Recent insights into the cell biology of thyroid angiofollicular units

Endocrine Reviews

Volumn 34, Issue 2, 2013, Pages 209-238

  Colin, Ides M ^a   Denef, Jean François ^a   Lengelé, Benoit ^a   Many, Marie Christine ^a   Gérard, Anne Catherine ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ENDOTHELIN 1; HYPOXIA INDUCIBLE FACTOR; IODIDE; IODINE; IODINE 123; NITRIC OXIDE; PENDRIN; PHOSPHATIDYLINOSITOL 3 KINASE; POTASSIUM CHANNEL KCNE2; POTASSIUM CHANNEL KCNQ1; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TECHNETIUM 99M; THYROGLOBULIN; THYROID HORMONE; THYROTROPIN; THYROXINE; VASCULOTROPIN;

AMINO TERMINAL SEQUENCE; ANGIOFOLLICULAR UNIT; ANGIOGENESIS; APICAL MEMBRANE; AUTOREGULATION; BIOCHEMISTRY; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CELL FUNCTION; CELL HETEROGENEITY; CELL POLARITY; CELL PROLIFERATION; CELL STRUCTURE; COLLOID; CONGENITAL HYPOTHYROIDISM; CYTOLOGY; DIETARY INTAKE; ENDOCRINE FUNCTION; ENVIRONMENTAL FACTOR; GENE MUTATION; GENETIC ASSOCIATION; GRAVES DISEASE; HEREDITY; HUMAN; IODINE DEFICIENCY; MICROVASCULATURE; MICROVILLUS; NODULAR GOITER; NONHUMAN; NUTRIENT SUPPLY; OXYGEN SUPPLY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; THYROID CANCER; THYROID FOLLICLE; THYROID FOLLICLE CELL; THYROID FUNCTION; THYROID GLAND; THYROID HORMONE SYNTHESIS; TOXIC GOITER;

GOITER, NODULAR; HUMANS; IODINE; NEOVASCULARIZATION, PHYSIOLOGIC; THYROID GLAND; THYROID HORMONES;

EID: 84876068519     PISSN: 0163769X     EISSN: None     Source Type: Journal    
DOI: 10.1210/er.2012-1015     Document Type: Review

References (357)

1. Boelaert K, Franklyn JA. 2005 Thyroid hormone in health and disease. J Endocrinol 187:1-15
2. Zimmermann MB. 2011 The role of iodine in human growth and development. Semin Cell Dev Biol 22:645-652
3. Zimmermann MB. 2009 Iodine deficiency. Endocr Rev 30: 376-408
4. Courtois B. 1813 Découverte d'une substance nouvelle dans le Vareck. Ann Chim (Paris) 88:304-310
5. Taurog A. 2004 Iodine. In: Martini L, ed. Encyclopedia of endocrine diseases. New York: Academic Press; 82-88
6. Kendall E. 1914 The determination of iodine in connection with studies in thyroid activity. J Biol Chem 19:251-256
7. Houston R. 1999 Iodine: physiology, dietary sources and requirements. In: Strain JJ, Caballero B, eds. Encyclopedia of human nutrition. London: Academic Press; 66-74
8. Muramatsu Y, Wedepohl KH. 1998 The distribution of iodine in the earth's crust. Chem Geol 147:201-216
9. Osterc A, Stibilj V, Raspor P. 2011 Iodine in the environment. In: Nriagu J, ed. Encyclopedia of environmental health. Amsterdam, London: Elsevier; 280-287
10. Venturi S, Venturi M. 1999 Iodide, thyroid and stomach carcinogenesis: evolutionary story of a primitive antioxidant Eur J Endocrinol 140:371-372
11. Küpper FC, Carpenter LJ, McFiggans GB, Palmer CJ, Waite TJ, Boneberg EM, Woitsch S, Weiller M, Abela R, Grolimund D, Potin P, Butler A, Luther 3rd GW, Kroneck PM, Meyer-Klaucke W, Feiters MC.2008 Iodide accumulation provides kelp with an inorganic antioxidant impacting atmospheric chemistry. Proc Natl Acad Sci USA 105: 6954-6958
12. Lin RY. 2011 Thyroid cancer stem cells. Nat Rev Endocrinol 7:609-616
13. Kluge B, Renault N, Rohr KB. 2005 Anatomical and molecular reinvestigation of lamprey endostyle development provides new insight into thyroid gland evolution. Dev Genes Evol 215:32-40
14. Müller W. 1873 Über die Hypobranchialrinne der Tunicaten und deren Vorhandenstein bei Amphioxus und den Cyclostomen. Jena Z Med Naturw 7:327-332
15. Suzuki S, Kondo Y. 1973 Thyroidal morphogenesis and biosynthesis of thyroglobulin before and after metamorphasis in the lamprey, Lampetra reissneri. Gen Comp Endocrinol 21:451-460
16. Fujita H, Honma Y. 1969 Iodine metabolism of the endostyle of larval lampreys, Ammocoetes of Lampetra japonica. Electron microscopic autoradiography of 125-I. Z Zellforsch Mikrosk Anat 98:525-537
17. Wright GM, Filosa MF, Youson JH. 1978 Immunocytochemical localization of thyroglobulin in the endostyle of the anadromous sea lamprey, Petromyzon marinus L. Am J Anat 152:263-268
18. Wright GM, Filosa MF, Youson JH. 1978 Light and electron microscopic immunocytochemical localization of thyroglobulin in the thyroid gland of the anadromous sea lamprey, Petromyzon marinus L., during its upstream migration. Cell Tissue Res 187:473-478
19. Wright GM, Filosa MF, Youson JH. 1980 Immunocytochemical localization of thyroglobulin in the transforming endostyle of anadromous sea lampreys, Petromyzon marinus L., during metamorphosis. Gen Comp Endocrinol 42:187-194
20. Dunn AD. 1980 Properties of an iodinating enzyme in the ascidian endostyle. Gen Comp Endocrinol 40:484-493
21. Ogasawara M, Di Lauro R, Satoh N. 1999 Ascidian homologs of mammalian thyroid peroxidase genes are expressed in the thyroid-equivalent region of the endostyle. J Exp Zool 285:158-169
22. Ogasawara M. 2000 Overlapping expression of amphioxus homologs of the thyroid transcription factor-1 gene and thyroid peroxidase gene in the endostyle: insight into evolution of the thyroid gland. Dev Genes Evol 210:231-242.
23. Ogasawara M, Shigetani Y, Suzuki S, Kuratani S, Satoh N. 2001 Expression of thyroid transcription factor-1 (TTF-1) gene in the ventral forebrain and endostyle of the agnathan vertebrate, Lampetra japonica. Genesis 30:51-58
24. McCauley DW, Bronner-Fraser M. 2002 Conservation of Pax gene expression in ectodermal placodes of the lamprey. Gene 287:129-139
25. Venturi S, Donati FM, Venturi A, Venturi M. 2000 Environmental iodine deficiency: a challenge to the evolution of terrestrial life Thyroid 10:727-729
26. De Felice M, Di Lauro R. 2004 Thyroid development and its disorders: genetics and molecular mechanisms. Endocr Rev 25:722-746
27. De Felice M, Di Lauro R. 2011 Intrinsic and extrinsic factors in thyroid gland development: an update. Endocrinology 152:2948-2956
28. Dumont JE, Opitz R, Christophe D, Vassart G, Roger PP, Maenhaut C. 2008 The phylogeny, ontogeny, anatomy and regulation of the iodine metabolizing thyroid. In: DeGroot LJ, ed. Thyroid disease manager. South Dartmouth, MA: Endocrine Education, Inc.; 1-109
29. Cocchi M, Venturi S. 2000 Iodide, antioxidant function and omega-6 and omega-3 fatty acids: a new hypothesis of a biochemical cooperation Prog Nutr 2:15-19
30. Venturi S. 2001 Is there a role for iodine in breast diseases? Breast 10:379-382
31. Smyth PP. 2003 Role of iodine in antioxidant defence in thyroid and breast disease. Biofactors 19:121-130
32. Burek CL, Talor MV. 2009 Environmental triggers of autoimmune thyroiditis. J Autoimmun 33:183-189
33. Zimmermann MB, Jooste PL, Pandav CS. 2008 Iodine-deficiency disorders. Lancet 372:1251-1262
34. - symporter mediates active iodide uptake in the intestine. Am J Physiol Cell Physiol 296:C654-C662
35. Dunn JT. 1998 What's happening to our iodine? J Clin Endocrinol Metab 83:3398-3400
36. Dai G, Levy O, Carrasco N. 1996 Cloning and characterization of the thyroid iodide transporter. Nature 379:458-460
37. Smanik PA, Liu Q, Furminger TL, Ryu K, Xing S, Mazzaferri EL, Jhiang SM. 1996 Cloning of the human sodium lodide symporter. Biochem Biophys Res Commun 226: 339-345
38. Bizhanova A, Kopp P. 2009 The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid. Endocrinology 150:1084-1090
39. - symporter. Mechanism, stoichiometry, and specificity. J Biol Chem 272:27230-27238
40. +/I symporter (NIS) mediates electroneutral active transport of the environmental pollutant perchlorate. Proc Natl Acad Sci USA 104: 20250-20255
41. - symporter (NIS). Proc Natl Acad Sci USA 108:17933-17938
42. Riedel C, Levy O, Carrasco N. 2001 Post-transcriptional regulation of the sodium/iodide symporter by thyrotropin. J Biol Chem 276:21458-21463
43. - symporter mRNAs in dog thyroid. Mol Cell Endocrinol 131:195-203
44. Eng PH, Cardona GR, Fang SL, Previti M, Alex S, Carrasco N, Chin WW, Braverman LE. 1999 Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein. Endocrinology 140:3404-3410
45. Eng PH, Cardona GR, Previti MC, Chin WW, Braverman LE. 2001 Regulation of the sodium iodide symporter by iodide in FRTL-5 cells. Eur J Endocrinol 144:139-144
46. Serrano-Nascimento C, Calil-Silveira J, Goulart-Silva F, Nunes MT. 2012 New insights about the posttranscriptional mechanisms triggered by iodide excess on sodium/ iodide symporter (NIS) expression in PCCl3 cells. Mol Cell Endocrinol 349:154-161
47. Wolff J, Chaikoff IL. 1948 Plasma inorganic iodide as a homeostatic regulator of thyroid function. J Biol Chem 174:555-564
48. Bernier-Valentin F, Trouttet-Masson S, Rabilloud R, Selmi-Ruby S, Rousset B. 2006 Three-dimensional organization of thyroid cells into follicle structures is a pivotal factor in the control of sodium/iodide symporter expression. Endocrinology 147:2035-2042
49. [2009] Iodide deficiency-induced angiogenic stimulus in the thyroid occurs via HIFand ROS-dependent VEGF-A secretion from thyrocytes. Am J Physiol Endocrinol Metab 296:E1414-E1422
50. Gérard AC, Humblet K, Wilvers C, Poncin S, Derradji H, de Ville de Goyet C, Abou-el-Ardat K, Baatout S, Sonveaux P, Denef JF, Colin IM. 2012 Iodine-deficiency-induced long lasting angiogenic reaction in thyroid cancers occurs via a vascular endothelial growth factor-hypoxia inducible factor-1-dependent, but not a reactive oxygen speciesdependent, pathway. Thyroid 22:699-708
51. Roepke TK, King EC, Reyna-Neyra A, Paroder M, Purtell K, Koba W, Fine E, Lerner DJ, Carrasco N, Abbott GW. 2009 Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis. Nat Med 15:1186-1194
52. + channel is required for adequate thyroid Iuptake. FASEB J 26:3252-3259
53. De La Vieja A, Dohan O, Levy O, Carrasco N. 2000 Molecular analysis of the sodium/iodide symporter: impact on thyroid and extrathyroid pathophysiology. Physiol Rev 80:1083-1105
54. Dohán O, De la Vieja A, Paroder V, Riedel C, Artani M, Reed M, Ginter CS, Carrasco N. 2003 The sodium/iodide symporter (NIS): characterization, regulation, and medical significance. Endocr Rev 24:48-77
55. Everett LA, Glaser B, Beck JC, Idol JR, Buchs A, Heyman M, Adawi F, Hazani E, Nassir E, Baxevanis AD, Sheffield VC, Green ED. 1997 Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS). Nat Genet 17:411-422
56. Royaux IE, Suzuki K, Mori A, Katoh R, Everett LA, Kohn LD, Green ED. 2000 Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells. Endocrinology 141:839-845
57. Scott DA, Wang R, Kreman TM, Sheffield VC, Karniski LP. 1999 The Pendred syndrome gene encodes a chloride-iodide transport protein. Nat Genet 21:440-443
58. Pesce L, Bizhanova A, Caraballo JC, Westphal W, Butti ML, Comellas A, Kopp P. 2012 TSH regulates Pendrin membrane abundance and enhances iodide efflux in thyroid cells. Endocrinology 153:512-521
59. Kopp P, Bizhanova A. 2011 Clinical and molecular characteristics of Pendred syndrome. Ann Endocrinol (Paris) 72:88-94
60. van den Hove MF, Croizet-Berger K, Jouret F, Guggino SE, Guggino WB, Devuyst O, Courtoy PJ. 2006 The loss of the chloride channel, ClC-5, delays apical iodide efflux and induces a euthyroid goiter in the mouse thyroid gland. Endocrinology 147:1287-1296
61. Bizhanova A, Kopp P. 2011 Controversies concerning the role of pendrin as an apical iodide transporter in thyroid follicular cells. Cell Physiol Biochem 28:485-490
62. Twyffels L, Massart C, Golstein PE, Raspe E, Van Sande J, Dumont JE, Beauwens R, Kruys V. 2011 Pendrin: the thyrocyte apical membrane iodide transporter Cell Physiol Biochem 28:491-496
63. Fong P. 2011 Thyroid iodide efflux: a team effort? J Physiol 589:5929-5939
64. +-monocarboxylate cotransporter. J Physiol 557:719-731
65. +-coupled transporter for short-chain fatty acids. J Biol Chem 279:13293-13296
66. +/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: molecular characterization of SMCT. Proc Natl Acad Sci USA 103:7270-7275
67. Rodriguez AM, Perron B, Lacroix L, Caillou B, Leblanc G, Schlumberger M, Bidart JM, Pourcher T. 2002 Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes. J Clin Endocrinol Metab 87:3500-3503
68. Rivolta CM, Targovnik HM. 2006 Molecular advances in thyroglobulin disorders. Clin Chim Acta 374:8-24
69. Malthiéry Y, Lissitzky S. 1987 Primary structure of human thyroglobulin deduced from the sequence of its 8448-base complementary DNA. Eur J Biochem 165:491-498
70. Lee J, Wang X, Di Jeso B, Arvan P. 2009 The cholinesteraselike domain, essential in thyroglobulin trafficking for thyroid hormone synthesis, is required for protein dimerization. J Biol Chem 284:12752-12761.
71. Vono-Toniolo J, Rivolta CM, Targovnik HM, MedeirosNeto G, Kopp P. 2005 Naturally occurring mutations in the thyroglobulin gene. Thyroid 15:1021-1033
72. Suzuki K, Kawashima A, Yoshihara A, Akama T, Sue M, Yoshida A, Kimura HJ. 2011 Role of thyroglobulin on negative feedback autoregulation of thyroid follicular function and growth. J Endocrinol 209:169-174
73. Kimura S, Hong YS, Kotani T, Ohtaki S, Kikkawa F. 1989 Structure of the human thyroid peroxidase gene: comparison and relationship to the human myeloperoxidase gene. Biochemistry 28:4481-4489
74. Arnljots K, Olsson I. 1987 Myeloperoxidase precursors incorporate heme. J Biol Chem 262:10430-10433
75. 2 generated at the apical surface of thyroid cells in autocatalytic covalent heme binding. J Biol Chem 274:10533-10538
76. Niccoli P, Fayadat L, Panneels V, Lanet J, Franc JL. 1997 Human thyroperoxidase in its alternatively spliced form (TPO2) is enzymatically inactive and exhibits changes in intracellular processing and trafficking. J Biol Chem 272: 29487-29492
77. Taurog A, Wall M. 1998 Proximal and distal histidines in thyroid peroxidase: relation to the alternatively spliced form, TPO-2. Thyroid 8:185-191
78. Kuliawat R, Ramos-Castañeda J, Liu Y, Arvan P. 2005 Intracellular trafficking of thyroid peroxidase to the cell surface. J Biol Chem 280:27713-27718
79. Ahn CS, Rosenberg IN. 1971 Oxidation of 14C-formate in thyroid slices: effects of TSH, dibutyric cyclic 30,50-AMP (dbc-AMP) and prostaglandin E1 (PGE1). In: Hofer K, Fellinger R, eds. Vienna: Verlag Der Wiener Medizinischen Akademie; 825-837
80. Bénard B, Brault J. 1971 [Production of peroxide in the thyroid]. Union Med Can 100:701-705 (French)
81. Björkman U, Ekholm R, Denef JF. 1981 Cytochemical localization of hydrogen peroxide in isolated thyroid follicles. J Ultrastruct Res 74:105-115
82. 2 in isolated porcine thyroid follicles. Endocrinology 115:392398
83. Dupuy C, Ohayon R, Valent A, Noël-Hudson MS, Dème D, Virion A. 1999 Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas. J Biol Chem 274:37265-37269
84. De Deken X, Wang D, Many MC, Costagliola S, Libert F, Vassart G, Dumont JE, Miot F. 2000 Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. J Biol Chem 275:23227-23233
85. Lambeth JD. 2002 Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases. Curr Opin Hematol 9:11-17
86. Geiszt M, Witta J, Baffi J, Lekstrom K, Leto TL. 2003 Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. FASEB J 17:15021504
87. Geiszt M, Leto TL. 2004 The Nox family of NAD(P)H oxidases: host defense and beyond. J Biol Chem 279: 51715-51718
88. Meitzler JL, Ortiz de Montellano PR. 2009 Caenorhabditis elegans and human dual oxidase 1 (DUOX1) "peroxidase" domains: insights into heme binding and catalytic activity. J Biol Chem 284:18634-18643
89. Meitzler JL, Ortiz de Montellano PR. 2011 Structural stability and heme binding potential of the truncated human dual oxidase 2 (DUOX2) peroxidase domain. Arch Biochem Biophys 512:197-203
90. 2 generation catalyzed by thyroid plasma membranes. Studies with electron scavengers. Eur J Biochem 185:597-603
91. 2-generating system. Exp Cell Res 273:187-196
92. Morand S, Chaaraoui M, Kaniewski J, Dème D, Ohayon R, Noel-Hudson MS, Virion A, Dupuy C. 2003 Effect of iodide on nicotinamide adenine dinucleotide phosphate oxidase activity and Duox2 protein expression in isolated porcine thyroid follicles. Endocrinology 144:1241-1248 93.
93. Dupuy C, Virion A, Ohayon R, Kaniewski J, Dème D, Pommier J. 1991 Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane. J Biol Chem 266:3739-3743
94. 2-generating activity. J Biol Chem 280:30046-30054 95.
95. Forteza R, Salathe M, Miot F, Forteza R, Conner GE. 2005 Regulated hydrogen peroxide production by Duox in human airway epithelial cells. Am J Respir Cell Mol Biol 32:462-469
96. Rigutto S, Hoste C, Grasberger H, Milenkovic M, Communi D, Dumont JE, Corvilain B, Miot F, De Deken X. 2009 Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation. J Biol Chem 284:6725-6734
97. 2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult. J Endocrinol 192:615-626
98. Grasberger H, Refetoff S. 2006 Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent. J Biol Chem 281:18269-18272
99. Hoste C, Dumont JE, Miot F, De Deken X. 2012 The type of DUOX-dependent ROS production is dictated by defined sequences in DUOXA. Exp Cell Res 318:2353-2364 100.
100. Moreno JC, Bikker H, Kempers MJ, van Trotsenburg AS, Baas F, de Vijlder JJ, Vulsma T, Ris-Stalpers C. 2002 Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism. N Engl J Med 347:95-102
101. Maruo Y, Takahashi H, Soeda I, Nishikura N, Matsui K, Ota Y, Mimura Y, Mori A, Sato H, Takeuchi Y. 2008 Transient congenital hypothyroidism caused by biallelic mutations of the dual oxidase 2 gene in Japanese patients detected by a neonatal screening program. J Clin Endocrinol Metab 93:4261-4267
102. 2-generating enzyme DUOX2 associated with transient congenital hypothyroidism. Hum Mutat 31: E1304-E1319
103. 2 generation in thyroid slices from several species. Am J Physiol Endocrinol Metab 278:E692-E699
104. 2 production by iodoaldehydes in cultured dog thyroid cells. Mol Cell Endocrinol 102:167-176
105. 2 generation. Biochem Biophys Res Commun 154:1287-1292
106. Thomasz L, Oglio R, Rivandeira DT, Dagrosa MA, Jahn G, Pignataro OP, Piganataro OP, Sartorio G, Pisarev MA, Juvenal. GJ 2010 Inhibition of goiter growth and of cyclic AMP formation in rat thyroid by 2-iodohexadecanal. Mol Cell Endocrinol 317:141-147
107. Thomasz L, Oglio R, Dagrosa MA, Krawiec L, Pisarev MA, Juvenal GJ. 2010 6 Iodo-delta-lactone reproduces many but not all the effects of iodide. Mol Cell Endocrinol 323:161-166
108. Panneels V, Van Sande J, Van den Bergen H, Jacoby C, Braekman JC, Dumont JE, Boeynaems JM. 1994 Inhibition of human thyroid adenylyl cyclase by 2-iodoaldehydes. Mol Cell Endocrinol 106:41-50
109. Pisarev MA, Gartner R. 2000 Autoregulatory action of iodine. In: Braverman LE, Utigers RD, eds. The thyroid. 9th ed. Philadelphia: Lippincott; 85-90
110. Panneels V, Juvenal G, Boeynaems JM, Dumont JE, Van Sande J. 2009 Iodide effects on the thyroid. In: Preedy VR, Burrow GN, Watson R, eds. Comprehensive handbook of iodine: nutritional, endocrine, and pathological aspects. Oxford, UK: Academic Press; 99305-99316
111. Nunez J, Pommier J. 1982 Formation of thyroid hormones. Vitam Horm 39:175-229
112. 2-generating system modulates protein iodination and the activity of the pentose phosphate pathway in dog thyroid. Endocrinology 128:779-785
113. Taurog A, Dorris ML, Doerge DR 1996 Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase. Arch Biochem Biophys 330:24-32
114. Lamas L, Anderson PC, Fox JW, Dunn JT 1989 Consensus sequences for early iodination and hormonogenesis in human thyroglobulin. J Biol Chem 264:13541-13545
115. Moreno JC 2003 Identification of novel genes involved in congenital hypothyroidism using serial analysis of gene expression. Horm Res 60(Suppl 3):96-102
116. Gnidehou S, Caillou B, Talbot M, Ohayon R, Kaniewski J, Noël-Hudson MS, Morand S, Agnangji D, Sezan A, Courtin F, Virion A, Dupuy C 2004 Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site. FASEB J 18:1574-1576
117. Moreno JC, Klootwijk W, van Toor H, Pinto G, D'Alessandro M, Lèger A, Goudie D, Polak M, Grüters A, Visser TJ 2008 Mutations in the iodotyrosine deiodinase gene and hypothyroidism. N Engl J Med 358:1811-1818
118. Moreno JC, Visser TJ 2010 Genetics and phenomics of hypothyroidism and goiter due to iodotyrosine deiodinase (DEHAL1) gene mutations. Mol Cell Endocrinol 322: 91-98
119. Gnidehou S, Lacroix L, Sezan A, Ohayon R, Noël-Hudson MS, Morand S, Francon J, Courtin F, Virion A, Dupuy C 2006 Cloning and characterization of a novel isoform of iodotyrosine dehalogenase 1 (DEHAL1) DEHAL1C from human thyroid: comparisons with DEHAL1 and DEHAL1B. Thyroid 16:715-724
120. Bjorkman U, Ekholm R 1990 Biochemistry of thyroid hormone formation and secretion. In: Greer M, ed. The thyroid gland. New-York: Raven Press; 83-125
121. Pommier J, Deme D, Nunez J 1973 Effect of iodide concentration on thyroxine synthesis catalysed by thyroid peroxidase. Eur J Biochem 37:406-414
122. Morris DR, Hager LP 1966 Mechanism of the inhibition of enzymatic halogenation by antithyroid agents. J Biol Chem 241:3582-3589
123. Ohtaki S, Nakagawa H, Kimura S, Yamazaki I 1981 Analyses of catalytic intermediates of hog thyroid peroxidase during its iodinating reaction. J Biol Chem 256:805-810
124. Nakamura M, Yamazaki I, Nakagawa H, Ohtaki S 1983 Steady state kinetics and regulation of thyroid peroxidasecatalyzed iodination. J Biol Chem 258:3837-3842
125. Ohtaki S, Nakagawa H, Nakamura M, Kotani T 1996 Thyroid peroxidase: experimental and clinical integration. Endocr J 43:1-14
126. Morrison M, Schonbaum GR 1976 Peroxidase-catalyzed halogenation. Annu Rev Biochem 45:861-888
127. Magnusson RP, Taurog A, Dorris ML 1984 Mechanisms of thyroid peroxidaseand lactoperoxidase-catalyzed reactions involving iodide. J Biol Chem 259:13783-13790 128.
128. Magnusson RP, Taurog A, Dorris ML 1984 Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase. J Biol Chem 259:197-205
129. Dawson JH 1988 Probing structure-function relations in heme-containing oxygenases and peroxidases. Science 240:433-439
130. Taurog A, Dorris M, Doerge DR 1994 Evidence for a radical mechanism in peroxidase-catalyzed coupling. I. Steady-state experiments with various peroxidases. Arch Biochem Biophys 315:82-89
131. Friesema EC, Kuiper GG, Jansen J, Visser TJ, Kester MH 2006 Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism. Mol Endocrinol 20:2761-2772
132. Di Cosmo C, Liao XH, Dumitrescu AM, Philp NJ, Weiss RE, Refetoff S 2010 Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion. J Clin Invest 120:3377-3388
133. Visser WE, Friesema EC, Visser TJ 2011 Minireview: thyroid hormone transporters: the knowns and the unknowns. Mol Endocrinol 25:1-14
134. Friesema EC, Grueters A, Biebermann H, Krude H, von Moers A, Reeser M, Barrett TG, Mancilla EE, Svensson J, Kester MH, Kuiper GG, Balkassmi S, Uitterlinden AG, Koehrle J, Rodien P, Halestrap AP, Visser TJ 2004 Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation. Lancet 364:1435-1437
135. Dumitrescu AM, Liao XH, Best TB, Brockmann K, Refetoff S 2004 A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene. Am J Hum Genet 74: 168-175
136. Schwartz CE, May MM, Carpenter NJ, Rogers RC, Martin J, Bialer MG, Ward J, Sanabria J, Marsa S, Lewis JA, Echeverri R, Lubs HA, Voeller K, Simensen RJ, Stevenson RE 2005 Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene. Am J Hum Genet 77:41-53
137. Friesema EC, Visser WE, Visser TJ 2010 Genetics and phenomics of thyroid hormone transport by MCT8. Mol Cell Endocrinol 322:107-113
138. Wirth EK, Sheu SY, Chiu-Ugalde J, Sapin R, Klein MO, Mossbrugger I, Quintanilla-Martinez L, de Angelis MH, Krude H, Riebel T, Rothe K, Köhrle J, Schmid KW, Schweizer U, Grüters A 2011 Monocarboxylate transporter 8 deficiency: altered thyroid morphology and persistent high triiodothyronine/thyroxine ratio after thyroidectomy. Eur J Endocrinol 165:555-561
139. Zung A, Visser TJ, Uitterlinden AG, Rivadeneira F, Friesema EC 2011 A child with a deletion in the monocarboxylate transporter 8 gene: 7-year follow-up and effects of thyroid hormone treatment. Eur J Endocrinol 165:823830
140. Liao XH, Di Cosmo C, Dumitrescu AM, Hernandez A, Van Sande J, St Germain DL, Weiss RE, Galton VA, Refetoff S 2011 Distinct roles of deiodinases on the phenotype of Mct8 defect: a comparison of eight different mouse genotypes. Endocrinology 152:1180-1191
141. Bartalena L, Robbins J 1993 Thyroid hormone transport proteins. Clin Lab Med 13:583-598
142. Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ 2003 Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem 278:40128-40135
143. Bergh JJ, Lin HY, Lansing L, Mohamed SN, Davis FB, Mousa S, Davis PJ 2005 Integrin αVβ3 contains a cell surface receptor site for thyroid hormone that is linked to activation of mitogen-activated protein kinase and induction of angiogenesis. Endocrinology 146:2864-2871
144. Scarlett A, Parsons MP, Hanson PL, Sidhu KK, Milligan TP, Burrin JM 2008 Thyroid hormone stimulation of extracellular signal-regulated kinase and cell proliferation in human osteoblast-like cells is initiated at integrin αVβ3. J Endocrinol 196:509-517
145. Cao X, Kambe F, Moeller LC, Refetoff S, Seo H 2005 Thyroid hormone induces rapid activation of Akt/protein kinase B-mammalian target of rapamycin-p70S6K cascade through phosphatidylinositol 3-kinase in human fibroblasts. Mol Endocrinol 19:102-112
146. Hiroi Y, Kim HH, Ying H, Furuya F, Huang Z, Simoncini T, Noma K, Ueki K, Nguyen NH, Scanlan TS, Moskowitz MA, Cheng SY, Liao JK 2006 Rapid nongenomic actions of thyroid hormone. Proc Natl Acad Sci USA 103:1410414109
147. Kenessey A, Ojamaa K 2006 Thyroid hormone stimulates protein synthesis in the cardiomyocyte by activating the Akt-mTOR and p70S6K pathways. J Biol Chem 281: 20666-20672
148. Storey NM, Gentile S, Ullah H, Russo A, Muessel M, Erxleben C, Armstrong DL 2006 Rapid signaling at the plasma membrane by a nuclear receptor for thyroid hormone. Proc Natl Acad Sci USA 103:5197-5201
149. 3) is a survival factor for pancreatic β-cells undergoing apoptosis. J Cell Physiol 206:309-321
150. 3 in pancreatic β-cells. J Mol Endocrinol 38:221-233
151. Leonard JL 2008 Non-genomic actions of thyroid hormone in brain development. Steroids 73:1008-1012
152. Cheng SY, Leonard JL, Davis PJ 2010 Molecular aspects of thyroid hormone actions. Endocr Rev 31:139-170
153. Schneider PB 1964 Thyroidal iodine heterogeneity: "last come, first served" system of thyroid turnover. Endocrinology 74:973-980
154. Studer H, Gerber H 1991 Intrathyroidal iodine heterogeneity of iodocompounds and kinetic compartmentalization. Trends Endocrinol Metab 2:29-35
155. Herzog V, Berndorfer U, Saber Y 1992 Isolation of insoluble secretory product from bovine thyroid: extracellular storage of thyroglobulin in covalently cross-linked form. J Cell Biol 118:1071-1083
156. Berndorfer U, Wilms H, Herzog V 1996 Multimerization of thyroglobulin (TG) during extracellular storage: isolation of highly cross-linked TG from human thyroids. J Clin Endocrinol Metab 81:1918-1926
157. Gérard AC, Denef JF, Colin IM, van den Hove MF 2004 Evidence for processing of compact insoluble thyroglobulin globules in relation with follicular cell functional activity in the human and the mouse thyroid. Eur J Endocrinol 150:73-80
158. Baudry N, Lejeune PJ, Delom F, Vinet L, Carayon P, Mallet B 1998 Role of multimerized porcine thyroglobulin in iodine storage. Biochem Biophys Res Commun 242:292296
159. Den Hartog MT, De Boer M, Veenboer GJ, De Vijlder JJ 1990 Generation and characterization of monoclonal antibodies directed against noniodinated and iodinated thyroglobulin, among which are antibodies against hormonogenic sites. Endocrinology 127:3160-3165
160. Brix K, Lemansky P, Herzog V 1996 Evidence for extracellularly acting cathepsins mediating thyroid hormone liberation in thyroid epithelial cells. Endocrinology 137: 1963-1974
161. Brix K, Linke M, Tepel C, Herzog V 2001 Cysteine proteinases mediate extracellular prohormone processing in the thyroid. Biol Chem 382:717-725
162. Linke M, Herzog V, Brix K 2002 Trafficking of lysosomal cathepsin B-green fluorescent protein to the surface of thyroid epithelial cells involves the endosomal/lysosomal compartment. J Cell Sci 115:4877-4889
163. Friedrichs B, Tepel C, Reinheckel T, Deussing J, von Figura K, Herzog V, Peters C, Saftig P, Brix K 2003 Thyroid functions of mouse cathepsins B, K, and L. J Clin Invest 111:1733-1745
164. Dauth S, Arampatzidou M, Rehders M, Yu D, Führer D, Brix K 2011 Thyroid cathepsin K: roles in physiology and thyroid desease. Clin Rev Bone Miner Metab 9:94-106
165. Jordans S, Jenko-Kokalj S, Kühl NM, Tedelind S, Sendt W, Brömme D, Turk D, Brix K 2009 Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions. BMC Biochem 10:23
166. Tedelind S, Jordans S, Resemann H, Blum G, Bogyo M, Fuhrer D, Brix K 2011 Cathepsin B trafficking in thyroid carcinoma cells. Thyroid Res 4(Suppl 1):S2
167. Sloane BF, Moin K, Krepela E, Rozhin J 1990 Cathepsin B and its endogenous inhibitors: the role in tumor malignancy. Cancer Metastasis Rev 9:333-352
168. Marinò M, McCluskey RT 2000 Role of thyroglobulin endocytic pathways in the control of thyroid hormone release. Am J Physiol Cell Physiol 279:C1295-C1306
169. van den Hove MF, Couvreur M, de Visscher M, Salvatore G 1982 A new mechanism for the reabsorption of thyroid iodoproteins: selective fluid pinocytosis. Eur J Biochem 122:415-422
170. Dunn JT 1996 Thyroglobulin retrieval and the endocytic pathway. In: Braverman LE, Utigers RD, eds. The thyroid. A fundamental and clinical text. Philadelphia: LippincottRaven; 81-84
171. Marinò M, Friedlander JA, McCluskey RT, Andrews D 1999 Identification of a heparin-binding region of rat thyroglobulin involved in megalin binding. J Biol Chem 274: 30377-30386
172. Lisi S, Pinchera A, McCluskey RT, Willnow TE, Refetoff S, Marcocci C, Vitti P, Menconi F, Grasso L, Luchetti F, Collins AB, Marino M 2003 Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: a control mechanism for thyroid hormone release. Proc Natl Acad Sci USA 100:14858-14863
173. Miquelis R, Courageot J, Jacq A, Blanck O, Perrin C, Bastiani P 1993 Intracellular routing of GLcNAc-bearing molecules in thyrocytes: selective recycling through the Golgi apparatus. J Cell Biol 123:1695-1706
174. Kostrouch Z, Bernier-Valentin F, Munari-Silem Y, Rajas F, Rabilloud R, Rousset B 1993 Thyroglobulin molecules internalized by thyrocytes are sorted in early endosomes and partially recycled back to the follicular lumen. Endocrinology 132:2645-2653
175. Mezghrani A, Courageot J, Mani JC, Pugniere M, Bastiani P, Miquelis R 2000 Protein-disulfide isomerase (PDI) in FRTL5 cells. pH-dependent thyroglobulin/PDI interactions determine a novel PDI function in the post-endoplasmic reticulum of thyrocytes. J Biol Chem 275:1920-1929
176. Botta R, Lisi S, Pinchera A, Giorgi F, Marcocci C, Taddei AR, Fausto AM, Bernardini N, Ippolito C, Mattii L, Persani L, de Filippis T, Calebiro D, Madsen P, Petersen CM, Marinò M 2009 Sortilin is a putative postendocytic receptor of thyroglobulin. Endocrinology 150:509-518
177. Wang D, De Deken X, Milenkovic M, Song Y, Pirson I, Dumont JE, Miot F 2005 Identification of a novel partner of duox: EFP1, a thioredoxin-related protein. J Biol Chem 280:3096-3103
178. Song Y, Driessens N, Costa M, De Deken X, Detours V, Corvilain B, Maenhaut C, Miot F, Van Sande J, Many MC, Dumont JE 2007 Roles of hydrogen peroxide in thyroid physiology and disease. J Clin Endocrinol Metab 92: 3764-3773
179. Schweizer U, Chiu J, Köhrle J 2008 Peroxides and peroxide-degrading enzymes in the thyroid. Antioxid Redox Signal 10:1577-1592
180. Ohye H, Sugawara M 2010 Dual oxidase, hydrogen peroxide and thyroid diseases. Exp Biol Med (Maywood) 235: 424-433
181. Song Y, Ruf J, Lothaire P, Dequanter D, Andry G, Willemse E, Dumont JE, Van Sande J, De Deken X 2010 Association of duoxes with thyroid peroxidase and its regulation in thyrocytes. J Clin Endocrinol Metab 95:375-382
182. Fortunato RS, Lima de Souza EC, Ameziane-el Hassani R, Boufraqech M, Weyemi U, Talbot M, Lagente-Chevallier O, de Carvalho DP, Bidart JM, Schlumberger M, Dupuy C 2010 Functional consequences of dual oxidase-thyroperoxidase interaction at the plasma membrane. J Clin Endocrinol Metab 95:5403-5411
183. Senou M, Costa MJ, Massart C, Thimmesch M, Khalifa C, Poncin S, Boucquey M, Gérard AC, Audinot JN, Dessy C, Ruf J, Feron O, Devuyst O, Guiot Y, Dumont JE, Van Sande J, Many MC 2009 Role of caveolin-1 in thyroid phenotype, cell homeostasis, and hormone synthesis: in vivo study of caveolin-1 knockout mice. Am J Physiol Endocrinol Metab 297:E438-E451
184. Senou M, Khalifa C, Thimmesch M, Jouret F, Devuyst O, Col V, Audinot JN, Lipnik P, Moreno JC, Van Sande J, Dumont JE, Many MC, Colin IM, Gérard AC 2010 A coherent organization of differentiation proteins is required to maintain an appropriate thyroid function in the Pendred thyroid. J Clin Endocrinol Metab 95:4021-4030
185. Morand S, Ueyama T, Tsujibe S, Saito N, Korzeniowska A, Leto TL 2009 Duox maturation factors form cell surface complexes with Duox affecting the specificity of reactive oxygen species generation. FASEB J 23:1205-1218
186. Johnson KR, Marden CC, Ward-Bailey P, Gagnon LH, Bronson RT, Donahue LR 2007 Congenital hypothyroidism, dwarfism, and hearing impairment caused by a missense mutation in the mouse dual oxidase 2 gene, Duox2. Mol Endocrinol 21:1593-1602
187. Zamproni I, Grasberger H, Cortinovis F, Vigone MC, Chiumello G, Mora S, Onigata K, Fugazzola L, Refetoff S, Persani L, Weber G 2008 Biallelic inactivation of the dual oxidase maturation factor 2 (DUOXA2) gene as a novel cause of congenital hypothyroidism. J Clin Endocrinol Metab 93:605-610
188. Grasberger H 2010 Defects of thyroidal hydrogen peroxide generation in congenital hypothyroidism. Mol Cell Endocrinol 322:99-106
189. Grasberger H, De Deken X, Mayo OB, Raad H, Weiss M, Liao XH, Refetoff S 2012 Mice deficient in dual oxidase maturation factors are severely hypothyroid. Mol Endocrinol 26:481-492
190. Rothberg KG, Heuser JE, Donzell WC, Ying YS, Glenney JR, Anderson RG 1992 Caveolin, a protein component of caveolae membrane coats. Cell 68:673-682
191. Pilch PF, Liu L 2011 Fat caves: caveolae, lipid trafficking and lipid metabolism in adipocytes. Trends Endocrinol Metab 22:318-324
192. Costa MJ, Senou M, Van Rode F, Ruf J, Capello M, Dequanter D, Lothaire P, Dessy C, Dumont JE, Many MC, Van Sande J 2007 Reciprocal negative regulation between thyrotropin/3Universal-GreekwithMathPi.-1.H11032,5Universal-GreekwithMathPi.-1.H11032-cyclic adenosine monophosphate-mediated proliferation and caveolin-1 expression in human and murine thyrocytes. Mol Endocrinol 21:921-932
193. Couet J, Li S, Okamoto T, Ikezu T, Lisanti MP 1997 Identification of peptide and protein ligands for the caveolinscaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J Biol Chem 272:6525-6533
194. 2+ cascades in mediating the effects of thyrotropin and iodide on hormone synthesis and secretion in human thyroid slices. J Clin Endocrinol Metab 79:152-159
195. Mishina NM, Tyurin-Kuzmin PA, Markvicheva KN, Vorotnikov AV, Tkachuk VA, Laketa V, Schultz C, Lukyanov S, Belousov VV 2011 Does cellular hydrogen peroxide diffuse or act locally Antioxid Redox Signal 14:1-7
196. Denef JF, Many MC, van den Hove MF 1996 Iodine-induced thyroid inhibition and cell necrosis: two consequences of the same free-radical mediated mechanism? Mol Cell Endocrinol 121:101-103
197. Ehrenshaft M, Mason RP 2006 Protein radical formation on thyroid peroxidase during turnover as detected by immuno-spin trapping. Free Radic Biol Med 41:422-430
198. Poncin S, Colin IM, Gérard AC 2009 Minimal oxidative load: a prerequisite for thyroid cell function. J Endocrinol 201:161-167
199. Driessens N, Versteyhe S, Ghaddhab C, Burniat A, De Deken X, Van Sande J, Dumont JE, Miot F, Corvilain B 2009 Hydrogen peroxide induces DNA singleand doublestrand breaks in thyroid cells and is therefore a potential mutagen for this organ. Endocr Relat Cancer 16:845-856
200. 2 in RET/PTC1 chromosomal rearrangement produced by ionizing radiation in human thyroid cells. Cancer Res 70:4123-4132
201. Paschke R 2011 Molecular pathogenesis of nodular goiter. Langenbecks Arch Surg 396:1127-1136
202. Maier J, van Steeg H, van Oostrom C, Karger S, Paschke R, Krohn K 2006 Deoxyribonucleic acid damage and spontaneous mutagenesis in the thyroid gland of rats and mice. Endocrinology 147:3391-3397
203. Krohn K, Maier J, Paschke R 2007 Mechanisms of disease: hydrogen peroxide, DNA damage and mutagenesis in the development of thyroid tumors. Nat Clin Pract Endocrinol Metab 3:713-720
204. Björkman U, Ekholm R 1995 Hydrogen peroxide degradation and glutathione peroxidase activity in cultures of thyroid cells. Mol Cell Endocrinol 111:99-107
205. Kim H, Lee TH, Park ES, Suh JM, Park SJ, Chung HK, Kwon OY, Kim YK, Ro HK, Shong M 2000 Role of peroxiredoxins in regulating intracellular hydrogen peroxide and hydrogen peroxide-induced apoptosis in thyroid cells. J Biol Chem 275:18266-18270
206. Gérard AC, Many MC, Daumerie Ch, Knoops B, Colin IM 2005 Peroxiredoxin 5 expression in the human thyroid gland. Thyroid 15:205-209
207. Chiu-Ugalde J, Wirth EK, Klein MO, Sapin R, FradejasVillar N, Renko K, Schomburg L, Köhrle J, Schweizer U 2012 Thyroid function is maintained despite increased oxidative stress in mice lacking selenoprotein biosynthesis in thyroid epithelial cells. Antioxid Redox Signal 17:902913
208. Contempre B, Le Moine O, Dumont JE, Denef JF, Many MC 1996 Selenium deficiency and thyroid fibrosis. A key role for macrophages and transforming growth factor β (TGF-β). Mol Cell Endocrinol 124:7-15
209. Köhrle J, Jakob F, Contempré B, Dumont JE 2005 Selenium, the thyroid, and the endocrine system. Endocr Rev 26:944-984
210. Schomburg L 2012 Selenium, selenoproteins and the thyroid gland: interactions in health and disease. Nat Rev Endocrinol 8:160-171
211. Dröge W 2002 Free radicals in the physiological control of cell function. Physiol Rev 82:47-95
212. Poncin S, Van Eeckoudt S, Humblet K, Colin IM, Gérard AC 2010 Oxidative stress: a required condition for thyroid cell proliferation. Am J Pathol 176:1355-1363
213. Xing M 2012 Oxidative stress: a new risk factor for thyroid cancer. Endocr Relat Cancer 19:C7-C11
214. Xing M 2010 Genetic alterations in the phosphatidylinositol-3 kinase/Akt pathway in thyroid cancer. Thyroid 20: 697-706
215. Liu D, Xing M 2008 Potent inhibition of thyroid cancer cells by the MEK inhibitor PD0325901 and its potentiation by suppression of the PI3K and NF-κB pathways. Thyroid 18:853-864
216. Pacifico F, Leonardi A 2010 Role of NF-κB in thyroid cancer. Mol Cell Endocrinol 321:29-35
217. Arnold RS, Shi J, Murad E, Whalen AM, Sun CQ, Polavarapu R, Parthasarathy S, Petros JA, Lambeth JD 2001 Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1. Proc Natl Acad Sci USA 98:5550-5555
218. Polytarchou C, Hatziapostolou M, Papadimitriou E 2005 Hydrogen peroxide stimulates proliferation and migration of human prostate cancer cells through activation of activator protein-1 and up-regulation of the heparin affin regulatory peptide gene. J Biol Chem 280:40428-40435
219. Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M 2005 Reactive oxygen species promote TNFα-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120:649-661
220. Tonks NK 2005 Redox redux: revisiting PTPs and the control of cell signaling. Cell 121:667-670
221. Leslie NR, Bennett D, Lindsay YE, Stewart H, Gray A, Downes CP 2003 Redox regulation of PI 3-kinase signalling via inactivation of PTEN. EMBO J 22:5501-5510
222. Wang D, Feng JF, Zeng P, Yang YH, Luo J, Yang YW 2011 Total oxidant/antioxidant status in sera of patients with thyroid cancers. Endocr Relat Cancer 18:773-782
223. Lacroix L, Nocera M, Mian C, Caillou B, Virion A, Dupuy C, Filetti S, Bidart JM, Schlumberger M 2001 Expression of nicotinamide adenine dinucleotide phosphate oxidase flavoprotein DUOX genes and proteins in human papillary and follicular thyroid carcinomas. Thyroid 11:1017-1023
224. Gérard AC, Daumerie C, Mestdagh C, Gohy S, De Burbure C, Costagliola S, Miot F, Nollevaux MC, Denef JF, Rahier J, Franc B, De Vijlder JJ, Colin IM, Many MC 2003 Correlation between the loss of thyroglobulin iodination and the expression of thyroid-specific proteins involved in iodine metabolism in thyroid carcinomas. J Clin Endocrinol Metab 88:4977-4983
225. Faggiano A, Caillou B, Lacroix L, Talbot M, Filetti S, Bidart JM, Schlumberger M 2007 Functional characterization of human thyroid tissue with immunohistochemistry. Thyroid 17:203-211
226. Coclet J, Foureau F, Ketelbant P, Galand P, Dumont JE 1989 Cell population kinetics in dog and human adult thyroid. Clin Endocrinol (Oxf) 31:655-665
227. Poli G, Leonarduzzi G, Biasi F, Chiarpotto E 2004 Oxidative stress and cell signalling. Curr Med Chem 11:1163-1182
228. Lu H, Ouyang W, Huang C 2006 Inflammation, a key event in cancer development. Mol Cancer Res 4:221-233
229. Nucera C, Lawler J, Parangi S 2011 BRAF(V600E) and microenvironment in thyroid cancer: a functional link to drive cancer progression. Cancer Res 71:2417-2422
230. Boelaert K, Horacek J, Holder RL, Watkinson JC, Sheppard MC, Franklyn JA 2006 Serum thyrotropin concentration as a novel predictor of malignancy in thyroid nodules investigated by fine-needle aspiration. J Clin Endocrinol Metab 91: 4295-4301
231. Haymart MR, Glinberg SL, Liu J, Sippel RS, Jaume JC, Chen H 2009 Higher serum TSH in thyroid cancer patients occurs independent of age and correlates with extrathyroidal extension. Clin Endocrinol (Oxf) 71:434-439
232. van den Hove MF, Stoenoiu MS, Croizet K, Couvreur M, Courtoy PJ, Devuyst O, Colin IM 2002 Nitric oxide is involved in interleukin-1α-induced cytotoxicity in polarised human thyrocytes. J Endocrinol 173:177-185
233. Gérard AC, Boucquey M, van den Hove MF, Colin IM 2006 Expression of TPO and ThOXs in human thyrocytes is downregulated by IL-1α/IFN-γ, an effect partially mediated by nitric oxide. Am J Physiol Endocrinol Metab 291:E242-E253
234. Poncin S, Gérard AC, Boucquey M, Senou M, Calderon PB, Knoops B, Lengelé B, Many MC, Colin IM 2008 Oxidative stress in the thyroid gland: from harmlessness to hazard depending on the iodine content. Endocrinology 149:424-433
235. Poncin S, Lengelé B, Colin IM, Gérard AC 2008 Differential interactions between Th1/Th2, Th1/Th3, and Th2/ Th3 cytokines in the regulation of thyroperoxidase and dual oxidase expression, and of thyroglobulin secretion in thyrocytes in vitro. Endocrinology 149:1534-1542
236. Poncin S, Colin IM, Decallonne B, Clinckspooor I, Many MC, Denef JF, Gérard AC 2010 N-acetylcysteine and 15 deoxy-δ12,14-prostaglandin J2 exert a protective effect against autoimmune thyroid destruction in vivo but not against interleukin-1α/interferon γ-induced inhibitory effects in thyrocytes in vitro. Am J Pathol 177:219-228
237. Many MC, Denef JF, Haumont S, van den Hove-Vandenbroucke MF, Cornette C, Beckers C 1985 Morphological and functional changes during thyroid hyperplasia and involution in C3H mice: effects of iodine and 3,5,3′-triiodothyronine during involution. Endocrinology 116:798-806
238. Many MC, Denef JF, Hamudi S, Cornette C, Haumont S, Beckers C 1986 Effects of iodide and thyroxine on iodinedeficient mouse thyroid: a morphological and functional study. J Endocrinol 110:203-210
239. Mahmoud I, Colin I, Many MC, Denef JF 1986 Direct toxic effect of iodide in excess on iodine-deficient thyroid glands: epithelial necrosis and inflammation associated with lipofuscin accumulation. Exp Mol Pathol 44:259-271
240. Many MC, Denef JF 1992 Iodine and goiter involution. Thyroidology 4:23-26
241. Many MC, Mestdagh C, van den Hove MF, Denef JF 1992 In vitro study of acute toxic effects of high iodide doses in human thyroid follicles. Endocrinology 131:621-630
242. Mutaku JF, Poma JF, Many MC, Denef JF, van Den Hove MF 2002 Cell necrosis and apoptosis are differentially regulated during goitre development and iodine-induced involution. J Endocrinol 172:375-386
243. Toussaint-Demylle D, Many MC, Theisen H, Kraal G, Denef JF 1990 Effects of iodide on class II-MHC antigen expression in iodine deficient hyperplastic thyroid glands. Autoimmunity 7:51-62
244. Nagataki S, Eguchi K 1992 Cytokines and immune regulation in thyroid autoimmunity. Autoimmunity 13:27-34
245. Many MC, Maniratunga S, Varis I, Dardenne M, Drexhage HA, Denef JF 1995 Two-step development of Hashimoto-like thyroiditis in genetically autoimmune prone non-obese diabetic mice: effects of iodine-induced cell necrosis. J Endocrinol 147:311-320
246. Many MC, Maniratunga S, Denef JF 1996 The non-obese diabetic (NOD) mouse: an animal model for autoimmune thyroiditis. Exp Clin Endocrinol Diabetes 104(Suppl 3): 17-20
247. Andryskowski G, Owczarek T 2007 [The evaluation of selected oxidative stress parameters in patients with hyperthyroidism]. Pol Arch Med Wewn 117:285-289 (Polish)
248. Erdamar H, Demirci H, Yaman H, Erbil MK, Yakar T, Sancak B, Elbeg S, Bibero{eth}lu G, Yetkin I 2008 The effect of hypothyroidism, hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant status. Clin Chem Lab Med 46:1004-1010
249. Torun AN, Kulaksizoglu S, Kulaksizoglu M, Pamuk BO, Isbilen E, Tutuncu NB 2009 Serum total antioxidant status and lipid peroxidation marker malondialdehyde levels in overt and subclinical hypothyroidism. Clin Endocrinol (Oxf) 70:469-474
250. Aslan M, Cosar N, Celik H, Aksoy N, Dulger AC, Begenik H, Soyoral YU, Kucukoglu ME, Selek S 2011 Evaluation of oxidative status in patients with hyperthyroidism. Endocrine 40:285-289
251. Denef JF, Haumont S, Beckers C 1980 Morphological changes in mice thyroid induced by iodine deficiency. Virchows Arch B Cell Pathol Incl Mol Pathol 32:191-199
252. Denef JF, Haumont S, Cornette C, Beckers C 1981 Correlated functional and morphometric study of thyroid hyperplasia induced by iodine deficiency. Endocrinology 108:2352-2358
253. Many MC, Denef JF, Gathy P, Haumont S 1983 Morphological and functional changes during thyroid hyperplasia and involution in C3H Mice: evidence for folliculoneogenesis during involution. Endocrinology 112:1292-1302
254. Many MC, Denef JF, Haumont S 1984 Precocity of the endothelial proliferation during a course of rapid goitrogenesis. Acta Endocrinol (Copenh) 105:487-491
255. Denef JF, Ovaert C, Many MC 1989 [Experimental goitrogenesis]. Ann Endocrinol (Paris) 50:1-15 (French)
256. Krohn K, Führer D, Bayer Y, Eszlinger M, Brauer V, Neumann S, Paschke R 2005 Molecular pathogenesis of euthyroid and toxic multinodular goiter. Endocr Rev 26: 504-524
257. Paschke R 2011 Nodulogenesis and goitrogenesis. Ann Endocrinol (Paris) 72:117-119
258. Gérard AC, Xhenseval V, Colin IM, Many MC, Denef JF 2000 Evidence for co-ordinated changes between vascular endothelial growth factor and nitric oxide synthase III immunoreactivity, the functional status of the thyroid follicles, and the microvascular bed during chronic stimulation by low iodine and propylthiouracyl in old mice. Eur J Endocrinol 142:651-660
259. Gérard AC, Many MC, Daumerie C, Costagliola S, Miot F, DeVijlder JJ, Colin IM, Denef JF 2002 Structural changes in the angiofollicular units between active and hypofunctioning follicles align with differences in the epithelial expression of newly discovered proteins involved in iodine transport and organification. J Clin Endocrinol Metab 87:1291-1299
260. Gérard AC, Denef JF, Many MC, Gathy P, de Burbure C, van den Hove MF, Coppée F, Ledent C, Colin IM 2003 Relationships between cell division, expression of growth factors and microcirculation in the thyroids of Tg-A2aR transgenic mice and patients with Graves' disease. J Endocrinol 177:269-277
261. Wollman SH, Herveg JP, Zeligs JD, Ericson LE 1978 Blood capillary enlargement during the development of thyroid hyperplasia in the rat. Endocrinology 103:2306-2314
262. Ericson LE, Wollman SH 1980 Ultrastructural aspects of capillary fusion during the development of thyroid hyperplasia. J Ultrastruct Res 72:300-315
263. Ericson LW, Wollman SH 1980 Increase in the rough endoplasmic reticulum in capillary endothelial cells and pericytes in hyperplastic rat thyroid glands. Endocrinology 107:732-737
264. Zeligs JD, Wollman SH 1981 Ultrastructure of cytokinesis in blood capillary endothelial cells in thyroid gland in vivo. J Ultrastruct Res 75:291-299
265. Smeds S, Wollman SH 1983 3H-thymidine labeling of endothelial cells in thyroid arteries, veins, and lymphatics during thyroid stimulation. Lab Invest 48:285-291
266. Wollman SH, Herveg JP, Tachiwaki O 1990 Histologic changes in tissue components of the hyperplastic thyroid gland during its involution in the rat. Am J Anat 189: 35-44
267. Gérard AC, Poncin S, Caetano B, Sonveaux P, Audinot JN, Feron O, Colin IM, Soncin F 2008 Iodine deficiency induces a thyroid stimulating hormone-independent early phase of microvascular reshaping in the thyroid. Am J Pathol 172:748-760
268. Ramsden JD, Buchanan MA, Egginton S, Watkinson JC, Mautner V, Eggo MC 2005 Complete inhibition of goiter in mice requires combined gene therapy modification of angiopoietin, vascular endothelial growth factor, and fibroblast growth factor signaling. Endocrinology 146: 2895-2902
269. Imada M, Kurosumi M, Fujita H 1986 Three-dimensional aspects of blood vessels in thyroids from normal, low iodine diet-treated, TSH-treated, and PTU-treated rats. Cell Tissue Res 245:291-296
270. Michalkiewicz M, Huffman LJ, Connors JM, Hedge GA 1989 Alterations in thyroid blood flow induced by varying levels of iodine intake in the rat. Endocrinology 125: 54-60
271. Arntzenius AB, Smit LJ, Schipper J, van der Heide D, Meinders AE 1991 Inverse relation between iodine intake and thyroid blood flow: color Doppler flow imaging in euthyroid humans. J Clin Endocrinol Metab 73:1051-1055
272. Colin I, Berbinschi A, Denef JF, Ketelslegers JM 1992 Detection and identification of endothelin-1 immunoreactivity in rat and porcine thyroid follicular cells. Endocrinology 130:544-546
273. Colin IM, Selvais PL, Rebai T, Maiter DM, Adam E, vandenHove MF, Ketelslegers JM, Denef JF 1994 Expression of the endothelin-1 gene in the rat thyroid gland and changes in its peptide and mRNA levels in goiter formation and iodide-induced involution. J Endocrinol 143:65-74
274. Colin IM, Gerard AC 2010 The thyroid angiofollicular units, a biological model of functional and morphological integration. Bull Mémoires Acad Royale Belgique 165: 218-230
275. Richards OC, Raines SM, Attie AD 2010 The role of blood vessels, endothelial cells, and vascular pericytes in insulin secretion and peripheral insulin action. Endocr Rev 31: 343-363
276. Eberhard D, Kragl M, Lammert E 2010 'Giving and taking': endothelial and β-52-cells in the islets of Langerhans. Trends Endocrinol Metab 21:457-463
277. Jansson L, Hellerström C 1983 Stimulation by glucose of the blood flow to the pancreatic islets of the rat. Diabetologia 25:45-50
278. Nyman LR, Ford E, Powers AC, Piston DW 2010 Glucosedependent blood flow dynamics in murine pancreatic islets in vivo. Am J Physiol Endocrinol Metab 298:E807-E814
279. Carlsson PO, Olsson R, Källskog O, Bodin B, Andersson A, Jansson L 2002 Glucose-induced islet blood flow increase in rats: interaction between nervous and metabolic mediators. Am J Physiol Endocrinol Metab 283:E457-E464
280. Ballian N, Brunicardi FC 2007 Islet vasculature as a regulator of endocrine pancreas function. World J Surg 31: 705-714
281. Orci L, Unger RH 1975 Functional subdivision of islets of Langerhans and possible role of D cells. Lancet 2:12431244
282. Bergland RM, Page RB 1979 Pituitary-brain vascular relations: a new paradigm. Science 204:18-24
283. Maghnie M, Altobelli M, Di Iorgi N, Genovese E, Meloni G, Manca-Bitti ML, Cohen A, Bernasconi S 2004 Idiopathic central diabetes insipidus is associated with abnormal blood supply to the posterior pituitary gland caused by vascular impairment of the inferior hypophyseal artery system. J Clin Endocrinol Metab 89:1891-1896
284. de la Torre NG, Turner HE, Wass JA 2005 Angiogenesis in prolactinomas: regulation and relationship with tumour behaviour. Pituitary 8:17-23
285. Ferrara N, Houck K, Jakeman L, Leung DW 1992 Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev 13:18-32
286. Macchiarelli G, Nottola SA, Palmerini MG, Bianchi S, Maione M, Lorenzo C, Stifano G, Di Marco E, Correr S 2010 Morphological expression of angiogenesis in the mammalian ovary as seen by SEM of corrosion casts. Ital J Anat Embryol 115:109-114
287. Araujo VR, Duarte AB, Bruno JB, Pinho Lopes CA, de Figueiredo JR 2011 Importance of vascular endothelial growth factor (VEGF) in ovarian physiology of mammals. Zygote 1-10
288. Hinson JP, Vinson GP, Whitehouse BJ 1986 The relationship between perfusion medium flow rate and steroid secretion in the isolated perfused rat adrenal gland in situ. J Endocrinol 111:391-396
289. Feige JJ 2009 Angiogenesis in adrenocortical physiology and tumor development. Ann Endocrinol (Paris) 70:153-155
290. Kapitola J, Schullerova M, Schreiberova O 1971 Blood flow and radioiodine uptake in the thyroid gland of rats after administration and discontinuation of carbimazole and perchlorate. Acta Endocrinol (Copenh) 68:817-825
291. Kapitola J, Schullerova M, Schreiberova O, Vilimovska D, Josifko M 1974 Relation of TSH concentration in blood to the radioactive rubidium 86Rb uptake in the thyroid gland of rats: evidence of TSH regulatory effect on thyroid gland blood flow. Acta Endocrinol (Copenh) 77:266-275
292. Connors JM, Huffman LJ, Hedge GA 1988 Effects of thyrotropin on the vascular conductance of the thyroid gland. Endocrinology 122:921-929
293. Michalkiewicz M, Connors JM, Huffman LJ, Pietrzyk Z, Hedge GA 1991 Compensatory changes in thyroid blood flow are only partially mediated by thyrotropin. Am J Physiol 260:E608-E612
294. Eggo MC, Quiney VM, Campbell S 2003 Local factors regulating growth and function of human thyroid cells in vitro and in vivo. Mol Cell Endocrinol 213:47-58
295. Melander A, Ericson LE, Sundler F, Ingbar SH 1974 Sympathetic innervation of the mouse thyroid and its significance in thyroid hormone secretion. Endocrinology 94: 959-966
296. Melander A, Sundler F 1979 Presence and influence of cholinergic nerves in the mouse thyroid. Endocrinology 105:7-9
297. Huffman L, Hedge GA 1986 Effects of vasoactive intestinal peptide on thyroid blood flow and circulating thyroid hormone levels in the rat. Endocrinology 118:550-557
298. Ahrén B 1986 Thyroid neuroendocrinology: neural regulation of thyroid hormone secretion. Endocr Rev 7:149-155
299. Michalkiewicz M, Connors JM, Huffman LJ, Hedge GA 1989 Increases in thyroid gland blood flow after hemithyroidectomy in the rat. Endocrinology 124:1118-1123
300. Ahren B 1991 Regulatory peptides in the thyroid gland: a review on their localization and function. Acta Endocrinol (Copenh) 124:225-232
301. Young JB, Bürgi-Saville ME, Bürgi U, Landsberg L 2005 Sympathetic nervous system activity in rat thyroid: potential role in goitrogenesis. Am J Physiol Endocrinol Metab 288:E861-E867
302. Colin IM, Nava E, Toussaint D, Maiter DM, vanDenhove MF, Lüscher TF, Ketelslegers JM, Denef JF, Jameson JL 1995 Expression of nitric oxide synthase isoforms in the thyroid gland: evidence for a role of nitric oxide in vascular control during goiter formation. Endocrinology 136: 5283-5290
303. Bidey SP, Hill DJ, Eggo MC 1999 Growth factors and goitrogenesis. J Endocrinol 160:321-332
304. Ramsden JD 2000 Angiogenesis in the thyroid gland. J Endocrinol 166:475-480
305. Feige JJ, Baird A 1995 Crinopexy: extracellular regulation of growth factor action. Kidney Int Suppl 49:S15-S18
306. Eggo MC 2010 Molecular regulation of thyroid gland function. Curr Opin Endocrinol Diabetes Obes 17:396-401
307. de Araujo LF, Grozovsky R, dos Santos Pereira MJ, de Carvalho JJ, Vaisman M, Carvalho DP 2010 Expressions of vascular endothelial growth factor and nitric oxide synthase III in the thyroid gland of ovariectomized rats are upregulated by estrogen and selective estrogen receptor modulators. Thyroid 20:85-92
308. Jansson L, Andersson A, Bodin B, Kallskog O 2007 Pancreatic islet blood flow during euglycaemic, hyperinsulinaemic clamp in anaesthetized rats. Acta Physiol (Oxf) 189:319-324
309. Pedraza PE, Obregon MJ, Escobar-Morreale HF, del Rey FE, de Escobar GM 2006 Mechanisms of adaptation to iodine deficiency in rats: thyroid status is tissue specific. Its relevance for man. Endocrinology 147:2098-2108
310. Visser TJ 2006 The elemental importance of sufficient iodine intake: a trace is not enough. Endocrinology 147: 2095-2097
311. Kopp PA 2008 Reduce, recycle, reuse: iodotyrosine deiodinase in thyroid iodide metabolism. N Engl J Med 358: 1856-1859
312. Geers C, Colin IM, Gérard AC 2011 Delta-like 4/Notch pathway is differentially regulated in benign and malignant thyroid tissues. Thyroid 21:1323-1330
313. Rehman AO, Wang CY 2006 Notch signaling in the regulation of tumor angiogenesis. Trends Cell Biol 16:293-300
314. Sainson RC, Harris AL 2007 Anti-Dll4 therapy: can we block tumour growth by increasing angiogenesis Trends Mol Med 13:389-395
315. Roy M, Pear WS, Aster JC 2007 The multifaceted role of Notch in cancer. Curr Opin Genet Dev 17:52-59
316. Dufraine J, Funahashi Y, Kitajewski J 2008 Notch signaling regulates tumor angiogenesis by diverse mechanisms. Oncogene 27:5132-5137
317. Bray SJ 2006 Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 7:678-689
318. Ferretti E, Tosi E, Po A, Scipioni A, Morisi R, Espinola MS, Russo D, Durante C, Schlumberger M, Screpanti I, Filetti S, Gulino A 2008 Notch signaling is involved in expression of thyrocyte differentiation markers and is down-regulated in thyroid tumors. J Clin Endocrinol Metab 93:4080-4087
319. Studer H, Forster R, Conti A, Kohler H, Haeberli A, Engler H 1978 Transformation of normal follicles into thyrotropin-refractory "cold" follicles in the aging mouse thyroid gland. Endocrinology 102:1576-1586
320. Tamura S, Fujita H 1981 Fine structural aspects on the cold follicles in the aged mouse thyroid. Arch Histol Jpn 44: 177-188
321. Mestdagh C, Many MC, Halpern S, Briançon C, Fragu P, Denef JF 1990 Correlated autoradiographic and ion-microscopic study of the role of iodine in the formation of "cold" follicles in young and old mice. Cell Tissue Res 260:449-457
322. Meier CA 2000 Thyroid nodules: pathogenesis, diagnosis and treatment. Baillieres Best Pract Res Clin Endocrinol Metab 14:559-575
323. Peter HJ, Gerber H, Studer H, Smeds S 1985 Pathogenesis of heterogeneity in human multinodular goiter. A study on growth and function of thyroid tissue transplanted onto nude mice. J Clin Invest 76:1992-2002
324. Gerber H, Peter HJ, Studer H 1987 Age-related failure of endocytosis may be the pathogenetic mechanism responsible for "cold" follicle formation in the aging mouse thyroid. Endocrinology 120:1758-1764
325. Gerber H, Peter HJ, Bachmeier C, Kaempf J, Studer H 1987 Progressive recruitment of follicular cells with graded secretory responsiveness during stimulation of the thyroid gland by thyrotropin. Endocrinology 120:91-96
326. Smeds S, Peter HJ, Jörtsö E, Gerber H, Studer H 1987 Naturally occurring clones of cells with high intrinsic proliferation potential within the follicular epithelium of mouse thyroids. Cancer Res 47:1646-1651
327. Huber G, Derwahl M, Kaempf J, Peter HJ, Gerber H, Studer H 1990 Generation of intercellular heterogeneity of growth and function in cloned rat thyroid cells (FRTL-5). Endocrinology 126:1639-1645
328. Derwahl M, Studer H, Huber G, Gerber H, Peter HJ 1990 Intercellular propagation of individually programmed growth bursts in FRTL-5 cells. Implications for interpreting growth factor actions. Endocrinology 127:2104-2110
329. Roger PP, Baptist M, Dumont JE 1992 A mechanism generating heterogeneity in thyroid epithelial cells: suppression of the thyrotropin/cAMP-dependent mitogenic pathway after cell division induced by cAMP-independent factors. J Cell Biol 117:383-393
330. Studer H, Peter HJ, Gerber H 1989 Natural heterogeneity of thyroid cells: the basis for understanding thyroid function and nodular goiter growth. Endocr Rev 10:125-135
331. Kopp P, Kimura ET, Aeschimann S, Oestreicher M, Tobler A, Fey MF, Studer H 1994 Polyclonal and monoclonal thyroid nodules coexist within human multinodular goiters. J Clin Endocrinol Metab 79:134-139
332. Studer H, Derwahl M 1995 Mechanisms of nonneoplastic endocrine hyperplasia: a changing concept: a review focused on the thyroid gland. Endocr Rev 16:411-426
333. Kimura ET, Kopp P, Zbaeren J, Asmis LM, Ruchti C, Maciel RM, Studer H 1999 Expression of transforming growth factor β1, β2, and β3 in multinodular goiters and differentiated thyroid carcinomas: a comparative study. Thyroid 9:119-125
334. Derwahl M, Studer H 2000 Multinodular goitre: 'much more to it than simply iodine deficiency.' Baillieres Best Pract Res Clin Endocrinol Metab 14:577-600
335. Derwahl M, Studer H 2001 Nodular goiter and goiter nodules: Where iodine deficiency falls short of explaining the facts. Exp Clin Endocrinol Diabetes 109:250-260
336. Derwahl M, Studer H 2002 Hyperplasia versus adenoma in endocrine tissues: are they different Trends Endocrinol Metab 13:23-28
337. Many MC, Denef JF, Hamudi S, Haumont S 1986 Increased follicular heterogeneity in experimental colloid goiter produced by refeeding iodine excess after thyroid hyperplasia. Endocrinology 118:637-644
338. Jovanovic L, Delahunt B, McIver B, Eberhardt NL, Grebe SK 2003 Thyroid gland clonality revisited: the embryonal patch size of the normal human thyroid gland is very large, suggesting X-chromosome inactivation tumor clonality studies of thyroid tumors have to be interpreted with caution. J Clin Endocrinol Metab 88:3284-3291
339. Chen K, Wei Y, Sharp GC, Braley-Mullen H 2000 Characterization of thyroid fibrosis in a murine model of granulomatous experimental autoimmune thyroiditis. J Leukoc Biol 68:828-835
340. Cyniak-Magierska A, Januszkiewicz-Caulier J, Brzeziañska E, Lewiñski A 2010 Analysis of correlation between the process of thyroid fibrosis and TGFB1 gene expression level in fine-needle aspiration biopsy (FNAB) thyroid specimens collected from patients with Hashimoto's thyroiditis and non-toxic goitre. Exp Clin Endocrinol Diabetes 118: 420-426
341. Krohn K, Wohlgemuth S, Gerber H, Paschke R 2000 Hot microscopic areas of iodine-deficient euthyroid goitres contain constitutively activating TSH receptor mutations. J Pathol 192:37-42
342. Thomas T, Nowka K, Lan L, Derwahl M 2006 Expression of endoderm stem cell markers: evidence for the presence of adult stem cells in human thyroid glands. Thyroid 16: 537-544
343. Lin RY, Davies TF 2006 Derivation and characterization of thyrocyte-like cells from embryonic stem cells in vitro. Methods Mol Biol 330:249-261
344. Lan L, Cui D, Nowka K, Derwahl M 2007 Stem cells derived from goiters in adults form spheres in response to intense growth stimulation and require thyrotropin for differentiation into thyrocytes. J Clin Endocrinol Metab 92: 3681-3688
345. Hoshi N, Kusakabe T, Taylor BJ, Kimura S 2007 Side population cells in the mouse thyroid exhibit stem/progenitor cell-like characteristics. Endocrinology 148:42514258
346. Fierabracci A, Puglisi MA, Giuliani L, Mattarocci S, Gallinella-Muzi M 2008 Identification of an adult stem/progenitor cell-like population in the human thyroid. J Endocrinol 198:471-487
347. Derwahl M 2011 Linking stem cells to thyroid cancer. J Clin Endocrinol Metab 96:610-613
348. Davies TF, Latif R, Minsky NC, Ma R 2011 Clinical review: The emerging cell biology of thyroid stem cells. J Clin Endocrinol Metab 96:2692-2702
349. Reya T, Morrison SJ, Clarke MF, Weissman IL 2001 Stem cells, cancer, and cancer stem cells. Nature 414:105-111
350. Moore KA, Lemischka IR 2006 Stem cells and their niches. Science 311:1880-1885
351. Visvader JE, Lindeman GJ 2008 Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 8:755-768
352. Arufe MC, Lu M, Kubo A, Keller G, Davies TF, Lin RY 2006 Directed differentiation of mouse embryonic stem cells into thyroid follicular cells. Endocrinology 147: 3007-3015
353. Lin RY, Kubo A, Keller GM, Davies TF 2003 Committing embryonic stem cells to differentiate into thyrocyte-like cells in vitro. Endocrinology 144:2644-2649
354. Mitsutake N, Iwao A, Nagai K, Namba H, Ohtsuru A, Saenko V, Yamashita S 2007 Characterization of side population in thyroid cancer cell lines: cancer stem-like cells are enriched partly but not exclusively. Endocrinology 148:1797-1803
355. Zito G, Richiusa P, Bommarito A, Carissimi E, Russo L, Coppola A, Zerilli M, Rodolico V, Criscimanna A, Amato M, Pizzolanti G, Galluzzo A, Giordano C 2008 In vitro identification and characterization of CD133(pos) cancer stem-like cells in anaplastic thyroid carcinoma cell lines. PLoS One 3:e3544
356. Todaro M, Iovino F, Eterno V, Cammareri P, Gambara G, Espina V, Gulotta G, Dieli F, Giordano S, De Maria R, Stassi G 2010 Tumorigenic and metastatic activity of human thyroid cancer stem cells. Cancer Res 70:8874-8885
357. Malaguarnera R, Frasca F, Garozzo A, Gianì F, Pandini G, Vella V, Vigneri R, Belfiore A 2011 Insulin receptor isoforms and insulin-like growth factor receptor in human follicular cell precursors from papillary thyroid cancer and normal thyroid. J Clin Endocrinol Metab 96:766-774