarray-based analysis of microbial community RNAs by whole-community RNA amplification. Appl Environ Microbiol 2007: 73: 563-571.
107. Garlet GP. Destructive and protective roles of cytokines in periodontitis: a re-appraisal from host defense and tissue destruction viewpoints. J Dent Res 2010: 89: 1349-1363.
108. Garlet GP, Cardoso CR, Campanelli AP, Ferreira BR, Avila-Campos MJ, Cunha FQ, Silva JS. The dual role of p55 tumour necrosis factor-alpha receptor in Actinobacillus actinomycetemcomitans-induced experimental periodontitis: host protection and tissue destruction. Clin Exp Immunol 2007: 147: 128-138.
109. Garlet GP, Cardoso CR, Campanelli AP, Garlet TP, Avila-Campos MJ, Cunha FQ, Silva JS. The essential role of IFN-gamma in the control of lethal Aggregatibacter actinomycetemcomitans infection in mice. Microbes Infect 2008: 10: 489-496.
110. Garlet GP, Giozza SP, Silveira EM, Claudino M, Santos SB, Avila-Campos MJ, Martins W Jr, Cardoso CR, Trombone AP, Campanelli AP, Carvalho EM, Silva JS. Association of human T lymphotropic virus 1 amplification of periodontitis severity with altered cytokine expression in response to a standard periodontopathogen infection. Clin Infect Dis 2010: 50: e11-e18.
111. Geivelis M, Turner DW, Pederson ED, Lamberts BL. Measurements of interleukin-6 in gingival crevicular fluid from adults with destructive periodontal disease. J Periodontol 1993: 64: 980-983.
112. Gemmell E, Bird PS, Ford PJ, Ashman RB, Gosling P, Hu Y, Seymour GJ. Modulation of the antibody response by Porphyromonas gingivalis and Fusobacterium nucleatum in a mouse model. Oral Microbiol Immunol 2004: 19: 247-251.
113. Genco RJ, Loos BG. The use of genomic DNA fingerprinting in studies of the epidemiology of bacteria in periodontitis. J Clin Periodontol 1991: 18: 396-405.
114. Genco RJ, Slots J. Host responses in periodontal diseases. J Dent Res 1984: 63: 441-451.
115. Golub LM. Reduction with tetracyclines of excessive collagen degradation in periodontal and other diseases. N Y State Dent J 1990: 56: 24-26.
116. Golub LM, Goodson JM, Lee HM, Vidal AM, McNamara TF, Ramamurthy NS. Tetracyclines inhibit tissue collagenases. Effects of ingested low-dose and local delivery systems. J Periodontol 1985: 56: 93-97.
117. Golub LM, McNamara TF, Ryan ME, Kohut B, Blieden T, Payonk G, Sipos T, Baron HJ. Adjunctive treatment with subantimicrobial doses of doxycycline: effects on gingival fluid collagenase activity and attachment loss in adult periodontitis. J Clin Periodontol 2001: 28: 146-156.
118. Goncalves LF, Fermiano D, Feres M, Figueiredo LC, Teles FR, Mayer MP, Faveri M. Levels of Selenomonas species in generalized aggressive periodontitis. J Periodontal Res 2012: 47: 711-718.
119. Goodson JM, Haffajee AD, Socransky SS, Kent R, Teles R, Hasturk H, Bogren A, Van Dyke T, Wennstrom J, Lindhe J. Control of periodontal infections: a randomized controlled trial I. The primary outcome attachment gain and pocket depth reduction at treated sites. J Clin Periodontol 2012: 39: 526-536.
120. Goodson JM, Tanner AC, Haffajee AD, Sornberger GC, Socransky SS. Patterns of progression and regression of advanced destructive periodontal disease. J Clin Periodontol 1982: 9: 472-481.
121. Greene JC. Oral hygiene and periodontal disease. Am J Public Health Nations Health 1963: 53: 913-922.
122. Greisen K, Loeffelholz M, Purohit A, Leong D. PCR primers and probes for the 16S rRNA gene of most species of pathogenic bacteria, including bacteria found in cerebrospinal fluid. J Clin Microbiol 1994: 32: 335-351.
123. Grenier G, Gagnon G, Grenier D. Detection of herpetic viruses in gingival crevicular fluid of patients suffering from periodontal diseases: prevalence and effect of treatment. Oral Microbiol Immunol 2009: 24: 506-509.
124. Griffen AL, Beall CJ, Campbell JH, Firestone ND, Kumar PS, Yang ZK, Podar M, Leys EJ. Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing. ISME J 2012: 6: 1176-1185.
125. Guerrero A, Griffiths GS, Nibali L, Suvan J, Moles DR, Laurell L, Tonetti MS. Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial. J Clin Periodontol 2005: 32: 1096-1107.
126. Haffajee AD, Bogren A, Hasturk H, Feres M, Lopez NJ, Socransky SS. Subgingival microbiota of chronic periodontitis subjects from different geographic locations. J Clin Periodontol 2004: 31: 996-1002.
127. Haffajee AD, Cugini MA, Dibart S, Smith C, Kent RL Jr, Socransky SS. The effect of SRP on the clinical and microbiological parameters of periodontal diseases. J Clin Periodontol 1997: 24: 324-334.
128. Haffajee AD, Cugini MA, Tanner A, Pollack RP, Smith C, Kent RL Jr, Socransky SS. Subgingival microbiota in healthy, well-maintained elder and periodontitis subjects. J Clin Periodontol 1998: 25: 346-353.
129. Haffajee AD, Patel M, Socransky SS. Microbiological changes associated with four different periodontal therapies for the treatment of chronic periodontitis. Oral Microbiol Immunol 2008: 23: 148-157.
130. Haffajee AD, Socransky SS. Attachment level changes in destructive periodontal diseases. J Clin Periodontol 1986: 13: 461-475.
131. Haffajee AD, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000 1994: 5: 78-111.
132. Haffajee AD, Socransky SS, Dzink JL, Taubman MA, Ebersole JL. Clinical, microbiological and immunological features of subjects with refractory periodontal diseases. J Clin Periodontol 1988: 15: 390-398.
133. Haffajee AD, Socransky SS, Goodson JM. Comparison of different data analyses for detecting changes in attachment level. J Clin Periodontol 1983: 10: 298-310.
134. Haffajee AD, Socransky SS, Goodson JM. Periodontal disease activity. J Periodontal Res 1982: 17: 521-522.
135. Haffajee AD, Socransky SS, Gunsolley JC. Systemic anti-infective periodontal therapy. A systematic review. Ann Periodontol 2003: 8: 115-181.
136. Haffajee AD, Socransky SS, Patel MR, Song X. Microbial complexes in supragingival plaque. Oral Microbiol Immunol 2008: 23: 196-205.
137. Haffajee AD, Socransky SS, Smith C, Dibart S. Microbial risk indicators for periodontal attachment loss. J Periodontal Res 1991: 26: 293-296.
138. Haffajee AD, Socransky SS, Smith C, Dibart S. Relation of baseline microbial parameters to future periodontal attachment loss. J Clin Periodontol 1991: 18: 744-750.
139. Haffajee AD, Teles RP, Patel MR, Song X, Veiga N, Socransky SS. Factors affecting human supragingival biofilm composition. I. Plaque mass. J Periodontal Res 2009: 44: 511-519.
140. Haffajee AD, Teles RP, Patel MR, Song X, Yaskell T, Socransky SS. Factors affecting human supragingival biofilm composition. II. Tooth position. J Periodontal Res 2009: 44: 520-528.
141. Haffajee AD, Teles RP, Socransky SS. Association of Eubacterium nodatum and Treponema denticola with human periodontitis lesions. Oral Microbiol Immunol 2006: 21: 269-282.
142. Haffajee AD, Teles RP, Socransky SS. The effect of periodontal therapy on the composition of the subgingival microbiota. Periodontol 2000 2006: 42: 219-258.
143. Haffajee ADSSSFMX-FLA. Plaque microbiology in health and disease. In: Wilson HNNM, editor. Dental plaque revisited: oral biofilms in health and disease. Royal College of Physicians, London, UK: Bioline, 1999: 600.
144. Hamano-Hasegawa K, Morozumi M, Nakayama E, Chiba N, Murayama SY, Takayanagi R, Iwata S, Sunakawa K, Ubukata K. Comprehensive detection of causative pathogens using real-time PCR to diagnose pediatric community-acquired pneumonia. J Infect Chemother 2008: 14: 424-432.
145. Han X, Kawai T, Taubman MA. Interference with immune-cell-mediated bone resorption in periodontal disease. Periodontol 2000 2007: 45: 76-94.
146. Hasturk H, Kantarci A, Ebrahimi N, Andry C, Holick M, Jones VL, Van Dyke TE. Topical H2 antagonist prevents periodontitis in a rabbit model. Infect Immun 2006: 74: 2402-2414.
147. Hasturk H, Kantarci A, Goguet-Surmenian E, Blackwood A, Andry C, Serhan CN, Van Dyke TE. Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. J Immunol 2007: 179: 7021-7029.
148. Hausmann E, Weinfeld N, Miller WA. Effects of lipopolysaccharides on bone resorption in tissue culture. Calcif Tissue Res 1972: 9: 272-282.
149. Heasman PA, Benn DK, Kelly PJ, Seymour RA, Aitken D. The use of topical flurbiprofen as an adjunct to non-surgical management of periodontal disease. J Clin Periodontol 1993: 20: 457-464.
150. Heitz-Mayfield LJ. How effective is surgical therapy compared with nonsurgical debridement?Periodontol 2000 2005: 37: 72-87.
151. Herrera D, Sanz M, Jepsen S, Needleman I, Roldan S. A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients. J Clin Periodontol 2002: 3: 136-159. discussion 160-162.
152. Hill AB. The environment and disease: association or causation?Proc R Soc Med 1965: 58: 295-300.
153. Ho W, Eubank T, Leblebicioglu B, Marsh C, Walters J. Azithromycin decreases crevicular fluid volume and mediator content. J Dent Res 2010: 89: 831-835.
154. Howell TH. Blocking periodontal disease progression with anti-inflammatory agents. J Periodontol 1993: 64: 828-833.
155. Hudler P, Gubina M, Ihan Hren N, Seme K, Malovrh T, Gale N, Ihan A. A mouse model of chronic bacterial lesions (a cotton trap) for studying oral bacteria-lymphocyte interactions. Pflugers Arch 2000: 440: R91-R93.
156. Hujoel P. Grading Evidence with a Focus on Etiology, Surrogates, and Clinical Devices. In: Lesaffre E, Feine J, Leroux B, Declerck D, editors. Statistical and Methodological Aspects of Oral Health Research. Chichester: John Wiley & Sons Ltd, 2009: 13-26.
157. Huse SM, Huber JA, Morrison HG, Sogin ML, Welch DM. Accuracy and quality of massively parallel DNA pyrosequencing. Genome Biol 2007: 8: R143.
158. Huttenhower C, Hofmann O. A quick guide to large-scale genomic data mining. PLoS Comput Biol 2010: 6: e1000779.
159. Hutter G, Schlagenhauf U, Valenza G, Horn M, Burgemeister S, Claus H, Vogel U. Molecular analysis of bacteria in periodontitis: evaluation of clone libraries, novel phylotypes and putative pathogens. Microbiology 2003: 149: 67-75.
160. Imbronito AV, Grande SR, Freitas NM, Okuda O, Lotufo RF, Nunes FD. Detection of Epstein-Barr virus and human cytomegalovirus in blood and oral samples: comparison of three sampling methods. J Oral Sci 2008: 50: 25-31.
161. Ismail AI, Morrison EC, Burt BA, Caffesse RG, Kavanagh MT. Natural history of periodontal disease in adults: findings from the Tecumseh Periodontal Disease Study, 1959-87. J Dent Res 1990: 69: 430-435.
162. Jandik KA, Belanger M, Low SL, Dorn BR, Yang MC, Progulske-Fox A. Invasive differences among Porphyromonas gingivalis strains from healthy and diseased periodontal sites. J Periodontal Res 2008: 43: 524-530.
163. Jeffcoat MK. Safety of oral bisphosphonates: controlled studies on alveolar bone. Int J Oral Maxillofac Implants 2006: 21: 349-353.
164. Jeffcoat MK, Cizza G, Shih WJ, Genco R, Lombardi A. Efficacy of bisphosphonates for the control of alveolar bone loss in periodontitis. J Int Acad Periodontol 2007: 9: 70-76.
165. Jeffcoat MK, Reddy MS, Haigh S, Buchanan W, Doyle MJ, Meredith MP, Nelson SL, Goodale MB, Wehmeyer KR. A comparison of topical ketorolac, systemic flurbiprofen, and placebo for the inhibition of bone loss in adult periodontitis. J Periodontol 1995: 66: 329-338.
166. Jeraldo P, Chia N, Goldenfeld N. On the suitability of short reads of 16S rRNA for phylogeny-based analyses in environmental surveys. Environ Microbiol 2011: 13: 3000-3009.
167. Jin L, Soder B, Corbet EF. Interleukin-8 and granulocyte elastase in gingival crevicular fluid in relation to periodontopathogens in untreated adult periodontitis. J Periodontol 2000: 71: 929-939.
168. Kaeberlein T, Lewis K, Epstein SS. Isolating 'uncultivable' microorganisms in pure culture in a simulated natural environment. Science 2002: 296: 1127-1129.
169. Kamma JJ, Contreras A, Slots J. Herpes viruses and periodontopathic bacteria in early-onset periodontitis. J Clin Periodontol 2001: 28: 879-885.
170. Kantarci A, Hasturk H, Van Dyke TE. Host-mediated resolution of inflammation in periodontal diseases. Periodontol 2000 2006: 40: 144-163.
171. Kantarci A, Van Dyke TE. Lipoxin signaling in neutrophils and their role in periodontal disease. Prostaglandins Leukot Essent Fatty Acids 2005: 73: 289-299.
172. Keijser BJ, Zaura E, Huse SM, van der Vossen JM, Schuren FH, Montijn RC, ten Cate JM, Crielaard W. Pyrosequencing analysis of the oral microflora of healthy adults. J Dent Res 2008: 87: 1016-1020.
173. Keyes P. Are periodontal pathoses caused by bacterial infections on cervicoradicular surfaces of teeth?J Dent Res 1970: 2: 223-228.
174. Keyes PH, Rams TE. A rationale for management of periodontal diseases: rapid identification of microbial 'therapeutic targets' with phase-contrast microscopy. J Am Dent Assoc 1983: 106: 803-812.
175. Kidane D, Carrasco B, Manfredi C, Rothmaier K, Ayora S, Tadesse S, Alonso JC, Graumann PL. Evidence for different pathways during horizontal gene transfer in competent Bacillus subtilis cells. PLoS Genet 2009: 5: e1000630.
176. Kigure T, Saito A, Seida K, Yamada S, Ishihara K, Okuda K. Distribution of Porphyromonas gingivalis and Treponema denticola in human subgingival plaque at different periodontal pocket depths examined by immunohistochemical methods. J Periodontal Res 1995: 30: 332-341.
177. Koehler A, Karch H, Beikler T, Flemmig TF, Suerbaum S, Schmidt H. Multilocus sequence analysis of Porphyromonas gingivalis indicates frequent recombination. Microbiology 2003: 149: 2407-2415.
178. Kolenbrander PE, Palmer RJ Jr, Rickard AH, Jakubovics NS, Chalmers NI, Diaz PI. Bacterial interactions and successions during plaque development. Periodontol 2000 2006: 42: 47-79.
179. Konstantinidis A, Sakellari D, Papa A, Antoniadis A. Real-time polymerase chain reaction quantification of Epstein-Barr virus in chronic periodontitis patients. J Periodontal Res 2005: 40: 294-298.
180. Kopczynski ED, Bateson MM, Ward DM. Recognition of chimeric small-subunit ribosomal DNAs composed of genes from uncultivated microorganisms. Appl Environ Microbiol 1994: 60: 746-748.
181. Kopitar AN, Ihan Hren N, Ihan A. Commensal oral bacteria antigens prime human dendritic cells to induce Th1, Th2 or Treg differentiation. Oral Microbiol Immunol 2006: 21: 1-5.
182. Kornman KS. Mapping the pathogenesis of periodontitis: a new look. J Periodontol 2008: 79: 1560-1568.
183. Krasse B. Oral aggregations of microbes. J Dent Res 1963: 2: 521-528.
184. Kroes I, Lepp PW, Relman DA. Bacterial diversity within the human subgingival crevice. Proc Natl Acad Sci U S A 1999: 96: 14547-14552.
185. Kubar A, Saygun I, Ozdemir A, Yapar M, Slots J. Real-time polymerase chain reaction quantification of human cytomegalovirus and Epstein-Barr virus in periodontal pockets and the adjacent gingiva of periodontitis lesions. J Periodontal Res 2005: 40: 97-104.
186. Kuboniwa M, Inaba H, Amano A. Genotyping to distinguish microbial pathogenicity in periodontitis. Periodontol 2000 2010: 54: 136-159.
187. Kumar PS, Brooker MR, Dowd SE, Camerlengo T. Target region selection is a critical determinant of community fingerprints generated by 16S pyrosequencing. PLoS One 2011: 6: e20956.
188. Kumar PS, Griffen AL, Barton JA, Paster BJ, Moeschberger ML, Leys EJ. New bacterial species associated with chronic periodontitis. J Dent Res 2003: 82: 338-344.
189. Kumar PS, Griffen AL, Moeschberger ML, Leys EJ. Identification of candidate periodontal pathogens and beneficial species by quantitative 16S clonal analysis. J Clin Microbiol 2005: 43: 3944-3955.
190. Kumar PS, Leys EJ, Bryk JM, Martinez FJ, Moeschberger ML, Griffen AL. Changes in periodontal health status are associated with bacterial community shifts as assessed by quantitative 16S cloning and sequencing. J Clin Microbiol 2006: 44: 3665-3673.
191. Kumar PS, Mason MR, Brooker MR, O'Brien K. Pyrosequencing reveals unique microbial signatures associated with healthy and failing dental implants. J Clin Periodontol 2012: 39: 425-433.
192. Kunin V, Engelbrektson A, Ochman H, Hugenholtz P. Wrinkles in the rare biosphere: pyrosequencing errors can lead to artificial inflation of diversity estimates. Environ Microbiol 2010: 12: 118-123.
193. Laine ML, Appelmelk BJ, van Winkelhoff AJ. Prevalence and distribution of six capsular serotypes of Porphyromonas gingivalis in periodontitis patients. J Dent Res 1997: 76: 1840-1844.
194. Lamont RJ, Chan A, Belton CM, Izutsu KT, Vasel D, Weinberg A. Porphyromonas gingivalis invasion of gingival epithelial cells. Infect Immun 1995: 63: 3878-3885.
195. Lamont RJ, Jenkinson HF. Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalis. Microbiol Mol Biol Rev 1998: 62: 1244-1263.
196. Lang NP, Cumming BR, Loe H. Toothbrushing frequency as it relates to plaque development and gingival health. J Periodontol 1973: 44: 396-405.
197. Lang NP, Joss A, Orsanic T, Gusberti FA, Siegrist BE. Bleeding on probing. A predictor for the progression of periodontal disease?J Clin Periodontol 1986: 13: 590-596.
198. Lawrence JG, Retchless AC. The interplay of homologous recombination and horizontal gene transfer in bacterial speciation. Methods Mol Biol 2009: 532: 29-53.
199. Lee A, Ghaname CB, Braun TM, Sugai JV, Teles RP, Loesche WJ, Kornman KS, Giannobile WV, Kinney JS. Bacterial and salivary biomarkers predict the gingival inflammatory profile. J Periodontol 2012: 83: 79-89.
200. Lewis K. Persister cells, dormancy and infectious disease. Nat Rev Microbiol 2007: 5: 48-56.
201. Lewis K. Riddle of biofilm resistance. Antimicrob Agents Chemother 2001: 45: 999-1007.
202. Leys EJ, Lyons SR, Moeschberger ML, Rumpf RW, Griffen AL. Association of Bacteroides forsythus and a novel Bacteroides phylotype with periodontitis. J Clin Microbiol 2002: 40: 821-825.
203. Li J, Helmerhorst EJ, Leone CW, Troxler RF, Yaskell T, Haffajee AD, Socransky SS, Oppenheim FG. Identification of early microbial colonizers in human dental biofilm. J Appl Microbiol 2004: 97: 1311-1318.
204. Lin YL, Chang PC, Wang Y, Li M. Identification of novel viral interleukin-10 isoforms of human cytomegalovirus AD169. Virus Res 2008: 131: 213-223.
205. Lin YL, Li M. Human cytomegalovirus and Epstein-Barr virus inhibit oral bacteria-induced macrophage activation and phagocytosis. Oral Microbiol Immunol 2009: 24: 243-248.
206. Lindhe J, Hamp SE, Loe H. Experimental periodontitis in the beagle dog. Int Dent J 1973: 23: 432-437.
207. Listgarten MA. The structure of dental plaque. Periodontol 2000 1994: 5: 52-65.
208. Listgarten MA. Structure of the microbial flora associated with periodontal health and disease in man. A light and electron microscopic study. J Periodontol 1976: 47: 1-18.
209. Liu B, Faller LL, Klitgord N, Mazumdar V, Ghodsi M, Sommer DD, Gibbons TR, Treangen TJ, Chang YC, Li S, Stine OC, Hasturk H, Kasif S, Segrè D, Pop M, Amar S. Deep sequencing of the oral microbiome reveals signatures of periodontal disease. PLoS One 2012: 7: e37919.
210. Loe H. Human research models for the production and prevention of marginal periodontal disease and caries. Annu Meet Am Inst Oral Biol 1973: 30: 48-58.
211. Loe H, Anerud A, Boysen H, Morrison E. Natural history of periodontal disease in man. Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46years of age. J Clin Periodontol 1986: 13: 431-445.
212. Loe H, Anerud A, Boysen H, Smith M. The natural history of periodontal disease in man. The rate of periodontal destruction before 40years of age. J Periodontol 1978: 49: 607-620.
213. Loe H, Theilade E, Jensen SB. Experimental gingivitis in man. J Periodontol 1965: 36: 177-187.
214. Loenen WA, Bruggeman CA, Wiertz EJ. Immune evasion by human cytomegalovirus: lessons in immunology and cell biology. Semin Immunol 2001: 13: 41-49.
215. Loesche WJ, Bretz WA, Kerschensteiner D, Stoll J, Socransky SS, Hujoel P, Lopatin DE. Development of a diagnostic test for anaerobic periodontal infections based on plaque hydrolysis of benzoyl-DL-arginine-naphthylamide. J Clin Microbiol 1990: 28: 1551-1559.
216. Loos BG, Dyer DW. Restriction fragment length polymorphism analysis of the fimbrillin locus, fimA, of Porphyromonas gingivalis. J Dent Res 1992: 71: 1173-1181.
217. Loos BG, Dyer DW, Whittam TS, Selander RK. Genetic structure of populations of Porphyromonas gingivalis associated with periodontitis and other oral infections. Infect Immun 1993: 61: 204-212.
218. Loos BG, Mayrand D, Genco RJ, Dickinson DP. Genetic heterogeneity of Porphyromonas (Bacteroides) gingivalis by genomic DNA fingerprinting. J Dent Res 1990: 69: 1488-1493.
219. Loos BG, van Winkelhoff AJ, Dunford RG, Genco RJ, de Graaff J, Dickinson DP, Dyer DW. A statistical approach to the ecology of Porphyromonas gingivalis. J Dent Res 1992: 71: 353-358.
220. Lopez NJ, Gamonal JA, Martinez B. Repeated metronidazole and amoxicillin treatment of periodontitis. A follow-up study. J Periodontol 2000: 71: 79-89.
221. Lopez NJ, Socransky SS, Da Silva I, Japlit MR, Haffajee AD. Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis. J Clin Periodontol 2006: 33: 648-660.
222. Lopez NJ, Socransky SS, Da Silva I, Japlit MR, Haffajee AD. Subgingival microbiota of chilean patients with chronic periodontitis. J Periodontol 2004: 75: 717-725.
223. Lovdal A, Arno A, Schei O, Waerhaug J. Combined effect of subgingival scaling and controlled oral hygiene on the incidence of gingivitis. Acta Odontol Scand 1961: 19: 537-555.
224. Lovdal A, Arno A, Waerhaug J. Incidence of clinical manifestations of periodontal disease in light of oral hygiene and calculus formation. J Am Dent Assoc 1958: 56: 21-33.
225. Mager DL, Ximenez-Fyvie LA, Haffajee AD, Socransky SS. Distribution of selected bacterial species on intraoral surfaces. J Clin Periodontol 2003: 30: 644-654.
226. Magnusson I, Lindhe J, Yoneyama T, Liljenberg B. Recolonization of a subgingival microbiota following scaling in deep pockets. J Clin Periodontol 1984: 11: 193-207.
227. Marchesi JR, Sato T, Weightman AJ, Martin TA, Fry JC, Hiom SJ, Dymock D, Wade WG. Design and evaluation of useful bacterium-specific PCR primers that amplify genes coding for bacterial 16S rRNA. Appl Environ Microbiol 1998: 64: 795-799.
228. Mark KE, Wald A, Magaret AS, Selke S, Olin L, Huang ML, Corey L. Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults. J Infect Dis 2008: 198: 1141-1149.
229. Marsh PD. Are dental diseases examples of ecological catastrophes?Microbiology 2003: 149: 279-294.
230. Marsh PD. Microbial ecology of dental plaque and its significance in health and disease. Adv Dent Res 1994: 8: 263-271.
231. Marsh PD, Devine DA. How is the development of dental biofilms influenced by the host?J Clin Periodontol 2011: 38(Suppl 11): 28-35.
232. Matarazzo F, Figueiredo LC, Cruz SE, Faveri M, Feres M. Clinical and microbiological benefits of systemic metronidazole and amoxicillin in the treatment of smokers with chronic periodontitis: a randomized placebo-controlled study. J Clin Periodontol 2008: 35: 885-896.
233. Matto J, Saarela M, von Troil-Linden B, Kononen E, Jousimies-Somer H, Torkko H, Alaluusua S, Asikainen S. Distribution and genetic analysis of oral Prevotella intermedia and Prevotella nigrescens. Oral Microbiol Immunol 1996: 11: 96-102.
234. Mawardi H, Giro G, Kajiya M, Ohta K, Almazrooa S, Alshwaimi E, Woo SB, Nishimura I, Kawai T. A role of oral bacteria in bisphosphonate-induced osteonecrosis of the jaw. J Dent Res 2011: 90: 1339-1345.
235. Mayanagi G, Sato T, Shimauchi H, Takahashi N. Detection frequency of periodontitis-associated bacteria by polymerase chain reaction in subgingival and supragingival plaque of periodontitis and healthy subjects. Oral Microbiol Immunol 2004: 19: 379-385.
236. Mayer Y, Balbir-Gurman A, Machtei EE. Anti-tumor necrosis factor-alpha therapy and periodontal parameters in patients with rheumatoid arthritis. J Periodontol 2009: 80: 1414-1420.
237. McCracken GI, Preshaw PM, Steen IN, Swan M, deJager M, Heasman PA. Measuring plaque in clinical trials: index or weight?J Clin Periodontol 2006: 33: 172-176.
238. McKillip JL, Jaykus LA, Drake M. rRNA stability in heat-killed and UV-irradiated enterotoxigenic Staphylococcus aureus and Escherichia coli O157:H7. Appl Environ Microbiol 1998: 64: 4264-4268.
239. Menard C, Mouton C. Clonal diversity of the taxon Porphyromonas gingivalis assessed by random amplified polymorphic DNA fingerprinting. Infect Immun 1995: 63: 2522-2531.
240. Mestnik MJ, Feres M, Figueiredo LC, Duarte PM, Lira EA, Faveri M. Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis. J Clin Periodontol 2010: 37: 353-365.
241. Migliorati CA, Siegel MA, Elting LS. Bisphosphonate-associated osteonecrosis: a long-term complication of bisphosphonate treatment. Lancet Oncol 2006: 7: 508-514.
242. Miller WD. The microorganisms of the human mouth. The local and general diseases which are caused by them. Philadelphia (PA): SS White, 1890: 274-441.
243. Mogensen TH, Paludan SR. Molecular pathways in virus-induced cytokine production. Microbiol Mol Biol Rev 2001: 65: 131-150.
244. Mombelli A. Microbiological monitoring. J Clin Periodontol 1996: 23: 251-257.
245. Mombelli A, Cionca N, Almaghlouth A. Does adjunctive antimicrobial therapy reduce the perceived need for periodontal surgery?Periodontol 2000 2011: 55: 205-216.
246. Moore WE, Moore LV. The bacteria of periodontal diseases. Periodontol 2000 1994: 5: 66-77.
247. Mousques T, Listgarten MA, Phillips RW. Effect of scaling and root planing on the composition of the human subgingival microbial flora. J Periodontal Res 1980: 15: 144-151.
248. Munson MA, Banerjee A, Watson TF, Wade WG. Molecular analysis of the microflora associated with dental caries. J Clin Microbiol 2004: 42: 3023-3029.
249. Munson MA, Pitt-Ford T, Chong B, Weightman A, Wade WG. Molecular and cultural analysis of the microflora associated with endodontic infections. J Dent Res 2002: 81: 761-766.
250. Nachtwey J, Spencer JV. HCMV IL-10 suppresses cytokine expression in monocytes through inhibition of nuclear factor-kappaB. Viral Immunol 2008: 21: 477-482.
251. Nakagawa I, Amano A, Ohara-Nemoto Y, Endoh N, Morisaki I, Kimura S, Kawabata S, Hamada S. Identification of a new variant of fimA gene of Porphyromonas gingivalis and its distribution in adults and disabled populations with periodontitis. J Periodontal Res 2002: 37: 425-432.
252. Nalbant A, Zadeh HH. Actinobacillus actinomycetemcomitans induces apoptosis of T lymphocytes by the Fas and Fas ligand pathway. Oral Microbiol Immunol 2002: 17: 277-284.
253. Newman MG, Socransky SS, Savitt ED, Propas DA, Crawford A. Studies of the microbiology of periodontosis. J Periodontol 1976: 47: 373-379.
254. Nichols D, Lewis K, Orjala J, Mo S, Ortenberg R, O'Connor P, Zhao C, Vouros P, Kaeberlein T, Epstein SS. Short peptide induces an 'uncultivable' microorganism to grow in vitro. Appl Environ Microbiol 2008: 74: 4889-4897.
255. Nocker A, Camper AK. Selective removal of DNA from dead cells of mixed bacterial communities by use of ethidium monoazide. Appl Environ Microbiol 2006: 72: 1997-2004.
256. Noiri Y, Ebisu S. Identification of periodontal disease-associated bacteria in the 'plaque-free zone'. J Periodontol 2000: 71: 1319-1326.
257. Noiri Y, Li L, Ebisu S. The localization of periodontal-disease-associated bacteria in human periodontal pockets. J Dent Res 2001: 80: 1930-1934.
258. Noiri Y, Li L, Yoshimura F, Ebisu S. Localization of Porphyromonas gingivalis-carrying fimbriae in situ in human periodontal pockets. J Dent Res 2004: 83: 941-945.
259. Noiri Y, Ozaki K, Nakae H, Matsuo T, Ebisu S. An immunohistochemical study on the localization of Porphyromonas gingivalis, Campylobacter rectus and Actinomyces viscosus in human periodontal pockets. J Periodontal Res 1997: 32: 598-607.
260. Nonnenmacher C, Dalpke A, Rochon J, Flores-de-Jacoby L, Mutters R, Heeg K. Real-time polymerase chain reaction for detection and quantification of bacteria in periodontal patients. J Periodontol 2005: 76: 1542-1549.
261. Offenbacher S, Barros SP, Beck JD. Rethinking periodontal inflammation. J Periodontol 2008: 79: 1577-1584.
262. Offenbacher S, Barros SP, Paquette DW, Winston JL, Biesbrock AR, Thomason RG, Gibb RD, Fulmer AW, Tiesman JP, Juhlin KD, Wang SL, Reichling TD, Chen KS, Ho B. Gingival transcriptome patterns during induction and resolution of experimental gingivitis in humans. J Periodontol 2009: 80: 1963-1982.
263. Olson JC, Cuff CF, Lukomski S, Lukomska E, Canizales Y, Wu B, Crout RJ, Thomas JG, McNeil DW, Weyant RJ, Marazita ML, Paster BJ, Elliott T. Use of 16S ribosomal RNA gene analyses to characterize the bacterial signature associated with poor oral health in West Virginia. BMC Oral Health 2011: 11: 7.
264. Ouverney CC, Armitage GC, Relman DA. Single-cell enumeration of an uncultivated TM7 subgroup in the human subgingival crevice. Appl Environ Microbiol 2003: 69: 6294-6298.
265. Ozmeric N, Preus NR, Olsen I. Genetic diversity of Porphyromonas gingivalis and its possible importance to pathogenicity. Acta Odontol Scand 2000: 58: 183-187.
266. Page RC, Kornman KS. The pathogenesis of human periodontitis: an introduction. Periodontol 2000 1997: 14: 9-11.
267. Page RC, Offenbacher S, Schroeder HE, Seymour GJ, Kornman KS. Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions. Periodontol 2000 1997: 14: 216-248.
268. Page RC, Schroeder HE. Pathogenesis of inflammatory periodontal disease. A summary of current work. Lab Invest 1976: 34: 235-249.
269. Page RC, Sturdivant EC. Noninflammatory destructive periodontal disease (NDPD). Periodontol 2000 2002: 30: 24-39.
270. Papaioannou W, Gizani S, Haffajee AD, Quirynen M, Mamai-Homata E, Papagiannoulis L. The microbiota on different oral surfaces in healthy children. Oral Microbiol Immunol 2009: 24: 183-189.
271. Papapanou PN, Baelum V, Luan WM, Madianos PN, Chen X, Fejerskov O, Dahlén G. Subgingival microbiota in adult Chinese: prevalence and relation to periodontal disease progression. J Periodontol 1997: 68: 651-666.
272. Papapanou PN, Behle JH, Kebschull M, Celenti R, Wolf DL, Handfield M, Pavlidis P, Demmer RT. Subgingival bacterial colonization profiles correlate with gingival tissue gene expression. BMC Microbiol 2009: 9: 221.
273. Papapanou PN, Teanpaisan R, Obiechina NS, Pithpornchaiyakul W, Pongpaisal S, Pisuithanakan S, Baelum V, Fejerskov O, Dahlén G. Periodontal microbiota and clinical periodontal status in a rural sample in southern Thailand. Eur J Oral Sci 2002: 110: 345-352.
274. Parfrey LW, Knight R. Spatial and temporal variability of the human microbiota. Clin Microbiol Infect 2012: 18(Suppl 4): 8-11.
275. Pashine A, John B, Rath S, George A, Bal V. Th1 dominance in the immune response to live Salmonella typhimurium requires bacterial invasiveness but not persistence. Int Immunol 1999: 11: 481-489.
276. Paster BJ, Boches SK, Galvin JL, Ericson RE, Lau CN, Levanos VA, Sahasrabudhe A, Dewhirst FE. Bacterial diversity in human subgingival plaque. J Bacteriol 2001: 183: 3770-3783.
277. Paster BJ, Dewhirst FE. Molecular microbial diagnosis. Periodontol 2000 2009: 51: 38-44.
278. Paster BJ, Olsen I, Aas JA, Dewhirst FE. The breadth of bacterial diversity in the human periodontal pocket and other oral sites. Periodontol 2000 2006: 42: 80-87.
279. Paterson GK, Maskell DJ. Genetic determinants of bacterial pathogenesis. In: Locht C, Simonet M, editors. Bacterial Pathogenesis Molecular and Cellular Mechanisms. Norfolk: Caister Academic Press, 2012: 51-68.
280. Petit MD, van Steenbergen TJ, Scholte LM, van der Velden U, de Graaff J. Epidemiology and transmission of Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans among children and their family members. A report of 4 surveys.. J Clin Periodontol 1993: 20: 641-650.
281. Polz MF, Cavanaugh CM. Bias in template-to-product ratios in multitemplate PCR. Appl Environ Microbiol 1998: 64: 3724-3730.
282. Potempa J, Banbula A, Travis J. Role of bacterial proteinases in matrix destruction and modulation of host responses. Periodontol 2000 2000: 24: 153-192.
283. Quirynen M, Bollen CML. The influence of surface roughness and surface free energy on supragingival and subgingival plaque formation in man - a review of the literature. J Clin Periodontol 1995: 22: 1-14.
284. Quirynen M, Marechal M, Busscher HJ, Weerkamp AH, Darius PL, van Steenberghe D. The influence of surface free energy and surface roughness on early plaque formation. An in vivo study in man. J Clin Periodontol 1990: 17: 138-144.
285. Rams TE, Keyes PH. A rationale for the management of periodontal diseases: effects of tetracycline on subgingival bacteria. J Am Dent Assoc 1983: 107: 37-41.
286. Razumov AS. Direct method for counting bacteria in water. A comparison with the method after Koch. Mikrobiologiya (Moscow) 1932: 1: 131.
287. Reddy MS, Weatherford TW 3rd, Smith CA, West BD, Jeffcoat MK, Jacks TM. Alendronate treatment of naturally-occurring periodontitis in beagle dogs. J Periodontol 1995: 66: 211-217.
288. Relman DA. The human microbiome: ecosystem resilience and health. Nutr Rev 2012: 70(Suppl 1): S2-S9.
289. Relman DA. New technologies, human-microbe interactions, and the search for previously unrecognized pathogens. J Infect Dis 2002: 186(Suppl 2): S254-S258.
290. Reysenbach AL, Giver LJ, Wickham GS, Pace NR. Differential amplification of rRNA genes by polymerase chain reaction. Appl Environ Microbiol 1992: 58: 3417-3418.
291. Riley MA, Lizotte-Waniewski M. Population genomics and the bacterial species concept. Methods Mol Biol 2009: 532: 367-377.
292. Ritz HL. Microbial population shifts in developing human dental plaque. Arch Oral Biol 1967: 12: 1561-1568.
293. Riviere GR, Elliot KS, Adams DF, Simonson LG, Forgas LB, Nilius AM, Lukehart SA. Relative proportions of pathogen-related oral spirochetes (PROS) and Treponema denticola in supragingival and subgingival plaque from patients with periodontitis. J Periodontol 1992: 63: 131-136.
294. Riviere GR, Wagoner MA, Baker-Zander SA, Weisz KS, Adams DF, Simonson L, Lukehart SA. Identification of spirochetes related to Treponema pallidum in necrotizing ulcerative gingivitis and chronic periodontitis. N Engl J Med 1991: 325: 539-543.
295. Riviere GR, Weisz KS, Simonson LG, Lukehart SA. Pathogen-related spirochetes identified within gingival tissue from patients with acute necrotizing ulcerative gingivitis. Infect Immun 1991: 59: 2653-2657.
296. Roberts FA, Darveau RP. Beneficial bacteria of the periodontium. Periodontol 2000 2002: 30: 40-50.
297. Rothman K, Greenland S. Causation and Causal Inference. In: Rothman K, Greenland S, editors. Modern Epidemiology. 2nd edn. Philadelphia: Lippincott Williams & Wilkins, 1998: 7-28.
298. Rotola A, Cassai E, Farina R, Caselli E, Gentili V, Lazzarotto T, Trombelli L. Human herpesvirus 7, Epstein-Barr virus and human cytomegalovirus in periodontal tissues of periodontally diseased and healthy subjects. J Clin Periodontol 2008: 35: 831-837.
299. Sachdeo A, Haffajee AD, Socransky SS. Biofilms in the edentulous oral cavity. J Prosthodont 2008: 17: 348-356.
300. Saglie FR, Carranza FA Jr, Newman MG. The presence of bacteria within the oral epithelium in periodontal disease. I. A scanning and transmission electron microscopic study. J Periodontol 1985: 56: 618-624.
301. Saglie R, Carranza FA Jr, Newman MG, Pattison GA. Scanning electron microscopy of the gingival wall of deep periodontal pockets in humans. J Periodontal Res 1982: 17: 284-293.
302. Sakamoto M, Takeuchi Y, Umeda M, Ishikawa I, Benno Y. Rapid detection and quantification of five periodontopathic bacteria by real-time PCR. Microbiol Immunol 2001: 45: 39-44.
303. Sakamoto M, Umeda M, Ishikawa I, Benno Y. Comparison of the oral bacterial flora in saliva from a healthy subject and two periodontitis patients by sequence analysis of 16S rDNA libraries. Microbiol Immunol 2000: 44: 643-652.
304. Salari MH, Kadkhoda Z. Rate of cultivable subgingival periodontopathogenic bacteria in chronic periodontitis. J Oral Sci 2004: 46: 157-161.
305. Salvi GE, Franco LM, Braun TM, Lee A, Rutger Persson G, Lang NP, Giannobile WV. Pro-inflammatory biomarkers during experimental gingivitis in patients with type 1 diabetes mellitus: a proof-of-concept study. J Clin Periodontol 2010: 37: 9-16.
306. Salvi GE, Lang NP. The effects of non-steroidal anti-inflammatory drugs (selective and non-selective) on the treatment of periodontal diseases. Curr Pharm Des 2005: 11: 1757-1769.
307. Santos AL, Siqueira JF Jr, Rocas IN, Jesus EC, Rosado AS, Tiedje JM. Comparing the bacterial diversity of acute and chronic dental root canal infections. PLoS One 2011: 6: e28088.
308. Sanz M, van Winkelhoff AJ, Herrera D, Dellemijn-Kippuw N, Simon R, Winkel E. Differences in the composition of the subgingival microbiota of two periodontitis populations of different geographical origin. A comparison between Spain and The Netherlands. Eur J Oral Sci 2000: 108: 383-392.
309. Saygun I, Kubar A, Ozdemir A, Slots J. Periodontitis lesions are a source of salivary cytomegalovirus and Epstein-Barr virus. J Periodontal Res 2005: 40: 187-191.
310. Saygun I, Kubar A, Ozdemir A, Yapar M, Slots J. Herpesviral-bacterial interrelationships in aggressive periodontitis. J Periodontal Res 2004: 39: 207-212.
311. Saygun I, Kubar A, Sahin S, Sener K, Slots J. Quantitative analysis of association between herpesviruses and bacterial pathogens in periodontitis. J Periodontal Res 2008: 43: 352-359.
312. Sbordone L, Ramaglia L, Gulletta E, Iacono V. Recolonization of the subgingival microflora after scaling and root planing in human periodontitis. J Periodontol 1990: 61: 579-584.
313. Schatzle M, Loe H, Burgin W, Anerud A, Boysen H, Lang NP. Clinical course of chronic periodontitis. I. Role of gingivitis. J Clin Periodontol 2003: 30: 887-901.
314. Schatzle M, Loe H, Lang NP, Burgin W, Anerud A, Boysen H. The clinical course of chronic periodontitis. J Clin Periodontol 2004: 31: 1122-1127.
315. Schei O, Waerhaug J, Lovdal A, Arno A. Alveolar bone loss as related to oral hygiene and age. J Periodontol 1959: 30: 7-16.
316. Scheu PM, Berghof K, Stahl U. Detection of pathogenic and spoilage microorganisms in food with the polymerase chain reaction. Food Microbiol 1998: 15: 13-31.
317. Schillinger C, Petrich A, Lux R, Riep B, Kikhney J, Friedmann A, Wolinsky LE, Göbel UB, Daims H, Moter A. Co-localized or randomly distributed? Pair cross correlation of in vivo grown subgingival biofilm bacteria quantified by digital image analysis. Plos One 2012: 7: e37583.
318. Shaddox LM, Huang H, Lin T, Hou W, Harrison PL, Aukhil I, Walker CB, Klepac-Ceraj V, Paster BJ. Microbiological characterization in children with aggressive periodontitis. J Dent Res 2012: 91: 927-933.
319. Shah D, Zhang Z, Khodursky A, Kaldalu N, Kurg K, Lewis K. Persisters: a distinct physiological state of E. coli. BMC Microbiol 2006: 6: 53.
320. Siegrist BE, Brecx MC, Gusberti FA, Joss A, Lang NP. In vivo early human dental plaque formation on different supporting substances. A scanning electron microscopic and bacteriological study. Clin Oral Implants Res 1991: 2: 38-46.
321. Silva MP, Feres M, Sirotto TA, Soares GM, Mendes JA, Faveri M, Figueiredo LC. Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial. J Clin Periodontol 2011: 38: 828-837.
322. Silva N, Dutzan N, Hernandez M, Dezerega A, Rivera O, Aguillon JC, Aravena O, Lastres P, Pozo P, Vernal R, Gamonal J. Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells. J Clin Periodontol 2008: 35: 206-214.
323. Sizova MV, Hohmann T, Hazen A, Paster BJ, Halem SR, Murphy CM, Panikov NS, Epstein SS. New approaches for isolation of previously uncultivated oral bacteria. Appl Environ Microbiol 2012: 78: 194-203.
324. Slots J. Herpesviruses, the missing link between gingivitis and periodontitis?J Int Acad Periodontol 2004: 6: 113-119.
325. Slots J. Herpesviral-bacterial synergy in the pathogenesis of human periodontitis. Curr Opin Infect Dis 2007: 20: 278-283.
326. Slots J. Herpesviral-bacterial interactions in periodontal diseases. Periodontol 2000 2010: 52: 117-140.
327. Slots J. Human viruses in periodontitis. Periodontol 2000 2010: 53: 89-110.
328. Slots J, Contreras A. Herpesviruses: a unifying causative factor in periodontitis?Oral Microbiol Immunol 2000: 15: 277-280.
329. Slots J, Emrich LJ, Genco RJ, Rosling BG. Relationship between some subgingival bacteria and periodontal pocket depth and gain or loss of periodontal attachment after treatment of adult periodontitis. J Clin Periodontol 1985: 12: 540-552.
330. Slots J, Saygun I, Sabeti M, Kubar A. Epstein-Barr virus in oral diseases. J Periodontal Res 2006: 41: 235-244.
331. Smillie CS, Smith MB, Friedman J, Cordero OX, David LA, Alm EJ. Ecology drives a global network of gene exchange connecting the human microbiome. Nature 2011: 480: 241-244.
332. Socransky SS. Relationship of bacteria to the etiology of periodontal disease. J Dent Res 1970: 49: 203-222.
333. Socransky SS, Gibbons RJ, Dale AC, Bortnick L, Rosenthal E, Macdonald JB. The microbiota of the gingival crevice area of man. I. Total microscopic and viable counts and counts of specific organisms. Arch Oral Biol 1963: 8: 275-280.
334. Socransky SS, Haffajee AD. The bacterial etiology of destructive periodontal disease: current concepts. J Periodontol 1992: 63: 322-331.
335. Socransky SS, Haffajee AD. Evidence of bacterial etiology: a historical perspective. Periodontol 2000 1994: 5: 7-25.
336. Socransky SS, Haffajee AD. Periodontal microbial ecology. Periodontol 2000 2005: 38: 135-187.
337. Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque. J Clin Periodontol 1998: 25: 134-144.
338. Socransky SS, Haffajee AD, Smith C, Dibart S. Relation of counts of microbial species to clinical status at the sampled site. J Clin Periodontol 1991: 18: 766-775.
339. Socransky SS, Haffajee AD, Smith C, Martin L, Haffajee JA, Uzel NG, Goodson JM. Use of checkerboard DNA-DNA hybridization to study complex microbial ecosystems. Oral Microbiol Immunol 2004: 19: 352-362.
340. Socransky SS, Haffajee AD, Smith GL, Dzink JL. Difficulties encountered in the search for the etiologic agents of destructive periodontal diseases. J Clin Periodontol 1987: 14: 588-593.
341. Socransky SS, Smith C, Martin L, Paster BJ, Dewhirst FE, Levin AE. 'Checkerboard' DNA-DNA hybridization. Biotechniques 1994: 17: 788-792.
342. Sorsa T, Tjaderhane L, Konttinen YT, Lauhio A, Salo T, Lee HM, Golub LM, Brown DL, Mäntylä P. Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation. Ann Med 2006: 38: 306-321.
343. Staley JT, Konopka A. Measurement of in situ activities of nonphotosynthetic microorganisms in aquatic and terrestrial habitats. Annu Rev Microbiol 1985: 39: 321-346.
344. Stashenko P, Dewhirst FE, Peros WJ, Kent RL, Ago JM. Synergistic interactions between interleukin 1, tumor necrosis factor, and lymphotoxin in bone resorption. J Immunol 1987: 138: 1464-1468.
345. Stashenko P, Dewhirst FE, Rooney ML, Desjardins LA, Heeley JD. Interleukin-1 beta is a potent inhibitor of bone formation in vitro. J Bone Miner Res 1987: 2: 559-565.
346. Stern J, Shai E, Zaks B, Halabi A, Houri-Haddad Y, Shapira L, Palmon A. Reduced expression of gamma interferon in serum and marked lymphoid depletion induced by Porphyromonas gingivalis increase murine morbidity and mortality due to cytomegalovirus infection. Infect Immun 2004: 72: 5791-5798.
347. Sugano N, Ikeda K, Oshikawa M, Idesawa M, Tanaka H, Sato S, Ito K. Relationship between Porphyromonas gingivalis, Epstein-Barr virus infection and reactivation in periodontitis. J Oral Sci 2004: 46: 203-206.
348. Sumi Y, Kagami H, Ohtsuka Y, Kakinoki Y, Haruguchi Y, Miyamoto H. High correlation between the bacterial species in denture plaque and pharyngeal microflora. Gerodontology 2003: 20: 84-87.
349. Sunde PT, Olsen I, Enersen M, Beiske K, Grinde B. Human cytomegalovirus and Epstein-Barr virus in apical and marginal periodontitis: a role in pathology?J Med Virol 2008: 80: 1007-1011.
350. Sunde PT, Olsen I, Enersen M, Grinde B. Patient with severe periodontitis and subgingival Epstein-Barr virus treated with antiviral therapy. J Clin Virol 2008: 42: 176-178.
351. Suomi JD, Greene JC, Vermillion JR, Doyle J, Chang JJ, Leatherwood EC. The effect of controlled oral hygiene procedures on the progression of periodontal disease in adults: results after third and final year. J Periodontol 1971: 42: 152-160.
352. Suzuki MT, Giovannoni SJ. Bias caused by template annealing in the amplification of mixtures of 16S rRNA genes by PCR. Appl Environ Microbiol 1996: 62: 625-630.
353. Tanner AC, Dzink JL, Socransky SS, Des Roches CL. Diagnosis of periodontal disease using rapid identification of 'activity-related' gram-negative species. J Periodontal Res 1987: 22: 207-208.
354. Tanner AC, Kent R Jr, Kanasi E, Lu SC, Paster BJ, Sonis ST, Murray LA, Van Dyke TE. Clinical characteristics and microbiota of progressing slight chronic periodontitis in adults. J Clin Periodontol 2007: 34: 917-930.
355. Tanner AC, Sonis AL, Lif Holgerson P, Starr JR, Nunez Y, Kressirer CA, Paster BJ, Johansson I. White-spot lesions and gingivitis microbiotas in orthodontic patients. J Dent Res 2012: 91: 853-858.
356. Teanpaisan R, Douglas CW, Eley AR, Walsh TF. Clonality of Porphyromonas gingivalis, Prevotella intermedia and Prevotella nigrescens isolated from periodontally diseased and healthy sites. J Periodontal Res 1996: 31: 423-432.
357. Teles F, Haffajee AD, Socransky SS. Multiple displacement amplification as an aid in checkerboard DNA-DNA hybridization. Oral Microbiol Immunol 2007: 22: 118-125.
358. Teles FR, Haffajee AD, Socransky SS. The reproducibility of curet sampling of subgingival biofilms. J Periodontol 2008: 79: 705-713.
359. Teles FR, Teles RP, Martin L, Socransky SS, Haffajee AD. Relationships among interleukin-6, tumor necrosis factor-alpha, adipokines, vitamin D, and chronic periodontitis. J Periodontol 2012: 83: 1183-1191.
360. Teles FR, Teles RP, Sachdeo A, Uzel NG, Song XQ, Torresyap G, Singh M, Papas A, Haffajee AD, Socransky SS. Comparison of microbial changes in early redeveloping biofilms on natural teeth and dentures. J Periodontol 2012: 83: 1139-1148.
361. Teles FR, Teles RP, Siegelin Y, Paster B, Haffajee AD, Socransky SS. RNA-oligonucleotide quantification technique (ROQT) for the enumeration of uncultivated bacterial species in subgingival biofilms. Mol Oral Microbiol 2011: 26: 127-139.
362. Teles R, Sakellari D, Teles F, Konstantinidis A, Kent R, Socransky S, Haffajee A. Relationships among gingival crevicular fluid biomarkers, clinical parameters of periodontal disease, and the subgingival microbiota. J Periodontol 2010: 81: 89-98.
363. Teles RP, Gursky LC, Faveri M, Rosa EA, Teles FR, Feres M, Socransky SS, Haffajee AD. Relationships between subgingival microbiota and GCF biomarkers in generalized aggressive periodontitis. J Clin Periodontol 2010: 37: 313-323.
364. Teles RP, Haffajee AD, Socransky SS. Microbiological goals of periodontal therapy. Periodontol 2000 2006: 42: 180-218.
365. Teles RP, Patel M, Socransky SS, Haffajee AD. Disease progression in periodontally healthy and maintenance subjects. J Periodontol 2008: 79: 784-794.
366. Teughels W, Van Assche N, Sliepen I, Quirynen M. Effect of material characteristics and/or surface topography on biofilm development. Clin Oral Implant Res 2006: 17: 68-81.
367. Theilade E, Budtz-Jorgensen E, Theilade J. Predominant cultivable microflora of plaque on removable dentures in patients with healthy oral mucosa. Arch Oral Biol 1983: 28: 675-680.
368. Theilade E, Wright WH, Jensen SB, Loe H. Experimental gingivitis in man. II. A longitudinal clinical and bacteriological investigation. J Periodontal Res 1966: 1: 1-13.
369. Touchon M, Hoede C, Tenaillon O, Barbe V, Baeriswyl S, Bidet P, Bingen E, Bonacorsi S, Bouchier C, Bouvet O, Calteau A, Chiapello H, Clermont O, Cruveiller S, Danchin A, Diard M, Dossat C, Karoui ME, Frapy E, Garry L, Ghigo JM, Gilles AM, Johnson J, Le Bouguénec C, Lescat M, Mangenot S, Martinez-Jéhanne V, Matic I, Nassif X, Oztas S, Petit MA, Pichon C, Rouy Z, Ruf CS, Schneider D, Tourret J, Vacherie B, Vallenet D, Médigue C, Rocha EP, Denamur E. Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths. PLoS Genet 2009: 5: e1000344.
370. Tribble GD, Rigney TW, Dao DH, Wong CT, Kerr JE, Taylor BE, Pacha S, Kaplan HB. Natural competence is a major mechanism for horizontal DNA transfer in the oral pathogen Porphyromonas gingivalis. MBio 2012: 3.
371. Tsalikis LE, Kaklamanos EG, Kavadia-Tsatala S, Chasapopoulou E, Pidonia-Manika I. Association of gingival crevicular fluid and serum intracytoplasmic enzyme levels in periodontally healthy homozygous (major) beta-thalassemia patients. J Clin Periodontol 2004: 31: 356-363.
372. Tuite-McDonnell M, Griffen AL, Moeschberger ML, Dalton RE, Fuerst PA, Leys EJ. Concordance of Porphyromonas gingivalis colonization in families. J Clin Microbiol 1997: 35: 455-461.
373. Uzel NG, Teles FR, Teles RP, Song XQ, Torresyap G, Socransky SS, Haffajee AD. Microbial shifts during dental biofilm re-development in the absence of oral hygiene in periodontal health and disease. J Clin Periodontol 2011: 38: 612-620.
374. Valenza G, Veihelmann S, Peplies J, Tichy D, Roldan-Pareja Mdel C, Schlagenhauf U, Vogel U. Microbial changes in periodontitis successfully treated by mechanical plaque removal and systemic amoxicillin and metronidazole. Int J Med Microbiol 2009: 299: 427-438.
375. Valm AM, Mark Welch JL, Rieken CW, Hasegawa Y, Sogin ML, Oldenbourg R, Dewhirst FE, Borisy GG. Systems-level analysis of microbial community organization through combinatorial labeling and spectral imaging. Proc Natl Acad Sci U S A 2011: 108: 4152-4157.
376. Valverde P. Pharmacotherapies to manage bone loss-associated diseases: a quest for the perfect benefit-to-risk ratio. Curr Med Chem 2008: 15: 284-304.
377. van der Velden U, Abbas F, Armand S, de Graaff J, Timmerman MF, van der Weijden GA, van Winkelhoff AJ, Winkel EG. The effect of sibling relationship on the periodontal condition. J Clin Periodontol 1993: 20: 683-690.
378. Van der Weijden GA, Timmerman MF, Reijerse E, Wolffe GN, van Winkelhoff AJ, van der Velden U. The prevalence of A. actinomycetemcomitans, P. gingivalis and P. intermedia in selected subjects with periodontitis. J Clin Periodontol 1994: 21: 583-588.
379. Van Dyke TE. The management of inflammation in periodontal disease. J Periodontol 2008: 79: 1601-1608.
380. van Steenbergen TJ, Petit MD, Scholte LH, van der Velden U, de Graaff J. Transmission of Porphyromonas gingivalis between spouses. J Clin Periodontol 1993: 20: 340-345.
381. van Steenbergen TJ, van Winkelhoff AJ, de Graaff J. Pathogenic synergy: mixed infections in the oral cavity. Antonie Van Leeuwenhoek 1984: 50: 789-798.
382. van Winkelhoff AJ, Herrera D, Oteo A, Sanz M. Antimicrobial profiles of periodontal pathogens isolated from periodontitis patients in The Netherlands and Spain. J Clin Periodontol 2005: 32: 893-898.
383. van Winkelhoff AJ, Loos BG, van der Reijden WA, van der Velden U. Porphyromonas gingivalis, Bacteroides forsythus and other putative periodontal pathogens in subjects with and without periodontal destruction. J Clin Periodontol 2002: 29: 1023-1028.
384. van Winkelhoff AJ, Rijnsburger MC, van der Velden U. Clonal stability of Porphyromonas gingivalis in untreated periodontitis. J Clin Periodontol 2008: 35: 674-679.
385. van Winkelhoff AJ, Rodenburg JP, Goene RJ, Abbas F, Winkel EG, de Graaff J. Metronidazole plus amoxycillin in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis. J Clin Periodontol 1989: 16: 128-131.
386. Vardjan N, Kopitar AN, Ihan Hren N, Malovrh T, Wraber B, Ihan A. Immune response in lymphocyte cultures stimulated by oral bacteria preparations. Pflugers Arch 2000: 440: R67-R69.
387. Vartoukian SR, Downes J, Palmer RM, Wade WG. Fretibacterium fastidiosum gen. nov., sp. nov., isolated from the human oral cavity. Int J Syst Evol Microbiol 2012: July 13: doi: 10.1099/ijs.0.041038-0.
388. Vartoukian SR, Palmer RM, Wade WG. Cultivation of a Synergistetes strain representing a previously uncultivated lineage. Environ Microbiol 2010: 12: 916-928.
389. Vartoukian SR, Palmer RM, Wade WG. Diversity and morphology of members of the phylum 'synergistetes' in periodontal health and disease. Appl Environ Microbiol 2009: 75: 3777-3786.
390. Vartoukian SR, Palmer RM, Wade WG. Strategies for culture of 'unculturable' bacteria. FEMS Microbiol Lett 2010: 309: 1-7.
391. Vianna ME, Horz HP, Gomes BP, Conrads G. Microarrays complement culture methods for identification of bacteria in endodontic infections. Oral Microbiol Immunol 2005: 20: 253-258.
392. von Wintzingerode F, Gobel UB, Stackebrandt E. Determination of microbial diversity in environmental samples: pitfalls of PCR-based rRNA analysis. FEMS Microbiol Rev 1997: 21: 213-229.
393. Wade WG. Has the use of molecular methods for the characterization of the human oral microbiome changed our understanding of the role of bacteria in the pathogenesis of periodontal disease?J Clin Periodontol 2011: 38(Suppl 11): 7-16.
394. Wadelius M, Chen LY, Downes K, Ghori J, Hunt S, Eriksson N, Wallerman O, Melhus H, Wadelius C, Bentley D, Deloukas P. Common VKORC1 and GGCX polymorphisms associated with warfarin dose. Pharmacogenomics J 2005: 5: 262-270.
395. Waters JC. Accuracy and precision in quantitative fluorescence microscopy. J Cell Biol 2009: 185: 1135-1148.
396. Weinberg A, Belton CM, Park Y, Lamont RJ. Role of fimbriae in Porphyromonas gingivalis invasion of gingival epithelial cells. Infect Immun 1997: 65: 313-316.
397. Wendisch VF, Zimmer DP, Khodursky A, Peter B, Cozzarelli N, Kustu S. Isolation of Escherichia coli mRNA and comparison of expression using mRNA and total RNA on DNA microarrays. Anal Biochem 2001: 290: 205-213.
398. Williams RC, Jeffcoat MK, Howell TH, Rolla A, Stubbs D, Teoh KW, Reddy MS, Goldhaber P. Altering the progression of human alveolar bone loss with the non-steroidal anti-inflammatory drug flurbiprofen. J Periodontol 1989: 60: 485-490.
399. Winkel EG, van Winkelhoff AJ, Timmerman MF, van der Velden U, van der Weijden GA. Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study. J Clin Periodontol 2001: 28: 296-305.
400. Wu JY, Jiang XT, Jiang YX, Lu SY, Zou F, Zhou HW. Effects of polymerase, template dilution and cycle number on PCR based 16 S rRNA diversity analysis using the deep sequencing method. BMC Microbiol 2010: 10: 255.
401. Wu YM, Yan J, Ojcius DM, Chen LL, Gu ZY, Pan JP. Correlation between infections with different genotypes of human cytomegalovirus and Epstein-Barr virus in subgingival samples and periodontal status of patients. J Clin Microbiol 2007: 45: 3665-3670.
402. Wyss C, Choi BK, Schupbach P, Moter A, Guggenheim B, Gobel UB. Treponema lecithinolyticum sp. nov., a small saccharolytic spirochaete with phospholipase A and C activities associated with periodontal diseases. Int J Syst Bacteriol 1999: 49(Pt 4): 1329-1339.
403. Wyss C, Moter A, Choi BK, Dewhirst FE, Xue Y, Schupbach P, Göbel UB, Paster BJ, Guggenheim B. Treponema putidum sp. nov., a medium-sized proteolytic spirochaete isolated from lesions of human periodontitis and acute necrotizing ulcerative gingivitis. Int J Syst Evol Microbiol 2004: 54: 1117-1122.
404. Ximenez-Fyvie LA, Haffajee AD, Socransky SS. Comparison of the microbiota of supra- and subgingival plaque in health and periodontitis. J Clin Periodontol 2000: 27: 648-657.
405. Ximenez-Fyvie LA, Haffajee AD, Socransky SS. Microbial composition of supra- and subgingival plaque in subjects with adult periodontitis. J Clin Periodontol 2000: 27: 722-732.
406. Zadeh HH, Nalbant A, Park K. Large-scale early in vitro response to Actinobacillus actinomycetemcomitans suggests superantigenic activation of T-cells. J Dent Res 2001: 80: 356-362.
407. Zadeh HH, Tanavoli S, Haines DD, Kreutzer DL. Despite large-scale T cell activation, only a minor subset of T cells responding in vitro to Actinobacillus actinomycetemcomitans differentiate into effector T cells. J Periodontal Res 2000: 35: 127-136.
408. Zambon JJ, Sunday GJ, Smutko JS. Molecular genetic analysis of Actinobacillus actinomycetemcomitans epidemiology. J Periodontol 1990: 61: 75-80.
409. Zappa U, Reinking-Zappa M, Graf H, Espeland M. Cell populations and episodic periodontal attachment loss in humans. J Clin Periodontol 1991: 18: 508-515.
410. Zaura E, Keijser BJ, Huse SM, Crielaard W. Defining the healthy 'core microbiome' of oral microbial communities. BMC Microbiol 2009: 9: 259.
411. Zijnge V, van Leeuwen MBM, Degener JE, Abbas F, Thurnheer T, Gmur R, Harmsen HJ. Oral biofilm architecture on natural teeth. PLoS One 2010: 5: e9321.
412. Zou S, Zhou J. [Relationship between the activity of leukocyte chemokines in gingival crevicular fluid and periodontitis]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 1997: 19: 442-446.
413. Zuger J, Luthi-Schaller H, Gmur R. Uncultivated Tannerella BU045 and BU063 are slim segmented filamentous rods of high prevalence but low abundance in inflammatory disease-associated dental plaques. Microbiology 2007: 153: 3809-3816.