Mapping the pathogenesis of periodontitis: A new look

Journal of Periodontology

Volumn 79, Issue 8 SUPPL., 2008, Pages 1560-1568

  Kornman, Kenneth S ^a  

^a Interleukin Genetics   (United States)

Author keywords

Pathogenesis; Periodontal disease; Periodontitis; Systems biology

Indexed keywords

AUTACOID;

BACTERIUM; BIOLOGICAL MODEL; CHRONIC DISEASE; CONFERENCE PAPER; DISEASE PREDISPOSITION; ENVIRONMENT; GENETIC VARIABILITY; GENETICS; HUMAN; IMMUNOLOGY; MICROBIOLOGY; PERIODONTITIS; PHYSIOLOGY; TOOTH PLAQUE;

BACTERIA; CHRONIC DISEASE; DENTAL PLAQUE; DISEASE SUSCEPTIBILITY; ENVIRONMENT; HUMANS; INFLAMMATION MEDIATORS; MODELS, BIOLOGICAL; PERIODONTITIS; VARIATION (GENETICS);

EID: 49449101942     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2008.080213     Document Type: Conference Paper

References (84)

1. Hood L, Heath JR, Phelps ME, Lin B. Systems biology and new technologies enable predictive and preventative medicine. Science 2004;306:640-643.
2. Tatakis DN, Kumar PS. Etiology and pathogenesis of periodontal diseases. Dent Clin North Am 2005;49:491-516.
3. Offenbacher S, Barros SP, Singer RE, Moss K, Williams RC, Beck JD. Periodontal disease at the biofilm-gingival interface. J Periodontol 2007;78:1911-1925.
4. Taubman MA, Kawai T, Han X. The new concept of periodontal disease pathogenesis requires new and novel therapeutic strategies. J Clin Periodontol 2007;34:367-369.
5. Lindhe J, Hamp S, Löe H. Experimental periodontitis in the beagle dog. J Periodontal Res 1973;8:1-10.
6. Löe H, Theilade E, Jensen SB. Experimental gingivitis in man. J Periodontol 1965;36:177-187.
7. Slots J. Subgingival microflora and periodontal disease. J Clin Periodontol 1979;6:351-382.
8. Socransky SS. Microbiology of periodontal disease - Present status and future considerations. J Periodontol 1977;48:497-504.
9. Listgarten MA. The role of dental plaque in gingivitis and periodontitis. J Clin Periodontol 1988;15:485-487.
10. Newman MG. Anaerobic oral and dental infection. Rev Infect Dis 1984;6(Suppl. 1):S107-S114.
11. Theilade E. The non-specific theory in microbial etiology of inflammatory periodontal diseases. J Clin Periodontol 1986;13:905-911.
12. Page RC, Schroeder HE. Pathogenesis of inflammatory periodontal disease. A summary of current work. Lab Invest 1976;34:235-249.
13. Nisengard RJ. The role of immunology in periodontal disease. J Periodontol 1977;48:505-516.
14. Seymour GJ, Powell RN, Davies WI. Conversion of a stable T-cell lesion to a progressive B-cell lesion in the pathogenesis of chronic inflammatory periodontal disease: An hypothesis. J Clin Periodontol 1979;6:267-277.
15. Page RC, Schroeder HE. Current status of the host response in chronic marginal periodontitis. J Periodontol 1981;52:477-491.
16. Van Dyke TE. Role of the neutrophil in oral disease: Receptor deficiency in leukocytes from patients with juvenile periodontitis. Rev Infect Dis 1985;7:419-425.
17. Ranney RR. Immunologic mechanisms of pathogenesis in periodontal diseases: An assessment. J Periodontal Res 1991;26:243-254.
18. Seymour GJ. Possible mechanisms involved in the immunoregulation of chronic inflammatory periodontal disease. J Dent Res 1987;66:2-9.
19. Genco RJ, Van Dyke TE, Levine MJ, Nelson RD, Wilson ME. 1985 Kreshover lecture. Molecular factors influencing neutrophil defects in periodontal disease. J Dent Res 1986;65:1379-1391.
20. Newman MG, Socransky SS, Savitt ED, Propas DA, Crawford A. Studies of the microbiology of periodontosis. J Periodontol 1976;47:373-379.
21. Slots J. The predominant cultivable organisms in juvenile periodontitis. Scand J Dent Res 1976;84:1-10.
22. Johnson RJ, Matthews JL, Stone MJ, Hurt WC, Newman JT. Immunopathology of periodontal disease. I. Immunologic profiles in periodontitis and juvenile periodontitis. J Periodontol 1980;51:705-712.
23. Nisengard RJ, Newman MN, Myers D, Horikoshi A. Humoral immunologic responses in idiopathic juvenile periodontitis (periodontosis). J Periodontol 1980;51:30-33.
24. Page RC, Offenbacher S, Schroeder HE, Seymour GJ, Kornman KS. Advances in the pathogenesis of periodontitis: Summary of developments, clinical implications and future directions. Periodontol 2000 1997;14:216-248.
25. Lindhe J, Hamp SE, Löe H. Plaque induced periodontal disease in beagle dogs. A 4-year clinical, roentgenographical and histometrical study. J Periodontal Res 1975;10:243-255.
26. Löe H, Anerud A, Boysen H, Morrison E. Natural history of periodontal disease in man. Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age. J Clin Periodontol 1986;13:431-445.
27. Löe H, Anerud A, Boysen H, Smith M. The natural history of periodontal disease in man. The rate of periodontal destruction before 40 years of age. J Periodontol 1978;49:607-620.
28. Löe H, Anerud A, Boysen H, Smith M. The natural history of periodontal disease in man. Study design and baseline data. J Periodontal Res 1978;13:550-562.
29. Corey LA, Nance WE, Hofstede P, Schenkein HA. Self-reported periodontal disease in a Virginia twin population. J Periodontol 1993;64:1205-1208.
30. Michalowicz BS, Aeppli D, Virag JG, et al. Periodontal findings in adult twins. J Periodontol 1991;62:293-299.
31. Michalowicz BS, Aeppli DP, Kuba RK, et al. A twin study of genetic variation in proportional radiographic alveolar bone height. J Dent Res 1991;70:1431-1435.
32. Michalowicz BS, Diehl SR, Gunsolley JC, et al. Evidence of a substantial genetic basis for risk of adult periodontitis. J Periodontol 2000;71:1699-1707.
33. Kornman KS, Crane A, Wang HY, et al. The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol 1997;24:72-77.
34. Preber H, Bergstrom J. Occurrence of gingival bleeding in smoker and non-smoker patients. Acta Odontol Scand 1985;43:315-320.
35. Preber H, Bergstrom J. Cigarette smoking in patients referred for periodontal treatment. Scand J Dent Res 1986;94:102-108.
36. Bergstrom J. Periodontitis and smoking: An evidence-based appraisal. J Evid Based Dent Pract 2006;6:33-41.
37. Haber J, Wattles J, Crowley M, Mandell R, Joshipura K, Kent RL. Evidence for cigarette smoking as a major risk factor for periodontitis. J Periodontol 1993;64:16-23.
38. Bissada NF, Manouchehr-Pour M, Haddow M, Spagnuolo PJ. Neutrophil functional activity in juvenile and adult onset diabetic patients with mild and severe periodontitis. J Periodontal Res 1982;17:500-502.
39. Emrich LJ, Shlossman M, Genco RJ. Periodontal disease in non-insulin-dependent diabetes mellitus. J Periodontol 1991;62:123-131.
40. Genco RJ. Current view of risk factors for periodontal diseases. J Periodontol 1996;67(10 Suppl.):1041-1049.
41. Grossi SG, Skrepcinski FB, DeCaro T, Zambon JJ, Cummins D, Genco RJ. Response to periodontal therapy in diabetics and smokers. J Periodontol 1996;67(10 Suppl.):1094-1102.
42. Papapanou PN. Periodontal diseases: Epidemiology. Ann Periodontol 1996;1:1-36.
43. Tervonen T, Knuuttila M. Relation of diabetes control to periodontal pocketing and alveolar bone level. Oral Surg Oral Med Oral Pathol 1986;61:346-349.
44. Page RC, Kornman KS. The pathogenesis of human periodontitis: An introduction. Periodontol 2000 1997;14:9-11.
45. Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque. J Clin Periodontol 1998;25:134-144.
46. Ximenez-Fyvie LA, Haffajee AD, Socransky SS. Comparison of the microbiota of supra- and subgingival plaque in health and periodontitis. J Clin Periodontol 2000;27:648-657.
47. Thomson WM, Broadbent JM, Welch D, Beck JD, Poulton R. Cigarette smoking and periodontal disease among 32-year-olds: A prospective study of a representative birth cohort. J Clin Periodontol 2007;34:828-834.
48. Beck JD, Slade G, Offenbacher S. Oral disease, cardiovascular disease and systemic inflammation. Periodontol 2000 2000;23:110-120.
49. Offenbacher S, Beck JD, Lieff S, Slade G. Role of periodontitis in systemic health: Spontaneous preterm birth. J Dent Educ 1998;62:852-858.
50. Taylor GW, Loesche WJ, Terpenning MS. Impact of oral diseases on systemic health in the elderly: Diabetes mellitus and aspiration pneumonia. J Public Health Dent 2000;60:313-320.
51. Tezal M, Wactawski-Wende J, Grossi SG, Ho AW, Dunford R, Genco RJ. The relationship between bone mineral density and periodontitis in postmenopausal women. J Periodontol 2000;71:1492-1498.
52. Beck JD, Offenbacher S. The association between periodontal diseases and cardiovascular diseases: A state-of-the-science review. Ann Periodontol 2001;6:9-15.
53. Offenbacher S, Lieff S, Boggess KA, et al. Maternal periodontitis and prematurity. Part I: Obstetric outcome of prematurity and growth restriction. Ann Periodontol 2001;6:164-174.
54. Elter JR, Champagne CM, Offenbacher S, Beck JD. Relationship of periodontal disease and tooth loss to prevalence of coronary heart disease. J Periodontol 2004;75:782-790.
55. Scannapieco FA, Bush RB, Paju S. Associations between periodontal disease and risk for atherosclerosis, cardiovascular disease, and stroke. A systematic review. Ann Periodontol 2003;8:38-53.
56. D'Aiuto F, Tonetti MS. Contribution of periodontal therapy on individual cardiovascular risk assessment. Arch Intern Med 2005;165:1920-1921.
57. Craig RG, Kotanko P, Kamer AR, Levin NW. Periodontal diseases - A modifiable source of systemic inflammation for the end-stage renal disease patient on haemodialysis therapy? Nephrol Dial Transplant 2007;22:312-315.
58. Michaud DS, Joshipura K, Giovannucci E, Fuchs CS. A prospective study of periodontal disease and pancreatic cancer in US male health professionals. J Natl Cancer Inst 2007;99:171-175.
59. Southerland JH, Taylor GW, Moss K, Beck JD, Offenbacher S. Commonality in chronic inflammatory diseases: Periodontitis, diabetes, and coronary artery disease. Periodontol 2000 2006;40:130-143.
60. Yamazaki K, Ohsawa Y, Yoshie H. Elevated proportion of natural killer T cells in periodontitis lesions: A common feature of chronic inflammatory diseases. Am J Pathol 2001;158:1391-1398.
61. Van Dyke TE, Serhan CN. Resolution of inflammation: A new paradigm for the pathogenesis of periodontal diseases. J Dent Res 2003;82:82-90.
62. Tsuda K, Amano A, Umebayashi K, et al. Molecular dissection of internalization of Porphyromonas gingivalis by cells using fluorescent beads coated with bacterial membrane vesicle. Cell Struct Funct 2005;30:81-91.
63. Inagaki S, Onishi S, Kuramitsu HK, Sharma A. Porphyromonas gingivalis vesicles enhance attachment, and the leucine-rich repeat BspA protein is required for invasion of epithelial cells by "Tannerella forsythia." Infect Immun 2006;74:5023-5028.
64. Popadiak K, Potempa J, Riesbeck K, Blom AM. Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement system. J Immunol 2007;178:7242-7250.
65. Libby P, Ridker PM. Inflammation and atherosclerosis: Role of C-reactive protein in risk assessment. Am J Med 2004;116(Suppl. 6A):9S-16S.
66. Ridker PM. Inflammatory biomarkers and risks of myocardial infarction, stroke, diabetes, and total mortality: Implications for longevity. Nutr Rev 2007;65:S253-S259.
67. Ridker PM, Morrow DA. C-reactive protein, inflammation, and coronary risk. Cardiol Clin 2003;21:315-325.
68. Chen Y, Zhu J, Lum PY, et al. Variations in DNA elucidate molecular networks that cause disease. Nature 2008;452:429-435.
69. Kitano H. Biological robustness in complex host-pathogen systems. Prog Drug Res 2007;64:239, 241-263.
70. Loscalzo J, Kohane I, Barabasi AL. Human disease classification in the postgenomic era: A complex systems approach to human pathobiology. Mol Syst Biol 2007;3:124.
71. Zheng Y, Kreuwel HT, Young DL, et al. The virtual NOD mouse: Applying predictive biosimulation to research in type 1 diabetes. Ann N Y Acad Sci 2007;1103:45-62.
72. Sato S, Hanada R, Kimura A, et al. Central control of bone remodeling by neuromedin U. Nat Med 2007;13:1234-1240.
73. Takeda S, Karsenty G. Molecular bases of the sympathetic regulation of bone mass. Bone 2008;42:837-840.
74. Karthikeyan BV, Pradeep AR. Leptin levels in gingival crevicular fluid in periodontal health and disease. J Periodontal Res 2007;42:300-304.
75. Shen J, Arnett DK, Peacock JM, et al. Interleukin 1beta genetic polymorphisms interact with polyunsaturated fatty acids to modulate risk of the metabolic syndrome. J Nutr 2007;137:1846-1851.
76. Branch-Mays GL, Dawson D, Gunsolley JC, et al. The effects of a calorie-reduced diet on periodontal inflammation and disease in a non-human primate model. J Periodontol 2008;79:1184-1191.
77. Duarte PM, Neto JB, Casati MZ, Sallum EA, Nociti FH Jr. Diabetes modulates gene expression in the gingival tissues of patients with chronic periodontitis. Oral Dis 2007;13:594-599.
78. Papapanou PN, Abron A, Verbitsky M, et al. Gene expression signatures in chronic and aggressive periodontitis: A pilot study. Eur J Oral Sci 2004;112:216-223.
79. Koshi R, Sugano N, Orii H, Fukuda T, Ito K. Microarray analysis of nicotine-induced changes in gene expression in a macrophage-like human cell line. J Periodontal Res 2007;42:518-526.
80. Kubota T, Itagaki M, Hoshino C, et al. Altered gene expression levels of matrix metalloproteinases and their inhibitors in periodontitis-affected gingival tissue. J Periodontol 2008;79:166-173.
81. Papapanou PN, Sedaghatfar MH, Demmer RT, et al. Periodontal therapy alters gene expression of peripheral blood monocytes. J Clin Periodontol 2007;34:736-747.
82. Peruzzo DC, Benatti BB, Antunes IB, et al. Chronic stress may modulate periodontal disease: A study in rats. J Periodontol 2008;79:697-704.
83. Zhou Q, Amar S. Identification of signaling pathways in macrophage exposed to Porphyromonas gingivalis or to its purified cell wall components. J Immunol 2007;179:7777-7790.
84. Roach JC, Smith KD, Strobe KL, et al. Transcription factor expression in lipopolysaccharide-activated peripheral-blood-derived mononuclear cells. Proc Natl Acad Sci USA 2007;104:16245-16250.