Age-by-disease biological interactions: Implications for late-life depression

Frontiers in Genetics

Volumn 3, Issue NOV, 2012, Pages

  McKinney, Brandon C ^a   Oh, Hyunjung ^a,b   Me, Etienne Sib ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Depression; Epigenetic modifications; Gene expression; Late life depression; Molecular aging; Oxidative stress; Telomere

Indexed keywords

EID: 84876129842     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2012.00237     Document Type: Article

References (91)

1. Abe, N., Uchida, S., Otsuki, K., Hobara, T., Yamagata, H., Higuchi, E, et al. (2011). Altered sirtuin deacetylase gene expression in patients with a mood disorder.J. Psychiatr. Res. 45, 1106-1112.
2. Ahmed, S., Passos, J. E, Birket, M. J., Beckmann, T., Brings, S., Peters, H., et al. (2008). Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress.J. Cell Sci. 121, 1046-1053.
3. Alexopoulos, G. S., Meyers, B. S., Young, R. C, Campbell, S., Silbersweig, D., and Charlson, M. (1997). "Vascular depression' hypothesis. Arch. Gen. Psychiatry 54,915-922.
4. Alexopoulos, G. S., and Morimoto, S. S. (2011). The inflammation hypothesis in geriatric depression. Int. J. Geri-atr. Psychiatry doi: 10.1002/gps.2672 [Epub ahead of print].
5. American Psychiatric Association. (2000). Diagnostic Criteria from DSM-IV-TR. Washington, DC: American Psychiatric Association.
6. Ammendola, R., Mesuraca, M., Russo, T., and Cimino, E (1992). Spl DNA binding efficiency is highly reduced in nuclear extracts from aged rat tissues. J. Biol Chem. 267,17944-17948.
7. Ammendola, R., Mesuraca, M., Russo, T., and Cimino, E (1994). The DNA-binding efficiency of Sp 1 is affected by redox changes. Eur. J. Biochem. 225, 483-489.
8. Avramopoulos, D., Szymanski, M., Wang, R., and Bassett.S. (2011). Gene expression reveals overlap between normal aging and Alzheimer's disease genes. Neurobiol. Aging 32,2319.e27-2319.e34.
9. Barascu, A., Le Chalony C, Pennarun, G., Genet, D., Imam, N., Lopez, B., et al. (2012). Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin Bl accumulation. EMBOJ. 31, 1080-1094.
10. Bhardwaj, R. D., Curtis, M. A., Spalding, K. L, Buchholz, B. A., Fink, D., Bjork-Eriksson, T., et al. (2006). Neocortical neurogenesis in humans is restricted to development. Proc. Natl. Acad. Sci. U.S.A. 103, 12564-12568.
11. Blalock, E. M., Chen, K. C, Sharrow, K., Herman, J. P., Porter, N. M., Foster, T. C, et al. (2003). Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment. j. Neurosci. 23, 3807-3819.
12. Bruchas, M. R., Schindler, A. G., Shankar, H., Messinger, D. I., Miy-atake, M., Land, B. B., et al. (2011). Selective p38alpha MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction. Neuron 71,498-511.
13. Byers, A. L., and Yaffe, K. (2011). Depression and risk of developing dementia. Nat. Rev. Neurol. 7, 323-331.
14. Chin, L., Artandi, S. E., Shen, Q., Tarn, A., Lee, S. L, Gottlieb, G. J., et al. (1999). p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97, 527-538.
15. Choi, J., Southworth, L. K., Sarin, K. Y, Venteicher, A. S., Ma, W., Chang, W, et al. (2008). TERT promotes epithelial proliferation through transcriptional control of a Myc-and Wnt-related developmental program. PLoS Genet. 4, el0. doi: 10.1371/journal.pgen.0040010
16. Covington, H. E. Ill, Maze, I., Sun, H., Bomze, H. M., Demaio, K. D., Wu, E. Y, et al. (2011). A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron 71, 656-670.
17. Dombrovski, A. Y, Mulsant, B. H., Houck, P. R., Mazumdar, S., Lenze, E. J., Andreescu, C, et al. (2007). Residual symptoms and recurrence during maintenance treatment of late-life depression. J. Affect. Disord. 103, 77-82.
18. Douillard-Guilloux, G., Guilloux, J. P., Lewis, D. A., and Sibille, E. (2012). Anticipated brain molecular aging in major depression. Am. J. Geriatr. Psychiatry doi: 10.1097/JGP. 0b013e318266b7ad [Epub ahead of print].
19. Epel, E. S. (2009). Psychological and metabolic stress: a recipe for accelerated cellular aging? Hormones (Athens) 8, 7-22.
20. Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, E S., Adler, N. E., Morrow, J. D., et al. (2004). Accelerated telomere shortening in response to life stress. Proc. Natl. Acad. Sci. U.S.A. 101,17312-17315.
21. Erraji-Benchekroun, L., Underwood, M. D., Arango, V., Galfalvy, H., Pavlidis, P., Smyrniotopoulos, P., et al. (2005). Molecular aging in human prefrontal cortex is selective and continuous throughout adult life. Biol. Psychiatry 57, 549-558.
22. Ferron, S. R., Marques-Torrejon, M. A., Mira, H., Flores, I., Taylor, K., Blasco, M. A., et al. (2009). Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis. J. Neurosci. 29, 14394-14407.
23. Flores, I., and Blasco, M. A. (2009). A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres. PLoS ONE 4, e4934. doi: 10.1371/journal.pone.0004934
24. Fu, W, Lu, C, and Mattson, M. P. (2002). Telomerase mediates the cell survival-promoting actions of brain-derived neurotrophic factor and secreted amyloid precursor protein in developing hippocampal neurons. J. Neurosci. 22, 10710-10719.
25. Ganguli, M., Dodge, H. H., and Mulsant, B. H. (2002). Rates and predictors of mortality in an aging, rural, community-based cohort: the role of depression. Arch. Gen. Psychiatry 59, 1046-1052.
26. Glorioso, C, Oh, S., Douillard, G. G., and Sibille, E. (2011). Brain molecular aging, promotion of neurological disease and modulation by sirtuin 5 longevity gene polymorphism. Neurobiol. Dis. 41,279-290.
27. Glorioso, C, and Sibille, E. (2011). Between destiny and disease: genetics and molecular pathways of human central nervous system aging. Prog. Neurobiol. 93, 165-181.
28. Good, C. D., Johnsrude, I. S., Ashburner, J., Henson, R. N., Friston, K. J., and Frackowiak, R. S. (2001). A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 14,21-36.
29. Guilloux, J. P., Douillard-Guilloux, G., Kota, R., Wang, X., Gardier, A. M., Martinowich, K., et al. (2011). Molecular evidence for BDNF-and GABA-related dysfunctions in the amygdala of female subjects with major depression. Mol. Psychiatry doi: 10.1038/mp.2011.113 [Epub ahead of print].
30. Haendeler, J., Hoffmann, J., Diehl, J. E, Vasa, M., Spyridopoulos, I., Zeiher, A. M., et al. (2004). Antioxi-dants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells. Circ. Res. 94, 768-775.
31. Hayflick, L., and Moorhead, P. S. (1961). The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585-621.
32. Issa, J. P., Ottaviano, Y L., Celano, P., Hamilton, S. R., Davidson, N. E., and Baylin, S. B. (1994). Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat. Genet. 7, 536-540.
33. Issa, J. P., Vertino, P. M., Boehm, C. D., Newsham, I. E, and Baylin, S. B. (1996). Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis. Proc. Natl. Acad. Sci. U.S.A. 93, 11757-11762.
34. Jiang, C. H., Tsien, J. Z., Schultz, P. G., and Hu, Y (2001). The effects of aging on gene expression in the hypothalamus and cortex of mice. Proc. Natl. Acad. Sci. U.S.A. 98, 1930-1934.
35. Joseph, J. A., Shukitt-Hale, B., Casadesus, G., and Fisher, D. (2005). Oxidative stress and inflammation in brain aging: nutritional considerations. Neurochem. Res. 30, 927-935.
36. Jucker, M., and Ingram, D. K. (1997). Murine models of brain aging and age-related neurodegenerative diseases. Behav. Brain Res. 85, 1-26.
37. Kanfi, Y, Naiman, S., Amir, G., Peshti, V., Zinman, G., Nahum, L., et al. (2012). The sirtuin SIRT6 regulates lifespan in male mice. Nature 483, 218-221.
38. Kanfi, Y, Peshti, V., Gil, R., Naiman, S., Nahum, L, Levin, E., et al. (2010). SIRT6 protects against pathological damage caused by diet-induced obesity. Aging Cell 9, 162-173.
39. Kang, H. J., Choi, Y S., Hong, S. B., Kim, K. W., Woo, R. S., Won, S. J., et al. (2004). Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity. J. Neurosci. 24, 1280-1287.
40. Kasahara, T., Kubota, M., Miyauchi, T., Noda, Y., Mouri, A., Nabeshima, T., et al. (2006). Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes. Mol. Psychiatry 11,577-593.
41. Kawahara, T. L., Michishita, E., Adler, A. S., Damian, M., Berber, E., Lin, M., et al. (2009). SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell 136,62-74.
42. Kessler, R. C, Berglund, P., Dernier, O., Jin, R., Koretz, D., Merikangas, K. R., et al. (2003). The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 289, 3095-3105.
43. Koenig, H. G., and Blazer, D. G. (1992). Epidemiology of geriatric affective disorders. Clin. Geriatr. Med. 8, 235-251.
44. Koo, J. W., Russo, S. J., Ferguson, D., Nestler, E. J., and Duman, R. S. (2010). Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc. Natl. Acad. Sci. U.S.A. 107, 2669-2674.
45. Lee, C. K., Klopp, R. G., Weindruch, R., and Prolla, T. A. (1999). Gene expression profile of aging and its retardation by caloric restriction. Science 285, 1390-1393.
46. Lee, C. K., Weindruch, R., and Prolla, T. A. (2000). Gene-expression profile of the ageing brain in mice. Nat. Genet. 25,294-297.
47. Lee,H. C.,and Wei,Y.H. (2007). Oxida-tive stress, mitochondrial DNA mutation, and apoptosis in aging. Exp. Biol. Med. (Maywood) 232, 592-606.
48. Lenze, E. J., Schulz, R., Martire, L. M., Zdaniuk, B., Glass, T., Kop, W. J., et al. (2005). The course of functional decline in older people with persistently elevated depressive symptoms: longitudinal findings from the Cardiovascular Health Study. J. Am. Geriatr. Soc. 53, 569-575.
49. Libert, S., Pointer, K., Bell, E. L, Das, A., Cohen, D. E., Asara, J. M., et al. (2011). SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive. Cell 147, 1459-1472.
50. Lin, M. T., Simon, D. K., Ahn, C. H., Kim, L. M., and Beal, M. F. (2002). High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain. Hum. Mol. Genet. 11, 133-145.
51. Longo, V. D., and Kennedy, B. K. (2006). Sirtuins in aging and age-related disease. Cell 126, 257-268.
52. Lu, T., Pan, Y., Kao, S. Y., Li, C, Kohane, I., Chan, J., et al. (2004). Gene regulation and DNA damage in the ageing human brain. Nature 429, 883-891.
53. Lundberg, A. S., Hahn, W. C, Gupta, P., andWeinberg.R.A. (2000). Genes involved in senescence and immortalization. Curr. Opin. Cell Biol. 12, 705-709.
54. Mao, Z., Hine, C, Tian, X., Van Meter, M., Au, M., Vaidya, A., et al. (2011). SIRT6 promotes DNA repair under stress by activating PARP1. Science 332,1443-1446.
55. McGowan, P. O., Sasaki, A., D'Alessio, A. C, Dymov, S., Labonte, B., Szyf, M., et al. (2009). Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat. Neurosci. 12, 342-348.
56. McKinney, B. C, and Sibille, E. (2012). The age-by-disease interaction hypothesis of late-life depression. Am. J. Geriatr. Psychiatry doi: 10.1097/JGP.0b013e31826ce80d [Epub ahead of print].
57. Michishita, E., Mccord, R. A., Berber, E., Kioi, M., Padilla-Nash, H., Damian, M., et al. (2008). SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 452,492-496.
58. Miller, J. A., Oldham, M. C, and Geschwind, D. H. (2008). A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging. J. Neurosci. 28, 1410-1420.
59. Morris, H. M., Hashimoto, T., and Lewis, D. A. (2008). Alterations in somatostatin mRNA expression in the dorsolateral prefrontal cortex of subjects with schizophrenia or schizoaffective disorder. Cereb. Cortex 18, 1575-1587.
60. Morrison, J. H., and Hof, P. R. (1997). Life and death of neurons in the aging brain. Science 278, 412-419.
61. Numata, S., Ye, T., Hyde, T. M., Guitart-Navarro, X., Tao, R., Wininger, M., et al. (2012). DNA methylation signatures in development and aging of the human prefrontal cortex. Am. J. Hum. Genet. 90, 260-272.
62. Pakkenberg, B., and Gundersen, H. J. (1997). Neocortical neuron number in humans: effect of sex and age.J. Comp. Neurol. 384, 312-320.
63. Peters, A. (2002). Structural changes in the normally aging cerebral cortex of primates. Prog. Brain Res. 136, 455-465.
64. Resnick, S. M., Pham, D. L., Kraut, M. A., Zonderman, A. B., and Davatzikos, C. (2003). Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain. J. Neurosci. 23,3295-3301.
65. Rezin, G. T., Amboni, G., Zugno, A. I., Quevedo, J., and Streck, E. L. (2009). Mitochondrial dysfunction and psychiatric disorders. Neurochem. Res. 34, 1021-1029.
66. Sahin, E., and DePinho, R. A. (2012). Axis of ageing: telomeres, p53 and mitochondria. Nat. Rev. Mol. Cell Biol. 13,397-404.
67. Santarelli, L., Saxe, M., Gross, C, Sur-get, A., Battaglia, F., Dulawa, S., et al. (2003). Requirement of hippocam-pal neurogenesis for the behavioral effects of antidepressants. Science 301,805-809.
68. Saretzki, G. (2009). Telomerase, mitochondria and oxidative stress. Exp. Gerontol. AA, 485-492.
69. Schapira, A. H. (2008). Mitochondria in the aetiology and pathogenesis of Parkinson's disease. Lancet Neurol. 7, 97-109.
70. Sen, S., Duman, R., and Sanacora, G. (2008). Serum brain-derived neu-rotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol. Psychiatry 64,527-532.
71. Sharpless, N. E., and DePinho, R. A. (2004). Telomeres, stem cells, senescence, and cancer. J. Clin. Invest. 113, 160-168.
72. Sibille, E., Morris, H. M., Kota, R. S., and Lewis, D. A. (2011). GABA-related transcripts in the dorsolateral prefrontal cortex in mood disorders. Int. J. Neuropsycho-pharmacol. 14,721-734.
73. Sibille, E., Su, J., Leman, S., Le Guis-quet, A. M., Ibarguen-Vargas, Y, Joeyen-Waldorf, J., et al. (2007). Lack of serotoniniB receptor expression leads to age-related motor dysfunction, early onset of brain molecular aging and reduced longevity. Mol. Psychiatry 12, 1042-1056.
74. Smith, L. L., Coller, H. A., and Roberts, J. M. (2003). Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat. Cell Biol. 5,474-479.
75. So, K., Tamura, G., Honda, T., Homma, N.,Waki,T.,Togawa,N.,et al. (2006). Multiple tumor suppressor genes are increasingly methylated with age in non-neoplastic gastric epithe-lia. Cancer Sci. 97, 1155-1158.
76. Sowell, E. R., Peterson, B. S., Thompson, P. M., Welcome, S. E., Henkenius, A. L, and Toga, A. W. (2003). Mapping cortical change across the human life span. Nat.Neurosci. 6, 309-315.
77. Tennen, R. I., Bua, D. J., Wright, W E., and Chua, K. F. (2011). SIRT6 is required for maintenance of telomere position effect in human cells. Nat. Commun. 2,433.
78. Toliver-Kinsky, T., Papaconstantinou, J., and Perez-Polo, J. R. (1997). Age-associated alterations in hippocam-pal and basal forebrain nuclear factor kappa B activity. J. Neurosci. Res. 48, 580-587.
79. Trifunovic, A., Wredenberg, A., Falken-berg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., et al. (2004). Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429,417-423.
80. Tripp, A., Kota, R. S., Lewis, D. A., and Sibille, E. (2011). Reduced somatostatin in subgenual anterior cingulate cortex in major depression. Neuro-biol. Dis.A 2, 116-124.
81. Uchida, S., Hara, K., Kobayashi, A., Otsuki, K., Yamagata, H., Hobara, T., et al. (2011). Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events. Neuron 69, 359-372.
82. Van Orden, K., and Conwell, Y. (2011). Suicides in late life. Curr. Psychiatry Rep. 13,234-241.
83. Viollet, C, Lepousez, G., Loudes, C, Videau, C, Simon, A., and Epel-baum, J. (2008). Somatostatinergic systems in brain: networks and functions. Mol. Cell. Endocrinol. 286, 75-87.
84. Wagner, E. E, and Nebreda, A. R. (2009). Signal integration by JNK and p38 MAPK pathways in cancer development. Nat. Rev. Cancer 9, 537-549.
85. Webster, M. J., Weickert, C. S., Herman, M. M., and Kleinman, J. E. (2002). BDNF mRNA expression during postnatal development, maturation and aging of the human prefrontal cortex. Dev. Brain Res. 139, 139-150.
86. Wolkowitz, O. M., Mellon, S. H., Epel, E. S., Lin, J., Dhabhar, F. S., Su, Y, et al. (2011a). Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress -preliminary findings. PLoS ONE 6, el7837. doi: 10.1371/joumal.pone.0017837
87. Wolkowitz, O. M., Reus, V I., and Mellon, S. H. (2011b). Of sound mind and body: depression, disease, and accelerated aging. Dialogues Clin. Neurosci. 13,25-39.
88. Wu, X., Bishopric, N. H., Discher, D. J., Murphy, B. J., and Webster, K. A. (1996). Physical and functional sensitivity of zinc finger transcription factors to redox change. Mol. Cell. Biol. 16, 1035-1046.
89. Yankner, B. A., Lu, T., and Loerch, P. (2008). The aging brain. Annu. Rev. Pathol. 3,41-66.
90. Zeng, Y, Tan, M., Kohyama, J., Sned-don, M., Watson, J. B., Sun, Y. E., et al. (2011). Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging. J. Neurosci. 31, 17800-17810.
91. Zhou, Q. G., Hu, Y, Wu, D. L., Zhu, L. J., Chen, C, Jin, X., et al. (2011). Hip-pocampal telomerase is involved in the modulation of depressive behaviors.J Neurosci. 31, 12258-12261.