A role of oral bacteria in bisphosphonate-induced osteonecrosis of the jaw

Journal of Dental Research

Volumn 90, Issue 11, 2011, Pages 1339-1345

  Mawardi, H ^a,b,c   Giro, G ^a,d   Kajiya, M ^a,b   Ohta, K ^a,b   Almazrooa, S ^a,b,c   Alshwaimi, E ^e   Woo, S B ^b   Nishimura, I ^f   Kawai, T ^a,b  

^a FORSYTH INSTITUTE   (United States)

^b HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^c KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^d SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^e IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY   (Saudi Arabia)

^f UCLA SCHOOL OF DENTISTRY   (United States)

Author keywords

bisphosphonate induced osteonecrosis of the jaw; Fusobacterium nucleatum; gingival fibroblast; KGF; pamidronate; wound healing

Indexed keywords

ANTIINFECTIVE AGENT; BISPHOSPHONIC ACID DERIVATIVE; BONE DENSITY CONSERVATION AGENT; KERATINOCYTE GROWTH FACTOR; PAMIDRONIC ACID;

ANIMAL; APOPTOSIS; ARTICLE; BIOSYNTHESIS; BONE NECROSIS; CELL CULTURE; CELL MOTION; CELL SURVIVAL; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DISEASE MODEL; EPITHELIUM CELL; FEMALE; FIBROBLAST; FUSOBACTERIUM NUCLEATUM; GINGIVA; JAW DISEASE; METABOLISM; MICROBIOLOGY; MOUSE; PATHOGENICITY; SURGICAL INFECTION; TOOTH EXTRACTION;

ANIMALS; ANTI-BACTERIAL AGENTS; APOPTOSIS; BONE DENSITY CONSERVATION AGENTS; CELL MOVEMENT; CELL SURVIVAL; CELLS, CULTURED; DIPHOSPHONATES; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; FEMALE; FIBROBLAST GROWTH FACTOR 7; FIBROBLASTS; FUSOBACTERIUM NUCLEATUM; GINGIVA; JAW DISEASES; MICE; OSTEONECROSIS; SURGICAL WOUND INFECTION; TOOTH EXTRACTION;

EID: 80053650189     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034511420430     Document Type: Article

References (25)

1. Barasch A, Cunha-Cruz J, Curro FA, Hujoel P, Sung AH, Vena D, et al. Risk factors for osteonecrosis of the jaws: a case-control study from the CONDOR dental PBRN. J Dent Res. 2011 ; 90: 439-444
2. Bi Y, Gao Y, Ehirchiou D, Cao C, Kikuiri T, Le A, et al. Bisphosphonates cause osteonecrosis of the jaw-like disease in mice. Am J Pathol. 2010 ; 177: 280-290
3. Coleman RE. Risks and benefits of bisphosphonates. Br J Cancer. 2008 ; 98: 1736-1740 (Pubitemid 351748847)
4. Fellows JL, Rindal DB, Barasch A, Gullion CM, Rush W, Pihlstrom DJ, et al. ONJ in two dental practice-based research network regions. J Dent Res. 2011 ; 90: 433-438
5. Fournier P, Boissier S, Filleur S, Guglielmi J, Cabon F, Colombel M, et al. Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats. Cancer Res. 2002 ; 62: 6538-6544 (Pubitemid 35364119)
6. Hansen T, Kunkel M, Weber A, Kirkpatrick CJ. Osteonecrosis of the jaws in patients treated with bisphosphonates-histomorphologic analysis in comparison with infected osteoradionecrosis. J Oral Pathol Med. 2006 ; 35: 155-160
7. Hansen T, Kunkel M, Springer E, Walter C, Weber A, Siegel E, et al. Actinomycosis of the jaws-histopathological study of 45 patients shows significant involvement in bisphosphonate-associated osteonecrosis and infected osteoradionecrosis. Virchows Arch. 2007 ; 451: 1009-1017 (Pubitemid 350165265)
8. Kajiya M, Shiba H, Komatsuzawa H, Ouhara K, Fujita T, Takeda K, et al. The antimicrobial peptide LL37 induces the migration of human pulp cells: a possible adjunct for regenerative endodontics. J Endod. 2010 ; 36: 1009-1013
9. Kobayashi Y, Hiraga T, Ueda A, Wang L, Matsumoto-Nakano M, Hata K, et al. Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in mice. J Bone Miner Metab. 2010 ; 28: 165-175
10. Longo R, Castellana MA, Gasparini G. Bisphosphonate-related osteonecrosis of the jaw and left thumb. J Clin Oncol. 2009 ; 27: e242 - e243
11. Marx RE, Sawatari Y, Fortin M, Broumand V. Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg. 2005 ; 63: 1567-1575 (Pubitemid 41525412)
12. Mawardi H, Treister N, Richardson P, Anderson K, Munshi N, Faiella RA, et al. Sinus tracts-an early sign of bisphosphonate-associated osteonecrosis of the jaws?. J Oral Maxillofac Surg. 2009 ; 67: 593-601
13. Moreira MS, Katayama E, Bombana AC, Marques MM. Cytotoxicity analysis of alendronate on cultured endothelial cells and subcutaneous tissue. a pilot study. Dent Traumatol. 2005 ; 21: 329-335 (Pubitemid 41687773)
14. Polizzotto MN, Cousins V, Schwarer AP. Bisphosphonate-associated osteonecrosis of the auditory canal. Br J Haematol. 2006 ; 132: 114
15. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell. 2004 ; 118: 229-241 (Pubitemid 38962578)
16. Reid IR, Bolland MJ, Grey AB. Is bisphosphonate-associated osteonecrosis of the jaw caused by soft tissue toxicity?. Bone. 2007 ; 41: 318-320 (Pubitemid 47199147)
17. Reszka AA, Halasy-Nagy J, Rodan GA. Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation. Mol Pharmacol. 2001 ; 59: 193-202 (Pubitemid 32108550)
18. Rheinwald JG, Green H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell. 1975 ; 6: 331-343
19. Sedghizadeh PP, Kumar SK, Gorur A, Schaudinn C, Shuler CF, Costerton JW. Identification of microbial biofilms in osteonecrosis of the jaws secondary to bisphosphonate therapy. J Oral Maxillofac Surg. 2008 ; 66: 767-775 (Pubitemid 351381805)
20. Siris ES, Oster MW, Bilezikian JP. More on reports of esophageal cancer with oral bisphosphonate use. N Engl J Med. 2009 ; 360: 1791
21. Smola H, Thiekotter G, Fusenig NE. Mutual induction of growth factor gene expression by epidermal-dermal cell interaction. J Cell Biol. 1993 ; 122: 417-429 (Pubitemid 23210468)
22. Sonis ST, Watkins BA, Lyng GD, Lerman MA, Anderson KC. Bony changes in the jaws of rats treated with zoledronic acid and dexamethasone before dental extractions mimic bisphosphonate-related osteonecrosis in cancer patients. Oral Oncol. 2009 ; 45: 164-172
23. Werner S, Smola H. Paracrine regulation of keratinocyte proliferation and differentiation. Trends Cell Biol. 2001 ; 11: 143-146 (Pubitemid 32295911)
24. Woo SB, Mawardi H, Treister N. Comments on "Osteonecrosis of the jaws in intravenous bisphosphonate use: proposal for a modification of the clinical classification". Oral Oncol. 2009 ; 45: 740
25. Wood J, Bonjean K, Ruetz S, Bellahcene A, Devy L, Foidart JM, et al. Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid. J Pharmacol Exp Ther. 2002 ; 302: 1055-1061 (Pubitemid 34920226)